{"id":10060,"date":"2022-10-14T07:43:40","date_gmt":"2022-10-13T23:43:40","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10060"},"modified":"2022-10-14T07:43:40","modified_gmt":"2022-10-13T23:43:40","slug":"moegling-julians-team-published-research-in-angewandte-chemie-international-edition-in-2018-cas-20154-03-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10060","title":{"rendered":"Moegling, Julian’s team published research in Angewandte Chemie, International Edition in 2018 | CAS: 20154-03-4"},"content":{"rendered":"

In 2018,Moegling, Julian; Hoffmann, Alexander; Thomas, Fabian; Orth, Nicole; Liebhaeuser, Patricia; Herber, Ulrich; Rampmaier, Robert; Stanek, Julia; Fink, Gerhard; Ivanovic-Burmazovic, Ivana; Herres-Pawlis, Sonja published \u300aDesigned To React: Terminal Copper Nitrenes and Their Application in Catalytic C-H Aminations\u300b.Angewandte Chemie, International Edition published the findings.Electric Literature of C4H3F3N2<\/a> The information in the text is summarized as follows:<\/p>\n

Heteroscorpionate ligands of the bis(pyrazolyl)methane family have been applied in the stabilization of terminal copper tosyl nitrenes. These species are highly active intermediates in the copper-catalyzed direct C-H amination and nitrene transfer. Novel perfluoroalkyl-pyrazolyl- and pyridinyl-containing ligands were synthesized to coordinate to a reactive copper nitrene center. Four distinct copper tosyl nitrenes were prepared at low temperatures by the reaction with SO2tBuPhINTs and copper(I) acetonitrile complexes. Their stoichiometric reactivity has been elucidated regarding the imination of phosphines and the aziridination of styrenes. The formation and thermal decay of the copper nitrenes were investigated by UV\/Vis spectroscopy of the highly colored species. Addnl., the compounds were studied by cryo-UHR-ESI mass spectrometry and DFT calculations In addition, a mild catalytic procedure has been developed where the copper nitrene precursors enable the C-H amination of cyclohexane and toluene and the aziridination of styrenes. In the experimental materials used by the author, we found 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Electric Literature of C4H3F3N2<\/a>)<\/p>\n

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Electric Literature of C4H3F3N2<\/a><\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Electric Literature of C4H3F3N2<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[205,131],"tags":[128],"class_list":["post-10060","post","type-post","status-publish","format-standard","hentry","category-20154-03-4","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"\nMoegling, Julian's team published research in Angewandte Chemie, International Edition in 2018 | CAS: 20154-03-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"In 2018,Moegling, Julian; Hoffmann, Alexander; Thomas, Fabian; Orth, Nicole; Liebhaeuser, Patricia; Herber, Ulrich; Rampmaier, Robert; Stanek, Julia; Fink, Gerhard; Ivanovic-Burmazovic, Ivana; Herres-Pawlis, Sonja published \u300aDesigned To React: Terminal Copper Nitrenes and Their Application in Catalytic C-H Aminations\u300b.Angewandte Chemie, International Edition published the findings.Electric Literature of C4H3F3N2 The information in the text is summarized as follows:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10060\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Moegling, Julian's team published research in Angewandte Chemie, International Edition in 2018 | CAS: 20154-03-4 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"In 2018,Moegling, Julian; Hoffmann, Alexander; Thomas, Fabian; Orth, Nicole; Liebhaeuser, Patricia; Herber, Ulrich; Rampmaier, Robert; Stanek, Julia; Fink, Gerhard; Ivanovic-Burmazovic, Ivana; Herres-Pawlis, Sonja published \u300aDesigned To React: Terminal Copper Nitrenes and Their Application in Catalytic C-H Aminations\u300b.Angewandte Chemie, International Edition published the findings.Electric Literature of C4H3F3N2 The information in the text is summarized as follows:\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10060\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-13T23:43:40+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10060\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10060\",\"name\":\"Moegling, Julian's team published research in Angewandte Chemie, International Edition in 2018 | CAS: 20154-03-4 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-10-13T23:43:40+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"In 2018,Moegling, Julian; Hoffmann, Alexander; Thomas, Fabian; Orth, Nicole; Liebhaeuser, Patricia; Herber, Ulrich; Rampmaier, Robert; Stanek, Julia; Fink, Gerhard; Ivanovic-Burmazovic, Ivana; Herres-Pawlis, Sonja published \u300aDesigned To React: Terminal Copper Nitrenes and Their Application in Catalytic C-H Aminations\u300b.Angewandte Chemie, International Edition published the findings.Electric Literature of C4H3F3N2 The information in the text is summarized as follows:\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10060#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=10060\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10060#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Moegling, Julian’s team published research in Angewandte Chemie, International Edition in 2018 | CAS: 20154-03-4\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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