{"id":10183,"date":"2022-10-17T09:12:10","date_gmt":"2022-10-17T01:12:10","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10183"},"modified":"2022-10-17T09:12:10","modified_gmt":"2022-10-17T01:12:10","slug":"hatcher-john-m-s-team-published-research-in-acs-medicinal-chemistry-letters-in-2016-cas-847818-72-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10183","title":{"rendered":"Hatcher, John M.’s team published research in ACS Medicinal Chemistry Letters in 2016 | CAS: 847818-72-8"},"content":{"rendered":"

HPLC of Formula: 847818-72-8<\/a>On May 12, 2016 ,\u300aDiscovery of a Highly Potent and Selective Indenoindolone Type 1 Pan-FLT3 Inhibitor\u300b appeared in ACS Medicinal Chemistry Letters. The author of the article were Hatcher, John M.; Weisberg, Ellen; Sim, Taebo; Stone, Richard M.; Liu, Suiyang; Griffin, James D.; Gray, Nathanael S.. The article conveys some information:<\/p>\n

For a subpopulation of acute myeloid leukemia (AML) patients, the mutationally activated tyrosine kinase FLT3, has emerged as a promising target for therapy. The development of drug resistance due to mutation is a growing concern for mutant FLT3 inhibitors, such as PKC412, Quizartinib, PLX3397, and Crenolanib. Thus, there is a need to develop novel FLT3 inhibitors that overcome these mutations. Here the authors report the development of a novel type I ATP competitive inhibitor, I, that is extremely potent and selective for FLT3. I also has the highest affinity for three constitutively active isoforms of FLT3 (FLT3-ITD, FLT3-N841I, and FLT3-D835V) compared to a panel 456 other kinases. The unique and specific kinase inhibition profile suggests that this chemotype may represent an attractive starting point for the development of further improved FLT3 inhibitors with therapeutic potential in tumors harboring deregulated FLT3 activity. In the experimental materials used by the author, we found N,N-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-propanamine(cas: 847818-72-8HPLC of Formula: 847818-72-8<\/a>)<\/p>\n

N,N-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-propanamine(cas: 847818-72-8) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities. HPLC of Formula: 847818-72-8<\/a><\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

N,N-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-propanamine(cas: 847818-72-8) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities. HPLC of Formula: 847818-72-8<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[746,131],"tags":[129],"class_list":["post-10183","post","type-post","status-publish","format-standard","hentry","category-847818-72-8","category-pyrazoles-derivatives","tag-200-300"],"yoast_head":"\nHatcher, John M.'s team published research in ACS Medicinal Chemistry Letters in 2016 | CAS: 847818-72-8 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"HPLC of Formula: 847818-72-8On May 12, 2016 ,\u300aDiscovery of a Highly Potent and Selective Indenoindolone Type 1 Pan-FLT3 Inhibitor\u300b appeared in ACS Medicinal Chemistry Letters. The author of the article were Hatcher, John M.; Weisberg, Ellen; Sim, Taebo; Stone, Richard M.; Liu, Suiyang; Griffin, James D.; Gray, Nathanael S.. 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