Tag: M.W:200-300

Adding a certain compound to certain chemical reactions, such as: 141573-95-7, name is Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 141573-95-7, HPLC of Formula: C8H10F2N2O2

Example 9 (0339) (0340) At room temperature under a nitrogen atmosphere, 5.91 parts (purity: 95.9%, R isomers/S isomers=95.4/4.6) of (R)-1,1,3-trimethyl-4-aminoindane, 21.5 parts of tetrahydrofuran, and 1.29 parts (purity: 60%) of sodium hydride were mixed. The obtained mixture was heated and refluxed for 1 hour. The reaction liquid was cooled to room temperature. To the obtained solution was added dropwise a solution in which 6.13 parts (purity: 97.8%) of ethyl 1-methyl-3-difluoromethylpyrazole-4-carboxylate had been dissolved in 9.2 parts of tetrahydrofuran. The obtained mixture was heated in an oil bath at 90 C. and stirred for 8 hours while tetrahydrofuran was evaporated. At this time, tetrahydrofuran in the same amount of the evaporated tetrahydrofuran was added thereto freshly at times, such that the concentration of the reaction liquid became constant. The obtained mixture was cooled to room temperature and then 92.0 parts of toluene was added thereto. The obtained mixture was washed sequentially with 5% hydrochloric acid, a saturated sodium bicarbonate solution, and saturated physiological saline. The obtained organic layer was concentrated under reduced pressure to obtain 13.1 parts of (R)-(-)-N-(1,1,3-trimethylindan-4-yl)-1-methyl-3-difluoromethylpyrazole-4-carboxylic acid amide. The content of (R)-(-)-N-(1,1,3-trimethylindan-4-yl)-1-methyl-3-difluoromethylpyrazole-4-carboxylic acid amide was 64.8% (the yield with respect to ethyl 1-methyl-3-difluoromethylpyrazole-4-carboxylate of 86.4%). Further, the ratio of R isomers/S isomers of (R)-(-)-N-(1,1,3-trimethylindan-4-yl)-1-methyl-3-difluoromethylpyrazole-4-carboxylic acid amide was 95.4/4.6.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.

Electric Literature of 1150271-23-0, These common heterocyclic compound, 1150271-23-0, name is tert-Butyl 4-bromo-1H-pyrazole-1-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred degassed solution of 4-bromo-pyrazole-1 -carboxylic acid tert- butyl ester (300 mg, 1 .21 mmol) in DMF (3 mL) were added phenyl acetylene (0.24 ml_, 2.18 mmol), triethyl amine (0.84 mL, 6.05 mmol), Cul (40.16 mg, 0.24 mmol) followed by Pd(PPh3)4 (279.58 mg, 0.24 mmol). Resulting reaction mixture was heated at 70C for 6 hours. After completion, the reaction mixture was diluted with water and extracted with ethyl acetate. Combined organic layer was dried over sodium sulfate and concentrated under reduced pressure. Crude compound was purified by column chromatography (10-20% ethyl acetate in hexane) to get tert-butyl 4-(2-phenylethynyl)-1 H-pyrazole-1-carboxylate (230 mg, 70%) as brown liquid. MS (ESI): m/z 269.3 [M+1]+.

The synthetic route of 1150271-23-0 has been constantly updated, and we look forward to future research findings.

Related Products of 345637-71-0, The chemical industry reduces the impact on the environment during synthesis 345637-71-0, name is 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, I believe this compound will play a more active role in future production and life.

Step D: Preparation of 1-[4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-3,6-dihydro-1(2H)-pyridinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone To a solution of 4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-1,2,3,6-tetrahydropyridine hydrochloride (i.e. the product of Example 13, Step C) (0.250 g, 0.720 mmol) and 5-methyl-3-(trifluoromethyl)-1H-pyrazole-1-acetic acid (0.150 g, 0.720 mmol) in dichloromethane (10 mL) was added N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide (0.138 g, 0.720 mmol), 1-hydroxybenzotriazole (0.024 g, 0.177 mmol), and triethylamine (0.145 g, 1.44 mmol) at room temperature. The reaction mixture was stirred at room temperature for 24 h. The reaction mixture was diluted with dichloromethane (30 mL) and washed with water (20 mL) and brine (20 mL). The organic layer was separated, washed with water, dried (Na2SO4), and concentrated under reduced pressure and purified by medium-pressure liquid chromatography using 3% methanol in chloroform as eluant to give 200 mg of the title product as a white solid. 1H NMR (CDCl3): delta 2.3 (s, 3H), 2.71-2.75 (m, 2H), 3.42-3.46 (m, 1H), 3.74-3.88 (m, 3H), 4.24-4.27 (m, 2H), 5.02 (s, 2H), 5.71-5.76 (m, 1H), 6.32 (s, 1H), 6.57 (s, 1H), 7.3-7.38 (m, 5H), 7.64 (s, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 70951-85-8, name is 4-Bromo-1-(tert-butyl)-1H-pyrazole, A new synthetic method of this compound is introduced below., Safety of 4-Bromo-1-(tert-butyl)-1H-pyrazole

