Tag: M.W:100-200

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about A Robust Nickel Catalyst for Cyanomethylation of Aldehydes: Activation of Acetonitrile under Base-Free Conditions, the main research direction is nickel catalyst cyanomethylation aldehyde acetonitrile; CH bond activation; aldol reaction; nickel; phosphane ligands; synthetic methods.COA of Formula: C9H9NO.

In this article, the author discusses an inexpensive, air- and moisture-stable nickel cyanomethyl complex capable of catalyzing the coupling of aldehydes and acetonitrile without adding any base or additive. The catalytic turnover numbers (TONs up to 82000) are the highest ever for such a transformation. A preliminary mechanistic study is consistent with the mode of activation of acetonitrile.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, European Journal of Organic Chemistry called Reaction of the Electrogenerated Cyanomethyl Anion with Carbonyl Compounds: A Clean and Safe Synthesis of β-Hydroxynitriles, Author is Bianchi, Gabriele; Feroci, Marta; Rossi, Leucio, which mentions a compound: 17190-29-3, SMILESS is N#CCC(O)C1=CC=CC=C1, Molecular C9H9NO, SDS of cas: 17190-29-3.

The electrogenerated cyanomethyl anion reacts with carbonyl compounds to yield the corresponding β-hydroxy nitriles in moderate to high yields. The reported methodol. is very clean and safe, avoiding the use of any classical base or catalyst. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009).

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Quality Control of 2-Amino-4,6-dichloro-5-methylpyrimidine. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Amino-4,6-dichloro-5-methylpyrimidine, is researched, Molecular C5H5Cl2N3, CAS is 7153-13-1, about 5-Substituted 2-amino-4,6-dihydroxypyrimidines and 2-amino-4,6-dichloropyrimidines. Synthesis and inhibitory effects on immune-activated nitric oxide production. Author is Jansa, Petr; Holy, Antonin; Dracinsky, Martin; Kolman, Viktor; Janeba, Zlatko; Kostecka, Petra; Kmonickova, Eva; Zidek, Zdenek.

A series of 5-substituted 2-amino-4,6-dihydroxypyrimidines were prepared by a modified condensation of the corresponding monosubstituted malonic acid diesters with guanidine in an excess of sodium ethoxide. The optimized procedure using Vilsmeier-Haack-Arnold reagent, followed by immediate deprotection of the (dimethylamino)methylene protecting groups, was developed to convert the 2-amino-4,6-dihydroxypyrimidine analogs to novel 5-substituted 2-amino-4,6-dichloropyrimidines in high yields. Pilot screening for biol. properties of the prepared compounds was done in mouse peritoneal cells using the in vitro nitric oxide (NO) assay. Irresp. of the substituent at the 5 position, 2-amino-4,6-dichloropyrimidines inhibited immune-activated NO production The most effective was 5-fluoro-2-amino-4,6-dichloropyrimidine with an IC50 of 2 μM (higher activity than the most potent reference compound) while the IC50s of other derivatives were within the range of 9-36 μM. The 2-amino-4,6-dihydroxypyrimidine counterparts were devoid of any NO-inhibitory activity. The compounds had no suppressive effects on the viability of cells.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Tsuruoka, Akihiko; Negi, Shigeto; Yanagisawa, Manabu; Nara, Kazumasa; Naito, Toshihiko; Minami, Norio researched the compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ).Synthetic Route of C9H9NO.They published the article 《Practical oxirane ring opening with in situ prepared LiCN; synthesis of (2S, 3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)-1-butanenitrile》 about this compound( cas:17190-29-3 ) in Synthetic Communications. Keywords: oxirane regioselective ring cleavage lithium cyanide; cyanation haloalkylbenzene lithium cyanide. We’ll tell you more about this compound (cas:17190-29-3).

The title compound was obtained in 73% yield by regiospecific opening of an oxirane ring with LiCN, prepared in situ from acetone cyanohydrin and LiH, providing this key intermediate for a new antifungal agent on a multi-kg scale. Ring opening of other oxiranes and nucleophilic substitution are also described.

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Safety of 3-Hydroxy-3-phenylpropanenitrile. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Connecting Neutral and Cationic Pathways in Nickel-Catalyzed Insertion of Benzaldehyde into a C-H Bond of Acetonitrile. Author is Smith, Jacob B.; Miller, Alexander J. M..

Nickel catalysts supported by diethylamine- or aza-crown ether-containing aminophosphinite (NCOP) pincer ligands catalyze the insertion of benzaldehyde into a C-H bond of acetonitrile. The catalytic activity of neutral (NCOP)Ni(OtBu) and cationic [(NCOP)Ni(NCCH3)]+ are starkly different. The neutral tert-butoxide precatalysts are active without any added base and give good yields of product after 24 h, while the cationic precatalysts require a base cocatalyst and still operate much more slowly (120 h in typical runs). A series of in situ spectroscopic studies identified several intermediates, including a nickel cyanoalkoxide complex that was observed in all of the reactions regardless of the choice of precatalyst. Reaction monitoring also revealed that the neutral tert-butoxide precatalysts decompose to form the cationic acetonitrile complex during catalysis; this deactivation involves alkoxide abstraction and can be hastened by the addition of lithium salts. While the deactivated cationic species is inactive under standard base-free conditions, catalysis can be re-initiated by the addition of catalytic amounts of base.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Benzenesulfonylnitrile oxide: a useful intermediate for the syn-cyanohydroxylation of alkenes.SDS of cas: 17190-29-3.

