Tag: M.W:100-200

15366-34-4, Adding some certain compound to certain chemical reactions, such as: 15366-34-4, name is Methyl 1H-pyrazole-3-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15366-34-4.

To a solution of 6-chloro-4-methyl-2-phenylbenzo[d]thiazole (24, 300mg, 1.15mmol) in tetrachloromethane (7.5mL) were added N-bromosuccinimide (246mg, 1.39mmol) and azoisobutyronitrile (19.0mg, 0.115mmol) at room temperature, and the mixture was stirred at reflux temperature for 8h. After cooling to room temperature, saturated aq. sodium thiosulfate and saturated aq. sodium bicarbonate were added to the mixture. The mixture was extracted with diethyl ether. The organic extracts were washed with brine, dried over sodium sulfate and concentrated in vacuo. The crude material was purified by flash column chromatography on silica gel (hexane:AcOEt=1:1) to give 4-(bromomethyl)-6-chloro-2-phenylbenzo[d]thiazole. Meanwhile, in a separate flask, sodium hydride (38.0mg, 0.799mmol, 60% oil suspension) was added to a solution of ethyl 5-methyl-1H-pyrazole-3-carboxylate (82.1mg, 0.530mmol) in DMF (0.9mL) at 0C. After the mixture was stirred at room temperature for 10min, 4-(bromomethyl)-6-chloro-2-phenylbenzo[d]thiazole was slowly added at 0C. After stirring at 0C for 0.5h, saturated aq. ammonium chloride was added to the mixture. The mixture was extracted with ethyl acetate. The combined organic layer was washed with water and brine, then dried over sodium sulfate and concentrated in vacuo. The crude material was purified by flash column chromatography on silica gel (hexane:AcOEt=2:1) to give the title compound 25 as a colorless solid (53.0mg, 11%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 15366-34-4.

14521-80-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14521-80-3 name is 3-Bromo-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 1: To 3-bromopyrazole (1.0 g, 6.81 mmol) under ice bathSodium hydrogen (545 mg, 13 ¡¤ 6 mmol, 60%) was added in portions to a solution of tetrahydrofuran (15 mL).And stirring at this temperature for 0.5 hours, followed by dropwise addition of 2-(trimethylsilyl)ethoxymethyl chloride (1.36 g, 8.16 mmol).Stir at room temperature overnight. The reaction was quenched by the addition of water (10 mL).The organic phase was dried over anhydrous sodium sulfate and concentrated.The residue was flash chromatographed (petroleum ether / ethyl acetate = 1/1)Purification afforded 3-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole (1.2 g, yield: 64%) it is a yellow oil.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Bromo-1H-pyrazole, and friends who are interested can also refer to it.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 139756-02-8 name is 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 139756-02-8

To a 250 ml three-necked flask was added 6.52 g of 2-ethoxybenzaldehyde, 1-methyl-3-propyl-4-aminopyrazole-5-methyl Amide 9.6 g and isopropyl alcohol, and the mixture was stirred at room temperature for 3 hours. To the reaction system, oxygen was added to the reaction system, 8.56 g of anhydrous ferric chloride was added and heated at 60 C for 3 hours. Purified water, filtered and dried to

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide, and friends who are interested can also refer to it.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 31037-02-2 as follows. 31037-02-2

To a stirred solution of step 2 intermediate (4.8 g, 28.37 mmol) in ethanol (28 mL), aqueous solution of potassium hydroxide (2.0 M, 28 mL, 42.555 mmol) was added and the reaction mixture was refluxed for overnight. The reaction mixture was cooled to RT, concentrated under reduced pressure. The residue was stirred in 1.0 N citric acid (80 mL). The solid precipitated was filtered and dried to yield 3.59 g of the titled product. lU NMR (300 MHz DMSO- 6): delta 3.51 (s, 3H), 6.13 (br s, 2H), 7.38 (s, 1H), 11.74 (s, 1H).

According to the analysis of related databases, 31037-02-2, the application of this compound in the production field has become more and more popular.

5744-59-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5744-59-2, name is 1,5-Dimethyl-1H-pyrazole-3-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Step (e) benzyl 4-(3-(3′-(3-((ls,4s)-4-(l,5-dimethyl-lH-pyrazole-3- carboxamido)cyclohexylcarbamoyl)-5-fluoropyridin-2-yloxy)biphenyl-3- yl)propyl)piperazine-l-carboxylate To a solution of benzyl 4-(3-(3′-(3-((ls,4s)-4-aminocyclohexylcarbamoyl)-5-fluoropyridin-2- yloxy)biphenyl-3-yl)propyl)piperazine-l-carboxylate (0.17 g, 0.26 mmol) and 1,5-dimethyl- lH-pyrazole-3-carboxylic acid (0.036 g, 0.26 mmol) in acetonitrile (2 mL) was added triethylamine (0.356 mL, 2.55 mmol). The initial suspension was left for 10 min to become a solution. 1.57M T3P in THF (0.171 mL, 0.27 mmol) was then added and the mixture stirred for 2 h. The solution was diluted with water and extracted with EtOAc. The organics were combined, dried (MgSO4) and concentrated in vacuo to give the sub-title compound as a white fluffy foam. Yield: 0.18g MS: [M+H]+=788 (MultiMode+)

The synthetic route of 5744-59-2 has been constantly updated, and we look forward to future research findings.

1128-54-7, A common heterocyclic compound, 1128-54-7, name is 3-Methyl-1-phenyl-1H-pyrazole, molecular formula is C10H10N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To 100 ml round bottom flask was added 3-methyl-1-phenyl -1H- pyrazole (1.58 g, 0.010 mol), was added 50 ml of carbon tetrachloride was added N- bromosuccinimide at room temperature (2.20 g, 0.012 mol), was added a catalytic amount of azobisisobutyronitrile (of AIBN), the reaction was warmed to reflux and maintained under reflux conditions for 2 hours. After the reaction was stopped, cooled to room temperature, filtered to remove the solid in the system, the filtrate was concentrated by column chromatography (eluent: ethyl acetate: petroleum ether = 1: 100) to obtain 1.60 g of 1-phenyl-3-bromo methyl -1H- pyrazole as a white solid in 70% yield.

The synthetic route of 1128-54-7 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 16034-46-1, name is 1-Methyl-1H-pyrazole-5-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16034-46-1, 16034-46-1

1) N-methoxy-N,1-dimethyl-1H-pyrazol-5-carboxamide N,O-dimethylhydroxylamine hydrochloride (1.30 g) was added to an dimethylformamide (32 mL) solution that contained 1-methyl-1H-pyrazol-5-carboxylic acid (1.21 g), O-(7-azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (4.38 g) and diisopropylethylamine (3.34 mL) at a room temperature, and the obtained solution was then stirred for 2 hours. Thereafter, water was added to the reaction solution, and the obtained mixture was then extracted with ethyl acetate. The organic layer was washed with water and a saturated saline, and was then dried over anhydrous magnesium sulfate, followed by vacuum concentration. The residue was purified by column chromatography (silica gel cartridge, chloroform_methanol=100:0 to 95:5), so as to obtain the title compound (1.03 g) in the form of a yellow oily substance. 1H NMR (200 MHz, CHLOROFORM-d) delta ppm 3.36 (s, 3H) 3.66 (s, 3H) 4.13 (s, 3H) 6.77 (d, J=2.20 Hz, 1H) 7.48 (d, J=2.20 Hz, 1H); MS (ESI pos.) m/z: 170 [M+H]+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-pyrazole-5-carboxylic acid, other downstream synthetic routes, hurry up and to see.

4522-35-4,Some common heterocyclic compound, 4522-35-4, name is 3-Iodo-1H-pyrazole, molecular formula is C3H3IN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 3-iodo-1H-pyrazole (10 g, 51.55 mmol, 1 eq) in DMF (100 mL) was added NaHMDS (1 M, 61.86 mL, 1.2 eq) at 0 C. The reaction mixture was stirred at 0 C for 0.5 hours. Then a solution of 2-iodopropane (10.52 g, 61.86 mmol, 1.2 eq) in DMF (20 mL) was added dropwise to the above mixture. The reaction mixture was warmed to 25 C and stirred for 12 hours. The reaction mixture was quenched with water (100 mL) and extracted EtOAc (3 ¡Á 80 mL). The organic layers were dried over anhydrous Na2SO4, filtered and concentrated in vacuum. The residue was purified by column chromatography (SiO2, petroleum ether: ethyl acetate 1:0 to 50:1) to give the title compound (6.9 g, 56% yield) as a yellow oil.1H NMR (400 MHz, CDCl3): d 7.26 (d, 1 H), 6.40 (d, 1 H), 4.56-4.48 (m, 1 H) and 1.50 (d, 6 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Iodo-1H-pyrazole, its application will become more common.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5932-27-4, name is Ethyl 1H-pyrazole-3-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. 5932-27-4

Ethylpyrazole-3-carboxylate (1.00 g, 7.14 mmol) was dissolved in acetonitrile (28 mL) N-iodosuccinimide (1.77 g, 7.85 mmol) and trifluoroacetic acid (0.16 mL, 2.14 mmol) were successively added thereto, followed by stirring at room temperature for 3 hours. After completion of the reaction, the reaction mixture was diluted with ethyl acetate and washed with a 5percent aqueous solution of sodium hydrogencarbonate and distilled water. The organic layer was dried over anhydrous sodium sulfate and concentrated. The resulting residue was purified by silica gel column chromatography (ethyl acetate: n-hexane = 4: 6) to give the title compound 75-a (1.69 g, 89percent) as a yellow solid .

The synthetic route of 5932-27-4 has been constantly updated, and we look forward to future research findings.

139756-02-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 139756-02-8, name is 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide, A new synthetic method of this compound is introduced below.

General procedure: We intended to synthesize compounds based on 1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one scaffold by using microwave assisted protocol (Scheme 1). In this direction we started the studies for optimization of synthesis of 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 3a. The optimization studies were initiated by screening of different oxidizing agents as depicted in Table1, see Supplementary data using DMSO:Water in 1:1 proportion to see the conversion in desired product. Amongst all oxidants, the best result was observed with K2S2O8, in equivalence studies for catalyst, 3eq. of catalyst has given maximum yields (Table1, see Supplementary data). Therefore, all reactions were conducted using this condition after optimization of catalyst. However, oxone has also given the product 3a with minor yields. After screening of the catalyst we started study of selectivity for solvent that could affect the formation of 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 3a. The solvent screening was carried out to find out the best conversion, the mixture of DMSO:H2O in 1:1 proportion has given the best results with excellent yields (Table2, see Supplementary data). The microwave protocols were optimized for this reaction as mentioned in Table 3, see Supplementary data; the reactions carried under different microwave Watt powers have given varied results. Wherein, entry 3(b) (Table3, see Supplementary data) was found to be the best condition for maximum conversion. A series of compounds based on 1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one scaffold was synthesized using these optimized conditions, wherein, all kind of substrates with diversity around aryl ring were chosen for conversion and in all cases products obtained in good to excellent yields (Table1).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.