Tag: M.W=0-100

Authors Glukhacheva, VS; Il’yasov, SG; Kazantsev, IV; Shestakova, EO; Il’yasov, DS; Eltsov, IV; Nefedov, AA; Gatilov, YV in AMER CHEMICAL SOC published article about ANTIBACTERIAL; ANTIFUNGAL; COMPLEXES; SERIES; ACID in [Glukhacheva, Vera S.; Il’yasov, Sergey G.; Kazantsev, Igor, V; Shestakova, Elena O.; Il’yasov, Dmitri S.] Russian Acad Sci IPCET SB RAS, Inst Problems Chem & Energet Technol, Siberian Branch, Biisk 659322, Russia; [Eltsov, Ilia, V; Nefedov, Andrey A.] Novosibirsk State Univ, Novosibirsk 630090, Russia; [Nefedov, Andrey A.; Gatilov, Yuri, V] Russian Acad Sci NIOCh SB RAS, Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia in 2021.0, Cited 40.0. SDS of cas: 67-51-6. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

A new approach is suggested herein for the synthesis of pyrazole derivatives by reacting 4-nitrosemicarbazide with acetylacetone. Additional studies were done on the reaction of acetylacetone with semicarbazide and its derivatives (4-aminosemicarbazide, methylsemicarbazide, and dimethylsemicarbazide). The study on the reaction with acetylacetone resulted in monocyclic 3,5-dimethyl-N-nitropyrazole-1-carboxamide, monocyclic 5-hydroxy-3,5-dimethyl-2-pyrazoline, and bicyclic bis(3,5-dimethylpyrazole-1-carbonyl)hydrazine, and conditions for the formation of acetone semicarbazone were identified. The structures of the resultant compounds were validated by physicochemical analytical methods, including X-ray diffraction. The computer-aided screening in the PASS prediction software discovered a high biological activity of the newly obtained compounds.

SDS of cas: 67-51-6. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Glukhacheva, VS; Il’yasov, SG; Kazantsev, IV; Shestakova, EO; Il’yasov, DS; Eltsov, IV; Nefedov, AA; Gatilov, YV or concate me.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

An article Diazole and triazole inhibition of nitrification process in return activated sludge WOS:000509791600086 published article about CORROSION-INHIBITORS; WASTE-WATER; TOXICITY; OXIDE; SOIL in [Li, Guangbin; Field, James A.; Zeng, Chao; Madeira, Camila Leite; Chi Huynh Nguyen; Jog, Kalyani Vikas; Sierra-Alvarez, Reyes] Univ Arizona, Dept Chem & Environm Engn, POB 210011, Tucson, AZ 85721 USA; [Speed, David] GLOBALFOUNDRIES, Hopewell Jct, NY USA in 2020.0, Cited 40.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6. Category: pyrazoles-derivatives

Azoles are emerging contaminants that are resistant to biodegradation during wastewater treatment. Their presence has been widely reported in wastewater effluents and receiving waters. In this work, the potential inhibition of nitrification process by six different azole compounds in wastewater treatment plants was investigated in batch bioassays. The azoles studied included three diazoles: pyrazole (Pz); 1-methylpyrazole (MePz); 3,5-dimethylpyrazole (DMePz); and three triazoles: 1,2,4-triazole (Tz); benzotriazole (BTz); and 5-methyl benzotriazole (MeBTz). The concentration of azoles causing 50% inhibition (IC50) increased (azoles became less inhibitory) in the following order (mg L-1): BTz (1.99) < MeBTz (218) < Pz (2.69) < Tz (3.53) < DMePz (17.3) < MePz (49.6). No clear structure-inhibitory relationships were found using Log P and pKa as structural properties. The toxicity of any given azole may be related to the role of substituent groups on disabling/enabling binding to the active sites of metallo-enzymes in nitrifying microorganisms. This is exemplified by the low toxicity of MePz, which has a cyclic N blocked by a methyl group. The observed inhibition caused to nitrifying bacteria is more severe than their cytotoxicity to other target organisms (e.g., methanogens and heterotrophic bacteria), suggesting a specific inhibition to the copper-containing enzyme, ammonium monooxygenase, in ammonia oxidizing nitrifying microorganisms. (C) 2019 Elsevier Ltd. All rights reserved. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Li, GB; Field, JA; Zeng, C; Madeira, CL; Nguyen, CH; Jog, KV; Speed, D; Sierra-Alvarez, R or concate me.. Category: pyrazoles-derivatives

