Tag: M.W=250-300

Zhi, Li-Hua published the artcile3-Methyl-1-phenyl-4-[(Z)-phenyl(4-acetamidoanilino)methylidene]-1H-pyrazol-5(4H)-one, COA of Formula: C17H14N2O2, the publication is Acta Crystallographica, Section E: Structure Reports Online (2012), 68(7), o2132, database is CAplus and MEDLINE.

In the title compound, C₂₅H₂₂N₄O₂, the dihedral angles between the central pyrazole ring and the Ph and benzene rings are 37.01(3), 75.58(7) and 49.67(8)°. An intramol. N-H···O H bond generates an S(6) motif. In the crystal, N-H···O H bonds link mols. into a zigzag chain extended along the b axis. Crystallog. data and at. coordinates are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C6H4ClN3S, COA of Formula: C17H14N2O2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Asegbeloyin, Jonnie N. published the artcileSynthesis, characterization, and biological activity of N’-[(Z)-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)(phenyl)methyl]benzohydrazide and its Co(II), Ni(II), and Cu(II) complexes, Recommanded Product: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, the publication is Bioinorganic Chemistry and Applications (2014), 718175/1-718175/11, 12 pp., database is CAplus and MEDLINE.

Reaction of 1-phenyl-3-methyl-4-benzoyl-pyrazol-5-one and benzoyl hydrazide in refluxing EtOH gave N’-[(Z)-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)(phenyl)methyl]benzohydrazide (HL1), which was characterized by NMR spectroscopy and single-crystal x-ray structure study. X-ray diffraction analyses of the crystals revealed a nonplanar mol., existing in the keto-amine form, with intermol. H bonding forming a seven-membered ring system. The reaction of HL1 with Co(II), Ni(II), and Cu(II) halides gave the corresponding complexes, which were characterized by elemental anal., molar conductance, magnetic measurements, and IR and electronic spectral studies. The compounds were screened for their in vitro cytotoxic activity against HL-60 human promyelocytic leukemia cells and antimicrobial activity against some bacteria and yeasts. The compounds are potent against HL-60 cells with the IC50 value â‰? μM, while some of the compounds were active against few studied Gram-pos. bacteria.

Bioinorganic Chemistry and Applications published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Recommanded Product: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Atanassova, Maria published the artcileCoordination chemistry of a para-tert-octylcalix[4]arene fitted with phosphinoyl pendant arms towards 4f-elements: Extraction, synergism, separation, Recommanded Product: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, the publication is Separation Science and Technology (Philadelphia, PA, United States) (2016), 51(1), 49-56, database is CAplus.

The solvent extraction of trivalent lanthanoids (Ln³⁺) by 5,11,17,23-tetra(para-tert-octyl)-25,26,27,28-tetrakis(dimethylphosphinoylmethoxy)calix[4]arene (S), bearing four phosphine oxide donor groups at the lower rim as synergistic agent in combination with a 4-benzoyl-3-methyl-1-phenyl-2-pyrazolin-5-one (HP) in CHCl₃ from chloride medium at μ = 0.1 was quant. described in the form of LnP₃·S complexes. The role of the synergistic agent on the extraction process was discussed. The values of the separation factors have been evaluated. On the basis of the IR and NMR spectra the stoichiometry and the structure of the solid mixed complex of Eu(III) with HP and S were proposed.

Separation Science and Technology (Philadelphia, PA, United States) published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Recommanded Product: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Guo, X. Q. published the artcileDual dispersive extraction combined with electrothermal vaporization inductively coupled plasma mass spectrometry for determination of trace REEs in water and sediment samples, Category: pyrazoles-derivatives, the publication is RSC Advances (2014), 4(38), 19960-19969, database is CAplus.

A simple and efficient two-step method based on dispersive solid phase extraction (D-SPE) and dispersive liquid-liquid microextraction (DLLME) was developed for the separation and preconcentration of 15 rare earth elements (REEs) from environmental water and sediment samples, followed by electrothermal vaporization-inductively coupled plasma mass spectrometry (ETV-ICP-MS) detection. With Chelex 100 as the adsorbent of D-SPE, target REEs were firstly extracted and the retained REEs were then desorbed by 0.1 mol L^-1 HNO₃. After 125 mmol L^-1 Tris and 40 mmol L^-1 1-phenyl-3-methyl-4-benzoylpyrazolone (PMBP) were added into the above elution solution, target REEs were further preconcd. into CCl₄ by DLLME. The developed dual extraction technique exhibited high enrichment factors (234 to 566-fold) and good anti-interference ability. Various parameters affecting the extraction of target REEs by D-SPE and DLLME were investigated in detail. Nder the optimal conditions, the limits of detection (LODs, 3σ) for target REEs were in the range of 0.003-0.073 ng L^-1 with the RSDs (C_{Y,La,Ce,Pr,Nd,Gd,Dy} = 1.0 ng L^-1, C_{Sm,Eu,Tb,Ho,Er,Tm,Yb,Lu} = 0.2 ng L^-1, n = 7) ranging from 6.7 to 11.5%. The proposed method of D-SPE-DLLME-ETV-ICP-MS was successfully applied to the determination of 15 REEs in water and sediment samples with the recoveries of 78-115% and 75-117% for the spiked water and sediment samples, resp. To validate the accuracy of the method, a Certified Reference Material of GBW07301a stream sediment was analyzed and the determined values were in good agreement with the certified values.

