Tag: M.W:100-200

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, European Journal of Organic Chemistry called Exploring the synthetic applicability of a cyanobacterium nitrilase as catalyst for nitrile hydrolysis, Author is Mukherjee, Chandrani; Zhu, Dunming; Biehl, Edward R.; Hua, Ling, which mentions a compound: 17190-29-3, SMILESS is N#CCC(O)C1=CC=CC=C1, Molecular C9H9NO, Related Products of 17190-29-3.

The substrate specificity and synthetic applicability of the nitrilase from cyanobacterium Synechocystis sp. strain PCC 6803 have been examined This nitrilase catalyzed the hydrolysis of both aromatic and aliphatic nitriles to the corresponding acids in high yields. Furthermore, the stereoselective hydrolysis of phenyl-substituted β-hydroxy nitriles to (S)-enriched β-hydroxy carboxylic acids and selective hydrolysis of α,ω-dinitriles with five or less methylene groups to ω-cyano carboxylic acids have been achieved. This suggested that nitrilase from Synechocystis sp. PCC 6803 could be a useful enzyme catalyst for the “”green”” nitrile hydrolysis.

In addition to the literature in the link below, there is a lot of literature about this compound(3-Hydroxy-3-phenylpropanenitrile)Related Products of 17190-29-3, illustrating the importance and wide applicability of this compound(17190-29-3).

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ) is researched.Safety of 3-Hydroxy-3-phenylpropanenitrile.Kamal, Ahmed; Khanna, G. B. Ramesh; Ramu, R. published the article 《Chemoenzymatic synthesis of both enantiomers of fluoxetine, tomoxetine and nisoxetine: lipase-catalyzed resolution of 3-aryl-3-hydroxypropanenitriles》 about this compound( cas:17190-29-3 ) in Tetrahedron: Asymmetry. Keywords: aryl hydroxyphenylpropanenitrile preparation ring opening styrene oxide sodium cyanide; kinetic resolution aryl hydroxyphenylpropanenitrile transesterification lipase catalyst; chemoenzymic preparation enantiomer fluoxetine tomoxetine nisoxetine. Let’s learn more about this compound (cas:17190-29-3).

A facile preparation of (±)-3-hydroxy-3-phenylpropanenitrile has been carried out by ring-opening of styrene oxide with NaCN in aqueous ethanol. Subsequent kinetic resolution of this material via lipase-mediated transesterification gave the S-alc. and R-acetate in excellent yields and high enantioselectivities, particularly with lipase PS-C Amano’ II. The effect of solvents and immobilization of the lipase has also been investigated. It is interesting to note that the use of immobilized lipase for this transesterification process in hydrophobic solvents (diisopropyl ether, toluene and hexane) enhanced the reaction rate drastically and gave optimal yields with high enantioselectivity (>99%). Moreover, enantiopure 3-hydroxy-3-phenylpropanenitrile products have been converted via enantioconvergent routes into the (R)- and (S)-enantiomers of the important anti-depressants fluoxetine, tomoxetine, nisoxetine and norfluoxetine.

In addition to the literature in the link below, there is a lot of literature about this compound(3-Hydroxy-3-phenylpropanenitrile)Safety of 3-Hydroxy-3-phenylpropanenitrile, illustrating the importance and wide applicability of this compound(17190-29-3).

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Computed Properties of C9H9NO. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about The Stevens rearrangement of sulfur ylide generated by electrochemical reduction of sulfonium salt. Author is Okazaki, Yuichi; Asai, Tatsuro; Ando, Fumio; Koketsu, Jugo.

The cathodic reduction or a base treatment of a 1-cyanomethyltetrahydrothiophenonium salt gave the stabilized ylides which were conformed by the reaction with benzaldehyde. In the absence of benzaldehyde, the ring expanded product was obtained through the Stevens rearrangement in good yield by both methods. The reaction mechanism was investigated by using B3LYP d. functional calculations

In addition to the literature in the link below, there is a lot of literature about this compound(3-Hydroxy-3-phenylpropanenitrile)Computed Properties of C9H9NO, illustrating the importance and wide applicability of this compound(17190-29-3).

