{"id":10171,"date":"2022-10-17T09:11:19","date_gmt":"2022-10-17T01:11:19","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10171"},"modified":"2022-10-17T09:11:19","modified_gmt":"2022-10-17T01:11:19","slug":"manfredini-stefanos-team-published-research-in-journal-of-medicinal-chemistry-in-1992-cas-15366-34-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10171","title":{"rendered":"Manfredini, Stefano&#8217;s team published research in Journal of Medicinal Chemistry in 1992 | CAS: 15366-34-4"},"content":{"rendered":"<p><a href=\"https:\/\/www.ambeed.com\/products\/15366-34-4.html\">Reference of Methyl 1H-pyrazole-3-carboxylate<\/a>In 1992 ,\u300aPyrazole-related nucleosides. Synthesis and antiviral\/antitumor activity of some substituted pyrazole and pyrazolo[4,3-d]-1,2,3-triazin-4-one nucleosides\u300b appeared in Journal of Medicinal Chemistry. The author of the article were Manfredini, Stefano; Bazzanini, Rita; Baraldi, Pier Giovanni; Guarneri, Mario; Simoni, Daniele; Marongiu, Maria E.; Pani, Alessandra; La Colla, Paolo; Tramontano, Enzo. The article conveys some information:<\/p>\n<p>Several pyrazole and pyrazolo[4,3-d]-1,2,3-triazin-4-oneribonucleosides, e.g. I (R = R1 = H; R = R1 = H, Me, R = Br, iodo, R1 = H) and II (R2 = Me, CMe3, CH2Ph), were prepared and tested for antiviral\/antitumor activities. Appropriate heterocyclic bases were prepared by standard methodologies. All compounds were evaluated in vitro for cytostatic and antiviral activity. In the experiment, the researchers used many compounds, for example, Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4<a href=\"https:\/\/www.ambeed.com\/products\/15366-34-4.html\">Reference of Methyl 1H-pyrazole-3-carboxylate<\/a>)<\/p>\n<p>Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.<a href=\"https:\/\/www.ambeed.com\/products\/15366-34-4.html\">Reference of Methyl 1H-pyrazole-3-carboxylate<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.<a href=\"https:\/\/www.ambeed.com\/products\/15366-34-4.html\">Reference of Methyl 1H-pyrazole-3-carboxylate<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[174,131],"tags":[128],"class_list":["post-10171","post","type-post","status-publish","format-standard","hentry","category-15366-34-4","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Manfredini, Stefano&#039;s team published research in Journal of Medicinal Chemistry in 1992 | CAS: 15366-34-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Reference of Methyl 1H-pyrazole-3-carboxylateIn 1992 ,\u300aPyrazole-related nucleosides. Synthesis and antiviral\/antitumor activity of some substituted pyrazole and pyrazolo[4,3-d]-1,2,3-triazin-4-one nucleosides\u300b appeared in Journal of Medicinal Chemistry. The author of the article were Manfredini, Stefano; Bazzanini, Rita; Baraldi, Pier Giovanni; Guarneri, Mario; Simoni, Daniele; Marongiu, Maria E.; Pani, Alessandra; La Colla, Paolo; Tramontano, Enzo. The article conveys some information:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10171\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Manfredini, Stefano&#039;s team published research in Journal of Medicinal Chemistry in 1992 | CAS: 15366-34-4 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Reference of Methyl 1H-pyrazole-3-carboxylateIn 1992 ,\u300aPyrazole-related nucleosides. Synthesis and antiviral\/antitumor activity of some substituted pyrazole and pyrazolo[4,3-d]-1,2,3-triazin-4-one nucleosides\u300b appeared in Journal of Medicinal Chemistry. The author of the article were Manfredini, Stefano; Bazzanini, Rita; Baraldi, Pier Giovanni; Guarneri, Mario; Simoni, Daniele; Marongiu, Maria E.; Pani, Alessandra; La Colla, Paolo; Tramontano, Enzo. 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Synthesis and antiviral\/antitumor activity of some substituted pyrazole and pyrazolo[4,3-d]-1,2,3-triazin-4-one nucleosides\u300b appeared in Journal of Medicinal Chemistry. The author of the article were Manfredini, Stefano; Bazzanini, Rita; Baraldi, Pier Giovanni; Guarneri, Mario; Simoni, Daniele; Marongiu, Maria E.; Pani, Alessandra; La Colla, Paolo; Tramontano, Enzo. 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Synthesis and antiviral\/antitumor activity of some substituted pyrazole and pyrazolo[4,3-d]-1,2,3-triazin-4-one nucleosides\u300b appeared in Journal of Medicinal Chemistry. The author of the article were Manfredini, Stefano; Bazzanini, Rita; Baraldi, Pier Giovanni; Guarneri, Mario; Simoni, Daniele; Marongiu, Maria E.; Pani, Alessandra; La Colla, Paolo; Tramontano, Enzo. The article conveys some information:","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=10171","og_locale":"en_US","og_type":"article","og_title":"Manfredini, Stefano's team published research in Journal of Medicinal Chemistry in 1992 | CAS: 15366-34-4 | pyrazoles-derivatives","og_description":"Reference of Methyl 1H-pyrazole-3-carboxylateIn 1992 ,\u300aPyrazole-related nucleosides. 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