{"id":1012,"date":"2020-11-12T10:53:29","date_gmt":"2020-11-12T02:53:29","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1012"},"modified":"2020-11-12T10:53:29","modified_gmt":"2020-11-12T02:53:29","slug":"research-on-new-synthetic-routes-about-1453-58-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1012","title":{"rendered":"Research on new synthetic routes about 1453-58-3"},"content":{"rendered":"

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1453-58-3, name is 3-Methylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. 1453-58-3<\/a><\/p>\n

Potassium t-butoxide (3.9 g, 0.33 mmol) was dissolved in DMSO (25 mL). Tothis solution was added 3-methyl pyrazole (2.7 g, 0.33 mmol) and the reactionwas heated at 50 C for 30 min. 1-Bromo-4-chloro-2-fluorobenzene (4.6 g, 0.22mmol) was then added and the reaction was stirred at 50 C for 16 h. The reaction was cooled to RT and extractedwith water and ethyl acetate, washed with brine, and dried over Na2SO4,filtered and concentrated in vacuo. Purification by normal phase silica gelcolumn chromatography (ethyl acetate\/heptane) provided 1-(2-bromo-5-chlorophenyl)-3-methyl-1H-pyrazoleand 1-(2-bromo-5-chlorophenyl)-5-methyl-1H-pyrazole as a 4:1 mixture (41 & 42) that was used in the nextstep directly (5.4 g).<\/p>\n

The synthetic route of 1453-58-3 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 1453-58-3 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[175,131],"tags":[145],"class_list":["post-1012","post","type-post","status-publish","format-standard","hentry","category-1453-58-3","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nResearch on new synthetic routes about 1453-58-3<\/title>\n<meta name=\"description\" content=\"In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1453-58-3, name is 3-Methylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. 1453-58-3\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1012\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research on new synthetic routes about 1453-58-3\" \/>\n<meta property=\"og:description\" content=\"In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1453-58-3, name is 3-Methylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. 1453-58-3\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1012\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2020-11-12T02:53:29+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1012\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1012\",\"name\":\"Research on new synthetic routes about 1453-58-3\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2020-11-12T02:53:29+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"In the next few decades, the world population will flourish. 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