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Hull, R.; Lovell, B. J.; Openshaw, H. T.; Todd, A. R. published the article 《Synthetic antimalarials. XI. Effect of variation of substituents in derivatives of mono- and dialkylpyrimidines》. Keywords: MALARIA/therapy; PYRIMIDINES.They researched the compound: 2-Amino-4,6-dichloro-5-methylpyrimidine( cas:7153-13-1 ).Synthetic Route of C5H5Cl2N3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:7153-13-1) here.

cf. C.A. 41, 134b. Following the discovery that certain 2-amino-4-dialkylaminoalkylamino-5, 6-dialkylpyrimidines (C.A. 40, 5057.4) have marked antimalarial activity, a more extended investigation has been made of the effects of variation of substituents in compounds of this type; several other series of simple mono- and dimethylpyrimidine derivatives have been synthesized. 2-Amino-4-hydroxy-5-methylpyrimidine (m. 277-9°; preparation in 17% yield given) (5 g.) and 30 cc. POCl3, refluxed 45 min., give 68% 4-chloro-2-amino-5-methylpyrimidine, m. 184-5°; 4-(2-diethylaminoethylamino) analog, straw color, b. 170° (bath temperature)/3 × 10-4 mm. (dipicrate, yellow, m. 195-6°); 4-(3-diethylaminopropylamino) analog m. 70-1°. HCO2Et and PhOCH2CO2Et with Na in absolute Et2O, followed by guanidine, give 55% 2-amino-4-hydroxy-5-phenoxypyrimidine (I), m. 255-6°; 5 g. with POCl3 (refluxed 15 min.) gives 4.4 g. of the 4-Cl analog, m. 157.5°. I (3 g.), 1.53 cc. Ac2O, and 15 cc. anhydrous C5H5N, refluxed 2 h., give 2.05 g. of a compound, C24H20O5N6, m. 239-40°; with POCl3, 13.3 g. gives 13.5 g. 4-chloro-2-acetamido-5-phenoxypyrimidine (II), m. 163°. II (1.5 g.) and Et2N(CH2)2NH2, refluxed 5 h. and the product refluxed with 30 cc. 10% HCl 6 h., give 89% 2-amino-4-(2-diethylaminoethylamino)-5-phenoxypyrimidine, m. 114-15°; 4-(3-diethylaminopropylamino) homolog, m. 130.5-1°, 98%. Dropwise addition of 17 cc. Br to 40 g. 2-amino-4-hydroxy-6-methylpyrimidine in 350 cc. AcOH during 30 min. gives the 5-Br derivative, m. 250° (decomposition); POCl3 gives 79% 4-chloro-5-bromo-2-amino-6-methylpyrimidine, m. 206-7°; 4-(2-diethylaminoethylamino) analog, yellow viscous oil, b. 200°/10-2 mm. (bath temperature), 80%; 4-(3-diethylaminopropylamino) analog m. 105.5-7°, 91.5%. 4-Chloro-2,6-diaminopyrimidine (III) (preparation in 84% yield given) (5.78 g.) and 4.45 g Et2N(CH2)2NH2 in 13 cc. dry C5H5N, refluxed 16 h., give 62% 2,6-diamino-4-(2-diethylaminoethylamino)pyrimidine, b. 270°/10-3 (bath temperature) (dipicrate, m. 204-6°); the 4-(3-diethylaminopropylamino) homolog b. 250°/10-3 (dipicrate, m. 202.-3°). III (6.5 g.) and 20.8 g. Et2N(CH2) 2NH2, refluxed 6 h., give 9.25 g. (crude) 2-amino-4,6-bis(2-diethylaminoethylamino) pyrimidine, m. 58-60° (picrate m. 177.5-8.5°); this results also from 4-chloro-2-amino-6-(2-diethylaminoethylamino)pyrimidine and Et2N(CH2)2NH2 on heating 6 h. at 150°; 4,6-bis(3-diethylaminopropylamino) homolog b. 270°/4 × 10-4 mm. (bath temperature). 4-Chloro-2,6-diamino-5-methylpyrimidine gives 88% of the 4-(2-diethylaminoethylamino) analog, m. 102°, and 81% of the 4-(3-diethylaminopropylamino) analog, yellow, b. 250-70°/10-2 mm. (bath temperature) [bis-(3,5-dinitrobenzoate), m. 213°], which forms a hygroscopic, waxy solid. 