{"id":10114,"date":"2022-10-14T07:45:02","date_gmt":"2022-10-13T23:45:02","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10114"},"modified":"2022-10-14T07:45:02","modified_gmt":"2022-10-13T23:45:02","slug":"kabir-m-shahjahans-team-published-research-in-bioorganic-medicinal-chemistry-in-2010-cas-20154-03-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10114","title":{"rendered":"Kabir, M. Shahjahan&#8217;s team published research in Bioorganic &#038; Medicinal Chemistry in 2010 | CAS: 20154-03-4"},"content":{"rendered":"<p>In 2010,Kabir, M. Shahjahan; Namjoshi, Ojas A.; Verma, Ranjit; Polanowski, Rebecca; Krueger, Sarah M.; Sherman, David; Rott, Marc A.; Schwan, William R.; Monte, Aaron; Cook, James M. published \u300aA new class of potential anti-tuberculosis agents: Synthesis and preliminary evaluation of novel acrylic acid ethyl ester derivatives\u300b.Bioorganic &#038; Medicinal Chemistry published the findings.<a href=\"https:\/\/www.ambeed.com\/products\/20154-03-4.html\">Name: 3-(Trifluoromethyl)-1H-pyrazole<\/a> The information in the text is summarized as follows:<\/p>\n<p>Novel acrylic acid Et ester derivatives were synthesized and evaluated as potential agents against Mycobacterium species. A versatile and efficient copper-catalyzed coupling process was developed and used to prepare a library of substituted acrylic acid Et ester analogs. Min. inhibitory concentration assays indicated that two of these compounds 3 and 4 (I) have greater in vitro activity against Mycobacterium smegmatis than rifampin, one of the current, first-line anti-mycobacterial chemotherapeutic agents. Moreover, members of this new class of compounds appear to exhibit a specific anti-mycobacterial effect and do not inhibit the growth of the other Gram-pos. or Gram-neg. species tested. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4<a href=\"https:\/\/www.ambeed.com\/products\/20154-03-4.html\">Name: 3-(Trifluoromethyl)-1H-pyrazole<\/a>)<\/p>\n<p>3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.<a href=\"https:\/\/www.ambeed.com\/products\/20154-03-4.html\">Name: 3-(Trifluoromethyl)-1H-pyrazole<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.<a href=\"https:\/\/www.ambeed.com\/products\/20154-03-4.html\">Name: 3-(Trifluoromethyl)-1H-pyrazole<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[205,131],"tags":[128],"class_list":["post-10114","post","type-post","status-publish","format-standard","hentry","category-20154-03-4","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Kabir, M. Shahjahan&#039;s team published research in Bioorganic &amp; Medicinal Chemistry in 2010 | CAS: 20154-03-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"In 2010,Kabir, M. Shahjahan; Namjoshi, Ojas A.; Verma, Ranjit; Polanowski, Rebecca; Krueger, Sarah M.; Sherman, David; Rott, Marc A.; Schwan, William R.; Monte, Aaron; Cook, James M. published \u300aA new class of potential anti-tuberculosis agents: Synthesis and preliminary evaluation of novel acrylic acid ethyl ester derivatives\u300b.Bioorganic &amp; Medicinal Chemistry published the findings.Name: 3-(Trifluoromethyl)-1H-pyrazole The information in the text is summarized as follows:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10114\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Kabir, M. 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Shahjahan; Namjoshi, Ojas A.; Verma, Ranjit; Polanowski, Rebecca; Krueger, Sarah M.; Sherman, David; Rott, Marc A.; Schwan, William R.; Monte, Aaron; Cook, James M. published \u300aA new class of potential anti-tuberculosis agents: Synthesis and preliminary evaluation of novel acrylic acid ethyl ester derivatives\u300b.Bioorganic &amp; Medicinal Chemistry published the findings.Name: 3-(Trifluoromethyl)-1H-pyrazole The information in the text is summarized as follows:\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10114\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-13T23:45:02+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10114\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10114\",\"name\":\"Kabir, M. 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Shahjahan; Namjoshi, Ojas A.; Verma, Ranjit; Polanowski, Rebecca; Krueger, Sarah M.; Sherman, David; Rott, Marc A.; Schwan, William R.; Monte, Aaron; Cook, James M. published \u300aA new class of potential anti-tuberculosis agents: Synthesis and preliminary evaluation of novel acrylic acid ethyl ester derivatives\u300b.Bioorganic & Medicinal Chemistry published the findings.Name: 3-(Trifluoromethyl)-1H-pyrazole The information in the text is summarized as follows:\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10114#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=10114\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10114#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Kabir, M. 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