{"id":10202,"date":"2022-10-17T09:12:57","date_gmt":"2022-10-17T01:12:57","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10202"},"modified":"2022-10-17T09:12:57","modified_gmt":"2022-10-17T01:12:57","slug":"subramanyam-chakrapanis-team-published-research-in-synthetic-communications-in-1995-cas-15366-34-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10202","title":{"rendered":"Subramanyam, Chakrapani&#8217;s team published research in Synthetic Communications in 1995 | CAS: 15366-34-4"},"content":{"rendered":"<p><a href=\"https:\/\/www.ambeed.com\/products\/15366-34-4.html\">HPLC of Formula: 15366-34-4<\/a>In 1995 ,\u300a4-Methoxybenzyl, a versatile protecting group for the regiospecific lithiation and functionalization of pyrazoles\u300b appeared in Synthetic Communications. The author of the article were Subramanyam, Chakrapani. The article conveys some information:<\/p>\n<p>The use of the 4-methoxybenzyl protecting group for the regiospecific metalation\/functionalization of pyrazole was reported. The protection of 1H-pyrazole gave 1-[(4-methoxyphenyl)methyl]-1H-pyrazole which underwent regioselective lithiation to give 5-lithio-1-[(4-methoxyphenyl)methyl]-1H-pyrazole. Treatment of the latter with Et N-methoxy-N-methylcarbamate gave di-[1-[(4-methoxyphenyl)methyl]-1H-pyrazol-5-yl] methanone. Deprotection of the latter gave the desired di(1H-pyrazol-3-yl) methanone.Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4<a href=\"https:\/\/www.ambeed.com\/products\/15366-34-4.html\">HPLC of Formula: 15366-34-4<\/a>) was used in this study.<\/p>\n<p>Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.<a href=\"https:\/\/www.ambeed.com\/products\/15366-34-4.html\">HPLC of Formula: 15366-34-4<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.<a href=\"https:\/\/www.ambeed.com\/products\/15366-34-4.html\">HPLC of Formula: 15366-34-4<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[174,131],"tags":[128],"class_list":["post-10202","post","type-post","status-publish","format-standard","hentry","category-15366-34-4","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Subramanyam, Chakrapani&#039;s team published research in Synthetic Communications in 1995 | CAS: 15366-34-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"HPLC of Formula: 15366-34-4In 1995 ,\u300a4-Methoxybenzyl, a versatile protecting group for the regiospecific lithiation and functionalization of pyrazoles\u300b appeared in Synthetic Communications. 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