{"id":10190,"date":"2022-10-17T09:12:10","date_gmt":"2022-10-17T01:12:10","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10190"},"modified":"2022-10-17T09:12:10","modified_gmt":"2022-10-17T01:12:10","slug":"nale-sagar-d-s-team-published-research-in-asian-journal-of-organic-chemistry-in-2021-cas-20154-03-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10190","title":{"rendered":"Nale, Sagar D.&#8217;s team published research in Asian Journal of Organic Chemistry in 2021 | CAS: 20154-03-4"},"content":{"rendered":"<p>Nale, Sagar D.; Thombal, Raju S.; Lee, Yong Rok published their research in Asian Journal of Organic Chemistry in 2021. The article was titled \u300aRuthenium(II)-Catalyzed Direct Ortho Functionalization of 1-Arylpyrazoles with Maleimides: A Condition Controlled Installation of Succinimides and Maleimides on Arenes\u300b.<a href=\"https:\/\/www.ambeed.com\/products\/20154-03-4.html\">Electric Literature of C4H3F3N2<\/a> The article contains the following contents:<\/p>\n<p>Ruthenium(II)-catalyzed switchable ortho functionalization of 1-arylpyrazoles I (R1 = 2-Me, 4-OMe, 4-Cl, etc.; R2 = H, Me, CF3) and 1-(1-naphthalenyl)-1H-pyrazole with maleimides II (R3 = C2H5, C6H5, 4-BrC6H4, etc.) is developed in this study. This divergent reaction proceeds via five-membered ruthenacycle formation and selectively installs diverse succinimides III (R4 = 3-Me, 5-OMe, 5-Cl, etc.) and maleimides IV substituents on the aromatic ring of 1-arylpyrazoles I through alkylation and alkenylation under acidic and basic conditions. This methodol. features broad substrate scope, high functional group tolerance, selective functionalization, and superior reactivity. The experimental part of the paper was very detailed, including the reaction process of 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4<a href=\"https:\/\/www.ambeed.com\/products\/20154-03-4.html\">Electric Literature of C4H3F3N2<\/a>)<\/p>\n<p>3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.<a href=\"https:\/\/www.ambeed.com\/products\/20154-03-4.html\">Electric Literature of C4H3F3N2<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.<a href=\"https:\/\/www.ambeed.com\/products\/20154-03-4.html\">Electric Literature of C4H3F3N2<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[205,131],"tags":[128],"class_list":["post-10190","post","type-post","status-publish","format-standard","hentry","category-20154-03-4","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Nale, Sagar D.&#039;s team published research in Asian Journal of Organic Chemistry in 2021 | CAS: 20154-03-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Nale, Sagar D.; Thombal, Raju S.; Lee, Yong Rok published their research in Asian Journal of Organic Chemistry in 2021. The article was titled \u300aRuthenium(II)-Catalyzed Direct Ortho Functionalization of 1-Arylpyrazoles with Maleimides: A Condition Controlled Installation of Succinimides and Maleimides on Arenes\u300b.Electric Literature of C4H3F3N2 The article contains the following contents:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10190\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nale, Sagar D.&#039;s team published research in Asian Journal of Organic Chemistry in 2021 | CAS: 20154-03-4 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Nale, Sagar D.; Thombal, Raju S.; Lee, Yong Rok published their research in Asian Journal of Organic Chemistry in 2021. The article was titled \u300aRuthenium(II)-Catalyzed Direct Ortho Functionalization of 1-Arylpyrazoles with Maleimides: A Condition Controlled Installation of Succinimides and Maleimides on Arenes\u300b.Electric Literature of C4H3F3N2 The article contains the following contents:\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10190\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-17T01:12:10+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10190\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10190\",\"name\":\"Nale, Sagar D.'s team published research in Asian Journal of Organic Chemistry in 2021 | CAS: 20154-03-4 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-10-17T01:12:10+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Nale, Sagar D.; Thombal, Raju S.; Lee, Yong Rok published their research in Asian Journal of Organic Chemistry in 2021. The article was titled \u300aRuthenium(II)-Catalyzed Direct Ortho Functionalization of 1-Arylpyrazoles with Maleimides: A Condition Controlled Installation of Succinimides and Maleimides on Arenes\u300b.Electric Literature of C4H3F3N2 The article contains the following contents:\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10190#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=10190\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10190#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Nale, Sagar D.&#8217;s team published research in Asian Journal of Organic Chemistry in 2021 | CAS: 20154-03-4\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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The article was titled \u300aRuthenium(II)-Catalyzed Direct Ortho Functionalization of 1-Arylpyrazoles with Maleimides: A Condition Controlled Installation of Succinimides and Maleimides on Arenes\u300b.Electric Literature of C4H3F3N2 The article contains the following contents:","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=10190","og_locale":"en_US","og_type":"article","og_title":"Nale, Sagar D.'s team published research in Asian Journal of Organic Chemistry in 2021 | CAS: 20154-03-4 | pyrazoles-derivatives","og_description":"Nale, Sagar D.; Thombal, Raju S.; Lee, Yong Rok published their research in Asian Journal of Organic Chemistry in 2021. 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