Tag: M.W:100-200

14521-80-3, A common compound: 14521-80-3, name is 3-Bromo-1H-pyrazole, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

A mixture of 0.28 g of 2-(3-fluoropyridin-4-yl)-5-(trifluoromethyl)benzoxazole, 0.19 g of 3-bromopyrazole, 0.55 g of potassium carbonate and 2 ml of DMF was stirred while heating at 50C for 1.5 hours. Then, the reaction mixture was cooled to room temperature. Water was added to the reaction mixture, followed by extraction with ethyl acetate twice. The combined organic layers were washed with a saturated sodium chloride solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to give 0.31 g of 2-[3-(3- bromopyrazole-l-yl)pyridin-4-yl]-5-(trifluoromethyl)benzoxazole (hereinafter, referred to as “active compound 59”).Active compound 59-NMR (CDC13) delta: 8.92 (s, IH), 8.89 (d, J=5.1 Hz, IH), 8.16 (d, J=5.1 Hz, IH), 8.08-8.07 (m, IH), 7.69 (dd, J=8.8, 1.2 Hz, IH), 7.66 (d, J=2.4 Hz, IH), 7.59 (d, J=8.8 Hz, IH), 6.57 (d, J=2.4 Hz, IH)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromo-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

15878-00-9,Some common heterocyclic compound, 15878-00-9, name is 4-Chloro-1H-pyrazole, molecular formula is C3H3ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE Preparation of 2-{4- [4- (4-chloro-1-pyrazolyl)-butyl]-1-piperazinyl}pyrimidine. To a mixture of 2- (1-piperazinyl)pyrimidine (32.8 g; 0.2 mol), 1,4-dibromobutane (47.5 g; 0.22 mol) and K2 CO3 (69 g; 0.5 tool) in 400 ml of dimethylformamide is added 4 -chloropyrazole (20.5 g; 0.2 mol), and the mixture is held at the reflux for 17 hours. The reaction mixture is filtered hot and evaporated to dryness. The residue is dissolved in HCl, washed with CHCl3, rendered alkaline with dilute NaOH and extracted in basic medium with CHCl3. The organic phase is then dried and subsequently evaporated to dryness, and 61 g (95%) of 2-{4-[4-(4-chloro-1-pyrazolyl)butyl]-1-piperazinyl}pyrimidine are obtained. Spectroscopic data: IR (film); 2843, 1586, 1547, 1358, 983 cm-1. 1 H NMR (delta, CDCl3): 8.25 (d, 2H, J=4.7 Hz); 7.39 (s, 1H); 7.35 (s, 1H); 6.44 (t, 1H, J=4.7 Hz); 4.0 (t, 2H, J=6.8 Hz); 3.80 (m, 4H); 2.43 (m, 6H); 1.90 (m, 2H) 1.52 (m, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 15878-00-9, its application will become more common.

176969-34-9, These common heterocyclic compound, 176969-34-9, name is 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1-methyl-3-difluoromethyl-1H-pyrazole-4-carboxylic acid (7.76 g, 40 mmol) represented by formula (III) was refluxed with thionyl chloride (47.6 g, 0.4 mol) for 4 hours. When the reaction system turns to a pale yellow transparent liquid, the reaction is continued for 30 min. The reaction is stopped, and after cooling down to room temperature, 1-methyl-3-difluoromethyl-1H-pyrazole-4-acyl chloride is obtained by distillation under reduced pressure. 1-methyl-3-difluoromethyl-1H-pyrazole-4-carbonyl chloride (2 mmol) was added to 15 ml of dichloromethane, Phenylmethanamine (2.1 mmol) was added followed by slow triethylamine (0.3 g, 3 mmol) stirring overnight at room temperature; followed by TLC (EA:PE=2:1 (V)) until the reaction was complete with dichloromethane. Three times extraction with water=1:1 (V) system, concentration of organic layer, extraction with toluene or 75% ethanol, and column chromatography (EA:PE=2:1(V)) to obtain N-benzyl as shown in (K11). 1-Methyl-3-(difluoromethyl)-1H-pyrazole-4-carboxamide

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 176969-34-9.

These common heterocyclic compound, 2075-46-9, name is 4-Nitro-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 2075-46-9

Example 1 3-Chloro-1H-pyrazol-4-amine hydrochloride (1a) A 1000-mL, multi-neck cylindrical jacketed reactor, fitted with a mechanical stirrer, temperature probe and nitrogen (N2) inlet, was charged with 4-nitropyrazole (50.0 g, 429 mmol) and palladium on alumina (5 wt %, 2.5 g). Ethanol (150 mL) was added, followed by a slow addition of concentrated hydrochloric acid (37 wt %, 180 mL). The reaction was cooled to 15 C., and triethylsilane (171 mL, 1072 mmol) was added slowly via addition funnel over 1 hour, while maintaining the internal temperature at 15 C. The reaction was stirred at 15 C. for 72 hours, after which the reaction mixture was filtered through a Celite pad and the pad was rinsed with warm ethanol (40 C., 2*100 mL). The combined filtrates were separated and the aqueous layer (bottom layer) was concentrated to ?100 mL. Acetonitrile (200 mL) was added and the resulting suspension was concentrated to ?100 mL. Acetonitrile (200 mL) was added and the resulting suspension was concentrated to ?100 mL. Acetonitrile (200 mL) was added and the resulting suspension was stirred at 20 C. for 1 hour and filtered. The filter cake was rinsed with acetonitrile (2*100 mL) and dried under vacuum at 20 C. to afford a white solid (?10:1 mixture of 1a and 1H-pyrazol-4-amine, 65.5 g, 99%): 1H NMR (400 MHz, DMSO-d6) delta 10.52 (bs, 3H), 8.03 (s, 1H); EIMS m/z 117 ([M]+).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2075-46-9.

A common compound: 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 5334-40-7

2-(methylamino)ethanol (2.00 g, 26.63 mmol) and 4-nitro-1H-pyrazole-3-carboxylic acid (3.54 g, 22.52 mmol) in toluene (24.44 mL) were stirred at 15 ¡ãC. SOd2 (4.52 mL, 62.28 mmol) was slowly added followed by DMF (171.44 jiL, 2.21 mmol). The reaction mixturewas stirred at 55 ¡ãC for 10 minutes then 70 ¡ãC for 18 h. Solvents were evaporated. The residue was taken up into DMF (20.62 mL) and TEA (16.66 mL) was added slowly. The reaction mixture was stirred at rt for 12 h. Water was added and the mixture was extracted twice with EtOAc, dried over Mg504, filtered and evaporated. The crude residue was purified via silica gel chromatography (Stationary phase: irregular SiOH 15-40 jim, 80 g,mobile phase gradient: from 100percent DCM to 97percent DCM, 3percent MeOH (+ 10percent NH4OH)) to give 1.96 g of intermediate 14b (38percent yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5334-40-7, other downstream synthetic routes, hurry up and to see.

82560-12-1, Adding some certain compound to certain chemical reactions, such as: 82560-12-1, name is 3-Amino-5-tert-butylpyrazole, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 82560-12-1.

A solution of Intermediate 55a (2.64 g, 6.50 mmol), 3-tert-butyl-lH-pyrazole-5- amine (997 mg, 7.1 mmol) and trans-N,N-dimethylcyclohexane-diamine (185 mg, 0.33 mmol) was formed in toluene (25 mL). Potassium carbonate (1.9 g, 13.7 mmol) was added and the mixture degassed by bubbling nitrogen through it. Copper(I) iodide (64.0 mg, 1.30 mmol) was added and the mixture was refluxed at 110 C for 24 h. The solvent was evaporated under reduce pressure and the residue was partitioned between EtO Ac/Water and extracted with EtOAc. The combined organics were dried over Na2S04, filtered and evaporated. Purification by FCC eluting with a gradient of 0-50% EtOAc in cyclohexane gave the title compound (1.72 g, 64%). LCMS (Method 3): Rt 3.69 min, m/z 418 [MH+].

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 82560-12-1.

16034-46-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16034-46-1, name is 1-Methyl-1H-pyrazole-5-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 1-methyl-1 H-pyrazole-5-carboxylic acid (1.0 g, 7.93 mmol), BH3. DMS (39.6 mL, 79 mmol) in THF (40 mL) was stirred at reflux overnight. The mixture was diluted with MeOH (30 mL) and stirred for 30 min, and the mixture was concentrated in vacuo. The residue was purified by silica gel column chromatography, eluting with CH2Cl2/MeOH. The residue was dissolved in DCM (20 mL) and to the solution was added SOCl2(5 mL, 68.5 mmol) at room temperature. The mixture was stirred for 3 h then concentrated to afford the product as an oil which was used in the next step without further purification. MS (ESI) calc? d for (C5H7ClN2) [M+H]+, 131.0, found, 131.0

The synthetic route of 1-Methyl-1H-pyrazole-5-carboxylic acid has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 1128-54-7, name is 3-Methyl-1-phenyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1128-54-7, 1128-54-7

To the reaction flaskwas added 3-methyl-1-phenyl -1H- pyrazole (0.50 g, 0.003 mol), 5 ml of toluene,heated to 70 C, the reaction solution was added N- bromosuccinimide (0.40 g,0.003 mol), azobisisobutyronitrile (catalytic amount), plus Was completed, thereaction solution was warmed to reflux, the reaction was refluxed for 1 hour.After the reaction was cooled to below 30 C, the reaction solution was pouredinto 50 ml Liters of water with 3 ¡Á 50 ml of ethyl acetate and extracted, theresultant organic phase was washed with saturated aqueous sodium bicarbonate(50 ml), saturated After aqueous sodium chloride solution (50 ml), dried overanhydrous magnesium sulfate, and concentrated under reduced pressure, theresidue was purified by column chromatography (Eluent: ethyl acetate: petroleumether = 1: 100) to give 0.40 g of 3-bromo-1-phenyl -1H- pyrazole as a yellowoil, yield 56 %.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Methyl-1-phenyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

A common heterocyclic compound, 27258-33-9, name is 1-Methyl-1H-pyrazole-5-carbaldehyde, molecular formula is C5H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 27258-33-9.

To a mixture of compound OI-5a (2 g, 18.2 mmol, 1.0 eq) in DMF (20 mL) was added NBS (4.86 g, 27.3 mmol, 1.5 eq). The mixture was stirred at room temperature for 16 h under nitrogen atmosphere. Then the mixture was filtered and extracted with water and ethyl acetate. The organic phase was dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue was purified by silica gel chromatography to afford compound OI-5b (2.3 g, 67%).

The synthetic route of 1-Methyl-1H-pyrazole-5-carbaldehyde has been constantly updated, and we look forward to future research findings.

31037-02-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31037-02-2, name is Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Alternative preparation according to Process B: 540g (2.26 mmol) of 2-fluoro-4-methyl-5-[(2,2,2-trifluoroethyl)sulphanyl]aniline are initially charged in dry dichloromethane.The flask is flushed with argon, and 2.5 ml of a 2Msolution of trimethylaluminium in toluene are added dropwise.The reaction mixture is stirred at room temperature for30min, and405 mg (2.39 mmol) ofethyl5-amino-1-methyl-1H-pyrazole-4-carboxylate are then added. The mixture isstirred at room temperature overnight, and a 1 0% strengthpotassium/sodium tartrate solution is then added. The organicphase is separated off and the aqueous phase is extractedtwice with dichloromethane. The combined organic phasesare dried over sodium sulphate and the mixture is applied toRP(C-18) material. Removal of the solvents is followed bypurification by means of MPLC on an RP(C-18) columnusing water/acetonitrile. This gives 577 mg (1 00% pure, 71%of theory) of the title compound.

The synthetic route of 31037-02-2 has been constantly updated, and we look forward to future research findings.