Tag: M.W:200-300

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Oxalic Acid Monothioester for Palladium-Catalyzed Decarboxylative Thiocarbonylation and Hydrothiocarbonylation, published in 2019-12-06, which mentions a compound: 52287-51-1, Name is 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, Molecular C8H7BrO2, Formula: C8H7BrO2.

Oxalic acid monothioester (OAM), an easily accessible and storable reagent, was reported herein as a thioester synthetic equivalent for palladium-catalyzed decarboxylative thiocarbonylation of organohalides and hydrothiocarbonylation of unsaturated carbon-carbon bonds at room temperature with high chemo- and regioselectivity. The reaction is applicable to the synthesis of cysteine-derived thioesters, thus allowing chem. modification of cysteine-containing peptides. Decarboxylation of OAM proceeds through oxidative addition of Pd(0) to the acyl-S bond, which accounts for the very mild reaction conditions.

The article 《Oxalic Acid Monothioester for Palladium-Catalyzed Decarboxylative Thiocarbonylation and Hydrothiocarbonylation》 also mentions many details about this compound(52287-51-1)Formula: C8H7BrO2, you can pay attention to it, because details determine success or failure

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

HPLC of Formula: 52287-51-1. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, is researched, Molecular C8H7BrO2, CAS is 52287-51-1, about Stereoselective synthesis of pentasubstituted 1,3-dienes via Ni-catalyzed reductive coupling of unsymmetrical internal alkynes. Author is Zhou, Zhijun; Chen, Jiachang; Chen, Herong; Kong, Wangqing.

The nickel-catalyzed reductive coupling of two unsym. internal alkynes overcomed the above-mentioned limitations by using a hemilabile directing group strategy to control the regioselectivity was reported. A series of synthetically challenging penta-substituted 1,3-dienes were obtained in good yields with high regio- and enantioselectivity (mostly > 20/1 rr, >90% ee).

The article 《Stereoselective synthesis of pentasubstituted 1,3-dienes via Ni-catalyzed reductive coupling of unsymmetrical internal alkynes》 also mentions many details about this compound(52287-51-1)HPLC of Formula: 52287-51-1, you can pay attention to it or contacet with the author(wqkong@whu.edu.cn; wqkong@whu.edu.cn; wqkong@whu.edu.cn; wqkong@whu.edu.cn) to get more information.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Quality Control of Tin(II) oxalate. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Tin(II) oxalate, is researched, Molecular C2O4Sn, CAS is 814-94-8, about Preparation and study of morphology of mesoporous anodic films grown on tin foil. Author is Vasilieva, T. A.; Uvarov, N. F.; Bokhonov, B. B..

Mesoporous anodic layers were obtained on high-purity tin foils in electrolyte of two types: 0.3 M oxalic acid and 1 M NaOH in various anodizing modes. It was demonstrated that in both cases at low voltages below 4 V barrier films form. In acidic electrolyte the formation of tin (II) oxalate was observed whereas in basic electrolytes SnO2·nH2O seems to be formed. At intermediate voltage values from 4 to 8 V mesoporous films may be obtained with average size of pores of 20-40 nm, mesopores are rather uniformly distributed along the surface. It was found that in contrast to alumina anode films no linear dependency between pore diameter and voltage was observed at anodizing of tin foil. At voltages above 8 V and/or long-term anodization the film cracks and the film split to sep. islands.

Different reactions of this compound(Tin(II) oxalate)Quality Control of Tin(II) oxalate require different conditions, so the reaction conditions are very important.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 52287-51-1. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, is researched, Molecular C8H7BrO2, CAS is 52287-51-1, about Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids. Author is Cincinelli, Raffaella; Dallavalle, Sabrina; Nannei, Raffaella; Merlini, Lucio; Penco, Sergio; Giannini, Giuseppe; Pisano, Claudio; Vesci, Loredana; Ferrara, Fabiana Fosca; Zuco, Valentina; Zanchi, Chiara; Zunino, Franco.

Atypical retinoids, or retinoid-related mols. (RRMs), represent a class of proapoptotic agents with a promising potential in the treatment of neoplastic diseases. In the present work, the synthesis and structure-activity relationship of a series of 3′-adamantan-1-yl-biphenyl-4-yl-acrylic acids substituted in ring A were studied. The synthesized compounds were evaluated for their antiproliferative activity in a human promyelocytic leukemia cell line (NB4), and in an ovarian carcinoma cell system including IGROV-1, carrying a functional wild-type p53, and a cisplatin-resistant subline, IGROV-1/Pt-1. The presence of at least one oxygenated substituent in positions 4′ or 5′ appears determinant for the antiproliferative activity. With two substituents of this kind the activity increases, particularly in the case of alkylenedioxy compounds The activation of DNA damage response as indicated by phosphorylation of H2AX histone, RPA-2 protein, and p53 at serine 15 by the most apoptotic compounds provides addnl. support to the hypothesis that the genotoxic stress is a critical event mediating apoptosis induction by compounds of this group.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 814-94-8, is researched, SMILESS is O=C([O-])C([O-])=O.[Sn+2], Molecular C2O4SnJournal, Article, ChemSusChem called A Bronsted Acidic Ionic Liquid as an Efficient and Selective Catalyst System for Bioderived High Molecular Weight Poly(ethylene 2,5-furandicarboxylate), Author is Qu, Xiao-ling; Jiang, Min; Wang, Bing; Deng, Jin; Wang, Rui; Zhang, Qiang; Zhou, Guang-yuan; Tang, Jun, the main research direction is bronsted acidic ionic liquid catalyst bioderived polyethylene furandicarboxylate; ecofriendly bioderived polyester polyfuran ionic liquid catalyst green chem; Brønsted acids; biomass valorization; hydrogen bonding; ionic liquids; polymers.Product Details of 814-94-8.

Green synthesis of bioderived high-mol.-weight poly(ethylene 2,5-furandicarboxylate) (PEF) over metal-free catalysts is a significant challenge. This study focuses on PEF prepared from ethylene glycol and 2,5-furandicarboxylic acid (FDCA) through a direct esterification method with ecofriendly metal-free ionic liquids (ILs) as catalysts. The catalytic activities of a series of imidazolium cations in the presence of various anions are systematically investigated and found to be mainly governed by the anions. Among the ILs studied, 1-ethyl-3-methylimidazolium tetrafluoroborate ([C2MIM]BF4) is identified as the best catalyst, showing excellent catalytic activity, selectivity, and stability, even at low catalyst loadings (0.1 mol % w.r.t. FDCA). Optimization of the polymerization parameters enables [C2MIM]BF4-catalyzed production of PEF with a high number-average mol. weight (Mn=5.25×104 g mol-1). The relationship between Bronsted acidity and catalytic activity is also investigated and the results show that the trend in catalytic activity is in good agreement with that in Bronsted acidity, as determined by the Hammett method. Addnl., on the basis of exptl. results and d. functional theory calculations, an electrophilic activation mechanism induced by hydrogen bonds is proposed. This strategy of adjustable acidity and anion structure in ILs provides an opportunity to develop other ILs for bio-based polyesters through green synthesis pathways.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Zorina, L. N.; Safiev, O. G.; Chanyshev, R. R.; Zorin, V. V.; Rakhmankulov, D. L. published the article 《Preparation of halogenated benzodioxacycloalkanes》. Keywords: benzodioxole sodium hypochlorite halogenation; benzodioxan sodium hypobromite halogenation; halobenzodioxole preparation; halobenzodioxan preparation.They researched the compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine( cas:52287-51-1 ).Recommanded Product: 52287-51-1. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:52287-51-1) here.

Reaction of 1,3-benzodioxole (I) and 1,4-benzodioxan (II) with NaOCl and NaOBr in presence of sulfuric acid resulted in mono- and dihalogenated derivatives of I and II. Regioselectivity of this reaction depended on the reagents ratio.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Computed Properties of C8H7BrO2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, is researched, Molecular C8H7BrO2, CAS is 52287-51-1, about Rhodium-Catalyzed Direct Arylation of Furopyridine: Synthesis and the Cardiac Effects of Dictamnine Derivatives. Author is Du, Yufeng; Huang, Linyu; Wang, Neng; Li, Xiaohuan; Zhou, Xian-Li; Zhang, Lan; Huang, Shuai; Walsh, Patrick J.; Gao, Feng.

Synthesis of Rh2(OAc)4/IMes·HCl system promotes the chemoselective installation of aryl groups at the 2-position of furo[2,3-b]pyridines I (R = Ph, naphthalen-1-yl, 2,3-dihydro-1,4-benzodioxin-6-yl, etc.) (53-94% yields). The method is applicable to the direct modification of the natural furoquinoline alkaloid dictamnine. The cardiac effects of the fluorinated analogs II were improved, and compared to dictamnine at 160 μg/mL. Preliminary mechanism of action studies indicate that the effects might be related to epinephrine αreceptors, M-receptor and calcium channel receptor.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Recommanded Product: 52287-51-1. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, is researched, Molecular C8H7BrO2, CAS is 52287-51-1, about 6-(4-Benzylpiperazin-1-yl)benzodioxanes as selective ligands at cloned primate dopamine D4 receptors. Author is Hodgetts, Kevin J.; Kieltyka, Andrzej; Brodbeck, Robbin; Tran, Jennifer N.; Wasley, Jan W. F.; Thurkauf, Andrew.

A series of novel 6-(4-benzylpiperazin-1-yl)benzodioxanes were prepared and screened at selected dopamine receptor subtypes. 6-(4-[4-Chlorobenzyl]piperazin-1-yl)benzodioxane had high affinity and selectivity for the D4 dopamine receptor subtype and was identified as a D4 antagonist via its attenuation of dopamine-induced GTPγ35S binding at the D4 receptor.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

COA of Formula: C2O4Sn. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Tin(II) oxalate, is researched, Molecular C2O4Sn, CAS is 814-94-8, about A new lithium diffusion model in layered oxides based on asymmetric but reversible transition metal migration. Author is Ku, Kyojin; Kim, Byunghoon; Jung, Sung-Kyun; Gong, Yue; Eum, Donggun; Yoon, Gabin; Park, Kyu-Young; Hong, Jihyun; Cho, Sung-Pyo; Kim, Do-Hoon; Kim, Hyungsub; Jeong, Eunsuk; Gu, Lin; Kang, Kisuk.

Lithium-rich layered oxides (LLOs) are considered promising cathode materials for lithium-ion batteries because of their high reversible capacity, which is attributed to the exploitation of the novel anionic redox in addition to the conventional cationic redox process. Transition metal (TM) migration, which is known to be the main cause of the voltage decay in LLOs, is now understood to also be the critical factor triggering anionic redox, although this origin is still under debate. A better understanding of the specific TM migration behavior and its effect during charge/discharge would thus enable further development of this class of materials. Herein, we demonstrate that the unique TM migration during charge/discharge significantly alters the lithium diffusion mechanism/kinetics of LLO cathodes. We present clear evidence of the much more sluggish lithium diffusion occurring during discharge (lithiation) than during charge (de-lithiation), which contrasts with the traditional lithium diffusion model based on simple topotactic lithium intercalation/deintercalation in the layered framework. The reversible but asym. TM migration in the structure, which originates from the non-equivalent local environments around the TM during the charge and discharge processes, is shown to affect the lithium mobility. This correlation between TM migration and lithium mobility led us to propose a new lithium diffusion model for layered structures and suggests the importance of considering TM migration in designing new LLO cathode materials.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 52287-51-1, is researched, Molecular C8H7BrO2, about Pd-Catalyzed Direct Diversification of Natural Anti-Alzheimer’s Disease Drug: Synthesis and Biological Evaluation of N-Aryl Huperzine A Analogues, the main research direction is aryl huperzine preparation anti Alzheimer activity acetylcholinesterase SAR chemoselective; huperzine aryl bromide Buchwald Hartwig coupling palladium catalyst.Recommanded Product: 52287-51-1.

The first systematic direct diversification of a complex natural product by metal-catalyzed N-H functionalization was carried out. A new series of N-(hetero)aryl analogs I (Ar = Ph, 2-naphthyl, 4-methylpyridin-2-yl, etc.) of the natural anti-Alzheimer’s disease drug huperzine A (HPA) was prepared via palladium-catalyzed Buchwald-Hartwig cross-coupling reactions of HPA with various aryl bromides ArBr in good yields. Most of the N-aryl-huperzine A (N-aryl-HPA) analogs showed good acetylcholinesterase (AChE) inhibitory activity in in vitro experiments Three arylated huperzine A analogs I (Ar = 4-FC6H4, 4-methoxy-2,6-dimethylphenyl, 5-methoxypyridin-2-yl) exhibited stronger anti-AChE activity than HPA. The 5-methoxy-2-pyridyl analog I (Ar = 5-methoxypyridin-2-yl) displayed the most potent AChE inhibition activity, with an IC50 value of 1.5μM, which was 7.6-fold more active than HPA. Compound I (Ar = 5-methoxypyridin-2-yl) also exhibited better neuroprotective activity for H2O2-induced damage in SH-SY5Y cells than HPA. Structure-activity relationship anal. suggested that the electron d. of the installed aromatic ring or heteroaromatic ring played a significant role in inducing the AChE inhibition activity. Overall, compound I (Ar = 5-methoxypyridin-2-yl) showed the advantages of easy synthesis, high potency and selectivity, and improved neuroprotection, making it a potential huperzine-type lead compound for Alzheimer’s disease drug development.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics