{"id":10214,"date":"2022-10-18T07:09:49","date_gmt":"2022-10-17T23:09:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10214"},"modified":"2022-10-18T07:09:49","modified_gmt":"2022-10-17T23:09:49","slug":"he-yuanjuns-team-published-research-in-bioorganic-medicinal-chemistry-letters-in-2014-01-01-936250-20-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10214","title":{"rendered":"He, Yuanjun’s team published research in Bioorganic & Medicinal Chemistry Letters in 2014-01-01 | 936250-20-3"},"content":{"rendered":"

He, Yuanjun; Duckett, Derek; Chen, Weimin; Ling, Yuan Yuan; Cameron, Michael D.; Lin, Li; Ruiz, Claudia H.; LoGrasso, Philip V.; Kamenecka, Theodore M.; Koenig, Marcel published the artcile< Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors>, Computed Properties of 936250-20-3<\/a>, the main research area is pyridylisoxazole preparation JNK inhibitor SAR selectivity p38; Isoxazole; JNK; Kinase; c-Jun.<\/p>\n

The design and synthesis of isoxazole I is described, a potent JNK inhibitor with two fold selectivity over p38. Optimization of this scaffold led to compounds II and III which showed greatly improved selectivity over p38 by maintaining the JNK3 potency of compound I. Extensive SAR studies will be described as well as preliminary in vivo data of the two lead compounds<\/p>\n

Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 936250-20-3 belongs to class pyrazoles-derivatives, and the molecular formula is C10H17BN2O2, Computed Properties of 936250-20-3<\/a>.<\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 936250-20-3 belongs to class pyrazoles-derivatives, and the molecular formula is C10H17BN2O2, Computed Properties of 936250-20-3<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[736,131],"tags":[716],"class_list":["post-10214","post","type-post","status-publish","format-standard","hentry","category-936250-20-3","category-pyrazoles-derivatives","tag-m-w200-250"],"yoast_head":"\nHe, Yuanjun's team published research in Bioorganic & Medicinal Chemistry Letters in 2014-01-01 | 936250-20-3 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"He, Yuanjun; Duckett, Derek; Chen, Weimin; Ling, Yuan Yuan; Cameron, Michael D.; Lin, Li; Ruiz, Claudia H.; LoGrasso, Philip V.; Kamenecka, Theodore M.; Koenig, Marcel published the artcile< Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors>, Computed Properties of 936250-20-3, the main research area is pyridylisoxazole preparation JNK inhibitor SAR selectivity p38; Isoxazole; JNK; Kinase; c-Jun.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10214\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"He, Yuanjun's team published research in Bioorganic & Medicinal Chemistry Letters in 2014-01-01 | 936250-20-3 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"He, Yuanjun; Duckett, Derek; Chen, Weimin; Ling, Yuan Yuan; Cameron, Michael D.; Lin, Li; Ruiz, Claudia H.; LoGrasso, Philip V.; Kamenecka, Theodore M.; Koenig, Marcel published the artcile< Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors>, Computed Properties of 936250-20-3, the main research area is pyridylisoxazole preparation JNK inhibitor SAR selectivity p38; Isoxazole; JNK; Kinase; c-Jun.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10214\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-17T23:09:49+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10214\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10214\",\"name\":\"He, Yuanjun's team published research in Bioorganic & Medicinal Chemistry Letters in 2014-01-01 | 936250-20-3 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-10-17T23:09:49+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"He, Yuanjun; Duckett, Derek; Chen, Weimin; Ling, Yuan Yuan; Cameron, Michael D.; Lin, Li; Ruiz, Claudia H.; LoGrasso, Philip V.; Kamenecka, Theodore M.; Koenig, Marcel published the artcile< Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors>, Computed Properties of 936250-20-3, the main research area is pyridylisoxazole preparation JNK inhibitor SAR selectivity p38; Isoxazole; JNK; Kinase; c-Jun.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10214#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=10214\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10214#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"He, Yuanjun’s team published research in Bioorganic & Medicinal Chemistry Letters in 2014-01-01 | 936250-20-3\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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