{"id":10096,"date":"2022-10-14T07:44:21","date_gmt":"2022-10-13T23:44:21","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10096"},"modified":"2022-10-14T07:44:21","modified_gmt":"2022-10-13T23:44:21","slug":"yang-weibos-team-published-research-in-angewandte-chemie-international-edition-in-2015-cas-195447-83-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10096","title":{"rendered":"Yang, Weibo&#8217;s team published research in Angewandte Chemie, International Edition in 2015 | CAS: 195447-83-7"},"content":{"rendered":"<p>\u300aOrchestrated Triple C-H Activation Reactions Using Two Directing Groups: Rapid Assembly of Complex Pyrazoles\u300b was published in Angewandte Chemie, International Edition in 2015. These research results belong to Yang, Weibo; Ye, Shengqing; Fanning, Dewey; Coon, Timothy; Schmidt, Yvonne; Krenitsky, Paul; Stamos, Dean; Yu, Jin-Quan. <a href=\"https:\/\/www.ambeed.com\/products\/195447-83-7.html\">Reference of 3-(tert-Butyl)-1-ethyl-1H-pyrazole-5-carboxylic acid<\/a> The article mentions the following:<\/p>\n<p>A sequential triple C-H activation reaction directed by a pyrazole and an amide group leads to the well-controlled construction of sterically congested dihydrobenzo[e]indazole derivs I [R1 = H, 4-Me, 3-Me, 3,4-diMe, 4-Ph, 4-F, etc.; R2 = Me, (CH2)2Ph, (CH2)3Ph; R3 = Me, Et, iBu, cyclohexylmethyl; R2R3=(CH2)5; R4 = Me, Et]. This cascade reaction demonstrates that the often problematic competing C-H activation pathways in the presence of multiple directing groups can be harvested by design to improve step economy in synthesis. Pyrazole as a relatively weak coordinating group is shown to direct Csp3-H activation for the first time. In the experiment, the researchers used 3-(tert-Butyl)-1-ethyl-1H-pyrazole-5-carboxylic acid(cas: 195447-83-7<a href=\"https:\/\/www.ambeed.com\/products\/195447-83-7.html\">Reference of 3-(tert-Butyl)-1-ethyl-1H-pyrazole-5-carboxylic acid<\/a>)<\/p>\n<p>3-(tert-Butyl)-1-ethyl-1H-pyrazole-5-carboxylic acid(cas: 195447-83-7) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.<a href=\"https:\/\/www.ambeed.com\/products\/195447-83-7.html\">Reference of 3-(tert-Butyl)-1-ethyl-1H-pyrazole-5-carboxylic acid<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>3-(tert-Butyl)-1-ethyl-1H-pyrazole-5-carboxylic acid(cas: 195447-83-7) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.<a href=\"https:\/\/www.ambeed.com\/products\/195447-83-7.html\">Reference of 3-(tert-Butyl)-1-ethyl-1H-pyrazole-5-carboxylic acid<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[753,131],"tags":[128],"class_list":["post-10096","post","type-post","status-publish","format-standard","hentry","category-195447-83-7","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Yang, Weibo&#039;s team published research in Angewandte Chemie, International Edition in 2015 | CAS: 195447-83-7 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"\u300aOrchestrated Triple C-H Activation Reactions Using Two Directing Groups: Rapid Assembly of Complex Pyrazoles\u300b was published in Angewandte Chemie, International Edition in 2015. These research results belong to Yang, Weibo; Ye, Shengqing; Fanning, Dewey; Coon, Timothy; Schmidt, Yvonne; Krenitsky, Paul; Stamos, Dean; Yu, Jin-Quan. Reference of 3-(tert-Butyl)-1-ethyl-1H-pyrazole-5-carboxylic acid The article mentions the following:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=10096\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Yang, Weibo&#039;s team published research in Angewandte Chemie, International Edition in 2015 | CAS: 195447-83-7 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"\u300aOrchestrated Triple C-H Activation Reactions Using Two Directing Groups: Rapid Assembly of Complex Pyrazoles\u300b was published in Angewandte Chemie, International Edition in 2015. These research results belong to Yang, Weibo; Ye, Shengqing; Fanning, Dewey; Coon, Timothy; Schmidt, Yvonne; Krenitsky, Paul; Stamos, Dean; Yu, Jin-Quan. Reference of 3-(tert-Butyl)-1-ethyl-1H-pyrazole-5-carboxylic acid The article mentions the following:\" \/>\n<meta property=\"og:url\" content=\"http:\/\/www.pyrazoles-derivatives.com\/?p=10096\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-13T23:44:21+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=10096\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=10096\",\"name\":\"Yang, Weibo's team published research in Angewandte Chemie, International Edition in 2015 | CAS: 195447-83-7 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-10-13T23:44:21+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"\u300aOrchestrated Triple C-H Activation Reactions Using Two Directing Groups: Rapid Assembly of Complex Pyrazoles\u300b was published in Angewandte Chemie, International Edition in 2015. These research results belong to Yang, Weibo; Ye, Shengqing; Fanning, Dewey; Coon, Timothy; Schmidt, Yvonne; Krenitsky, Paul; Stamos, Dean; Yu, Jin-Quan. 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