RSC Advances published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Category: pyrazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Cheng, Yuan-Zheng published the artcileSynthesis and crystal structure of Pb(II) complex with 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone, Recommanded Product: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, the publication is Main Group Metal Chemistry (2014), 37(3-4), 101-106, database is CAplus.

A new Pb(II) complex, Pb(PMBP)₂ (PMBP = 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone), was synthesized and characterized by IR spectroscopy and x-ray single-crystal diffraction. X-ray crystallog. data showed that the complex crystallizes in the monoclinic space group C2 with a 22.060(7), b 6.981(2), c 9.127(3) Å, β = 90.768(7), C₃₄H₂₆N₄O₄Pb, Mr = 761.79, D = 1.800 g/cm³, μ(MoKa) = 6.050, F(000) = 744, Z = 2, final GooF = 1.067, R = 0.0195, and R_w = 0.0468 for 1353 observed reflections [I>2σ(I)]. The compound exhibits monomeric species that were linked by a C-H···π interaction, intermol. C-H···O H bonds, and intermol. longer secondary Pb···X (X = C or N) interactions; therefore, two-dimensional layered networks were obtained.

Main Group Metal Chemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Recommanded Product: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Gowri, M. published the artcileNovel Heterocyclic Schiff Base, (Z)-4-((2-((2-Aminophenyl)disulfanyl)phenylimino) (Phenyl)Methyl)-3-Methyl-1-Phenyl-1H-Pyrazol-5-ol Crystals for Enzymatic Studies, Name: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, the publication is Molecular Crystals and Liquid Crystals (2015), 606(1), 199-207, database is CAplus.

A new dithio Schiff base was synthesized and characterized by spectroscopic (FTIR, UV-visible, H¹-NMR, and C¹³-NMR) and x-ray diffraction studies. Mol. interactions (inter and intra) between the neutral entities are discussed. Schiff base ligand, (Z)-4-((2-((2-aminophenyl)disulfanyl)phenylimino)(phenyl)methyl)-3-methyl-1-phenyl-1H-pyrazol-5-ol (), was synthesized by the reaction between 2-phenyl-4-benzoyl-5-methyl-pyrazolin-3-one and 2-amino thio phenol (1:2 molar ratio). The structural elucidation was done by spectroscopic (FTIR, UV-visible, H¹-NMR, C¹³-NMR) and x-ray diffraction studies. Single crystal x-ray diffraction studies revealed that has monoclinic system with space group P21/c with a 15.654(4) Å, b 12.848(4) Å, c 14.219(4) Å; α 90., β 113.65(6), γ 90.°, and Z = 4. The possible intramol. (C-H···N) and intermol. (C-H···O, C-H···S, N-H···O) interactions of were also been discussed.

Molecular Crystals and Liquid Crystals published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Name: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Arkhipova, Anna Alexandrovna published the artcileSorbents with non-covalently immobilized β-diketones for preconcentration of rare earth elements, HPLC of Formula: 4551-69-3, the publication is Talanta (2016), 497-502, database is CAplus and MEDLINE.

A comparison of the efficiency of sorbents obtained by different methods of non-covalent immobilization of β-diketones on some low-polar matrixes with respect to extraction of rare earth elements (REEs) was carried out. Sorbents containing reagent amounts of 1-8 mmol/g can be obtained by sorption of reagents on low-polar matrixes from aqueous and aqueous-organic solutions, and the value for the maximum capacity of the sorbent correlates with the sp. surface of the matrix. Similar sorbents were also prepared by impregnating the matrix with reagent. It was found out that, under the chosen conditions, sorbents modified by extracting reagent from the aqueous solutions are more stable and extract lanthanum with higher distribution coefficients than those obtained by impregnation. We have found conditions for quant. extraction of REEs from seawater in the proposed preconcentration systems (pH 4.0, minicolumn dimensions 2×10 mm, v=4 mL/min). All REE may be quant. recovered in both ways: on modified sorbents and as complexes with reagents on unmodified matrixes. We have proposed a sorbent for lanthanum preconcentration from large volumes of water samples (500 mL). The sorbent is stable in dynamic conditions and is based on hyper cross-linked polystyrene modified with 1-phenyl-3-methyl-4-benzoylpyrazol-5-one (PMBP). Desorption could be carried out with 1-2 M HNO₃. REEs were determined by ICP-MS, LODs achieved were in ng/l range.

