Tag: M.W:200-300

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2033-45-6, name is 3,5-Dimethyl-4-iodopyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 3,5-Dimethyl-4-iodopyrazole

To a stirred degassed solution of 4-iodo-3,5-dimethyl-1 H-pyrazole (500 mg, 2.25 mmol) in DMF (5 mL) was added Zn(CN)2 (141 .2 mg, 1 .58 mmol) followed by Pd(dppf)CI2 (82.4 mg, 0.1 1 mmol) and Zn-dust (7.4 mg, 0.1 1 mmol) under inert atmosphere. Resulting mixture was heated at 100C for 4 hours. After completion, the reaction mixture was diluted with cold water and extracted with ethyl acetate. Combined organic layer was washed with water, brine, dried over sodium sulphate, filtered, and concentrated under reduced pressure. Crude compound was purified by column chromatography (30%-50% ethyl acetate-hexane) to afford 3,5-dimethyl-1 H- pyrazole-4-carbonitrile (120 mg, 44%) as light brown solid.

The synthetic route of 2033-45-6 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 83-10-3, name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C12H12N2O3

(Step 6) 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid[3-fluoro-4-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yloxy)-phenyl]-amide; 3-Fluoro-4-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yloxy)-phenylamine (80 mg, 0.25 mmol), 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (72 mg, 0.31 mmol) and HATU (190 mg, 0.5 mmol) were dissolved in dimethylformamide (3 mL). After adding triethylamine (0.04 mL, 0.5 mmol), the mixture was heated at 50 C. for 7 hours. The resulting reaction mixture was extracted with dichloromethane and water. The organic layer was washed with sodium chloride aqueous solution, dried with magnesium sulfate, and then filtered. The filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel chromatography (hexane:ethyl acetate=1:1) to give the target compound as a white solid (12 mg, 0.02 mmol, 9% yield).1H NMR (400 MHz, DMSO): 12.29 (br s, 1H), 10.95 (br s, 1H), 8.08 (d, J=5.6 Hz, 1H), 7.98 (d, J=2.4, 1H), 7.94 (m, 2H), 7.60 (m, 2H), 7.52 (m, 1H), 7.46 (m, 4H), 7.33 (m, 3H), 6.89 (d, J=2.0 Hz, 1H), 6.35 (d, J=5.6, 1H), 3.38 (s, 3H), 2.71 (s, 3H). MS (ESI pos. ion) m/z: 534, Calc’d exact mass for C31H24FN5O3: 533.55.

The synthetic route of 83-10-3 has been constantly updated, and we look forward to future research findings.

1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate

Under N2 protection and a condition free of water and oxygen, Intermediate 2 (604 mg, 2.87 mmol) wasdissolved in tetrahydrofuran (20 ml), which was cooled to 0C, and sodium hydride (180 mg, 60 wt%, 4.5 mmol) wasadded, followed by stirring for 30 min. Cyclopropylsulfonyl chloride (1.27 g, 9.0 mmol) was added dropwise, and thetemperature was allowed to rise spontaneously to room temperature, followed by reaction for 1 hour. The reaction was quenched by addition of water (20 ml) to the reaction solution, which was then extracted with ethyl acetate (20 ml32).The organic phases were combined, dried over anhydrous sodium sulfate, concentrated, re-dissolved in 5 ml tetrahydrofuran,and cooled to -10C to 0C. Potassium t-butoxide (36 mg, 0.32 mmol) was added, and the reaction was allowedto proceed for 28 hours at this temperature. After the reaction was completed, an aqueous solution of citric acid (1 ml,15%) was added, and water (10 ml) was added. The solution was extracted with ethyl acetate (20 mL33). The organicphases were combined, dried over anhydrous sodium sulfate, and concentrated. The residue was purified by silica gelcolumn chromatography (petroleum ether/ethyl acetate (v/v) = 2:1) to obtain a white solid 1a (660 mg, yield 73%).

The synthetic route of 1280210-79-8 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 398491-61-7, name is tert-Butyl 3-amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C12H20N4O2

4.0 M Hydrochloric acid (3.3 mL, 13.14 mmol) in dioxane was addedto tert-butyl 3-amino-6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate 9o (663.1 mg, 2.63 mmol) in ethanol (7.2mL) at room temperature and the reaction mixture was stirred fortwenty hours. The reaction mixture was concentrated to give 6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-amine dihydrochloride5af (611.2 mg, 2.58 mmol, 98% yield). 1H NMR (400MHz, CD3SOCD3) d 10.20 (br s, 2H), 4.16 (s, 2H), 1.62 (s, 6H); LC-MS (LC-ES) M+H = 153.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 398491-61-7.

Synthetic Route of 1264097-17-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1264097-17-7, name is 1-Benzyl-1H-pyrazol-4-amine hydrochloride belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A mixture of l-benzyl- lH-pyrazol-4-amine hydrochloride (2.43 g, 11.59 mmol, 1.20 equiv), 2,6-dichloro-9-(propan-2-yl)-9H-purine (2.23 g, 9.65 mmol, 1.00 equiv) and DIEA (1.24 g, 9.59 mmol, 0.99 equiv) in propan-2-ol (30 mL) was stirred for 2 h at 100 C in an oil bath. The resulting mixture was concentrated under vacuum. The residue was purified on a silica gel column with ethyl acetate/petroleum ether (1/1) to afford 2.3 g (65%) of N-(l -benzyl- 1H- pyrazol-4-yl)-2-chloro-9-(propan-2-yl)-9H-purin-6-amine as a dark red solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Benzyl-1H-pyrazol-4-amine hydrochloride, other downstream synthetic routes, hurry up and to see.