A solution of 4-bromo-1-tert-butyl-1H-pyrazole (973 mg, 4.79 mmol) in anhydrous THF (9.5 ml) was cooled to -78 C. under argon. A solution of n-BuLi in Hexanes (1.6 M, 3.2 mL, 5.12 mmol) was then added dropwise over 5 min and reaction mixture was stirred at -78 C. for 80 min. A solution of N-methoxy-N-methylacetamide (0.55 ml, 5.17 mmol) in THF (3 mL) was added dropwise and mixture was warmed to 0 C. After 4 hours, reaction mixture was quenched via addition of NH4Cl (aq) (10 mL) and mixture was extracted with ethyl acetate. Combined organic layers were washed with 50% brine, dried (Na2SO4), filtered, and concentrated under reduced pressure. Resulting residue was purified by silica gel column chromatography (0-50% ethyl acetate in hexanes) to yield 1-(1-tert-butyl-1H-pyrazol-4-yl)ethanone 5.14.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 345637-71-0, The chemical industry reduces the impact on the environment during synthesis 345637-71-0, name is 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, I believe this compound will play a more active role in future production and life.

Step D: Preparation of 1-[4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-3,6-dihydro-1(2H)-pyridinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone To a solution of 4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-1,2,3,6-tetrahydropyridine hydrochloride (i.e. the product of Example 13, Step C) (0.250 g, 0.720 mmol) and 5-methyl-3-(trifluoromethyl)-1H-pyrazole-1-acetic acid (0.150 g, 0.720 mmol) in dichloromethane (10 mL) was added N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide (0.138 g, 0.720 mmol), 1-hydroxybenzotriazole (0.024 g, 0.177 mmol), and triethylamine (0.145 g, 1.44 mmol) at room temperature. The reaction mixture was stirred at room temperature for 24 h. The reaction mixture was diluted with dichloromethane (30 mL) and washed with water (20 mL) and brine (20 mL). The organic layer was separated, washed with water, dried (Na2SO4), and concentrated under reduced pressure and purified by medium-pressure liquid chromatography using 3% methanol in chloroform as eluant to give 200 mg of the title product as a white solid. 1H NMR (CDCl3): delta 2.3 (s, 3H), 2.71-2.75 (m, 2H), 3.42-3.46 (m, 1H), 3.74-3.88 (m, 3H), 4.24-4.27 (m, 2H), 5.02 (s, 2H), 5.71-5.76 (m, 1H), 6.32 (s, 1H), 6.57 (s, 1H), 7.3-7.38 (m, 5H), 7.64 (s, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 70951-85-8, name is 4-Bromo-1-(tert-butyl)-1H-pyrazole, A new synthetic method of this compound is introduced below., Safety of 4-Bromo-1-(tert-butyl)-1H-pyrazole

A solution of 4-bromo-1-tert-butyl-1H-pyrazole (973 mg, 4.79 mmol) in anhydrous THF (9.5 ml) was cooled to -78 C. under argon. A solution of n-BuLi in Hexanes (1.6 M, 3.2 mL, 5.12 mmol) was then added dropwise over 5 min and reaction mixture was stirred at -78 C. for 80 min. A solution of N-methoxy-N-methylacetamide (0.55 ml, 5.17 mmol) in THF (3 mL) was added dropwise and mixture was warmed to 0 C. After 4 hours, reaction mixture was quenched via addition of NH4Cl (aq) (10 mL) and mixture was extracted with ethyl acetate. Combined organic layers were washed with 50% brine, dried (Na2SO4), filtered, and concentrated under reduced pressure. Resulting residue was purified by silica gel column chromatography (0-50% ethyl acetate in hexanes) to yield 1-(1-tert-butyl-1H-pyrazol-4-yl)ethanone 5.14.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, A new synthetic method of this compound is introduced below., Computed Properties of C9H12N2O4

