{"id":10043,"date":"2022-10-14T03:55:15","date_gmt":"2022-10-13T19:55:15","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10043"},"modified":"2022-10-14T03:55:15","modified_gmt":"2022-10-13T19:55:15","slug":"bongard-jenss-team-published-research-in-chemmedchem-in-2019-54346-19-9","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10043","title":{"rendered":"Bongard, Jens’s team published research in ChemMedChem in 2019 | 54346-19-9"},"content":{"rendered":"

Bongard, Jens; Schmitz, Anna Laura; Wolf, Alex; Zischinsky, Gunther; Pieren, Michel; Schellhorn, Birgit; Bravo-Rodriguez, Kenny; Schillinger, Jasmin; Koch, Uwe; Nussbaumer, Peter; Klebl, Bert; Steinmann, Joerg; Buer, Jan; Sanchez-Garcia, Elsa; Ehrmann, Michael; Kaiser, Markus published the artcile< Chemical Validation of DegS As a Target for the Development of Antibiotics with a Novel Mode of Action>, Computed Properties of 54346-19-9<\/a>, the main research area is DegS drug target antibiotic preparation; antibiotics; drug discovery; small molecules; synergism; synthesis.<\/p>\n

Despite the availability of hundreds of antibiotic drugs, infectious diseases continue to remain one of the most notorious health issues. In addition, the disparity between the spread of multidrug-resistant pathogens and the development of novel classes of antibiotics exemplify an important unmet medical need that can only be addressed by identifying novel targets. Herein we demonstrate, by the development of the first in vivo active DegS inhibitors based on a pyrazolo[1,5-a]-1,3,5-triazine scaffold, that the serine protease DegS and the cell envelope stress-response pathway \u03c3E represent a target for generating antibiotics with a novel mode of action. Moreover, DegS inhibition is synergistic with well-established membrane-perturbing antibiotics, thereby opening promising avenues for rational antibiotic drug design.<\/p>\n

ChemMedChem published new progress about Antibacterial agent resistance. 54346-19-9 belongs to class pyrazoles-derivatives, and the molecular formula is C6H5ClN4S, Computed Properties of 54346-19-9<\/a>.<\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

ChemMedChem published new progress about Antibacterial agent resistance. 54346-19-9 belongs to class pyrazoles-derivatives, and the molecular formula is C6H5ClN4S, Computed Properties of 54346-19-9<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[751,131],"tags":[716],"class_list":["post-10043","post","type-post","status-publish","format-standard","hentry","category-54346-19-9","category-pyrazoles-derivatives","tag-m-w200-250"],"yoast_head":"\nBongard, Jens's team published research in ChemMedChem in 2019 | 54346-19-9 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Bongard, Jens; Schmitz, Anna Laura; Wolf, Alex; Zischinsky, Gunther; Pieren, Michel; Schellhorn, Birgit; Bravo-Rodriguez, Kenny; Schillinger, Jasmin; Koch, Uwe; Nussbaumer, Peter; Klebl, Bert; Steinmann, Joerg; Buer, Jan; Sanchez-Garcia, Elsa; Ehrmann, Michael; Kaiser, Markus published the artcile< Chemical Validation of DegS As a Target for the Development of Antibiotics with a Novel Mode of Action>, Computed Properties of 54346-19-9, the main research area is DegS drug target antibiotic preparation; antibiotics; drug discovery; small molecules; synergism; synthesis.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10043\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bongard, Jens's team published research in ChemMedChem in 2019 | 54346-19-9 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Bongard, Jens; Schmitz, Anna Laura; Wolf, Alex; Zischinsky, Gunther; Pieren, Michel; Schellhorn, Birgit; Bravo-Rodriguez, Kenny; Schillinger, Jasmin; Koch, Uwe; Nussbaumer, Peter; Klebl, Bert; Steinmann, Joerg; Buer, Jan; Sanchez-Garcia, Elsa; Ehrmann, Michael; Kaiser, Markus published the artcile< Chemical Validation of DegS As a Target for the Development of Antibiotics with a Novel Mode of Action>, Computed Properties of 54346-19-9, the main research area is DegS drug target antibiotic preparation; antibiotics; drug discovery; small molecules; synergism; synthesis.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10043\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-13T19:55:15+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10043\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10043\",\"name\":\"Bongard, Jens's team published research in ChemMedChem in 2019 | 54346-19-9 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-10-13T19:55:15+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Bongard, Jens; 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