4,6-Dichloro-2-amino-5-methylpyrimidine (9.0 g.) and 5.8 g. Et2N(CH2) 2NH2 in 25 cc. C5H5N, refluxed 15 h., give 55% 4-chloro-2-amino-6-(2-diethylaminoethylamino)-5-methylpyrimidine, m. 99-101°; 6-(3-diethylaminopropylamino) homolog, m. 121-2°, results in 76% yield on heating the components in AcOH 4 h. at 110° and 2 h. at 130°. 4-Hydroxy-2-methylmercapto-5,6-dimethylpyrimidine (IV) and POCl3, warmed 5 min. on the steam bath, give 92% of the 4-Cl analog, m. 35-6°; an excess saturated anhydrous EtOH-NH3 6 h. at 115-25° gives 50% 4-amino-2-methylmercapto-5,6-dimethylpyrimidine (V), m. 158-9.5°. V (5.6 g.) and 8.6 g. Et2N (CH2)3NH2, heated 22 h. at 200-10°, give (after repeated distillation) 39% 4-amino-2-(3-diethylaminopropylamino)-5,6-dimethylpyrimidine, a viscous oil [bis-(3,5-dinitrobenzoate), pale yellow, m. 210-12°]. IV (5.7 g.) and 4.3 g. Et2N(CH2)2NH2, heated 3 h. at 160-70°, give 98% 2-(2-diethylaminoethylamino)-4-hydroxy-5,6-dimethylpyrimidine, m. 86.5-8°; POCl3 gives 81% of the 4-Cl analog, m. 46.5-7.5°, sublimes 90°/10-4 mm., which with saturated EtOH-NH3 (3 h. at 180-90°) yields 49% 4-amino-2-(2-diethylaminoethylamino)-5,6-dimethylpyrimidine, m. 130-1.5°; this results also from 0.85 g. V and 2.3 g. Et2N(CH2)2NH2 on heating 22 h. at 190-200°. 2-(3-Dibutylaminopropylamino)-4-hydroxy-5,6-dimethylpyrimidine was a pale yellow oil, b. 260-80°/2 × 10-4 mm. (bath temperature), which slowly solidified (96%) (dipicrate, m. 199-202°); POCl3 gives the 4-Cl analog, b. 185-90°/4 × 10-3 mm. (bath temperature) (dipicrate, bright yellow, m. 167.5-8.5°); EtOH-NH3 (4 h. at 200°) gives 74% of the 4-NH2 analog, yellow oil, b. 210-20°/2 × 10-3 mm. (bath temperature) (dipicrate, yellow, m. 167-9°). 2-(3-Dimethylaminopropylamino)-4-hydroxy-5,6-dimethylpyrimidine m. 113.5-15°; 4-Cl analog m. 36-8°, 55%; 4-NH2 analog, yellow, b. 180-90°/2 × 10-3, 28% (tartrate, m. 168-71°). The following 2-substituted 4-amino-6-methylpyrimidines were prepared from the appropriate 4-Cl derivatives (C.A. 40, 5060.6): 3-dimethylaminopropylamino (VI) as the bis(3,5-dinitrobenzoate), m. 223-5°; 2-diethylaminoethylamino, m. 98-100°; 3-diethylaminopropylamino as the bis(3,5-dinitrobenzoate), m. 218-20°; 3-dibutylaminopropylamino as the bis(3,5-dinitrobenzoate), m. 200-2°. 4-Chloro-2-methylmercapto-6-methylpyrimidine and concentrated EtOH-NH3, 5.5 h. at 125-35°, give 74% 4-amino-2-methylmercapto-6-methylpyrimidine, m. 133.5-5°; with Me2N(CH2)3NH2 (14 h. at 160-70°) this yields 93% VI. 4-Substituted 6-amino-2,5-dimethylpyrimidines: 2-diethylaminoethylamino, m. 82-2.5°; 3-dimethylaminopropylamino, m. 89-91° [bis(3,5-dinitrobenzoate) , m. 207.5-9°]; 3-diethylaminopropylamino, m. 99.5°. 4-Substituted 6-amino-5-methylpyrimidines: 2-diethylaminoethylamino, m. 95.5-6.5°; 3-diethylaminopropylamino, m. 93-4°. HC(:NH)NH2.HCl (42 g.) and 91 g. MeCH(CO2Et)2, added successively to 24.5 g. Na in 360 cc. EtOH at 20-5°, kept overnight at room temperature, and boiled 1 h., give 61% 4,6-dihydroxy-5-methylpyrimidine, decompose 320°; refluxed with POCl3 40 min., there results 66% 4,6-dichloro-5-methylpyrimidine, m. 56.5-7.5°; with EtOH-NH3 at 140° (3 h.) this yields 4-chloro-6-amino-5-methylpyrimidine, m. 237-8°. 5-Amino-4-hydroxy-2,6-dimethylpyrimidine (VII) (13.5 g.) in 75 cc. 98% HCO2H, refluxed 15 min., gives 92% 5-formamido-4-hydroxy-2,6-dimethylpyrimidine (VIII), m. 238-9° (decomposition); 9 g. VIII, added to 75 cc. ice-cold POCl3 and followed (below 50°) with 20 cc. PhNMe2 (3-4 cc. portions), gives 45% of the 4-Cl analog, m. 158-9.5°; ice-cold concentrated HCl gives 85% 4-chloro-5-amino-2,6-dimethylpyrimidine, m. 79-80°; 4-(3-diethylaminopropylamino) analog m. 68-70°, 78%; 4-(2-diethylaminoethylamino) analog m. 95-6°, 64%; 4-(3-dibutylaminopropylamino) analog, pale yellow oil, b. 230-40°/0.25 mm. (bath temperature). VII (6.2 g.) in 220 cc. Ac2O, heated on the steam bath 30 min., gives 88% of the 5-acetamido derivative, m. 275° (decomposition); POCl3 gives 54% 4-chloro-5-acetamido-2,6-dimethylpyrimidine, m. 141-2°; 4-(3-diethylaminopropylamino) analog (IX), pale yellow oil, b. 150-60°/10-4 (bath temperature) (flavianate-1H2O, bright yellow, m. 160°). IX (5.5 g.) in 30 cc. 30% H2SO4, heated 2 h. on the steam bath, gives 9-(3-diethylaminopropyl)-2,6,8-trimethylpurine, pale yellow, b. 140-50°/10-4 mm. (bath temperature) (dipicrate, pale yellow, m. 187-8°); the 2-diethylaminoethyl homolog, pale yellow, b. 130-5°/2 × 10-3 mm. (bath temperature) (flavianate, bright yellow, m. 248° (decomposition)); 3-diethylamino-1-methylbutyl analog b. 150-5°/10-4 mm. (bath temperature) (a crystalline derivative could not be prepared). Guanidine and PhN2CHAc2 in EtOH, kept 20 days at room temperature, give 58.5% 2-amino-5-phenylazo-4,6-dimethylpyrimidine (X), bright orange, m. 228-30°; reduction in absolute EtOH over Pd-BaSO4 at 90° and 75 atm. gives 100% 2,5-diamino-4,6-dimethylpyrimidine (XI), m. 183.5-4.5°. XI (8 g.) and 19.6 g. Et2N(CH2)2Cl in 40 cc. anhydrous C5H5N, refluxed 7 h., give 26% 2-amino-5-(2-diethylaminoethylamino)-4,6-dimethylpyrimidine, m. 95-6.5°; dipicrate, yellow, m. 187-9° (decomposition). X (1.1 g.) and 0.6 g. NaNH2 in 10 cc. PhMe, refluxed 10 h., treated with 8.8 g. Et2N(CH2)2Cl, and the refluxing continued 18 h. (160-70°), give 58% 2-(2-diethylaminoethylamino)-5-phenylazo-4,6-dimethylpyrimidine, red, m. 87-8°; catalytic reduction in EtOH over Pt oxide at room temperature and atm. pressure give 60% 5-amino-2-(2-diethylaminoethylamino)-4,6-dimethylpyrimidine, yellow oil, b. 160°/2 × 10-3 mm. (bath temperature) (dipicrate, bright yellow, m. 185-6°). H2NC(SMe):NH.HI (33 g.) and 18 g. Et2N(CH2)2NH2 in 150 cc. EtOH, refluxed 2 h., give 50% 2-diethylamino-ethylguanidine-2HI, m. 140-2°. 4-Amino-6-(3-diethylaminopropylamino)-2,5-dimethylpyrimidine is the most active of the simple pyrimidines prepared, appreciable activity being observed at a dose of 20 mg./kg. Data are given for the other compounds described above. No generalizations can be made about structure and antimalarial activity, but the most active compounds have structures which are compatible with the hypothetical mode of action advanced in Part III (C.A. 40, 5057.4). It is clearly impossible to argue the validity of any concept of action based on interference with the synthesis or functioning of enzyme components in the absence of extensive biol. investigations, but there would seem to be some justification for its retention as a basis for future work.

