Tag: M.W:100-200

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3-Hydroxy-3-phenylpropanenitrile(SMILESS: N#CCC(O)C1=CC=CC=C1,cas:17190-29-3) is researched.Application of 882562-40-5. The article 《Additions of acetonitrile and chloroform to aromatic aldehydes in the presence of tetrabutylammonium fluoride》 in relation to this compound, is published in Bulletin of the Korean Chemical Society. Let’s take a look at the latest research on this compound (cas:17190-29-3).

When the reaction of 4-substituted benzaldehyde with MeCN took place in the presence TBAF, cyanomethylation competed with oxidation depending on the electronic effect of the substituent, while the reaction in CHCl3 gave chloromethylated products only. Generally, cyanomethylation and trichloromethylation proceeded faster, as the electronic withdrawing effect increase, unless oxidation took place. To complete the reaction, excess of TBAF was needed in case of cyanomethylation, while excess of CHCl3 was needed in trichloromethylation.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Fan, Ye-Cheng; Du, Guang-Fen; Sun, Wan-Fu; Kang, Wei; He, Lin published an article about the compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3,SMILESS:N#CCC(O)C1=CC=CC=C1 ).Quality Control of 3-Hydroxy-3-phenylpropanenitrile. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:17190-29-3) through the article.

N-Heterocyclic carbenes (NHCs) have served as efficient catalysts for cyanomethylation of carbonyl compounds In the presence of 5 mol % NHC, various aldehydes and 2,2,2-trifluoroacetophenone reacted with trimethylsilylacetonitrile (TMSAN) to give β-hydroxynitriles in moderate to high yields.

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Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Formula: C9H9NO. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Synthesis of β-hydroxy nitriles and 1,3-amino alcohols from epoxides using acetone cyanohydrin as a LiCN precursor.

The reaction of acetone cyanohydrin with MeLi affords a LiCN·acetone complex that can be made to react with epoxides in THF, either in one-pot or using isolated samples of the cyanide complex, to cleanly afford β-hydroxy nitriles upon aqueous workup; in situ hydride reduction of nitriles affords 1,3-amino alcs.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application In Synthesis of 2-Amino-4,6-dichloro-5-methylpyrimidine. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Amino-4,6-dichloro-5-methylpyrimidine, is researched, Molecular C5H5Cl2N3, CAS is 7153-13-1, about Discovery of a Dual Tubulin Polymerization and Cell Division Cycle 20 Homologue Inhibitor via Structural Modification on Apcin.

Apcin is one of the few compounds that have been previously reported as a Cdc20 specific inhibitor, although Cdc20 is a very promising drug target. We reported here the design, synthesis, and biol. evaluations of 2,2,2-trichloro-1-aryl carbamate derivatives as Cdc20 inhibitors. Among these derivatives, compound 9f(I) was much more efficient than the pos. compound apcin in inhibiting cancer cell growth, but it had approx. the same binding affinity with apcin in SPR assays. It is possible that another mechanism of action might exist. Further evidence demonstrated that compound 9f also inhibited tubulin polymerization, disorganized the microtubule network, and blocked the cell cycle at the M phase with changes in the expression of cyclins. Thus, it induced apoptosis through the activation of caspase-3 and PARP. In addition, compound 9f inhibited cell migration and invasion in a concentration-dependent manner. These results provide guidance for developing the current series as potential new anticancer therapeutics.

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Pyrazole – Wikipedia,
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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Regioselective nucleophilic opening of epoxides and aziridines under neutral conditions in the presence of β-cyclodextrin in water, the main research direction is epoxide regioselective nucleophilic opening sodium cyanide cyclodextrin catalyst water; aziridine regioselective nucleophilic opening cyclodextrin catalyst water; hydroxy nitrile preparation; amino alc preparation.Quality Control of 3-Hydroxy-3-phenylpropanenitrile.

A variety of β-hydroxy nitriles and β-amino alcs. were synthesized by the regioselective ring opening of epoxides and aziridines under neutral and aqueous conditions in the presence of β-cyclodextrin in good yields.

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Kumagai, Naoya; Matsunaga, Shigeki; Shibasaki, Masakatsu published the article 《Cooperative catalysis of a cationic ruthenium complex, amine base, and Na salt: catalytic activation of acetonitrile as a nucleophile》. Keywords: aldehyde acetonitrile addition ruthenium DBU sodium fluorophosphate; aryl hydroxypropanenitrile preparation; aminopropanenitrile preparation; ruthenium DBU sodium fluorophosphate addition catalyst.They researched the compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ).Formula: C9H9NO. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:17190-29-3) here.

Cooperative catalysis of a cationic Ru complex, DBU, and NaPF6 is described. An exquisite combination of the catalytic triad enabled catalytic activation of acetonitrile as a nucleophile under mild amine-basic conditions. Addition of in situ-generated, Ru-bound, metalated nitrile to aldehydes and imines proceeded smoothly with catalytic amounts of Ru complex and DBU in the presence of a catalytic amount of NaPF6. Preliminary mechanistic studies suggested a role for each of the three catalytic components.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 17190-29-3, is researched, SMILESS is N#CCC(O)C1=CC=CC=C1, Molecular C9H9NOJournal, Article, Research Support, Non-U.S. Gov’t, Chemistry – A European Journal called Direct Catalytic Addition of Alkylnitriles to Aldehydes by Transition-Metal/NHC Complexes, Author is Sureshkumar, Devarajulu; Ganesh, Venkataraman; Kumagai, Naoya; Shibasaki, Masakatsu, the main research direction is beta hydroxynitrile enantioselective diastereoselective preparation; alkylnitrile aldehyde rhodium heterocyclic carbene catalyst addition reaction; N-heterocyclic carbenes; alkylnitriles; asymmetric catalysis; cooperative catalysis; rhodium.Recommanded Product: 17190-29-3.

Direct catalytic addition of alkylnitriles to aldehydes allowed for an atom-economical access to β-hydroxynitriles under proton transfer conditions. Direct use of alkylnitriles as pronucleophiles was hampered due to their low acidity resulting in an inability to generate α-cyano carbanions in a catalytic manner. A transition metal/N-heterocyclic carbene (NHC) complex prepared from [{Rh(OMe)(cod)}2] and an imidazolium-based carbene was identified as an effective catalyst to promote the reaction with as little as 1.25 mol % of catalyst loading. The corresponding Rh complex, derived from chiral triazolium salt, rendered the reaction enantioselective, albeit with moderate enantioselectivity.

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Application of 17190-29-3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Ring opening of epoxides with sodium cyanide catalyzed with Ce(OTf)4. Author is Iranpoor, N.; Shekarriz, M..

Efficient and regioselective conversion of epoxides I [R = Ph, Bu, Me2CHOCH2, H2C:CHCH2OCH2, ClCH2, PhOCH2; R1 = H; RR1 = (CH2)4] to β-hydroxy nitriles II with sodium cyanide in the presence of catalytic amounts of Ce(OTf)4 is described under solvent free conditions.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 17190-29-3, is researched, Molecular C9H9NO, about Methods for the stereoselective cis-cyanohydroxylation and -carboxyhydroxylation of olefins, the main research direction is stereoselectivity cyanohydroxylation carboxyhydroxylation olefin; hydroxylation cyano carboxy olefin; isoxazoline derivative preparation cleavage.Category: pyrazoles-derivatives.

EtO2CCNO (I) and THPOCH2CNO (THP = tetrahydropyranyl) (II) are valuable reagents for cis-stereospecific vicinal cyanohydroxylation and carboxyhydroxylation of olefins. The cyanohydroxylation process is based on the decarboxylative ring cleavage of 3-carboxyisoxazolines, prepared by the [3 + 2]-cycloaddition reaction of I with various alkenes. Fragmentation of the isoxazolines prepared from cis- and trans-2-butene occurs without crossover in stereochem. The carboxyhydroxylation process begins with the dipolar cycloaddition reaction of II with olefins. Deprotection, hydrogenation, and oxidative cleavage of the derived dihydroxy ketone yield the stereochemically pure β-hydroxycarboxylic acid.

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Reference:
Pyrazole – Wikipedia,
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HPLC of Formula: 17190-29-3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about 1,3-Dipolar cycloadditions. 72. Reactions of fulminic acid with unsaturated compounds.

The slow generation of fulminic acid (I), the parent substance of nitrile oxides, from ICH:NOH and NEt3 in organic media makes in situ cycloadditions to alkenes and alkynes of sufficient dipolarophilic activity possible. The NMR spectra allow the structural elucidation of the produced 2-isoxazolines and isoxazoles. The observed directions of cycloaddition correspond largely to those of benzonitrile oxide. On using dipolarophiles of lower activity, the oligomerization of formonitrile oxide competes with its cycloadditions; in some cases cycloadducts of the dimeric I HON:CHC:N+O- were isolated. The so far nearly unknown 2-isoxazolines unsubstituted in 3-position suffer a base-catalyzed ring opening which leads to the formal adducts of OH and CN to the double bond of the olefinic dipolarophile. Free I is not an intermediate in the formation of PhNHCOCN+O- from MeNO2 and PhNCO in the presence of NEt3 as shown by competition experiments

From this literature《1,3-Dipolar cycloadditions. 72. Reactions of fulminic acid with unsaturated compounds》,we know some information about this compound(17190-29-3)HPLC of Formula: 17190-29-3, but this is not all information, there are many literatures related to this compound(17190-29-3).

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