{"id":10124,"date":"2022-10-14T07:45:44","date_gmt":"2022-10-13T23:45:44","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10124"},"modified":"2022-10-14T07:45:44","modified_gmt":"2022-10-13T23:45:44","slug":"kwiatkowski-jaceks-team-published-research-in-journal-of-medicinal-chemistry-in-2020-cas-957345-28-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10124","title":{"rendered":"Kwiatkowski, Jacek&#8217;s team published research in Journal of Medicinal Chemistry in 2020 | CAS: 957345-28-7"},"content":{"rendered":"<p>Kwiatkowski, Jacek; Liu, Boping; Pang, Shermaine; Binte Ahmad, Nur Huda; Wang, Gang; Poulsen, Anders; Yang, Haiyan; Poh, Yong Rui; Tee, Doris Hui Ying; Ong, Esther; Retna, Priya; Dinie, Nurul; Kwek, Perlyn; Wee, John Liang Kuan; Manoharan, Vithya; Low, Choon Bing; Seah, Peck Gee; Pendharkar, Vishal; Sangthongpitag, Kanda; Joy, Joma; Baburajendran, Nithya; Jansson, Anna Elisabet; Nacro, Kassoum; Hill, Jeffrey; Keller, Thomas H.; Hung, Alvin W. published an article on January 23 ,2020. The article was titled \u300aStepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2\u300b, and you may find the article in Journal of Medicinal Chemistry.<a href=\"https:\/\/www.ambeed.com\/products\/957345-28-7.html\">Quality Control of 4-Bromo-5-cyclopropyl-1H-pyrazole<\/a> The information in the text is summarized as follows:<\/p>\n<p>Dysregulation of translation initiation factor 4E (eIF4E) activity occurs in various cancers. Mitogen-activated protein kinase (MAPK) interacting kinases 1 and 2 (MNK1 and MNK2) play a fundamental role in activation of eIF4E. Structure-activity relationship-driven expansion of a fragment hit led to discovery of dual MNK1 and MNK2 inhibitors based on a novel pyridine-benzamide scaffold. The compounds possess promising in vitro and in vivo pharmacokinetic profiles and show potent on target inhibition of eIF4E phosphorylation in cells. In the experiment, the researchers used 4-Bromo-5-cyclopropyl-1H-pyrazole(cas: 957345-28-7<a href=\"https:\/\/www.ambeed.com\/products\/957345-28-7.html\">Quality Control of 4-Bromo-5-cyclopropyl-1H-pyrazole<\/a>)<\/p>\n<p>4-Bromo-5-cyclopropyl-1H-pyrazole(cas: 957345-28-7) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, monoamine oxidase inhibitory, anti-inflammatory,  antidiabetic and antibacterial activities. <a href=\"https:\/\/www.ambeed.com\/products\/957345-28-7.html\">Quality Control of 4-Bromo-5-cyclopropyl-1H-pyrazole<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>4-Bromo-5-cyclopropyl-1H-pyrazole(cas: 957345-28-7) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, monoamine oxidase inhibitory, anti-inflammatory,  antidiabetic and antibacterial activities. <a href=\"https:\/\/www.ambeed.com\/products\/957345-28-7.html\">Quality Control of 4-Bromo-5-cyclopropyl-1H-pyrazole<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[757,131],"tags":[128],"class_list":["post-10124","post","type-post","status-publish","format-standard","hentry","category-957345-28-7","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Kwiatkowski, Jacek&#039;s team published research in Journal of Medicinal Chemistry in 2020 | CAS: 957345-28-7 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Kwiatkowski, Jacek; Liu, Boping; Pang, Shermaine; Binte Ahmad, Nur Huda; Wang, Gang; Poulsen, Anders; Yang, Haiyan; Poh, Yong Rui; Tee, Doris Hui Ying; Ong, Esther; Retna, Priya; Dinie, Nurul; Kwek, Perlyn; Wee, John Liang Kuan; Manoharan, Vithya; Low, Choon Bing; Seah, Peck Gee; Pendharkar, Vishal; Sangthongpitag, Kanda; Joy, Joma; Baburajendran, Nithya; Jansson, Anna Elisabet; Nacro, Kassoum; Hill, Jeffrey; Keller, Thomas H.; Hung, Alvin W. published an article on January 23 ,2020. The article was titled \u300aStepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2\u300b, and you may find the article in Journal of Medicinal Chemistry.Quality Control of 4-Bromo-5-cyclopropyl-1H-pyrazole The information in the text is summarized as follows:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10124\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Kwiatkowski, Jacek&#039;s team published research in Journal of Medicinal Chemistry in 2020 | CAS: 957345-28-7 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Kwiatkowski, Jacek; Liu, Boping; Pang, Shermaine; Binte Ahmad, Nur