Tag: M.W:100-200

27258-33-9, Name is 1-Methyl-1H-pyrazole-5-carbaldehyde, 27258-33-9, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

A mixture of 1-methyl-1H-pyrazole-5-carbaldehyde (5.0 g, 45.4 mmol), N-iodosuccinimide(15.3 g, 68.1 mmol), and TFA (50 mL) was stirred at room temperature for 1.5 h. H20 (50mL) was added, and the precipitate was filtered, rinsed with H20 (100 mL), and dried toafford the title compound (9.03 g, 84%).?H NMR (500 MHz, CDC13) oe ppm 4.19 (s, 3H), 7.58 (s, 1H), 9.80 (s, 1H)

Statistics shows that 1-Methyl-1H-pyrazole-5-carbaldehyde is playing an increasingly important role. we look forward to future research findings about 27258-33-9.

176969-34-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 176969-34-9 as follows.

To a solution of 600 mg of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid [compound (III)] and a catalytic amount of N,N-dimethylformamide in dichloromethane (7 mL), 450 mg of thionyl chloride were added dropwise. The mixture was refluxed for 2 h. The reaction was monitored by GC/MS. The solvent was evaporated in vacuo. The crude acid chloride obtained was used in the following step.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 176969-34-9, and friends who are interested can also refer to it.

A common heterocyclic compound, 31037-02-2, name is Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate, molecular formula is C7H11N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 31037-02-2.

To a solution of tBuONO (2.95 mL, 2.46 mmol) in acetonitrile(ACN) was added CuCl (1.76 g, 1.77 mmol), and then added 14 (2.5 g, 1.48 mmol) to the mixture in portions. The reaction was stirred at r.t. for 2 h, and then heated at 60C for 1 h.After completion as TLC monitored, the reaction mixture was cooled to r.t. and diluted with 2 N aq. HCl, then extracted with DCM (3¡Á). The combined phases were washed withbrine, dried over MgSO4, filtered, concentrated and purifiedby flash column chromatography to give 15 (2.08 g) in 75%yield. 1H-NMR (300 MHz, CDCl3) delta: 7.90 (1H, s), 4.30 (2H, q,J=5.4 Hz), 3.86 (3H, s), 1.34 (3H, t, J=5.4 Hz).

The synthetic route of Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.

31037-02-2, The chemical industry reduces the impact on the environment during synthesis 31037-02-2, name is Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate, I believe this compound will play a more active role in future production and life.

The ligand, L (0.169 g; 1 mmol), was dissolved in hot MeOH (5 cm3), and Cu(NO3)2¡¤3H2O (0.12 g; 0.5 mmol) was added. Three days later, brown plate-like microcrystals were filtered and washed with MeOH and Et2O. Yield: 0.159 g (60%). Calcd. (Found) for CuC14H22N8O10: C, 31.97; H, 4.18; N,21.30. (C, 31.76; H, 4.29; N, 21.13). IR bands [ v/cm-1]:3490, 3441, 3346, 1682, 1633, 1460, 1384, 1220, 1126, 771. Molar conductivity, LambdaM (S cm2 mol-1): 131 (DMF).

The chemical industry reduces the impact on the environment during synthesis Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate. I believe this compound will play a more active role in future production and life.

31037-02-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 31037-02-2, name is Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below.

Step 1. Synthesis of ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate Copper(II) bromide (99%, 20.0 g, 88.6 mmol) and tert-butyl nitrite (90%, 14.1 mL, 107 mmol) were combined in acetonitrile (65 mL) and heated to 65 C. Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate (10.0 g, 59.1 mmol) was slowly added portion-wise {Caution: gas evolution!} and the reaction was maintained at 65 C. for 24 hours. The mixture was cooled to room temperature, poured into aqueous hydrochloric acid (3 N, 600 mL), diluted with ethyl acetate (300 mL) and stirred for 10 minutes. The aqueous layer was extracted with ethyl acetate (150 mL), and the combined organic layers were dried over magnesium sulfate, filtered and concentrated in vacuo. The residue was purified via silica gel chromatography (Gradient: 5% to 100% ethyl acetate in heptane, with a 5-minute hold at 32%), affording the product as a pale yellow solid. Yield: 9.10 g, 39.0 mmol, 66%. LCMS m/z 233.3 (M+1). 1H NMR (500 MHz, CDCl3) delta 1.36 (t, J=7.1 Hz, 3H), 3.92 (s, 3H), 4.32 (q, J=7.1 Hz, 2H), 7.93 (s, 1H).

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These common heterocyclic compound, 26621-44-3, name is 3-Nitro-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 26621-44-3

Added to a 100mL single-necked flask 3g compound 3 and 18mL acetic acid, stirred, off-white cloudy liquid. Under cold water bath conditions 2.4mL of fuming nitric acid was slowly added dropwise to the mixed solution, maintaining vigorous stirring, turbid liquid becomes yellow, ensure that the reaction temperature does not exceed 30 deg. C. 6mL acetic anhydride was added to the mixture, after dropping, the mixture quickly became clear, dark yellow clear liquid. After the dropwise addition was stirred at room temperature for 3h. After completion of the reaction, the solution was slowly poured into 100mL crushed ice and stirred vigorously, a yellow precipitate was precipitated, filtered to give a white crystalline powder 2.0g, the filtrate was extracted with ethyl acetate to give pale yellow crystals 1.5608g. Yield: 84.7%, recrystallized from n-hexane. Weigh 50mg of compound 4 into thick-walled pressure bottle, and slowly warmed to 140 deg. C, 160 deg. C, 180 deg. C, at this temperature the reaction 1 ~ 3h to give the compound 5, the results shown in Table 2.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 26621-44-3.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, A new synthetic method of this compound is introduced below., 16617-46-2

Following the procedure described in Example 1 wherein METHANESULFONIC acid was used as the catalyst instead of hydrochloric acid, 83percent of the product was obtained after thorough washing with water and drying with m. p. 183-186 ¡ãC.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 26621-44-3, name is 3-Nitro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., 26621-44-3

At room temperature, water (15 mL) was added to a mixture of 3-nitro-1H-pyrazole (48a) (1 g, 8.90 mmol) and NBS (1.73 g, 9.70 mmol), and the reaction was stirred overnight. After thin layer chromatography indicated the reaction was complete, the reaction solution was diluted with water, extracted with ethyl acetate, washed with saturated brine, dried over anhydrous sodium sulfate, concentrated under reduced pressure, and rotary evaporated to dryness, to afford compound (48b) (1.66 g, yield: 93%, white solid). MS (ESI, m/z): 192 [M+H]+.

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402-61-9, Name is 5-Methyl-1H-pyrazole-3-carboxylic acid, 402-61-9, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

To a solution of 5-methyl-1H-pyrazole-3-carboxylic acid (45 g) in MeOH (450 mL) is added dropwise thionylchloride (58 mL). After addition the mixture is stirred for 16 h at room temperature. The mixture is concentrated in vacuo. The residue is dissolved in EtOAC, washed successively with saturated aqueous NaHCO3 and brine. After drying (MgSO4) the mixture is concentrated in vacuo to give the title compound. LC (Method 1): tR=0.64 min; Mass spectrum (ESI+): m/z=141 [M+H]+.

Statistics shows that 5-Methyl-1H-pyrazole-3-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 402-61-9.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16034-46-1 name is 1-Methyl-1H-pyrazole-5-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 16034-46-1

Oxalyl chloride (0.088 g, 0.693 mmol) was added to a slurry of 1 -methyl- 1 H- pyrazole-5-carboxylic acid (0.066 g, 0.523 mmol) in dichloromethane (2 ml). One drop dimethylformamide was added and the reaction left to stir at room temperature for 2 hours. The reaction was concentrated in vacuo and azeotroped with dichloromethane. The residue was dissolved in THF (2 ml) and to this was added diisopropylethylamine (0.0956 g, 0.693 mmol) and 4- pyrrolidinopyridine (0.005 g, 0.035 mmol). The solution was cooled in an ice/acetone bath and 3-(2,3,5-trichlorophenyl)pyridine-2,6-diamine (Preparation 6, 0.100 g, 0.347 mmol) added portion-wise over 1 minute. The reaction was warmed to room temperature and stirred for 18 hours. The reaction was diluted with dichloromethane and washed with a saturated aqueous solution of NH4CI (10 ml), followed by a saturated aqueous solution of NaHCO3 (10 ml) and then water (10 ml) before drying over MgSO4 and concentrating in vacuo to afford a brown gum. The residue was purified by trituration with pentane to afford the title compound as a yellow oil. 1HNMR (ck-DMSO): 4.09 (s, 3H), 5.60 (br s, 2H), 7.22 (d, 1 H), 7.33 (d, 1 H), 7.38 (d, 1 H), 7.42 (d, 1 H), 7.50 (d, 1 H), 7.84 (d, 1 H), 10.30 (br s, 1 H)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-pyrazole-5-carboxylic acid, and friends who are interested can also refer to it.