As far as I know, this compound(7153-13-1)Synthetic Route of C5H5Cl2N3 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Recommanded Product: 3-Hydroxy-3-phenylpropanenitrile. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about The Knoevenagel reaction in electrochemically activated solvents. Author is Feroci, M.; Orsini, M.; Sotgiu, G.; Inesi, A..

The electrochem. activation of organic solvents HS (CH3CN, CH3CH2CN, DMF, DMSO) containing Et4NPF6 as supporting electrolyte (i.e. their electrolysis under galvanostatic control) allows to induce in these solutions, in the absence of any catalyst, the Knoevenagel condensation between CH-acid CH2(CN)2 (1) and carbonylic substrates. Reaction products were isolated in good yields 97-48%. The progress of the Knoevenagel condensation is affected by Q (number of Faradays per mol of 1 supplied to the electrodes) and, moderately, by the nature of the solvents. The rates of the single steps are compared by elementary voltammetric anal.

There are many compounds similar to this compound(17190-29-3)Recommanded Product: 3-Hydroxy-3-phenylpropanenitrile. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ) is researched.Recommanded Product: 17190-29-3.Jinzaki, Takaaki; Arakawa, Mitsuru; Kinoshita, Hidenori; Ichikawa, Junji; Miura, Katsukiyo published the article 《Nucleophilic Addition of α-(Dimethylsilyl)nitriles to Aldehydes and Ketones》 about this compound( cas:17190-29-3 ) in Organic Letters. Keywords: beta hydroxynitrile preparation alpha dimethylsilylnitrile aldehyde ketone nucleophilic addition; nucleophilic addition dimethylsilylnitrile metal salt promoter catalyst. Let’s learn more about this compound (cas:17190-29-3).

α-Alkylated (dimethylsilyl)acetonitriles (Me2HSiCR3R4CN) react spontaneously with aldehydes in DMSO to give β-hydroxynitriles in good to high yields. The addition to ketones is effectively promoted by using MgCl2 or CaCl2. (Dimethylsilyl)acetonitrile (Me2HSiCH2CN) shows lower reactivity than the α-alkylated analogs. However, the parent reagent adds efficiently to aldehydes and ketones under catalysis by AcOLi or MgCl2.

There are many compounds similar to this compound(17190-29-3)Recommanded Product: 17190-29-3. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Highly regioselective conversion of epoxides to β-hydroxy nitriles using metal(II) Schiff base complexes as new catalysts under mild conditions, published in 2013-01-25, which mentions a compound: 17190-29-3, mainly applied to hydroxy nitrile preparation; regioselective ring opening epoxide metal Schiff base catalyst, COA of Formula: C9H9NO.

