Tag: M.W:200-300

Adding a certain compound to certain chemical reactions, such as: 98519-65-4, name is 4-Bromo-7-chloroquinoline, belongs to quinolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 98519-65-4, Safety of 4-Bromo-7-chloroquinoline

EXAMPLE 7 4-Hydroxymethyl-7-chloroquinoline STR17 A 200 ml stainless steel autoclave was loaded with 4-bromo-7-chloroquinoline (1.2 g, 5.0 mmol) (Can. Pat. CA 94-2133620 941004), bis(triphenylphosphine)palladium chloride (0.1 g), triethylamine (3 ml) and ethanol (40 ml) and pressurized to 200 psi with carbon monoxide. The autoclave was heated at 120 C. for 12 hours, cooled, and vented. Solids were removed by filtration through celite and the mother liquor concentrated in vacuo. The residue was taken up in chloroform (50 ml), washed with water (3*50 ml), saturated brine (50 ml), and dried (Na2 SO4). Filtration and removal of solvent left 1.3 g of a brown liquid. Flash chromatography on silica using 1 vol % CH3 CN in CH2 Cl2 as eluent afforded product as a colorless syrup which solidified to a waxy solid. This solid was dissolved in methanol (50 ml) and sodium borohydride was added over two hours until judged complete by TLC. The reaction was diluted with water and acidified with 1N hydrochloric acid and then neutralized with sodium bicarbonate. The resulting solid was recovered via filtration, dissolved in ethyl acetate and dried (MgSO4). Filtration and concentration afforded the desired compound (mp: 160 C., 0.66 g, 68% over two steps).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-7-chloroquinoline, other downstream synthetic routes, hurry up and to see.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3279-90-1 as follows. Safety of 6-Bromo-3,4-dihydro-1H-quinolin-2-one

00104] A solution of 6-bromo-3,4-dihydroquinolin-2(lH)-one, 13 (10.0 g, 44.2 mmol) in THF (25 mL) was added to stirred solution of 60% NaH (3.53 g, 88.4 mmol) in THF (100 mL) at 0 C and the mixture was stirred for 30 min. A solution of 2-(4-(bromomethyl)phenyl)-l,l, l,3,3,3- hexafluoropropan-2-ol, 2 (18.4 g, 55.3 mmol) in THF (25 mL) was added and the mixture was slowly heated to 65 C overnight. The progress of the reaction was monitored by TLC (TLC system: 30 % EtO Ac/Pet ether, Rf value: 0.45). [00105] After completion of the reaction, the reaction mixture was poured into ice cold water and extracted with ethyl acetate (2 x 200 mL). The combined organic layers were dried over anhydrous sodium sulfate and the solvent was removed under reduced pressure to afford crude product. The crude product was washed with pet ether followed by dichloromethane to afford 6- bromo- l-(4-(l,l, l,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)-3,4-dihydroquinolin-2(lH)-one, 14. LC/MS calc M+H 482, obs 482; lH NMR (400 MHz, DMSO-d6) delta: 8.65 (s, 1 H), 7.61 (d, 2 H, J = 8.4 Hz), 7.47 (d, 1 H, J= 2.0 Hz), 7.35-7.30 (m, 3 H), 6.85 (d, 1 H, J= 8.4 Hz), 5.17 (s, 2 H), 2.98 (t, 2 H, J= 6.8 Hz), 2.71 (m, 2 H).

According to the analysis of related databases, 3279-90-1, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 14548-51-7, name is 7-Bromo-3,4-dihydroquinolin-2(1H)-one, belongs to quinolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14548-51-7, Product Details of 14548-51-7

