{"id":10068,"date":"2022-10-14T07:43:40","date_gmt":"2022-10-13T23:43:40","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10068"},"modified":"2022-10-14T07:43:40","modified_gmt":"2022-10-13T23:43:40","slug":"buriol-lilians-team-published-research-in-journal-of-the-brazilian-chemical-society-in-2010-cas-20154-03-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10068","title":{"rendered":"Buriol, Lilian&#8217;s team published research in Journal of the Brazilian Chemical Society in 2010 | CAS: 20154-03-4"},"content":{"rendered":"<p><a href=\"https:\/\/www.ambeed.com\/products\/20154-03-4.html\">COA of Formula: C4H3F3N2<\/a>In 2010 ,\u300aPyrazole synthesis under microwave irradiation and solvent-free conditions\u300b appeared in Journal of the Brazilian Chemical Society. The author of the article were Buriol, Lilian; Frizzo, Clarissa P.; Marzari, Mara R. B.; Moreira, Dayse N.; Prola, Lizie D. T.; Zanatta, Nilo; Bonacorso, Helio G.; Martins, Marcos A. P.. The article conveys some information:<\/p>\n<p>Solvent-free reaction conditions using microwave irradiation (MW) were studied in preparation of 4,5-dihydro-1H-pyrazoles and dehydrated pyrazoles by the cyclocondensation reaction of 4-alkoxy-1,1,1-trifluoro-3-alken-2-ones [CF3C(O)CH=C(R1)OR, where R\/R1 = Et\/H, Me\/Me and Me\/Ph] with hydrazines [NH2NH-R2, where R2 = CO2Me, Ph, CH2CH2OH]. Some reactions were performed under the same reaction conditions using methanol as solvent. The results obtained using MW equipment for synthesis under solvent-free conditions were also compared with those described in literature for conventional thermal heating and heating with a domestic MW oven. In general, the products furnished by reaction in MW equipment for synthesis presented better yields and shorter reaction times. In addition, it was demonstrated that the reaction temperature altered the formation of products for each hydrazine showing that MW equipment for synthesis is efficient for reacting hydrazines and 4-alkoxy-1,1,1-trifluoro-3-alken-2-ones to procedure the products 4,5-dihydro-1H-pyrazoles and dehydrated pyrazoles. The experimental part of the paper was very detailed, including the reaction process of 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4<a href=\"https:\/\/www.ambeed.com\/products\/20154-03-4.html\">COA of Formula: C4H3F3N2<\/a>)<\/p>\n<p>3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.<a href=\"https:\/\/www.ambeed.com\/products\/20154-03-4.html\">COA of Formula: C4H3F3N2<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.<a href=\"https:\/\/www.ambeed.com\/products\/20154-03-4.html\">COA of Formula: C4H3F3N2<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[205,131],"tags":[128],"class_list":["post-10068","post","type-post","status-publish","format-standard","hentry","category-20154-03-4","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Buriol, Lilian&#039;s team published research in Journal of the Brazilian Chemical Society in 2010 | CAS: 20154-03-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"COA of Formula: C4H3F3N2In 2010 ,\u300aPyrazole synthesis under microwave irradiation and solvent-free conditions\u300b appeared in Journal of the Brazilian Chemical Society. The author of the article were Buriol, Lilian; Frizzo, Clarissa P.; Marzari, Mara R. B.; Moreira, Dayse N.; Prola, Lizie D. T.; Zanatta, Nilo; Bonacorso, Helio G.; Martins, Marcos A. P.. The article conveys some information:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10068\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Buriol, Lilian&#039;s team published research in Journal of the Brazilian Chemical Society in 2010 | CAS: 20154-03-4 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"COA of Formula: C4H3F3N2In 2010 ,\u300aPyrazole synthesis under microwave irradiation and solvent-free conditions\u300b appeared in Journal of the Brazilian Chemical Society. The author of the article were Buriol, Lilian; Frizzo, Clarissa P.; Marzari, Mara R. B.; Moreira, Dayse N.; Prola, Lizie D. T.; Zanatta, Nilo; Bonacorso, Helio G.; Martins, Marcos A. P.. 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The author of the article were Buriol, Lilian; Frizzo, Clarissa P.; Marzari, Mara R. B.; Moreira, Dayse N.; Prola, Lizie D. T.; Zanatta, Nilo; Bonacorso, Helio G.; Martins, Marcos A. P.. 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