Epoxides undergo efficient ring opening with potassium cyanide in acetonitrile in the presence of metal Schiff base complexes as catalysts. This method was carried out under neutral and mild conditions with both high yields and high regioselectivity within a short period of time. Thus, several β-hydroxy nitriles, useful intermediates for the synthesis of biol. active mols., were easily obtained at room temperature

There are many compounds similar to this compound(17190-29-3)COA of Formula: C9H9NO. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Catalytic nucleophilic activation of acetonitrile via a cooperative catalysis of cationic Ru complex, DBU, and NaPF6, published in 2007-08-27, which mentions a compound: 17190-29-3, Name is 3-Hydroxy-3-phenylpropanenitrile, Molecular C9H9NO, Recommanded Product: 17190-29-3.

The development of an efficient catalytic system for the direct addition of acetonitrile under mild amine basic conditions is described. A cooperative catalysis of CpRu complex, DBU, and NaPF6 enables chemoselective and catalytic generation of nucleophiles from barely acidic acetonitrile, which is integrated into the addition to aldehydes, imines, and activated ketones. Mechanistic investigations revealed that the three catalyst components work together to achieve high catalytic efficiency.

There are many compounds similar to this compound(17190-29-3)Recommanded Product: 17190-29-3. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Quality Control of 3-Hydroxy-3-phenylpropanenitrile. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Alkyliron and alkylcobalt reagents. IV. Aldehyde selective cyanoalkylation with cyanoalkyl derivatives of iron(II) and other transition metals. Author is Kauffmann, Thomas; Kieper, Hans Joerg; Pieper, Hans.

The Fe reagent NCCH2FeCl is a good alternative to the known Ti reagent NCCH2Ti(OCHMe2)3 for the transfer of the cyanomethyl residue with high aldehyde vs. ketone selectivity; analogous reagents with the metals Mn, Co, Ni or Cu are unfavorable. For the aldehyde vs. ketone-selective transfer of the branched residues 1-cyanoethyl and cyanoisopropyl, the Fe reagents are distinctly better than the Ti reagents.

Here is just a brief introduction to this compound(17190-29-3)Quality Control of 3-Hydroxy-3-phenylpropanenitrile, more information about the compound(3-Hydroxy-3-phenylpropanenitrile) is in the article, you can click the link below.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of C4H9Cl2N3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (1H-Imidazol-2-yl)methanamine dihydrochloride, is researched, Molecular C4H9Cl2N3, CAS is 22600-77-7, about Structure-Guided Screening for Functionally Selective D2 Dopamine Receptor Ligands from a Virtual Chemical Library. Author is Maennel, Barbara; Jaiteh, Mariama; Zeifman, Alexey; Randakova, Alena; Moeller, Dorothee; Huebner, Harald; Gmeiner, Peter; Carlsson, Jens.

Functionally selective ligands stabilize conformations of G protein-coupled receptors (GPCRs) that induce a preference for signaling via a subset of the intracellular pathways activated by the endogenous agonists. The possibility to fine-tune the functional activity of a receptor provides opportunities to develop drugs that selectively signal via pathways associated with a therapeutic effect and avoid those causing side effects. Animal studies have indicated that ligands displaying functional selectivity at the D2 dopamine receptor (D2R) could be safer and more efficacious drugs against neuropsychiatric diseases. In this work, computational design of functionally selective D2R ligands was explored using structure-based virtual screening. Mol. docking of known functionally selective ligands to a D2R homol. model indicated that such compounds were anchored by interactions with the orthosteric site and extended into a common secondary pocket. A tailored virtual library with close to 13 000 compounds bearing 2,3-dichlorophenylpiperazine, a privileged orthosteric scaffold, connected to diverse chem. moieties via a linker was docked to the D2R model. Eighteen top-ranked compounds that occupied both the orthosteric and allosteric site were synthesized, leading to the discovery of 16 partial agonists. A majority of the ligands had comparable maximum effects in the G protein and β-arrestin recruitment assays, but a subset displayed preference for a single pathway. In particular, compound I stimulated β-arrestin recruitment (EC50 = 320 nM, Emax = 16%) but had no detectable G protein signaling. The use of structure-based screening and virtual libraries to discover GPCR ligands with tailored functional properties will be discussed.

Here is just a brief introduction to this compound(22600-77-7)Electric Literature of C4H9Cl2N3, more information about the compound((1H-Imidazol-2-yl)methanamine dihydrochloride) is in the article, you can click the link below.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics