{"id":10066,"date":"2022-10-14T07:43:40","date_gmt":"2022-10-13T23:43:40","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10066"},"modified":"2022-10-14T07:43:40","modified_gmt":"2022-10-13T23:43:40","slug":"nakano-yoshihikos-team-published-research-in-journal-of-chemical-research-synopses-in-1991-cas-15366-34-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10066","title":{"rendered":"Nakano, Yoshihiko&#8217;s team published research in Journal of Chemical Research, Synopses in 1991 | CAS: 15366-34-4"},"content":{"rendered":"<p><a href=\"https:\/\/www.ambeed.com\/products\/15366-34-4.html\">Recommanded Product: Methyl 1H-pyrazole-3-carboxylate<\/a>In 1991 ,\u300aEffect of electron-withdrawing groups on the thermal ring opening of 3H-pyrazoles to diazoalkenes\u300b was published in Journal of Chemical Research, Synopses. The article was written by Nakano, Yoshihiko; Hamaguchi, Masashi; Nagai, Toshikazu. The article contains the following contents:<\/p>\n<p>3-Cyano-3H-pyrazoles, bearing a cyano, a p-chlorophenyl, or a p-chlorobenzyl group at C-3, e.g. I, generated from elimination reaction of the corresponding dihydropyrazoles with a leaving group such as a chlorine or p-chlorobenzoyloxy group, gave diazoalkene derivatives, resulting from the ring-opening of the 3H-pyrazoles. 3-Methoxycarbonyl-3H-pyrazoles bearing a methoxycarbonyl, a p-chlorophenyl, or p-chlorobenzyl group at C-3, prepared in a similar manner, gave mainly 1-methoxycarbonyl-1H-pyrazole derivatives, resulting from migration of the 3-methoxycarbonyl group to the adjacent nitrogen within the generated 3H-pyrazoles. Treatment of 3H-pyrazoles and 5-substituted 1-methoxycarbonyl-1H-pyrazoles with triethylamine gave 3-substituted 1-methoxycarbonyl-1H-pyrazoles, resulting from migration of the methoxycarbonyl group to the remote nitrogen. The experimental part of the paper was very detailed, including the reaction process of Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4<a href=\"https:\/\/www.ambeed.com\/products\/15366-34-4.html\">Recommanded Product: Methyl 1H-pyrazole-3-carboxylate<\/a>)<\/p>\n<p>Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.<a href=\"https:\/\/www.ambeed.com\/products\/15366-34-4.html\">Recommanded Product: Methyl 1H-pyrazole-3-carboxylate<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.<a href=\"https:\/\/www.ambeed.com\/products\/15366-34-4.html\">Recommanded Product: Methyl 1H-pyrazole-3-carboxylate<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[174,131],"tags":[128],"class_list":["post-10066","post","type-post","status-publish","format-standard","hentry","category-15366-34-4","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Nakano, Yoshihiko&#039;s team published research in Journal of Chemical Research, Synopses in 1991 | CAS: 15366-34-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Recommanded Product: Methyl 1H-pyrazole-3-carboxylateIn 1991 ,\u300aEffect of electron-withdrawing groups on the thermal ring opening of 3H-pyrazoles to diazoalkenes\u300b was published in Journal of Chemical Research, Synopses. The article was written by Nakano, Yoshihiko; Hamaguchi, Masashi; Nagai, Toshikazu. The article contains the following contents:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10066\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nakano, Yoshihiko&#039;s team published research in Journal of Chemical Research, Synopses in 1991 | CAS: 15366-34-4 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Recommanded Product: Methyl 1H-pyrazole-3-carboxylateIn 1991 ,\u300aEffect of electron-withdrawing groups on the thermal ring opening of 3H-pyrazoles to diazoalkenes\u300b was published in Journal of Chemical Research, Synopses. The article was written by Nakano, Yoshihiko; Hamaguchi, Masashi; Nagai, Toshikazu. 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