Pd(PPh3)4 (102 mg, 0.088 mmol) was added to a degassed solution of 7-bromo-3,4-dihydro-1H- quinolin-2-one (100 mg, 0.442 mmol), 1 ,3-dimethyl-5-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2- yl)pyridin-2-one (prepared using described procedure in U520130053362, 165 mg, 0.664 mmol), and C52CO3 (288 mg, 0.885 mmol) in DME (5 mL) and water (0.5 mL). The resulting mixture washeated to 80 C for 5 h and then cooled to rt. The mixture was diluted with saturated NaHCO3 (20 mL) and EtOAc (20 mL), and the aqueous phase was extracted with EtOAc (3 x 20 mL). The combined organic phases were dried over Mg504, filtered, and evaporated under reduced pressure. The material was purified by flash chromatography on silica gel using a mixture of DCM and MeOH as eluent to provide Intermediate 3 (56 mg, 47%). 1H NMR (500 MHz, MeOD) O 7.78(d, J = 2.5 Hz, 1H), 7.70 (dd, J = 2.5, 1.1 Hz, 1H), 7.24 (d, J = 7.8 Hz, 1H), 7.15 (dd, J = 7.8, 1.9 Hz, 1H), 6.98 (d, J = 1.8 Hz, 1H), 3.65 (5, 3H), 3.01 -2.94 (m, 2H), 2.62-2.56 (m, 2H), 2.22- 2.17 (m, 3H). MS (ESI) [M+H] 269.3.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Bromo-3,4-dihydroquinolin-2(1H)-one, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3279-90-1, name is 6-Bromo-3,4-dihydro-1H-quinolin-2-one, A new synthetic method of this compound is introduced below., Application In Synthesis of 6-Bromo-3,4-dihydro-1H-quinolin-2-one

Under nitrogen protection,100mL three bottles,The compound 6-bromo-3,4-dihydroquinolin-2 (1H) -one (2.5 g, 11.06 mmol)And N, N-dimethylformamide (2.5 g, 11.06 mmol) were dissolved in dry tetrahydrofuran (50 mL) and cooled to -78 C.A solution of tert-butyllithium (24.1 mL, 38.7 mmol, 1.6 M in pentane) was slowly added dropwise,After completion of the dropwise addition, the reaction was continued at -78 C for 4 hours,Acetic acid (2.5 mL) was added and the temperature was slowly warmed to room temperature.The reaction solution was diluted with ethyl acetate (100 mL) and washed successively with saturated sodium bicarbonate solution and brine. The organic phase was dried, filtered and concentrated to give 2-oxo-1,2,3,4-tetrahydroquinoline-6-carbaldehyde (0.6 g) in 30% yield.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 63149-33-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 63149-33-7 name is 8-Hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinoline-9-carbaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Sensor 1 was prepared by the reaction of 8-hydroxyjulolidine-9-carboxaldehyde (0.22 muL, 1.0 mmol) and furan-2-carbohydrazide (0.13 g, 1.0 mmol) in ethanol. Two drops ofHCl were added into the reaction solution, which was stirredfor 2 days at room temperature. A yellow precipitate was filtered,washed several times with cold ethanol, and dried invacuum. Yield: 0.29 g (89%). The 1H NMR spectra wererecorded in DMSO-d6, and the descriptions of the signalsinclude: s = singlet, d = doublet, t = triplet and m = multiplet(400 MHz, 25 C): delta = 11.82 (s, 1H), 11.66 (s, 1H), 8.29 (s,1H), 7.91 (d, 1H), 7.22 (d, 1H), 6.68 (d, 2H), 3.16 (m, 4H),2.48 (m, 4H), 1.84 (m, 4H); 13C NMR (100 MHz, CD3CN,25 C): delta = 154.91, 153.72, 151.35, 145.75, 128.56, 115.23,112.31, 106.07, 49.61, 26.82, 21.23. IR (KBr, nu cm-1) = 3209(m), 2938 (m), 2839 (m), 2361 (m), 2160 (m), 1627 (m), 1590(s), 1507 (s), 1461 (m), 1349 (m), 1292 (s), 1174 (s), 1086(m), 1013 (m), 968 (m), 844 (m), 744 (s), 662 (s). Anal. calcdfor C18H19N3O3: C, 66.45; H, 5.89; N, 12.91%. Found: C,66.27; H, 5.94; N, 12.83%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 8-Hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinoline-9-carbaldehyde, and friends who are interested can also refer to it.

Related Products of 18704-37-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 18704-37-5, name is Quinoline-8-sulfonyl chloride, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of 3-(1H-tetrazol-5-yl)aniline (1 eq.) in DCM dry (25 mL) at room temperature and under nitrogen atmosphere, pyridine (3 eq.) and the appropriate sulfonyl-chloride (1.2 eq.) were added. The mixture was reacted at room temperature for 2-12 h. The reaction was quenched with aqueous saturated solution of NH4Cl and acidified at pH 4 with aqueous 1N HCl. The aqueous phase was extracted with AcOEt, and the organic phase washed with brine, dried over Na2SO4 and concentrated. The crude was crystalized from MeOH or Et2O to give the desired product.

The chemical industry reduces the impact on the environment during synthesis Quinoline-8-sulfonyl chloride. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 661463-17-8, name is 4-Bromo-6-fluoroquinoline, A new synthetic method of this compound is introduced below., Recommanded Product: 661463-17-8

Under nitrogen protection and -70 C,Dissolve in 20 mL of THF containing 4-bromo-6-fluoroquinoline (1.4 g, 6.2 mmol)n-Butyllithium (1.6 M in n-hexane solution, 3.9 mL, 6.2 mmol) was added dropwise to the solution.The reaction mixture is stirred at -70 CAfter 30 min, a solution of 3-cyano-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (1.4 g, 5.6 mmol) in 5 mL THF was added dropwise.The system was stirred at 70 C for 2 h.Pour into 100mL of saturated ammonium chloride solution,Then extract with EA (50mL x 3),The organic phase is washed with saturated brine.The anhydrous Na2SO4 was sufficiently dried.Concentration under reduced pressure and column chromatography (DCM:MeOH = 30:1)Purification afforded 1.1 g (yield: 46%) of title compound.It is a yellow solid.

The synthetic route of 661463-17-8 has been constantly updated, and we look forward to future research findings.

29969-57-1, name is 2-Chloro-6-nitroquinoline, belongs to quinolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 2-Chloro-6-nitroquinoline

General procedure: To a solution of substituted quinolines (5a-b) (1.0-1.5equiv.), compound 8 (1.0equiv.) in degassed 1,4-dioxane were added Pd2(dba)3 (0.1-0.2 equiv.), t-butylXphos (0.1-0.2equiv.), and Cy2NMe (2.0 equiv.). The solution was stirred under N2 at 120C for 18-40h. The mixture was filtered through Celite and washed with EtOAc. The solution was washed with water and brine, and dried with Na2SO4. The crude material was purified by column chromatography (silica gel, Hexane/EtOAc).

The synthetic route of 29969-57-1 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 6541-19-1, name is 6,7-Dichloroquinoline-5,8-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 6541-19-1

General procedure: Procedure (II). A solution of the selected substituted arylthiols (2 equiv.) in ethanol (25 mL) was added dropwise to astirred solution of quinone [(2, 0.10 g, 0.44 mmol) or (3,0.10 g, 0.41 mmol)] in chloroform (10 mL). The reactionmixture was stirred at 30-40 C for 6-10 h until consumptionof the reactants.[22]

The synthetic route of 6,7-Dichloroquinoline-5,8-dione has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3279-90-1 as follows. SDS of cas: 3279-90-1

To a solution of 6-bromo-3,4-dihydro-1 H-quinolin-2-one (339 mg, 1.50 mmol) in 15 ml dry DMF was added potassium tert-butylate (336 mg, 3.0 mmol). After the mixture was stirred for 30 min at room temperature, a solution of methyl iodide (426 mg, 3.0 mmol) in 5 ml dry DMF was added. Following overnight stirring, the mixture was diluted with 100 ml 1 N HCI.Extraction with ethyl acetate (2 x 100 ml_) followed by washing of the organic extracts with water and brine, drying over MgSO4 and removal of the solvent in vacuo gave a light yellow solid. Purification by flash chromatography (hexanes/ethyl acetate, 7/3, R, = 0.21) gave 6- bromo-1-methyl-3,4-dihydro-1H-quinolin-2-one (281 mg, 1.17 mmol, 78 %) as colorless needles.

According to the analysis of related databases, 3279-90-1, the application of this compound in the production field has become more and more popular.