Tag: M.W=0-100

Recently I am researching about REGIOSELECTIVE IODINATION; NITROSYLSULFURIC ACID; AROMATIC-COMPOUNDS; EFFICIENT METHOD; NITROGEN-OXIDE; C-13 NMR; MILD; CONVENIENT; BROMINATION; 3,5-DIARYLISOXAZOLES, Saw an article supported by the Russian Foundation for Basic ResearchRussian Foundation for Basic Research (RFBR) [18-33-01109, 20-33-90030]; M.V. Lomonosov Moscow State University Program of Development. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Bondarenko, OB; Karetnikov, GL; Komarov, AI; Pavlov, AI; Nikolaeva, SN. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole. SDS of cas: 67-51-6

A new convenient and versatile halogenating system (R(4)NHal/NOHSO4), giving straightforward and general access to halogenated 3,5-diaryl- and alkylarylisoxazoles, pyrazoles and electron-rich benzenes from the corresponding scaffolds, is suggested. The method provides excellent regioselectivity, scalability to the gram scale, and a broad scope for both aromatics and halogens. A three-step, one-pot reaction protocol was developed, and a series of 3,5-diaryl-4-haloisoxazoles has been efficiently synthesized from 1,2-diarylcyclopropanes under suggested nitrosating-halogenating conditions.

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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Computed Properties of C5H8N2. I found the field of Chemistry very interesting. Saw the article Lithium Chloride Catalyzed Aza-Michael Addition of Pyrazoles to alpha,beta-Unsaturated Imides published in 2019.0, Reprint Addresses Zhou, HY (corresponding author), Gansu Agr Univ, Coll Sci, Lanzhou 730070, Peoples R China.; Zhou, HY; Yang, JY (corresponding author), Northwest Normal Univ, Coll Chem & Chem Engn, Lanzhou 730070, Peoples R China.. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole.

A lithium chloride catalyzed aza-Michael reaction of pyrazoles to alpha,beta-unsaturated imides has been developed. A range of aromatic and aliphatic alpha,beta-unsaturated imides are found to be suitable for the established method, providing the corresponding aza-Michael adducts in up to 93% yields. The inexpensive catalyst, good substrate tolerance, and ease of scale-up make this procedure highly practical.

Welcome to talk about 67-51-6, If you have any questions, you can contact Zhou, HY; Xiang, XC; Ma, B; Wang, GG; Zhang, ZX; Yang, JY or send Email.. Computed Properties of C5H8N2

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

An article Universal Anticancer Cu(DTC)(2) Discriminates between Thiols and Zinc(II) Thiolates Oxidatively WOS:000465413400046 published article about COPPER; COORDINATION; SPECTROSCOPY; BIOCHEMISTRY; STRESS; CANCER in [Xu, Luyan; Xu, Jialin; Yu, Na; Lin, Bo-Lin] ShanghaiTech Univ, Sch Phys Sci & Technol, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China; [Wang, Yu] Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, Shanghai Adv Res Inst, 239 Zhangheng Rd, Shanghai 201204, Peoples R China; [Zhu, Jingwei; Yao, Zijian; Deng, Wei] Shanghai Inst Technol, Sch Chem & Environm Engn, 100 Haiquan Rd, Shanghai 201418, Peoples R China; [Xu, Luyan; Lin, Bo-Lin] Chinese Acad Sci, Shanghai Inst Organ Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China; [Xu, Luyan; Lin, Bo-Lin] Univ Chinese Acad Sci, Beijing 100049, Peoples R China in 2019.0, Cited 24.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6. Safety of 3,5-Dimethyl-1H-pyrazole

Aerobic organisms must rely on abundant intracellular thiols to reductively protect various vital functional units, especially ubiquitous zinc(II) thiolate sites of proteins, from deleterious oxidations resulting from oxidizing environments. Disclosed here is the first well-defined model study for reactions between zinc(II) thiolate complexes and copper(II) complexes. Among all the studied ligands of copper(II), diethyldithiocarbamate (DTC) displays a unique redox-tuning ability that enables copper(II) to resist the reduction by thiols while retaining its ability to oxidize zinc(II) thiolates to form disulfides. This work proves for the first time that it is possible to develop oxidants to discriminate between thiols and zinc(II) thiolates, alluding to a new chemical principle for how oxidants, especially universal anticancer Cu(DTC)(2), might circumvent the intracellular reductive defense around certain zinc(II) thiolate sites of proteins to kill malignant cells.

Safety of 3,5-Dimethyl-1H-pyrazole. Bye, fridends, I hope you can learn more about C5H8N2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article (1,2-Azole)bis(bipyridyl)ruthenium(II) Complexes: Electrochemistry, Luminescent Properties, And Electro- And Photocatalysts for CO2 Reduction published in 2021.0. COA of Formula: C5H8N2, Reprint Addresses Villafane, F (corresponding author), Univ Valladolid, GIR MIOMeT IU Cinquima Quim Inorgan, Fac Ciencias, Campus Miguel Delibes, Valladolid 47011, Spain.. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole

New cis-(1,2-azole)-aquo bis(2,2′-bipyridyl)-ruthenium(II) (1,2-azole (az*H) = pzH (pyrazole), dmpzH (3,5-dimethylpyrazole), and indzH (indazole)) complexes are synthesized via chlorido abstraction from cis-[Ru(bipy)(2)Cl(az*H)]OTf. The latter are obtained from cis-[Ru(bipy)(2)Cl-2] after the subsequent coordination of the 1,2-azole. All the compounds are characterized by H-1, C-13, N-15 NMR spectroscopy as well as IR spectroscopy. Two chlorido complexes (pzH and indzH) and two aquo complexes (indzH and dmpzH) are also characterized by X-ray diffraction. Photophysical and electrochemical studies were carried out on all the complexes. The photophysical data support the phosphorescence of the complexes. The electrochemical behavior of all the complexes in an Ar atmosphere indicate that the oxidation processes assigned to Ru(II) -> Ru(III) occurs at higher potentials in the aquo complexes. The reduction processes under Ar lead to several waves, indicating that the complexes undergo successive electron-transfer reductions that are centered in the bipy ligands. The first electron reduction is reversible. The electrochemical behavior in CO2 media is consistent with CO2 electrocatalyzed reduction, where the values of the catalytic activity [i(cat)(CO2)/i(p)(Ar)] ranged from 2.9 to 10.8. Controlled potential electrolysis of the chlorido and aquo complexes affords CO and formic acid, with the latter as the major product after 2 h. Photocatalytic experiments in MeCN with [Ru(bipy)(3)]Cl-2 as the photosensitizer and TEOA as the electron donor, which were irradiated with >300 nm light for 24 h, led to CO and HCOOH as the main reduction products, achieving a combined turnover number (TONCO+HCOO-) as high as 107 for 2c after 24 h of irradiation.

COA of Formula: C5H8N2. Bye, fridends, I hope you can learn more about C5H8N2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

HPLC of Formula: C5H8N2. Xu, LY; Xu, JL; Zhu, JW; Yao, ZJ; Yu, N; Deng, W; Wang, Y; Lin, BL in [Xu, Luyan; Xu, Jialin; Yu, Na; Lin, Bo-Lin] ShanghaiTech Univ, Sch Phys Sci & Technol, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China; [Wang, Yu] Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, Shanghai Adv Res Inst, 239 Zhangheng Rd, Shanghai 201204, Peoples R China; [Zhu, Jingwei; Yao, Zijian; Deng, Wei] Shanghai Inst Technol, Sch Chem & Environm Engn, 100 Haiquan Rd, Shanghai 201418, Peoples R China; [Xu, Luyan; Lin, Bo-Lin] Chinese Acad Sci, Shanghai Inst Organ Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China; [Xu, Luyan; Lin, Bo-Lin] Univ Chinese Acad Sci, Beijing 100049, Peoples R China published Universal Anticancer Cu(DTC)(2) Discriminates between Thiols and Zinc(II) Thiolates Oxidatively in 2019.0, Cited 24.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6.

Aerobic organisms must rely on abundant intracellular thiols to reductively protect various vital functional units, especially ubiquitous zinc(II) thiolate sites of proteins, from deleterious oxidations resulting from oxidizing environments. Disclosed here is the first well-defined model study for reactions between zinc(II) thiolate complexes and copper(II) complexes. Among all the studied ligands of copper(II), diethyldithiocarbamate (DTC) displays a unique redox-tuning ability that enables copper(II) to resist the reduction by thiols while retaining its ability to oxidize zinc(II) thiolates to form disulfides. This work proves for the first time that it is possible to develop oxidants to discriminate between thiols and zinc(II) thiolates, alluding to a new chemical principle for how oxidants, especially universal anticancer Cu(DTC)(2), might circumvent the intracellular reductive defense around certain zinc(II) thiolate sites of proteins to kill malignant cells.

Welcome to talk about 67-51-6, If you have any questions, you can contact Xu, LY; Xu, JL; Zhu, JW; Yao, ZJ; Yu, N; Deng, W; Wang, Y; Lin, BL or send Email.. HPLC of Formula: C5H8N2

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

An article Novel one-dimensional polymeric Cu(II) complexes via Cu(II)-assisted hydrolysis of the 2,4-bis(3,5-dimethyl-1H-pyrazol-1-yl)-6-methoxy-1,3,5-triazine pincer ligand: Synthesis, structure, and antimicrobial activities WOS:000552262500001 published article about CRYSTAL-STRUCTURES; COPPER(II)-ASSISTED HYDROLYSIS; CARBONYL-COMPLEXES; RHODIUM COMPLEXES; 2,4,6-TRIS(2-PYRIDYL)-1,3,5-TRIAZINE; COPPER; 2,4,6-TRIS(2-PYRIMIDYL)-1,3,5-TRIAZINES; RUTHENIUM(II); FUNCTIONALS; MONONUCLEAR in [Soliman, Saied M.; El-Faham, Ayman] Alexandria Univ, Fac Sci, Dept Chem, POB 426, Alexandria 21321, Egypt; [El-Faham, Ayman] King Saud Univ, Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia; [El Silk, Sobhy E.] Tanta Univ, Fac Sci, Bot Dept, Bacteriol Unit, Tanta 31527, Egypt in 2020.0, Cited 70.0. COA of Formula: C5H8N2. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

Two unexpected one-dimensional coordination polymers, [Cu(PT)(H2O)Cl](n) 1 and [Cu-2(BPT)(ClO4)(3)(H2O)(4)](n)center dot 2nH(2)O 2, of symmetrical triazine-based ligands were synthesized by Cu(II)-mediated hydrolysis of the 2,4-bis(3,5-dimethyl-1H-pyrazol-1-yl)-6-methoxy-1,3,5-triazine (MBPT) pincer ligand. The reaction of Cu(ClO4)(2)center dot 6H(2)O with MBPT proceeded via hydrolysis of the methoxy group to produce the dicompartmental 4,6-bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,3,5-triazin-2(1H)-one ligand (HBPT) that then undergoes in situ complexation with Cu(II) to afford 2. In case of CuCl2, the reaction proceeds further with C-N cleavage of one pyrazolyl unit leading to the formation of 6-(3,5-dimethyl-1H-pyrazol-1-yl)-1,3,5-triazine-2,4(1H,3H)-dione ligand (HPT) that also undergoes in situ complexation with Cu(II) affording 1. The role of Cu(II) is to increase the Lewis acid reactivity of the water molecule where similar hydrolytic reactions for MBPT were observed in acidic medium in presence of an aqueous HCl (1:1 v/v) solution. The molecular and supramolecular structures of complexes 1 and 2 were investigated using X-ray diffraction of single crystal, Hirshfeld analysis, and density functional theory calculations. The Cl center dot center dot center dot H (11.7%) and O center dot center dot center dot H (24.7%) contacts are the most important in 1, whereas the molecular packing of 2 is controlled mainly by the O center dot center dot center dot H (58.7%) hydrogen bonds. Complex 2 showed better activity against Escherichia coli, Bacillus subtilis, and Candida albicans compared with the standard antibiotics amoxicillin, tetracycline, and ampicillin. In general, complexes 1 and 2 showed good antimicrobial activity than these antibiotics and have the advantage to be used as both antibacterial and antifungal agents.

COA of Formula: C5H8N2. Welcome to talk about 67-51-6, If you have any questions, you can contact Soliman, SM; El-Faham, A; El Silk, SE or send Email.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Name: 3,5-Dimethyl-1H-pyrazole. Champaka, G; Senthilkumar, K; David, E; Shanmugan, S; Palanisami, N in [Champaka, Gurudevaru; Senthilkumar, Kabali; David, Ezhumalai; Palanisami, Nallasamy] Vellore Inst Technol, Ctr Funct Mat, Dept Chem, Sch Adv Sci, Vellore 632014, Tamil Nadu, India; [Shanmugan, Swaminathan] SRM Inst Sci & Technol, Dept Chem, Fac Engn & Technol, Kancheepuram 603203, Tamil Nadu, India published Monomeric zinc ferrocene carboxylate [Zn(FcCOO)(3,5-dmp)(2)Cl] derived from 3,5-dimethylpyrazole: structural, optical, electrochemical and antimicrobial studies in 2021.0, Cited 40.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6.

Monomeric zinc ferrocene carboxylate [Zn(FcCOO)(3,5-dmp)(2)Cl] (1) has been synthesized from a reaction between the zinc chloride, sodium salt of ferrocene carboxylic acid (FcCOONa) and 3,5-dimethylpyrazole (3,5-dmp) at room temperature. Compound 1 was further characterized by elemental analysis, H-1 NMR, FT-IR, absorption, emission spectroscopic techniques, and molecular structure was confirmed by single-crystal X-ray diffraction studies. The molecular structure of compound 1 crystallized in triclinic system with P (1) over bar space group and the central Zn2+ ion is in a distorted tetrahedral geometry with -FeN2OCl coordination environment. Compound 1 was further stabilized with the aid of inter and intramolecular hydrogen bonding and pi-pi interaction between cyclopentadienyl ring of ferrocene and aromatic heterocyclic five membered 3,5-dimethylpyrazole. Compound 1 exhibits broad emission band, indicating ligandto-metal charger transfer (LMCT) or metal-to-ligand charger transfer (MLCT) nature. The electrochemical property of compound 1 revealed that one-electron anodic and cathodic peaks corresponding to the redox responsible of ferrocene/ferrocenium (FeII <-> Fe-III) moiety. Among the different strains of bacteria, the antibacterial activity of compound 1 showed comparatively a significant activity against gram negative bacterium Proteus vulgaris. (C) 2020 Elsevier B.V. All rights reserved.

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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

In 2019.0 RUSS J GEN CHEM+ published article about HETEROCYCLIC SYNTHESIS; ESTIMATE SOLUBILITY; CYANOACETIC ACID; DRUG DISCOVERY; DERIVATIVES; PERMEABILITY; INHIBITORS; CHEMISTRY in [Chigorina, E. A.] Kurchatov Inst, Inst Chem Reagents & High Pur Chem Subst, Natl Res Ctr, Moscow, Russia; [Bespalov, A. V.; Dotsenko, V. V.] Kuban State Univ, Krasnodar, Russia; [Dotsenko, V. V.] North Caucasian Fed Univ, Stavropol, Russia in 2019.0, Cited 46.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6. Quality Control of 3,5-Dimethyl-1H-pyrazole

3-Aminothieno[2,3-b]pyridine-2-carboxylic acid esters readily reacted with 3,5-dimethyl-1-(cyanoacetyl)-1H-pyrazole to give previously unknown N-(thieno[2,3-b]pyridin-3-yl)cyanoacetamides. Reactions of the latter with 2-(arylmethylidene)malononitriles were nonselective, and mixtures of different heterocyclization products were generally formed. The cyclization of ethyl 4,6-dimethyl-3-[(cyanoacetyl)amino]thieno[2,3-b]pyridine-2-carboxylate afforded 2,4-dihydroxy-7,9-dimethylthieno[2,3-b : 4,5-b’]dipyridine-3-carbonitrile whose tautomeric equilibrium was studied by DFT quantum chemical calculations. In silico analysis of biological activity of the synthesized compounds was performed.

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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Glukhacheva, VS; Il’yasov, SG; Kazantsev, IV; Shestakova, EO; Il’yasov, DS; Eltsov, IV; Nefedov, AA; Gatilov, YV in [Glukhacheva, Vera S.; Il’yasov, Sergey G.; Kazantsev, Igor, V; Shestakova, Elena O.; Il’yasov, Dmitri S.] Russian Acad Sci IPCET SB RAS, Inst Problems Chem & Energet Technol, Siberian Branch, Biisk 659322, Russia; [Eltsov, Ilia, V; Nefedov, Andrey A.] Novosibirsk State Univ, Novosibirsk 630090, Russia; [Nefedov, Andrey A.; Gatilov, Yuri, V] Russian Acad Sci NIOCh SB RAS, Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia published New Reaction Products of Acetylacetone with Semicarbazide Derivatives in 2021.0, Cited 40.0. HPLC of Formula: C5H8N2. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6.

A new approach is suggested herein for the synthesis of pyrazole derivatives by reacting 4-nitrosemicarbazide with acetylacetone. Additional studies were done on the reaction of acetylacetone with semicarbazide and its derivatives (4-aminosemicarbazide, methylsemicarbazide, and dimethylsemicarbazide). The study on the reaction with acetylacetone resulted in monocyclic 3,5-dimethyl-N-nitropyrazole-1-carboxamide, monocyclic 5-hydroxy-3,5-dimethyl-2-pyrazoline, and bicyclic bis(3,5-dimethylpyrazole-1-carbonyl)hydrazine, and conditions for the formation of acetone semicarbazone were identified. The structures of the resultant compounds were validated by physicochemical analytical methods, including X-ray diffraction. The computer-aided screening in the PASS prediction software discovered a high biological activity of the newly obtained compounds.

HPLC of Formula: C5H8N2. Bye, fridends, I hope you can learn more about C5H8N2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Formula: C5H8N2. Authors Sun, ML; Zhou, YH; Li, LQ; Wang, L; Ma, YM; Li, PH in ROYAL SOC CHEMISTRY published article about in [Sun, Mingli; Zhou, Yuhui; Wang, Lei; Ma, Yongmin] Taizhou Univ, Adv Res Inst, Taizhou 318000, Zhejiang, Peoples R China; [Sun, Mingli; Zhou, Yuhui; Wang, Lei; Ma, Yongmin] Taizhou Univ, Dept Chem, Taizhou 318000, Zhejiang, Peoples R China; [Sun, Mingli; Li, Laiqiang; Wang, Lei; Li, Pinhua] Huaibei Normal Univ, Dept Chem, Huaibei 235000, Anhui, Peoples R China; [Wang, Lei] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China in 2021.0, Cited 42.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

This paper reports a metal-free and external oxidant-free electrochemical method for the C-3 amination of 2H-indazoles. The protocol employs commercially available azoles and aliphatic amines as amination reagents and has a broad substrate scope, providing the corresponding C3-amination products in high yields at room temperature. Mechanistic studies indicate that an oxidative addition/elimination sequence is involved under electrochemical conditions.

Formula: C5H8N2. Welcome to talk about 67-51-6, If you have any questions, you can contact Sun, ML; Zhou, YH; Li, LQ; Wang, L; Ma, YM; Li, PH or send Email.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics