Tag: M.W=0-100

Recently I am researching about METAL-ORGANIC FRAMEWORKS; CRYSTAL-STRUCTURE; SUPRAMOLECULAR ASSOCIATION; STRUCTURAL-CHARACTERIZATION; LIGANDS SYNTHESIS; HOLE INTERACTION; ZINC-COMPLEXES; DNA-BINDING; PYRAZOLE; CU(II), Saw an article supported by the University Grants Commission (UGC), New DelhiUniversity Grants Commission, India [42-377/2013]; MINECO of Spain [CTQ2017-85821-R]. Published in ELSEVIER SCIENCE SA in LAUSANNE ,Authors: Gogoi, A; Das, A; Frontera, A; Verma, AK; Bhattacharyya, MK. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole. Product Details of 67-51-6

A new fumarato bridged Zn(II) coordination polymer viz. catena[mu-fumaratobis(3,5-dimethylpyrazole)zinc(II) trihydrate],{[Zn-2(mu-fum)(2)(Hdmpz)(4)]center dot 3H(2)O}(n) (1) (where, fum = fumarate, Hdmpz = 3,5-dimethylpyrazole) has been synthesized in purely aqueous medium at room temperature. The compound is structurally characterized by single crystal X-ray diffraction, FT-IR, electronic spectroscopy, PXRD and TGA. The zig-zag polymeric chain of 1 self assembles into a 2D supramolecular network via C-H center dot center dot center dot pi, C-H center dot center dot center dot C, N-H-center dot center dot center dot O and C-H center dot center dot center dot O interactions. Particularly relevant in 1, since in addition to the aforementioned non-covalent interactions, the electron rich pi-system of fumarate is involved in energetically significant unconventional pi-pi contacts with the electron poor pi-cloud of Hdmpz, which have been analyzed by DFT calculations and characterized using the non-covalent interaction (NCI) plot index. The strong H-bond agrees well with the MEP analysis since it is established between the H-bond donor involving NH group of Hdmpz and the H-bond acceptor involving O-atom of carboxylate moiety. The compound has been investigated for anticancer activities considering cell cytotoxicity, apoptosis and molecular docking as parameters in Dalton’s lymphoma (DL) malignant cancer cell line and results were compared with cisplatin (reference drug) under the same experimental conditions. Interestingly, negligible cytotoxic effect was observed against normal cells (PBMC) in comparison to the cancer cells (DL). The treatment of the compound caused appearance of apoptotic cells as evident by fluorescence based nuclear morphology study. The in silica study reveals that the compound interacts with the antiapoptotic proteins such as bcl-2, bcl-XL and Mcl-1 which may lead to apoptotic cell death.

Welcome to talk about 67-51-6, If you have any questions, you can contact Gogoi, A; Das, A; Frontera, A; Verma, AK; Bhattacharyya, MK or send Email.. Product Details of 67-51-6

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Kang, HJ; Lee, JH; Kim, DH; Cho, CG in [Kang, Hyung-Joon; Lee, Joon-Ho; Kim, Dong-Hyun; Cho, Cheon-Gyu] Hanyang Univ, Ctr New Direct Organ Synth, Dept Chem, Seoul 04763, South Korea published Imidazole-Selective Alkyne Hydroamination under Physiological Conditions in 2020.0, Cited 47.0. Quality Control of 3,5-Dimethyl-1H-pyrazole. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6.

Imidazole-selective intermolecular hydroamination reaction has been discovered. This unprecedented additive-free addition reaction proceeds in an exclusively regioselective and stereoselective manner with high atom economy under extremely mild reaction conditions.

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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Authors Guin, S; Saha, HK; Patel, AK; Gudimella, SK; Biswas, S; Samanta, S in PERGAMON-ELSEVIER SCIENCE LTD published article about ASYMMETRIC 1,6-CONJUGATE ADDITION; AZA-MICHAEL ADDITION; STEREOSELECTIVE-SYNTHESIS; COUPLING REACTIONS; EASY ACCESS; CARBAZOLES; 1,6-HYDROPHOSPHONYLATION; ADDITION/AROMATIZATION; 1,6-ADDITION; ALKYLATION in [Guin, Soumitra; Saha, Hemonta K.; Patel, Ashvani K.; Gudimella, Santosh K.; Biswas, Subhankar; Samanta, Sampak] Indian Inst Technol Indore, Discipline Chem, Simrol 453552, Madhya Pradesh, India in 2020.0, Cited 77.0. HPLC of Formula: C5H8N2. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

An efficient Zn(OTf)(2)-catalyzed regioselective C-N bond making reaction between a bunch of aryl/heteroaryl-substituted para-quinone methides as ideal 1,6-acceptors and various aromatic/non-aromatic aza-heterocycles bearing N-H moiety namely carbazoles, pyrazoles, indazole, benzotriazole and saccharin is reported. This 1,6-aza-Michael technique delivers predominantly NI-diarylmethyl-substituted heterocyclic scaffolds bearing a valuable phenolic moiety in good to high yields with an excellent regioselectivity. Furthermore, this LUMO lowering catalytic system allows different kinds of useful functionalities and excels with broad substrates under mild conditions. Importantly, our control experiments suggested that N2-adducts of indazole, benzotriazole and 3-methyl pyrazole as minor isomers were progressively converted into N1-adducts during the reaction via a retro-aza-Michael reaction triggered by Zn(OTf)(2), offering excellent regioselectivities of the products. (C) 2020 Elsevier Ltd. All rights reserved.

HPLC of Formula: C5H8N2. Bye, fridends, I hope you can learn more about C5H8N2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Authors Yue, CT; Xing, Q; Sun, P; Zhao, ZL; Lv, H; Li, FW in NATURE RESEARCH published article about in [Yue, Chengtao; Sun, Peng; Zhao, Zelun; Lv, Hui; Li, Fuwei] Chinese Acad Sci, Suzhou Res Inst LICP, Lanzhou Inst Chem Phys LICP, State Key Lab Oxo Synth & Select Oxidat, Lanzhou, Peoples R China; [Yue, Chengtao] Univ Chinese Acad Sci, Beijing, Peoples R China; [Xing, Qi] BayRay Innovat Ctr, Shenzhen Bay Lab, Shenzhen, Peoples R China in 2021.0, Cited 78.0. Product Details of 67-51-6. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

Catalyst deactivation caused by the aggregation of active metal species in the reaction process poses great challenges for practical applications of supported metal catalysts in solid-liquid catalysis. Herein, we develop a hypercrosslinked polymer integrated with N-heterocyclic carbene (NHC) as bifunctional support to stabilize palladium in heterogeneous C-C bond formations. This polymer supported palladium catalyst exhibits excellent stability in the one-pot fluorocarbonylation of indoles to four kinds of valuable indole-derived carbonyl compounds in cascade or sequential manner, as well as the representative Suzuki-Miyaura coupling reaction. Investigations on stabilizing effect disclose that this catalyst displays a molecular fence effect in which the coordination of NHC sites and confinement of polymer skeleton contribute together to stabilize the active palladium species in the reaction process. This work provides new insight into the development of supported metal catalysts with high stability and will also boost their efficient applications in advanced synthesis. Catalyst deactivation caused by the aggregation of active metal species poses great challenges for supported metal catalyzed solid-liquid reactions. Here, the authors develop a hypercrosslinked polymer integrated with N-heterocyclic carbene (NHC) as bifunctional support to stabilize palladium in heterogeneous C-C bond formations.

Product Details of 67-51-6. Bye, fridends, I hope you can learn more about C5H8N2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Synthesis of Polysubstituted Pyridopyrimidines, Pyrimidines, and Pyrazoles Based on 1,1-Bis(1H-benzotriazol-1-yl)-and 1,1-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-3,4,4-trichloro-2-nitrobuta-1,3-dienes published in 2020.0. Application In Synthesis of 3,5-Dimethyl-1H-pyrazole, Reprint Addresses Kolesnyk, IA (corresponding author), Natl Acad Sci Belarus, Inst Phys Organ Chem, Minsk 220072, BELARUS.. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole

The reaction of 3,4,4-trichloro-1,1-bis(3,5-dimethyl-1H-pyrazol-1-yl)-2-nitrobuta-1,3-diene with 2-aminopyridine gave a polysubstituted pyrido[1,2-a]pyrimidine derivative with an aminopyridine residue in the 2-position, whereas heterocyclization of 3,4,4-trichloro-1,1-bis(1H-benzotriazol-1-yl)-2-nitrobuta-1,3-diene with substituted 2-aminopyridines afforded 2-(1H-berrzotriazol-1-yl)pyrido[1,2-a]pyrimidines. 2-(Morpholin-4-yl), 2-amino, and 2-(2-hydroxyethylamino) derivatives of polysubstituted pyrido[1,2-a]pyrimidines were synthesized, and those containing a 2-hydroxyethylamino group were converted to the corresponding 4,5-dichloro-1,2-thiazole-1-carboxylates. Specific features of heterocyclizations of benzotriazolyl and dimethylpyrazolyl derivatives of trichloronitro-1,3-butadiene to pyrimidine and pyrazole systems were revealed.

Welcome to talk about 67-51-6, If you have any questions, you can contact Kolesnyk, IA; Petkevich, SK; Tsaryk, AD; Kurman, PV; Potkin, VI or send Email.. Application In Synthesis of 3,5-Dimethyl-1H-pyrazole

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Authors Li, GB; Field, JA; Zeng, C; Madeira, CL; Nguyen, CH; Jog, KV; Speed, D; Sierra-Alvarez, R in PERGAMON-ELSEVIER SCIENCE LTD published article about CORROSION-INHIBITORS; WASTE-WATER; TOXICITY; OXIDE; SOIL in [Li, Guangbin; Field, James A.; Zeng, Chao; Madeira, Camila Leite; Chi Huynh Nguyen; Jog, Kalyani Vikas; Sierra-Alvarez, Reyes] Univ Arizona, Dept Chem & Environm Engn, POB 210011, Tucson, AZ 85721 USA; [Speed, David] GLOBALFOUNDRIES, Hopewell Jct, NY USA in 2020.0, Cited 40.0. Name: 3,5-Dimethyl-1H-pyrazole. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

Azoles are emerging contaminants that are resistant to biodegradation during wastewater treatment. Their presence has been widely reported in wastewater effluents and receiving waters. In this work, the potential inhibition of nitrification process by six different azole compounds in wastewater treatment plants was investigated in batch bioassays. The azoles studied included three diazoles: pyrazole (Pz); 1-methylpyrazole (MePz); 3,5-dimethylpyrazole (DMePz); and three triazoles: 1,2,4-triazole (Tz); benzotriazole (BTz); and 5-methyl benzotriazole (MeBTz). The concentration of azoles causing 50% inhibition (IC50) increased (azoles became less inhibitory) in the following order (mg L-1): BTz (1.99) < MeBTz (218) < Pz (2.69) < Tz (3.53) < DMePz (17.3) < MePz (49.6). No clear structure-inhibitory relationships were found using Log P and pKa as structural properties. The toxicity of any given azole may be related to the role of substituent groups on disabling/enabling binding to the active sites of metallo-enzymes in nitrifying microorganisms. This is exemplified by the low toxicity of MePz, which has a cyclic N blocked by a methyl group. The observed inhibition caused to nitrifying bacteria is more severe than their cytotoxicity to other target organisms (e.g., methanogens and heterotrophic bacteria), suggesting a specific inhibition to the copper-containing enzyme, ammonium monooxygenase, in ammonia oxidizing nitrifying microorganisms. (C) 2019 Elsevier Ltd. All rights reserved. Name: 3,5-Dimethyl-1H-pyrazole. Welcome to talk about 67-51-6, If you have any questions, you can contact Li, GB; Field, JA; Zeng, C; Madeira, CL; Nguyen, CH; Jog, KV; Speed, D; Sierra-Alvarez, R or send Email.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

In 2019.0 SYNTHESIS-STUTTGART published article about ENANTIOSELECTIVE CONJUGATE ADDITION; BASIC IONIC LIQUID; BETA-AMINO ACIDS; N-HETEROCYCLES; ASYMMETRIC-SYNTHESIS; AMMONIA EQUIVALENTS; 2,4-DISUBSTITUTED 1,2,3-TRIAZOLES; NITROGEN-HETEROCYCLES; AROMATIC-AMINES; DERIVATIVES in [Zhou, Hongyan; Zhang, Zhixia] Gansu Agr Univ, Coll Sci, Lanzhou 730070, Peoples R China; [Zhou, Hongyan; Xiang, Xiancheng; Ma, Ben; Wang, Ganggang; Yang, Jingya] Northwest Normal Univ, Coll Chem & Chem Engn, Lanzhou 730070, Peoples R China in 2019.0, Cited 96.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6. COA of Formula: C5H8N2

A lithium chloride catalyzed aza-Michael reaction of pyrazoles to alpha,beta-unsaturated imides has been developed. A range of aromatic and aliphatic alpha,beta-unsaturated imides are found to be suitable for the established method, providing the corresponding aza-Michael adducts in up to 93% yields. The inexpensive catalyst, good substrate tolerance, and ease of scale-up make this procedure highly practical.

About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Zhou, HY; Xiang, XC; Ma, B; Wang, GG; Zhang, ZX; Yang, JY or concate me.. COA of Formula: C5H8N2

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

An article Potential 2,4-dimethyl-1H-pyrrole-3-carboxamide bearing benzimidazole template: Design, synthesis, in vitro anticancer and in silico ADME study WOS:000521282300031 published article about NATIONAL-CANCER-INSTITUTE; TYROSINE KINASE; DRUG DISCOVERY; HYBRID in [Basal, Nishant K.; Sonawane, Rahul B.; Jagtap, Sangeeta, V] Savitribai Phule Pune Univ, Baburaoji Gholap Coll, Dept Chem, Pune 411017, Maharashtra, India in 2020.0, Cited 26.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6. Application In Synthesis of 3,5-Dimethyl-1H-pyrazole

A new series of 2,4-dimethyl-1H-pyrrole-3-carboxamide derivatives bearing benzimidazole moiety was synthesized through a molecular hybridization approach and evaluated for in vitro anticancer activity by NCI-60 on leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate and breast cancer cell lines at a single dose (10 mu M). Among all the synthesized conjugates, some derivatives showed more or less good activity even at such a small dose, while, compound 5-(1H-benzo[d]imidazol-2-yl) N (1-cyclohexylethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (80 displayed significant antiproliferative activity specifically against MDA-MB human cancer cell lines. Compound 8f showed promising activity against MDA-MB-435 cell line of melanoma (Growth inhibition: 62.46%) and MDA-MB-468 cell line of breast (Growth inhibition: 40.24%). Computational ADME study qualified its significant physicochemical, pharmacokinetic and drug-likeness properties with good predicted oral bioavailability. Thus this new hybrid molecules would be useful for further anticancer drug development.

Application In Synthesis of 3,5-Dimethyl-1H-pyrazole. Welcome to talk about 67-51-6, If you have any questions, you can contact Basal, NK; Sonawane, RB; Jagtap, SV or send Email.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

SDS of cas: 67-51-6. Ishihara, K; Nishimura, K; Yamakawa, K in [Ishihara, Kazuaki; Nishimura, Kazuki; Yamakawa, Katsuya] Nagoya Univ, Grad Sch Engn, Chikusa Ku, B2-3 611,Furo Cho, Nagoya, Aichi 4648603, Japan published Enantio- and Site-Selective alpha-Fluorination of N-Acyl 3,5-Dimethylpyrazoles Catalyzed by Chiral pi-Cu-II Complexes in 2020.0, Cited 49.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6.

Catalytic enantioselective alpha-fluorination reactions of carbonyl compounds are among the most powerful and efficient synthetic methods for constructing optically active alpha-fluorinated carbonyl compounds. Nevertheless, alpha-fluorination of alpha-nonbranched carboxylic acid derivatives is still a big challenge because of relatively high pK(a)values of their alpha-hydrogen atoms and difficulty of subsequent synthetic transformation without epimerization. Herein we show that chiral copper(II) complexes of 3-(2-naphthyl)-l-alanine-derived amides are highly effective catalysts for the enantio- and site-selective alpha-fluorination ofN-(alpha-arylacetyl) andN-(alpha-alkylacetyl) 3,5-dimethylpyrazoles. The substrate scope of the transformation is very broad (25 examples including a quaternary alpha-fluorinated alpha-amino acid derivative). alpha-Fluorinated products were converted into the corresponding esters, secondary amides, tertiary amides, ketones, and alcohols with almost no epimerization in high yield.

SDS of cas: 67-51-6. Bye, fridends, I hope you can learn more about C5H8N2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

An article Crystal structure of bis{mu-2-[bis(2-hydroxyethyl)-amino]ethanolato]bis(mu-3,5-aimethyipyrazolato)-tricopper(II) dibromide sesquihyarate WOS:000577165000021 published article about COMPLEXES; CU(II); WELL in [Vynohradov, Oleksandr S.; Pavlenko, Vadim A.; Naumova, Dina D.; Partsevska, Sofiia, V] Taras Shevchenko Natl Univ Kyiv, Dept Chem, Volodymyrska Str 64-13, UA-01601 Kiev, Ukraine; [Shova, Sergiu] Poni Petru Inst Macromol Chem, Voda 41A, Iasi 700487, Romania; [Safarmamadov, Safarmamad M.] Tajik Natl Univ, Dept Chem, 17 Rudaki Ave, Dushanbe 734025, Tajikistan in 2020.0, Cited 22.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6. HPLC of Formula: C5H8N2

In the title bicyclic trinuclear pyrazolate aminoalcohol complex, [Cu-3(C5H7N2)(2)-(C6H14NO3)(2)]Br-2 center dot 1.5H(2)O, the central Cu atom lies on a center of symmetry and is involved in the formation of two five-membered rings. It has a coordination number of 4, is in a distorted tetrahedral environment and is connected by the bridging oxygen atoms of the deprotonated OH groups of different aminoalcohol groups, and by the N atoms of deprotonated dimethylpyrazole ligands. The peripheral Cu atom is in a trigonal-bipyramidal coordination environment formed by the nitrogen atom of the deprotonated bridging dimethylpyrazole unit, the bridging oxygen atom of the deprotonated OH group, two oxygen atoms of the protonated hydroxy groups and the nitrogen atom of triethanolamine. One of the C atoms and the Br- anion were found to be disordered over two positions with occupancy factors of 0.808 (9):0.192 (9) and 0.922 (3):0.078 (3), respectively.

HPLC of Formula: C5H8N2. Bye, fridends, I hope you can learn more about C5H8N2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics