{"id":10165,"date":"2022-10-17T09:11:19","date_gmt":"2022-10-17T01:11:19","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10165"},"modified":"2022-10-17T09:11:19","modified_gmt":"2022-10-17T01:11:19","slug":"goncalves-helena-a-s-team-published-research-in-journal-of-fluorine-chemistry-in-2016-cas-15366-34-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10165","title":{"rendered":"Goncalves, Helena A.&#8217;s team published research in Journal of Fluorine Chemistry in 2016 | CAS: 15366-34-4"},"content":{"rendered":"<p>\u300aSynthesis of 2,2,2-trifluoroethyl 1H-pyrazole carboxylates: Insight into the mechanism of trichloromethyl group hydrolysis\u300b was written by Goncalves, Helena A.; Pereira, Bruna A.; Teixeira, Wystan K. O.; Moura, Sidnei; Flores, Darlene C.; Flores, Alex F. C.. <a href=\"https:\/\/www.ambeed.com\/products\/15366-34-4.html\">HPLC of Formula: 15366-34-4<\/a>This research focused ontrichloro methoxyalkenone trifluoroethanol cyclocondensation hydrolysis; methyl pyrazole carboxylate trifluoroethyl pyrazole carboxylate preparation green chem; trifluoroethanol trichloro hydroxyalkenone cyclocondensation; trifluoroethyl pyrazole carboxylate preparation green chem. The article conveys some information:<\/p>\n<p>One-pot synthesis of 2,2,2-trifluoroethyl 1H-pyrazole-5(3)-carboxylates and via cyclocondensation of 1,1,1-trichloro-4-alkoxy-3-alken-2-ones, 1,1,1-trichloro-2,4-alkanediones and 1-aryl-4,4,4-trichloro-1,3-butanediones with hydrazine hydrochloride in 2,2,2-trifluoroethanol (TFE) was reported. Considering the low nucleophilicity of TFE in relation to methanol or ethanol, the results provided evidence for the mechanism of hydrolysis of the trichloromethyl group attached to the 1H-pyrazol ring. In the experiment, the researchers used Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4<a href=\"https:\/\/www.ambeed.com\/products\/15366-34-4.html\">HPLC of Formula: 15366-34-4<\/a>)<\/p>\n<p>Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.<a href=\"https:\/\/www.ambeed.com\/products\/15366-34-4.html\">HPLC of Formula: 15366-34-4<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.<a href=\"https:\/\/www.ambeed.com\/products\/15366-34-4.html\">HPLC of Formula: 15366-34-4<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[174,131],"tags":[128],"class_list":["post-10165","post","type-post","status-publish","format-standard","hentry","category-15366-34-4","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Goncalves, Helena A.&#039;s team published research in Journal of Fluorine Chemistry in 2016 | CAS: 15366-34-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"\u300aSynthesis of 2,2,2-trifluoroethyl 1H-pyrazole carboxylates: Insight into the mechanism of trichloromethyl group hydrolysis\u300b was written by Goncalves, Helena A.; Pereira, Bruna A.; Teixeira, Wystan K. O.; Moura, Sidnei; Flores, Darlene C.; Flores, Alex F. C.. HPLC of Formula: 15366-34-4This research focused ontrichloro methoxyalkenone trifluoroethanol cyclocondensation hydrolysis; methyl pyrazole carboxylate trifluoroethyl pyrazole carboxylate preparation green chem; trifluoroethanol trichloro hydroxyalkenone cyclocondensation; trifluoroethyl pyrazole carboxylate preparation green chem. The article conveys some information:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10165\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Goncalves, Helena A.&#039;s team published research in Journal of Fluorine Chemistry in 2016 | CAS: 15366-34-4 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"\u300aSynthesis of 2,2,2-trifluoroethyl 1H-pyrazole carboxylates: Insight into the mechanism of trichloromethyl group hydrolysis\u300b was written by Goncalves, Helena A.; Pereira, Bruna A.; Teixeira, Wystan K. O.; Moura, Sidnei; Flores, Darlene C.; Flores, Alex F. C.. HPLC of Formula: 15366-34-4This research focused ontrichloro methoxyalkenone trifluoroethanol cyclocondensation hydrolysis; methyl pyrazole carboxylate trifluoroethyl pyrazole carboxylate preparation green chem; trifluoroethanol trichloro hydroxyalkenone cyclocondensation; trifluoroethyl pyrazole carboxylate preparation green chem. 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O.; Moura, Sidnei; Flores, Darlene C.; Flores, Alex F. C.. HPLC of Formula: 15366-34-4This research focused ontrichloro methoxyalkenone trifluoroethanol cyclocondensation hydrolysis; methyl pyrazole carboxylate trifluoroethyl pyrazole carboxylate preparation green chem; trifluoroethanol trichloro hydroxyalkenone cyclocondensation; trifluoroethyl pyrazole carboxylate preparation green chem. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Goncalves, Helena A.'s team published research in Journal of Fluorine Chemistry in 2016 | CAS: 15366-34-4 | pyrazoles-derivatives","description":"\u300aSynthesis of 2,2,2-trifluoroethyl 1H-pyrazole carboxylates: Insight into the mechanism of trichloromethyl group hydrolysis\u300b was written by Goncalves, Helena A.; Pereira, Bruna A.; Teixeira, Wystan K. O.; Moura, Sidnei; Flores, Darlene C.; Flores, Alex F. C.. HPLC of Formula: 15366-34-4This research focused ontrichloro methoxyalkenone trifluoroethanol cyclocondensation hydrolysis; methyl pyrazole carboxylate trifluoroethyl pyrazole carboxylate preparation green chem; trifluoroethanol trichloro hydroxyalkenone cyclocondensation; trifluoroethyl pyrazole carboxylate preparation green chem. 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HPLC of Formula: 15366-34-4This research focused ontrichloro methoxyalkenone trifluoroethanol cyclocondensation hydrolysis; methyl pyrazole carboxylate trifluoroethyl pyrazole carboxylate preparation green chem; trifluoroethanol trichloro hydroxyalkenone cyclocondensation; trifluoroethyl pyrazole carboxylate preparation green chem. 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O.; Moura, Sidnei; Flores, Darlene C.; Flores, Alex F. C.. HPLC of Formula: 15366-34-4This research focused ontrichloro methoxyalkenone trifluoroethanol cyclocondensation hydrolysis; methyl pyrazole carboxylate trifluoroethyl pyrazole carboxylate preparation green chem; trifluoroethanol trichloro hydroxyalkenone cyclocondensation; trifluoroethyl pyrazole carboxylate preparation green chem. 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