A general procedure allowing the syn-cyanohydroxylation of alkenes is presented. Generation of PhSO2CNO (I) in the presence of alkenes affords 3-(phenylsulfonyl)isoxazolines. Even Me2C:CMe2 undergoes cycloaddition Treatment of the cycloadducts with 2% Na amalgam results in ring fragmentation completing the syn-cyanohydroxylation process. Treatment of the cycloadducts with strong nucleophiles (LiOMe, NaCN or NaBH4) results in substitution of the phenylsulfonyl group. This latter process, in conjunction with the initial cycloaddition, allows the use of I as a synthetic equivalent of other nitrile oxides.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Claisen-Schmidt condensation of acetonitrile with aromatic carbonyl compounds, published in 1969, which mentions a compound: 17190-29-3, mainly applied to benzaldehyde Claisen Schmidt condensations; Claisen Schmidt condensations benzaldehyde; acetophenone Claisen Schmidt condensations; benzophenone Claisen Schmidt condensations, Synthetic Route of C9H9NO.

Treatment of BzH with MeCN containing Na gave PhCH2OH, PhCH(OH)CH2CN and a small amount PhCH:CHCN; BzMe gave PhC(OH)(Me)CH2CN at room temperature and PhCMe:CHCN at reflux; and BzPh gave Ph2C:CHCN at room temperature and, in higher yield, at reflux.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Steric vs. electronic effects in the Lactobacillus brevis ADH-catalyzed bioreduction of ketones.Application of 17190-29-3.

Lactobacillus brevis ADH (LBADH) is an alc. dehydrogenase that is commonly employed to reduce alkyl or aryl ketones usually bearing a Me, an Et or a chloromethyl as a small ketone substituent to the corresponding (R)-alcs. Herein we have tested a series of 24 acetophenone derivatives differing in their size and electronic properties for their reduction employing LBADH. After plotting the relative activity against the measured substrate volumes we observed that apart from the substrate size other effects must be responsible for the activity obtained. Compared to acetophenone (100% relative activity), other small substrates such as propiophenone, α,α,α-trifluoroacetophenone, α-hydroxyacetophenone, and benzoylacetonitrile had relative activities lower than 30%, while medium-sized ketones such as α-bromo-, α,α-dichloro-, and α,α-dibromoacetophenone presented relative activities between 70% and 550%. Moreover, the comparison between the enzymic activity and the obtained final conversions using an excess or just 2.5 equivalent of the hydrogen donor 2-propanol, denoted again deviations between them. These data supported that these hydrogen transfer (HT) transformations are mainly thermodynamically controlled. For instance, bulky α-halogenated derivatives could be quant. reduced by LBADH even employing 2.5 equivalent of 2-propanol independently of their kinetic values. Finally, we found good correlations between the IR absorption band of the carbonyl groups and the degrees of conversion obtained in these HT processes, making this simple method a convenient tool to predict the success of these transformations.

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Name: 3-Hydroxy-3-phenylpropanenitrile. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Synthesis of β-hydroxy nitriles via indium-induced coupling of bromoacetonitrile with carbonyl compounds. Author is Araki, Shuki; Yamada, Masafumi; Butsugan, Yasuo.

The organoindium reagent, derived from indium metal and bromacetonitrile, reacted with carbonyl compounds in the presence of chlorotrimethylsilane to give, after hydrolysis, β-hydroxy nitriles. Thus, p-nitrobenzaldehyde afforded 58% p-O2NC6H4CH(OH)CH2CN by this reaction. The coupling proceeded with high chemoselectivity, though the diastereoselectivity was low.

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Pamies, Oscar; Backvall, Jan-E. published the article 《Efficient lipase-catalyzed kinetic resolution and dynamic kinetic resolution of β-hydroxy nitriles. Correction of absolute configuration and transformation to chiral β-hydroxy acids and γ-amino alcohols》. Keywords: kinetic enzymic resolution hydroxy nitrile transacetylation; hydroxy carboxylic acid stereoselective preparation enzymic resolution; amino alc stereoselective preparation enzymic resolution.They researched the compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ).SDS of cas: 17190-29-3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:17190-29-3) here.

Chemoenzymic dynamic kinetic resolution of β-hydroxy nitriles has been carried out using Candida antarctica lipase B and a ruthenium catalyst. The use of a hydrogen source to depress ketone formation in the dynamic kinetic resolution yields the acetates in good yield and high enantioselectivity. It is shown that the ruthenium catalyst and the enzyme can be recycled when used in sep. reactions. Enantiomerically pure β-hydroxy acid derivatives and γ-amino alcs. were prepared from the hydroxy nitriles and acetates. The latter compounds were also used to establish the correct absolute configuration of the hydroxy nitriles and acetates.

In some applications, this compound(17190-29-3)SDS of cas: 17190-29-3 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
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