{"id":10050,"date":"2022-10-14T03:55:15","date_gmt":"2022-10-13T19:55:15","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10050"},"modified":"2022-10-14T03:55:15","modified_gmt":"2022-10-13T19:55:15","slug":"adachi-ikuos-team-published-research-in-chemical-pharmaceutical-bulletin-in-1987-08-25-118430-74-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10050","title":{"rendered":"Adachi, Ikuo&#8217;s team published research in Chemical &#038; Pharmaceutical Bulletin  in 1987-08-25 | 118430-74-3"},"content":{"rendered":"<p>Adachi, Ikuo; Yamamori, Teruo; Hiramatsu, Yoshiharu; Sakai, Katsunori; Sato, Hatsuo; Kawakami, Masaru; Uno, Osamu; Ueda, Motohiko published the artcile< Studies on dihydropyridines. II. Synthesis of 4,7-dihydropyrazolo[3,4-b]pyridines with vasodilating and antihypertensive activities>,  <a href=\"https:\/\/www.ambeed.com\/products\/118430-74-3.html\">Formula: C7H11N3<\/a>,  the main research area is  coronary vasodilator dihydropyrazolopyridine preparation; structure property relationship dihydropyrazolopyridine antihypertensive; pyrazolopyridine dihydro antihypertensive preparation; aminopyrazole unsaturated ketoester cyclocondensation; calcium channel blocker dihydropyrazolopyridine.<\/p>\n<p>A series of 4-aryl-4,7-dihydropyrazolo[3,4-b]pyridine-5-carboxylate derivatives I (R = Me, Ph, cyclopentyl; R1 = Me, Et, CHMe2, cyclohexyl, substituted phenethyl, etc.; R2 = 2-O2NC6H4, 3-O2NC6H4, 2-ClC6H4, 2.8-Cl2C6H4, pyridyl; R3 = H, Me, CHMe2, Ph, cycloalkyl, CO2Et, pyridyl, etc.) was prepared and the compounds were tested for Ca-blocking activity in isolated guinea pig portal vein, antihypertensive activity in spontaneously hypertensive rats, and coronary vasodilating effect in isolated guinea pig heart. A number of derivatives had potent antihypertensive and coronary vasodilating activities. The structure-activity relationships of the series indicated that a 3-cyclopentyl or 3-cyclohexyl substituent and a hydrophobic 5-ester moiety with moderate bulkiness were effective for increasing the pharmacol. potencies.<\/p>\n<p>Chemical &#038; Pharmaceutical Bulletin published new progress about Antihypertensives. 118430-74-3 belongs to class pyrazoles-derivatives, and the molecular formula is C7H11N3, <a href=\"https:\/\/www.ambeed.com\/products\/118430-74-3.html\">Formula: C7H11N3<\/a>.<\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chemical &#038; Pharmaceutical Bulletin published new progress about Antihypertensives. 118430-74-3 belongs to class pyrazoles-derivatives, and the molecular formula is C7H11N3, <a href=\"https:\/\/www.ambeed.com\/products\/118430-74-3.html\">Formula: C7H11N3<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[233,131],"tags":[732],"class_list":["post-10050","post","type-post","status-publish","format-standard","hentry","category-118430-74-3","category-pyrazoles-derivatives","tag-m-w100-150"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Adachi, Ikuo&#039;s team published research in Chemical &amp; Pharmaceutical Bulletin in 1987-08-25 | 118430-74-3 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Adachi, Ikuo; Yamamori, Teruo; Hiramatsu, Yoshiharu; Sakai, Katsunori; Sato, Hatsuo; Kawakami, Masaru; Uno, Osamu; Ueda, Motohiko published the artcile&lt; Studies on dihydropyridines. II. Synthesis of 4,7-dihydropyrazolo[3,4-b]pyridines with vasodilating and antihypertensive activities&gt;, Formula: C7H11N3, the main research area is coronary vasodilator dihydropyrazolopyridine preparation; structure property relationship dihydropyrazolopyridine antihypertensive; pyrazolopyridine dihydro antihypertensive preparation; aminopyrazole unsaturated ketoester cyclocondensation; calcium channel blocker dihydropyrazolopyridine.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10050\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Adachi, Ikuo&#039;s team published research in Chemical &amp; Pharmaceutical Bulletin in 1987-08-25 | 118430-74-3 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Adachi, Ikuo; Yamamori, Teruo; Hiramatsu, Yoshiharu; Sakai, Katsunori; Sato, Hatsuo; Kawakami, Masaru; Uno, Osamu; Ueda, Motohiko published the artcile&lt; Studies on dihydropyridines. II. Synthesis of 4,7-dihydropyrazolo[3,4-b]pyridines with vasodilating and antihypertensive activities&gt;, Formula: C7H11N3, the main research area is coronary vasodilator dihydropyrazolopyridine preparation; structure property relationship dihydropyrazolopyridine antihypertensive; pyrazolopyridine dihydro antihypertensive preparation; aminopyrazole unsaturated ketoester cyclocondensation; calcium channel blocker dihydropyrazolopyridine.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10050\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-13T19:55:15+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10050\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10050\",\"name\":\"Adachi, Ikuo's team published research in Chemical & Pharmaceutical Bulletin in 1987-08-25 | 118430-74-3 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-10-13T19:55:15+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Adachi, Ikuo; Yamamori, Teruo; Hiramatsu, Yoshiharu; Sakai, Katsunori; Sato, Hatsuo; Kawakami, Masaru; Uno, Osamu; Ueda, Motohiko published the artcile< Studies on dihydropyridines. II. Synthesis of 4,7-dihydropyrazolo[3,4-b]pyridines with vasodilating and antihypertensive activities>, Formula: C7H11N3, the main research area is coronary vasodilator dihydropyrazolopyridine preparation; structure property relationship dihydropyrazolopyridine antihypertensive; pyrazolopyridine dihydro antihypertensive preparation; aminopyrazole unsaturated ketoester cyclocondensation; calcium channel blocker dihydropyrazolopyridine.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10050#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=10050\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10050#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Adachi, Ikuo&#8217;s team published research in Chemical &#038; Pharmaceutical Bulletin in 1987-08-25 | 118430-74-3\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Adachi, Ikuo's team published research in Chemical & Pharmaceutical Bulletin in 1987-08-25 | 118430-74-3 | pyrazoles-derivatives","description":"Adachi, Ikuo; Yamamori, Teruo; Hiramatsu, Yoshiharu; Sakai, Katsunori; Sato, Hatsuo; Kawakami, Masaru; Uno, Osamu; Ueda, Motohiko published the artcile< Studies on dihydropyridines. II. Synthesis of 4,7-dihydropyrazolo[3,4-b]pyridines with vasodilating and antihypertensive activities>, Formula: C7H11N3, the main research area is coronary vasodilator dihydropyrazolopyridine preparation; structure property relationship dihydropyrazolopyridine antihypertensive; pyrazolopyridine dihydro antihypertensive preparation; aminopyrazole unsaturated ketoester cyclocondensation; calcium channel blocker dihydropyrazolopyridine.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=10050","og_locale":"en_US","og_type":"article","og_title":"Adachi, Ikuo's team published research in Chemical & Pharmaceutical Bulletin in 1987-08-25 | 118430-74-3 | pyrazoles-derivatives","og_description":"Adachi, Ikuo; Yamamori, Teruo; Hiramatsu, Yoshiharu; Sakai, Katsunori; Sato, Hatsuo; Kawakami, Masaru; Uno, Osamu; Ueda, Motohiko published the artcile< Studies on dihydropyridines. 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Synthesis of 4,7-dihydropyrazolo[3,4-b]pyridines with vasodilating and antihypertensive activities>, Formula: C7H11N3, the main research area is coronary vasodilator dihydropyrazolopyridine preparation; structure property relationship dihydropyrazolopyridine antihypertensive; pyrazolopyridine dihydro antihypertensive preparation; aminopyrazole unsaturated ketoester cyclocondensation; calcium channel blocker dihydropyrazolopyridine.","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=10050","og_site_name":"pyrazoles-derivatives","article_published_time":"2022-10-13T19:55:15+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=10050","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=10050","name":"Adachi, Ikuo's team published research in Chemical & Pharmaceutical Bulletin in 1987-08-25 | 118430-74-3 | pyrazoles-derivatives","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2022-10-13T19:55:15+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Adachi, Ikuo; Yamamori, Teruo; Hiramatsu, Yoshiharu; Sakai, Katsunori; Sato, Hatsuo; Kawakami, Masaru; Uno, Osamu; Ueda, Motohiko published the artcile< Studies on dihydropyridines. 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