To a solution of diethyl 1H-pyrazole-3,5-dicarboxylate (0.25 g, 1.18 mmol) in acetone (10 ml) were added 2-bromo-1-(3-fluoro-4-methylphenyl)ethanone (0.33 g, 1.41 mmol) and potassium carbonate (0.41 g, 2.95 mmol). The mixture was stirred at RT over night. After filtering off the sol- ids, the filtrate was concentrated and the residue dried in vacuo to give 0.48 g (99% of theory, 87% purity) of the title compound. This compound was used without further purification. LC/MS [Method 3]: Rt = 2.07 min; MS (ESIpos): m/z = 363 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 345637-71-0,Some common heterocyclic compound, 345637-71-0, name is 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, molecular formula is C7H7F3N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A 0.15M solution of (2-Aminopyndin-4-yl)(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5- yl)methanone (Preparation 24, 500 uL, 75 umol) in DMA was added to [5-methyl-3- (trifluoromethyl)-1 H-pyrazol-1 -yl]acetic acid (75 uM) followed by NMM (25 uL, 150 umol), DMAP (3.5 umol) and a 0.15M solution of HATU (500 uL, 75 umol) in DMA. The reaction was shaken at 50C for 16 hours. The reaction was concentrated in vacuo and purified using preparative HPLC (Purification method 2 below, initial gradient 25% A, final gradient 55% A) to obtain the title compound as the TFA salt. LCMS Rt = 2.85 minutes MS m/z 472 [M+H]+ The following compounds were prepared as described above for Example 147 using (2- aminopyridin-4-yl)(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone (Preparation 24) and the appropriate acid with purification using preparative HPLC using one of the two methods below (initial and final gradients for each compound are reported in the table). Purification Method 1 : Column: YMC-pack ODS-AQ 150 x 30mm, 5 um, mobile phase A: acetonitrile; Mobile phase B: 0.1 % TFA in water. Gradient time: 8 minutes. Flow rate: 35 mL/min. Initial/end gradients are reported for each compound below. Purification Method 2: Column: Sepax BR-C18 100 x 21 .2 mm, 5 um, mobile phase A: acetonitrile; Mobile phase B: 0.1 % TFA in water. Gradient time: 8 minutes. Flow rate 30 mL/min. Initial/end gradients are reported for each compound below

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, A new synthetic method of this compound is introduced below., Safety of 4-Iodo-1-methyl-1H-pyrazole

To a solution of 3-iodo-l-methyl-lH-pyrazole (20 mg, 0.096 mmol) and intermediate C.5 (20 mg, 0.074 mmol) in anhydrous l,4-Dioxane (1 ml) was added (Irans)-N I .N2-dimethylcyclohexane- 1, 2-diamine (5 mg, 0.035 mmol), Cul (5 mg, 0.026 mmol) and K3PO4 (50 mg, 0.236 mmol). The resulting mixture was stirred at 90C for 16 hours. After filtering and concentrating the reaction solution, the residue was purified by prep-HPLC (basic) to afford example 6.1, 5-methyl-l-(l- methyl-lH-pyrazol-4-yl)-6-(l-(oxetan-3-yl)piperidin-4-yl)-lH-indazole. MS (ESI) m/z calc?d for C20H26N5O [M+H]+ 351, found 351. -NMR (500 MHz, CDC13) d 8.00 (s, 1H), 7.82 (s, 1H), 7.73 (s, 1H), 7.53 (s, 1H), 7.42 (s, 1H), 4.66-4.71 (m, 4H), 4.02 (s, 3H), 3.51-3.57 (m, 1H), 2.92 (m, 2H), 2.85 (m, 1H), 2.45 (s, 3H), 1.97-2.02 (m, 2H), 1.87 (m, 4H). LRRK2 IC50 1.1 nM.

The synthetic route of 39806-90-1 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 15802-75-2, name is 4-Iodo-3-methyl-1H-pyrazole, A new synthetic method of this compound is introduced below., Formula: C4H5IN2

Under nitrogen protection,To a 10 ml Schlek reaction tube (a glass instrument commonly used in anhydrous oxygenless operation) was added 1.0 mmolBromo-5- (4- (6-bromopyridyl-3) phenyl) pyridine, 2.2 mmol3-methyl-4-iodopyrazole,0.03 mmol of palladium acetate, 0.05 mmol of di-t-butyl (2 ‘, 4′, 6′-triisopropyl-3,6-dimethoxybiphenyl-2-yl) phosphine, 6.0 mmol of sodium tert-butoxide ,And 5 ml of toluene,The reaction tube was purged with nitrogen three times,And then heated to 110 C with an oil bath under magnetic stirring, and the reaction was refluxed for 24 hours. Down to room temperatureThe reaction solution was further added, 4.0 mmol of 4-carboxyphenylboronic acid, 0.03 mmol of palladium acetate,0.06 mmol 2′-dicyclohexylphosphino-2,6-di-I-propyl-4-sulfonate-1,1’-biphenyl sodium,8.0 mmol of potassium carbonate, and 100 mmol of water; and then heated to 100 C with an oil bath under magnetic stirring,The reaction was refluxed for 40 hours. Down to room temperature; add 20 ml of water, filtration, with concentrated hydrochloric acid to adjust the pH of the filtrate to 1,After stirring at room temperature for 3 h, the mixture was filtered, washed with ethanol and dried to obtain product 21, yield 77%.The mass spectrum (ESI) data for this product (C38H28N6O4) was 632.26.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.