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Authors Shirshin, KK; Esipovich, AL; Kazantsev, OA; Rumyantsev, M; Korotaev, MS; Rogozhin, AE in WILEY-V C H VERLAG GMBH published article about NUCLEOPHILIC REACTIONS; TERTIARY-AMINES; CATALYSTS; OPTIMIZATION; AMMONIOLYSIS; AMINOLYSIS; ALKYLATION; ALCOHOLS; MODEL in [Shirshin, Konstantin K.; Esipovich, Anton L.; Kazantsev, Oleg A.; Rumyantsev, Misha; Korotaev, Mikhail S.; Rogozhin, Anton E.] Nizhnii Novgorod State Tech Univ, 24 Ulitsa Minina Minin St, Nizhnii Novgorod, Russia in 2021.0, Cited 54.0. Safety of 3,5-Dimethyl-1H-pyrazole. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

Comparison of various organic compounds such as glycols, amines and alkanolamines as organocatalysts in amidation of fatty acid methyl esters with 3-(dimethylamino)-1-propylamine was made for the first time. It was experimentally detected that catalysts containing OH-groups (alcohols, glycols, glycerol and aminoalcohols) influence the reaction rate. Moreover, catalytic effect is depending on the catalysts geometry significantly. 1,5-diols (e. g. diethylene glycol and diethanolamine) were found to accelerate the reaction more than other OH-groups containing additives. It was supposed, that this catalytic effect is caused by specific associative interactions between reactants and 1,5-diols, what was confirmed by quantum mechanics calculations. Catalysts concentration effects on the reaction rate were also investigated.

Safety of 3,5-Dimethyl-1H-pyrazole. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Shirshin, KK; Esipovich, AL; Kazantsev, OA; Rumyantsev, M; Korotaev, MS; Rogozhin, AE or concate me.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

An article Synthesis and Biological Activities of Novel N-Substitutedphenyl-2-pyrazolylnicotinamides WOS:000469862900033 published article about INSECTICIDAL ACTIVITIES; ANTHRANILIC DIAMIDES; DESIGN; DERIVATIVES; SAR in [Shang, Junfeng; Liu, Qiaoxia; Wang, Baolei; Li, Zhengming] Nankai Univ, Coll Chem, State Key Lab Elementoorgan Chem, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China in 2019.0, Cited 18.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6. Safety of 3,5-Dimethyl-1H-pyrazole

Based on the agrochemical structure of anthranilic diamides, fourteen novel N-substittitedphenyl-2-pyrazolylnicotinamides were conveniently synthesized with 2-chloro-3-cyanopyridine and 4-bromopyrazole or 3,5-dimethylpyrazole as starting materials, via an acyl transposing design strategy. Their structures were characterized by 1H NMR, 13C NMR and HRMS. The preliminary bioassay tests indicated that most of these compounds exhibited obvious insecticidal activity at the test concentration of 200 mg/L, among which N-(4-chloro-2-(ethylcarbamoyl)-6-methylphenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)nicotinamide (II) possessed a 70% mortality rate against Mythimna separata Walker: some of the compounds displayed favorable fungicidal activities at 50 mg/L towards Physalospora piricola and Alternaria solani Sorauer, especially 2-(4-bromo-1H-pyrazol-1-yl)-N-(2-(cyclopropylcarbamoyl)-4-iodo-6-methylphenyl)nicotinamide (If) and 2-(4-bromo-1H-pyrazol-1-yl)-N-(4-chloro-2-(ethylcarbamoyl)-6-methylphenyl)nicotinamide (Ih) against Physalospora piricola, and 2-(4-bromo-1H-pyrazol-1-yl)-N-(4-chloro-2-(propylcarbamoyl)phenyl)nicotinamide (Id) against Alternaria solani Sorauer had growth inhibitory rates of 62.9%, 54.3% and 54.5%, respectively. These research results provide important reference for the further study of novel 2-pyrazolylnicotinamide derivatives.

About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Shang, JF; Liu, QX; Wang, BL; Li, ZM or concate me.. Safety of 3,5-Dimethyl-1H-pyrazole

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Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

In 2019.0 ACS OMEGA published article about RHENIUM(I) TRICARBONYL COMPLEXES; BRIDGING 1,2-DIAZINE LIGANDS; RE-I COMPLEX; CRYSTAL-STRUCTURES; PHOTOCATALYTIC REDUCTION; COPPER(II) COMPLEXES; SINGLET OXYGEN; EXCITED-STATE; MAGNETOSTRUCTURAL CORRELATIONS; ORGANOMETALLIC COMPLEXES in [Saldia, Marianela; Guzman, Nicolas; Palominos, Franco; Sandoval-Altamirano, Atalina; Pizarro, Nancy; Vega, Andres] Univ Andres Bello, Fac Ciencias Exactas, Dept Ciencias Quim, Av Quillota 980, Vina Del Mar 2531015, Chile; [Gunther, German] Univ Chile, Fac Ciencias Quim & Farmaceut, Dept Quim Organ & Fisicoquim, Sergio Livingstone 1007, Santiago 8380492, Chile; [Vega, Andres] CEDENNA, Ctr Desarrollo Nanociencia & Nanotecnol, Santiago, Chile; [Saldia, Marianela] Univ Cent, Fac Ciencias Salud, Inst Invest & Innovac Salud, Lord Cochrane 417, Santiago 8330507, Chile in 2019.0, Cited 90.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6. Quality Control of 3,5-Dimethyl-1H-pyrazole

The direct reaction of a series of substituted (1H-pyrazol-1-yl)pyridazine (L-I: 6-(1H-pyrazolyl)pyridazine; L-II: 3-chloro-6-(1H-pyrazole-1-yl)-pyridazine; L-III: 6-(1H-3,5-dimethylpyrazolyl)pyridazine-3-carboxylic acid; L-IV: 3,6-bis-N-pyrazolyl-pyridazine; and L-V: 3,6-bis-N-3-methylpyrazolyl-pyridazine) with the bromotricarbonyl(tetrahydrofuran)rhenium(I) dimer leads to the monometallic complexes [(L-X)Re(CO)(3)Br] (I-V), which displays a nonregular octahedral geometry around the Re-I center and a fac-isomerism for the carbonyl groups, whereas pyridazine and pyrazolyl rings remain highly coplanar after coordination to rhenium. Cyclic voltammetry shows one irreversible oxidation and one irreversible reduction for each compound as measured in N, N-dimethylformamide. Oxidation ranges from 0.94 V for III to 1.04 V for I and have been attributed to the Re-I/Re-II couple. In contrast, the reductions are ligand centered, ranging from -1.64 V for II to -1.90 V for III and V. Density functional theory calculations on the vertical one electron oxidized and one electron reduced species, using the gas-phase optimized geometry for the neutral complex confirm this assignment. Compounds I-V show two absorption bands, one around 410 nm (metal-to-ligand charge transfer (MLCT), Re-d pi -> pi*) and the other at similar to 300 nm (intraligand, pi -> pi*). Excitation at 400 nm at 77 K leads to unstructured and monoexponential emission with large Stokes shift, whose maxima vary between 570 (III) and 636 (II) nm. The quantum yields for these emissions in solution are intensified strongly going from air to argon equilibrated solution. Singlet oxygen quantum yields change from 0.03 (III) to 0.21 (IV). These data are consistent with emission from (MLCT)-M-3. The emission undergoes a bathochromic shift when R-1 is a pi-donating group (Cl or N-pyrazolyl) and a hypsochromic shift for a pi-acceptor (COOH). The bimolecular emission quenching rate constant by triethylamine (TEA) for II, IV, and V is 1.09, 0.745, and 0.583 x 10(8) M-1 s(-1), respectively. Photolysis in dichloromethane-CO2 saturated solution with TEA as a sacrificial electron donor leads in all cases to formic acid generation.

Quality Control of 3,5-Dimethyl-1H-pyrazole. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Saldia, M; Guzman, N; Palominos, F; Sandoval-Altamirano, A; Gunther, G; Pizarro, N; Vega, A or concate me.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

SDS of cas: 67-51-6. I found the field of Chemistry very interesting. Saw the article Nucleophilic Aromatic Substitution of Unactivated Fluoroarenes Enabled by Organic Photoredox Catalysis published in 2020.0, Reprint Addresses Nicewicz, DA (corresponding author), Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA.. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole.

Nucleophilic aromatic substitution (SNAr) is a classical reaction with well-known reactivity toward electron-poor fluoroarenes. However, electron-neutral and electron-rich fluoro(hetero)arenes are considerably underrepresented. Herein, we present a method for the nucleophilic defluorination of unactivated fluoroarenes enabled by cation radical-accelerated nucleophilic aromatic substitution. The use of organic photoredox catalysis renders this method operationally simple under mild conditions and is amenable to various nucleophile classes, including azoles, amines, and carboxylic acids. Select fluorinated heterocycles can be functionalized using this method. In addition, the late-stage functionalization of pharmaceuticals is also presented. Computational studies demonstrate that the site selectivity of the reaction is dictated by arene electronics.

SDS of cas: 67-51-6. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Pistritto, VA; Schutzbach-Horton, ME; Nicewicz, DA or concate me.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

HPLC of Formula: C5H8N2. Macarini, AF; Sobrinho, TUC; Rizzi, GW; Correa, R in [Macarini, Anelise F.; Rizzi, Gerusa W.; Correa, Rogerio] Univ Vale Itajai, Nucleo Invest Quim Farmaceut NIQFAR, Rua Uruguai 458, BR-88302901 Itajai, SC, Brazil; [Macarini, Anelise F.; Correa, Rogerio] Univ Vale Itajai UNIVALI, Programa Posgrad Ciencias Farmaceut, Rua Uruguai 458, BR-88302901 Itajai, SC, Brazil; [Sobrinho, Thales U. C.; Correa, Rogerio] Univ Vale Itajai, Curso Engn Quim, Escola Mar Ciencia & Tecnol, Rua Uruguai 458, BR-88302901 Itajai, SC, Brazil published Pyrazole-chalcone derivatives as selective COX-2 inhibitors: design, virtual screening, and in vitro analysis in 2019.0, Cited 49.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6.

In the process of research and development of new drugs, in silico analyzes are widely used. They address the pharmacokinetics of the molecules in study and can predict the binding mode and affinity, using a docking software. This approach can optimize the development of new drugs, reducing costs, time, and resources. In this study, a library of 300 pyrazole-chalcone derivatives were designed, the in silico ADMET (absorption, distribution, metabolism, excretion, and toxicity) properties were evaluated, and a structure-based virtual screening was performed using AutoDock Vina. The docking results exhibited that the derivatives binding mode at the COX-2 active site is similar to celecoxib, the reference drug, and presented similar binding energy. Six compounds were synthetized and tested for in vitro inhibition of the COX-1 and COX-2 isoenzymes and the selectivity index (SI) was calculated. The compound 2a11 showed the best activity for COX-2 (IC50COX-2=0.73M) whereas the control, celecoxib, resulted IC50COX-2=0.88M. All the other compounds synthetized presented better potency for COX-2 inhibition than the control. Compound 2a23 exhibited the higher SI, of 280.17 (IC50COX-1=210.13M/ IC50COX-2=0.75M), while celecoxib was 246.88 (IC50COX-1=217.26M/ IC50COX-2=0.88M). These results corroborate with a possible anti-inflammatory activity and COX-2 selectivity of the new compounds synthetized.

About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Macarini, AF; Sobrinho, TUC; Rizzi, GW; Correa, R or concate me.. HPLC of Formula: C5H8N2

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Application In Synthesis of 3,5-Dimethyl-1H-pyrazole. Authors Bhattacharyya, D; Sarmah, BK; Nandi, S; Srivastava, HK; Das, A in AMER CHEMICAL SOC published article about in [Srivastava, Hemant Kumar] Natl Inst Pharmaceut Educ & Res Guwahati, Dept Med Chem, Gauhati 781101, Assam, India; [Bhattacharyya, Dipanjan; Sarmah, Bikash Kumar; Nandi, Sekhar; Das, Animesh] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, Assam, India in 2021.0, Cited 78.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

Herein, a phosphine-free pincer ruthenium(III) catalyzed beta-alkylation of secondary alcohols with primary alcohols to alpha-alkylated ketones and two different secondary alcohols to beta-branched ketones are reported. Notably, this transformation is environmentally benign and atom efficient with H2O and H-2 gas as the only byproducts. The protocol is extended to gram-scale reaction and for functionalization of complex vitamin E and cholesterol derivatives.

About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Bhattacharyya, D; Sarmah, BK; Nandi, S; Srivastava, HK; Das, A or concate me.. Application In Synthesis of 3,5-Dimethyl-1H-pyrazole

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Product Details of 67-51-6. I found the field of Polymer Science very interesting. Saw the article The Passerini three-component reaction of aldehyde end-functionalized polymers via RAFT polymerization using chain transfer agents featuring aldehyde published in 2020.0, Reprint Addresses Kakuchi, R (corresponding author), Gunma Univ, Fac Sci & Technol, Div Mol Sci, 1-5-1 Tenjin, Kiryu, Gunma 3768515, Japan.. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole.

In this study, a novel pyrazole-carbodithioate-based chain transfer agent (CTA) featuring an aldehyde group (CTA-CHO) was designed and synthesized for RAFT polymerization. The obtained CTA-CHO was employed for the RAFT polymerization of styrene to afford well-defined polystyrenes bearing an aldehyde at their chain ends with low D values (similar to 1.1). In addition, the reactivity of the aldehyde moiety at the end of the chain was precisely evaluated, while the Passerini three-component reaction was successfully performed on the aldehyde group.

Product Details of 67-51-6. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Kakuchi, R; Okura, Y or concate me.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Recently I am researching about ALKENEDIAZONIUM SALTS; STEREOSELECTIVE-SYNTHESIS; HEXACHLOROANTIMONATE; REARRANGEMENT; CRYSTAL; ESTERS, Saw an article supported by the NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [GM62160]; Umm AlQura University. Recommanded Product: 3,5-Dimethyl-1H-pyrazole. Published in ELSEVIER SCI LTD in OXFORD ,Authors: Hawsawi, M; Pirrone, MG; Wickramasinghe, A; Crich, D. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole

The oxidative deamination of N-nitroso N-acetylneuraminic acid (NeuAc) derivatives is a useful reaction for the formation of 5-desamino-5-hydroxy NeuAc derivatives and their stereoisomers. We demonstrated previously that replacement of the classical nucleophile in these reactions, acetic acid, by phenols resulted in a novel double displacement process with substitution of the acetoxy group at the 4-position taking place in addition to that of the 5-acetamido group, for which we postulated a mechanism centered on the formation of a highly reactive vinyl diazonium ion. We now extend these studies to encompass the use of hydroxylaminebased systems and weakly basic amines as nucleophile. We find that the nature of the product depends significantly on the pKa of the nucleophile, with the more acidic species typically affording only substitution at the 5-position, while the less acidic species give mixtures of elimination products and disubstitution products. The use of aniline as nucleophile is of particular note as it affords a novel aziridine spanning positions 4- and 5- of the neuraminic acid skeleton.

Recommanded Product: 3,5-Dimethyl-1H-pyrazole. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Hawsawi, M; Pirrone, MG; Wickramasinghe, A; Crich, D or concate me.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics