{"id":10118,"date":"2022-10-14T07:45:44","date_gmt":"2022-10-13T23:45:44","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10118"},"modified":"2022-10-14T07:45:44","modified_gmt":"2022-10-13T23:45:44","slug":"morimoto-katsushis-team-published-research-in-journal-of-heterocyclic-chemistry-in-1997-cas-5952-93-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10118","title":{"rendered":"Morimoto, Katsushi&#8217;s team published research in Journal of Heterocyclic Chemistry in 1997 | CAS: 5952-93-2"},"content":{"rendered":"<p>\u300aSynthesis of halosulfuron-methyl via selective chlorination at the 3- and\/or 5-position of pyrazole-4-carboxylates\u300b was written by Morimoto, Katsushi; Sato, Toshiaki; Yamamoto, Susumu; Takeuchi, Hiroshi. <a href=\"https:\/\/www.ambeed.com\/products\/5952-93-2.html\">Reference of Methyl 1-methyl-1H-pyrazole-4-carboxylate<\/a> And the article was included in Journal of Heterocyclic Chemistry on April 30 ,1997. The article conveys some information:<\/p>\n<p>Heating Me pyrazole-4-carboxylates I (X = Cl, Y = H; X = H, Y = Cl; X = Y = H) with N-chlorosuccinimide without a solvent gave I (X = Y = Cl) in good yields. Reaction of I (X = Y = H) with NaSH led to nucleophilic substitution on the 5-position regioselectively to afford I (X = Cl, Y = SH); subsequent oxidative chlorination and amination gave I (X = Cl, Y = SO2NH2). Finally, the reaction of I (X = Cl, Y = SO2NH2) with Ph 4,6-dimethoxy-2-pyrimidinyl carbamate provided halosulfuron-Me (II), a promising herbicide for cornfields. In the experimental materials used by the author, we found Methyl 1-methyl-1H-pyrazole-4-carboxylate(cas: 5952-93-2<a href=\"https:\/\/www.ambeed.com\/products\/5952-93-2.html\">Reference of Methyl 1-methyl-1H-pyrazole-4-carboxylate<\/a>)<\/p>\n<p>Methyl 1-methyl-1H-pyrazole-4-carboxylate(cas: 5952-93-2) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.<a href=\"https:\/\/www.ambeed.com\/products\/5952-93-2.html\">Reference of Methyl 1-methyl-1H-pyrazole-4-carboxylate<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Methyl 1-methyl-1H-pyrazole-4-carboxylate(cas: 5952-93-2) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.<a href=\"https:\/\/www.ambeed.com\/products\/5952-93-2.html\">Reference of Methyl 1-methyl-1H-pyrazole-4-carboxylate<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[689,131],"tags":[128],"class_list":["post-10118","post","type-post","status-publish","format-standard","hentry","category-5952-93-2","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Morimoto, Katsushi&#039;s team published research in Journal of Heterocyclic Chemistry in 1997 | CAS: 5952-93-2 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"\u300aSynthesis of halosulfuron-methyl via selective chlorination at the 3- and\/or 5-position of pyrazole-4-carboxylates\u300b was written by Morimoto, Katsushi; Sato, Toshiaki; Yamamoto, Susumu; Takeuchi, Hiroshi. 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