Huda; Wang, Gang; Poulsen, Anders; Yang, Haiyan; Poh, Yong Rui; Tee, Doris Hui Ying; Ong, Esther; Retna, Priya; Dinie, Nurul; Kwek, Perlyn; Wee, John Liang Kuan; Manoharan, Vithya; Low, Choon Bing; Seah, Peck Gee; Pendharkar, Vishal; Sangthongpitag, Kanda; Joy, Joma; Baburajendran, Nithya; Jansson, Anna Elisabet; Nacro, Kassoum; Hill, Jeffrey; Keller, Thomas H.; Hung, Alvin W. published an article on January 23 ,2020. The article was titled \u300aStepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2\u300b, and you may find the article in Journal of Medicinal Chemistry.Quality Control of 4-Bromo-5-cyclopropyl-1H-pyrazole The information in the text is summarized as follows:\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10124\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-13T23:45:44+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10124\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10124\",\"name\":\"Kwiatkowski, Jacek's team published research in Journal of Medicinal Chemistry in 2020 | CAS: 957345-28-7 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-10-13T23:45:44+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Kwiatkowski, Jacek; Liu, Boping; Pang, Shermaine; Binte Ahmad, Nur Huda; Wang, Gang; Poulsen, Anders; Yang, Haiyan; Poh, Yong Rui; Tee, Doris Hui Ying; Ong, Esther; Retna, Priya; Dinie, Nurul; Kwek, Perlyn; Wee, John Liang Kuan; Manoharan, Vithya; Low, Choon Bing; Seah, Peck Gee; Pendharkar, Vishal; Sangthongpitag, Kanda; Joy, Joma; Baburajendran, Nithya; Jansson, Anna Elisabet; Nacro, Kassoum; Hill, Jeffrey; Keller, Thomas H.; Hung, Alvin W. published an article on January 23 ,2020. The article was titled \u300aStepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2\u300b, and you may find the article in Journal of Medicinal Chemistry.Quality Control of 4-Bromo-5-cyclopropyl-1H-pyrazole The information in the text is summarized as follows:\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10124#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=10124\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10124#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Kwiatkowski, Jacek&#8217;s team published research in Journal of Medicinal Chemistry in 2020 | CAS: 957345-28-7\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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The article was titled \u300aStepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2\u300b, and you may find the article in Journal of Medicinal Chemistry.Quality Control of 4-Bromo-5-cyclopropyl-1H-pyrazole The information in the text is summarized as follows:","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=10124","og_locale":"en_US","og_type":"article","og_title":"Kwiatkowski, Jacek's team published research in Journal of Medicinal Chemistry in 2020 | CAS: 957345-28-7 | pyrazoles-derivatives","og_description":"Kwiatkowski, Jacek; Liu, Boping; Pang, Shermaine; Binte Ahmad, Nur Huda; Wang, Gang; Poulsen, Anders; Yang, Haiyan; Poh, Yong Rui; Tee, Doris Hui Ying; Ong, Esther; Retna, Priya; Dinie, Nurul; Kwek, Perlyn; Wee, John Liang Kuan; Manoharan, Vithya; Low, Choon Bing; Seah, Peck Gee; Pendharkar, Vishal; Sangthongpitag, Kanda; Joy, Joma; Baburajendran, Nithya; Jansson, Anna Elisabet; Nacro, Kassoum; Hill, Jeffrey; Keller, Thomas H.; Hung, Alvin W. published an article on January 23 ,2020. 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The article was titled \u300aStepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2\u300b, and you may find the article in Journal of Medicinal Chemistry.Quality Control of 4-Bromo-5-cyclopropyl-1H-pyrazole The information in the text is summarized as follows:","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=10124#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=10124"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=10124#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"https:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"Kwiatkowski, Jacek&#8217;s team published research in Journal of Medicinal Chemistry in 2020 | CAS: 957345-28-7"}]},{"@type":"WebSite","@id":"https:\/\/www.pyrazoles-derivatives.com\/#website","url":"https:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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