Related Products of 83-10-3,Some common heterocyclic compound, 83-10-3, name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid, molecular formula is C12H12N2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 3-chloro-4-((7-methoxyquinolin-4-yl)oxy)aniline (345 mg, 1.16 mmol) and l,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-lH-pyrazole-4-carboxylic acid (325 mg, 1.37 mmol) in DCM (10 mL) was added EDCI (270 mg, 1.37 mmol) and HOAT (35 mg, 0.23 mmol). The reaction was stirred at 45 C for 16 hours, quenched with water (20 mL) and extracted with DCM (50 mL x 2). The combined organic phases were washed with brine (80 mL), dried over anhydrous Na2S04 and concentrated in vacuo. The residue was purified by a silica gel column chromatography (EtOAc/PE (v/v) = 2/1) to give the title compound as a white solid (540 mg, 91%). MS (ESI, pos. ion) m/z: 515.1 [M+H]+; NMR (400 MHz, DMSO-i): delta 10.95 (s, 1H), 8.59 (d, J= 5.2 Hz, 1H), 8.23 (d, J= 9.2 Hz, 1H), 8.17 (d, J= 2.4 Hz, 1H) , 7.57-7.61 (m, 2H), 7.49-7.53 (m, 2H), 7.41-7.45 (m, 4H), 7.30 (dd, J= 2.5 Hz, 9.2 Hz, 1H), 6.37-6.38 (m, 1H), 3.93 (s, 3H), 3.36 (s, 3H), 2.70 (s, 3H).

The synthetic route of 83-10-3 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3528-45-8, name is 1-(4-Methoxybenzyl)-1H-pyrazol-5-amine, A new synthetic method of this compound is introduced below., Product Details of 3528-45-8

A mixture of 1-(4-methoxybenzyl)-1H-pyrazol-5-amine (3 g, 10 mmol) and (ethoxymethylene)propanedioic acid, diethyl ester (3.8 g, 18 mmol) was heated at 120 C. for 1.5 h, then allowed to cool. After cooling, the mixture was concentrated and the resulting residue was purified with CombiFlash eluting with 0-30% EtOAc in hexanes to give an intermediate, LCMS (M+H): 374.1. The intermediate was dissolved in diphenyl ether (5 mL). The resulted solution was heated at 240 C. in microwave reactor for 1 h 20 min. After cooling, the solid crashed out was filtered and washed with hexanes to afford 4.0 g (80%) of the sub-title compound. LCMS calc. for C17H18N3O4 (M+H)+: m/z=328.1. Found: 328.1

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 5334-28-1,Some common heterocyclic compound, 5334-28-1, name is 5-Amino-1-(4-bromophenyl)-1H-pyrazole-4-carbonitrile, molecular formula is C10H7BrN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 5-amino-1-aryl-1H-pyrazole-4-carbonitriles 4(aei) (0.001 mol),2.0 mL of 1,2-diaminoethane (ethylenediamine) and carbon disulfide(0.004 mol) were added into a 50 mL round-bottom flaskadapted with a glass condenser. The mixture was kept at 110-115oCfor 12-14 hours. After that, the productwas poured into cold water,the precipitate was filtered out and washed with cold water. Thereactions were accompanied by means of TLC and dichloromethaneas eluent.

The synthetic route of 5334-28-1 has been constantly updated, and we look forward to future research findings.

Related Products of 1015845-73-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1015845-73-4 as follows.

General procedure: To a fine suspension of 1 mmol of the corresponding amine in 3 ml of anhydrous DMF was added 1 mmol of ethoxycarbonylisothiocyanate. After stirring the mixture for 1 h at room temperature, 30 ml of cold water was added. The precipitated product was filtered, washed with cold water and recrystallized from ethanol.

According to the analysis of related databases, 1015845-73-4, the application of this compound in the production field has become more and more popular.

Related Products of 37687-24-4, These common heterocyclic compound, 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 10A Diethyl 1-[2-(2,4-dichlorophenyl)-2-oxoethyl]-1H-pyrazole-3,5-dicarboxylate 5 g (23.6 mmol) of diethyl 1H-pyrazole-3,5-dicarboxylate were dissolved in 100 ml of acetone, and 6.3 g (23.6 mmol) of 2-bromo-2,4-dichloroacetophenone and 3.6 g (26 mmol) of potassium carbonate were added. The mixture was stirred at RT for 12 h. The reaction mixture was concentrated and the residue was taken up in water and dichloromethane. The organic phase was washed with saturated aqueous sodium chloride solution, dried over magnesium sulfate and concentrated on a rotary evaporator. The residue was triturated with diethyl ether, and the solid was filtered off with suction. This gave 9.48 g (94% of theory) of the product as a solid. LCMS (method 6): Rt=2.34 min. (m/z=399 (M+H)+) 1H-NMR (400 MHz, DMSO-d6): delta=8.02 (d, 1H), 7.84 (s, 1H), 7.68 (dd, 1H), 7.35 (s, 1H), 6.13 (s, 2H), 4.32 (q, 2H), 4.26 (q, 2H), 1.31 (t, 3H), 1.25 (t, 3H).

The synthetic route of 37687-24-4 has been constantly updated, and we look forward to future research findings.