Talanta published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, HPLC of Formula: 4551-69-3.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Zhang, Xingmei published the artcileCoupling of propylene sulfide (PS) and carbon disulfide (CS₂) catalyzed by the asymmetrical Cr(III)-bis-Schiff-base complex, Safety of 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, the publication is Inorganic Chemistry Communications (2017), 59-61, database is CAplus.

With an asym. Cr(III)-bis-Schiff-base complex [Cr(L)Cl] (1; H₂L obtained from reaction of HL⁰ ((Z)-4-((2-aminophenylimino)(phenyl)methyl)-3-methyl-1H-pyrazol-5(4H)-one) and 3,5-dibromo-2-hydroxybenzaldehyde) as the catalyst, the [PPN]Cl-assisted ([PPN]⁺ = [Ph₃P = N = PPh₃]⁺) coupling of PS (propylene sulfide) and CS₂ for the formation of poly[trithio]carbonate and [trithio]carbonate was efficiently realized, in which, the pre-activation of catalytic system and the coupling procedure have much influential to poly[trithio]carbonate selectivity.

Inorganic Chemistry Communications published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C21H37BO, Safety of 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Gouda, Ayman A. published the artcileDevelopment of cloud-point extraction method for preconcentration of trace quantities of cobalt and nickel in water and food samples, Related Products of pyrazoles-derivatives, the publication is RSC Advances (2016), 6(96), 94048-94057, database is CAplus.

A new, efficient, and sensitive cloud point methodol. was developed for preconcentration of trace quantities of cobalt and nickel in water and food samples prior to their determination by flame at. absorption spectrometry (FAAS). The metals react with 2-(benzothiazolylazo)-4-nitrophenol (BTANP) at pH 7.0 and micelle-mediated extraction using the nonionic surfactant Triton X-114 medium. The surfactant-rich phase was diluted with acidified methanol and the cobalt and nickel content was determined by FAAS. The optimum conditions (e.g. pH, reagent and surfactant concentrations, temperature and centrifugation times) were evaluated and optimized. The proposed CPE method showed linear calibration within the ranges 5.0-100 and 5.0-150 ng mL^-1 of cobalt and nickel, resp., and the limits of detection of the method was 1.4 and 1.0 ng mL^-1 of cobalt and nickel, resp. The interference effect of some cations and anions was also studied. The method was applied to the determination of both metals in water and food samples with a recovery from the spiked water samples in the range of 95-102%. The validation of the procedure was carried out by anal. of a certified reference material.

RSC Advances published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Related Products of pyrazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Teng, Qing-Hu published the artcileDesign, syntheses and antitumor activities evaluation of 1,5-diaryl substituted pyrazole secnidazole ester derivatives, Computed Properties of 13599-22-9, the publication is Journal of Heterocyclic Chemistry (2021), 58(8), 1656-1664, database is CAplus.

According to the drug hybridization principle, a series of novel 1,5-diaryl substituted pyrazole secnidazole ester derivatives I (R¹ = 4-I, 3-Me, 4-Cl, etc.; R² = H, Me, Cl) have been synthesized by the combinations of various 1,5-diarylpyrazole-3-carboxylic acids II with secnidazole. The in vitro antitumor/cytotoxicities activities against tumor and normal cell lines, including NCI-H460 (lung tumor cell), MCG-803 (gastric tumor cell), Skov-3 (ovarian tumor cell), BEL-7404 (liver tumor cell) and HL-7702 (normal liver cell), have been evaluated using MTT assay. All compounds I showed promising inhibitory activities against four tumor cell lines. The IC₅₀ of I (R¹ = 4-I; R² = H) against the BEL-7404 cell was 2.03μM, and those of I (R¹ = 3-Me; R² = H) against the NCI-H460, MCG-803 and Skov-3 were 1.34, 0.14, and 0.87μM, resp. All these values were much lower than those of the cisplatin. Furthermore, I (R¹ = 3-Me, R² = H; R¹ = 4-I, R² = H) were also verified to be considerably safe for normal human liver cell, since the lower IC₅₀ values than cisplatin. Based on these results, the cell cycle anal., apoptosis ratio detection and mitochondrial membrane potential assay of I (R¹ = 3-Me, R² = H; R¹ = 4-I, R² = H) were further performed aiming to investigate their inhibition mechanism of BEL-7404 cells. It is revealed that they have effectively inhibited the cell growth by arresting the BEL-7404 cells at S phase and induced apoptosis through the mitochondria-mediated pathway.

Journal of Heterocyclic Chemistry published new progress about 13599-22-9. 13599-22-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid,Benzene, name is 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid, and the molecular formula is C8H15ClN2, Computed Properties of 13599-22-9.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics