Tag: M.W=400-500

The important role of 191980-54-8

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Iodo-1-trityl-1H-pyrazole, its application will become more common.

Related Products of 191980-54-8,Some common heterocyclic compound, 191980-54-8, name is 4-Iodo-1-trityl-1H-pyrazole, molecular formula is C22H17IN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 4-iodo-l-trityl- lH-pyrazole (4.60 g, 10.5 mmol) in THF (50.0 mL) was purged with nitrogen 3 times. This was followed by dropwise addition of isopropylmagnesium bromide (2.9 M in THF, 4.18 mL, 12.1 mmol) at 0 C. The reaction mixture was stirred under a nitrogen atmosphere at 0 C for 1 h. To the reaction mixture was added a solution of 3-(benzyloxy)propanal (2.08 g, 12.7 mmol) in THF (3.0 mL) at 0 C. The resulting mixture was stirred at RT for 30 minutes. The reaction mixture was quenched with saturated NH4CI solution (2.0 mL), diluted with brine (30 mL) and extracted with ethyl acetate (3×10 mL). The combined organic extracts were dried over anhydrous Na2SC>4 and filtered. The filtrate was concentrated under vacuum. The residue was purified by silica gel chromatography (0 – 40% ethyl acetate in petroleum ether) to afford the title compound. MS = 497.1 (M+l).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Iodo-1-trityl-1H-pyrazole, its application will become more common.

Reference:
Patent; MERCK SHARP & DOHME CORP.; SHEN, Dong-Ming; YANG, Meng; CRESPO, Alexander; WILSON, Jonathan, E.; MCCRACKEN, Troy; WANG, Deping; PARKER, Dann; GUO, Zack Zhiqiang; (135 pag.)WO2016/154081; (2016); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

New learning discoveries about 120202-71-3

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 120202-71-3, in my other articles. COA of Formula: C16H18ClNO6S2.

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 120202-71-3, Name is (R)-Methyl 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate sulfate, molecular formula is , belongs to pyridine-derivatives compound. In a document, author is Mondal, Biswajit, COA of Formula: C16H18ClNO6S2.

Palladium catalyzed 8-aminoimidazo[1,2-a]pyridine (AIP) directed selective beta-C(sp(2))-H arylation

Palladium catalyzed arylation of the inert beta-C(sp(2))-H bond of carboxylic acid derivatives is reported herein for the first time utilizing 8-aminoimidazo[1,2-a]pyridine (AIP) as an efficacious and new inbuilt 6,5-fused bicyclic removable directing group. This protocol is scalable, exhibits high levels of beta-site selectivity and tolerates a broad spectrum of functional groups.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 120202-71-3, in my other articles. COA of Formula: C16H18ClNO6S2.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem