Tag: M.W:100-200

Application of 35100-92-6,Some common heterocyclic compound, 35100-92-6, name is 1,5-Dimethyl-1H-pyrazol-3-amine, molecular formula is C5H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The final product 03 (30 mg, 0.0927 mmol), 1,5-dimethyl-1H-pyrazole-3-amine (31 mg, 0.278 mmol) and Et3N (38 mg, 0.376 mmol) were weighed into a bottle, and 2 mL of DMF was added to dissolve Reaction reagent.The reaction was heated at 50 C overnight.The crude reaction product was directly purified by reverse-phase HPLC to obtain the target compound YB152 (54.7 mg).

The synthetic route of 35100-92-6 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 15953-45-4, name is 5-Chloro-3-methyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C4H5ClN2

(b) S-Chloropyrazole-S-carboxylic acidA mixture of 5-chloro-3-methylpyrazole (3.6 mmol; see step (a) above), water (6 mL) and fert-butanol (1.2 mL) was heated to 750C, after which KMnO4 (1.42 g, 9 mmol) was added. The mixture was stirred at 75 C overnight and filtered hot. The solids were washed with boiling water. The combined cooled filtrates were extracted with EtOAc, and the combined extracts washed with NaCl (sat., aq.), dried (MgSO4) and concentrated. The crude solid was recrystallised from EPO EtOAc/hexane/pentane to give the sub-title compound as white crystals (Yield:350 mg (67%)).1H-NMR (DMSO-d6, 400 MHz), delta 13.65 (br s, IH), 6.80 (s, IH)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 15953-45-4.

Related Products of 852227-86-2, These common heterocyclic compound, 852227-86-2, name is 5-(Chloromethyl)-1,3-dimethyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a stirred suspension of10(30 mg, 0.07 mmol) and potassium carbonate (20 mg, 0.15 mmol) in DMF (500 muL) was added 2-bromoacetamide (15 mg, 0.11 mmol) and the mixture heated to 80 C for 1 h. The reaction mixture was concentrated to dryness and 4 MHCl/dioxane (1 mL) added. After concentrating to dryness, the residue was purified by prepHPLC(high pH) to afford the title compound(8 mg, 30%) as a white powder.

Statistics shows that 5-(Chloromethyl)-1,3-dimethyl-1H-pyrazole is playing an increasingly important role. we look forward to future research findings about 852227-86-2.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25711-30-2, name is 1,5-Dimethyl-1H-pyrazole-4-carbaldehyde, A new synthetic method of this compound is introduced below., COA of Formula: C6H8N2O

Example 15 4-((1,5-Dimethyl-1H-pyrazol-4-yl)methylene)-2-(2-thienyl)-5(4H)-oxazolone To a screw-capped test tube, N-(2-thienylcarbonyl)glycine (56 mg, 0.3 mmol), 1,5-dimethyl-1H-pyrazol-4-carboxaldehyde (41 mg, 0.3 mmol), sodium acetate (25 mg, 0.3 mmol) and acetic anhydride (0.3 mL) were added. The test tube was sealed, and it was then stirred at an external temperature of 90 C. Three hours later, the temperature of the reaction solution was returned to room temperature, and water (1.5 mL) was then added thereto. The obtained mixture was stirred at the same temperature as described above for 1.5 hours. Thereafter, the precipitated crystal was collected by filtration, and it was washed with water (5 mL) and was then dried under reduced pressure, so as to obtain 35 mg of the above-captioned compound. 1H-NMR (400 MHz, DMSO-d6, delta). 8.34 (s, 1H), 8.04 (d, J=4.9 Hz, 1H), 7.90 (d, J=3.7 Hz, 1H), 7.32 (dd, J=3.8, 4.9 Hz, 1H), 7.19 (s, 1H), 3.81 (s, 3H), 2.45 (s, 3H). ESI-MS m/z 274 (M+H)+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 3994-50-1, name is 1-Methyl-4-nitro-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3994-50-1, Recommanded Product: 1-Methyl-4-nitro-1H-pyrazole

To a N2 flushed pressure vial was added (S)-tert-butyl (1-(4-chloropyridin-2-yl)but-3-en-1-yl)carbamate, prepared as described in Intermediate 23, (3.0 g, 10.61mmol), 1 -methyl-4-nitro- 1H-pyrazole (1 .348 g, 10.61 mmol), di(adamant- 1 -yl)(butyl) phosphine (1.141 g, 3.18 mmol), PvOH (0.369 ml, 3.18 mmol), K2C03 (4.40 g, 31.8 mmol) and DMF (21 mL). The reaction mixture was purged with N2 for 5 mm and Pd(OAc)2 (0.476 g, 2.122 mmol) was added. The reaction mixture was purged with N2.The vial was sealed and heated at 120 C for 4 h. The reaction mixture was cooled to rt and partitioned between 10% aqueous LiC1 (15 mL) and EtOAc (30 mL). The aqueous layer was extracted with EtOAc (2 x 20 mL) and the combined organic layers were washed with brine (15 mL), dried over MgSO4, filtered and concentrated. The crude product was then purified using normal phase chromatography to yield (S)-tert-butyl (1-(4-( 1 -methyl-4-nitro- 1H-pyrazol-5 -yl)pyridin-2-yl)but-3 -en-i -yl)carbamate (1.2 g, 29% yield) as a brown oil. MS(ESI) m/z: 374.4 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-4-nitro-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Reference of 304903-10-4, These common heterocyclic compound, 304903-10-4, name is 1-Ethyl-1H-pyrazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 24: {3′-[4-(l-Ethyl-lH-pyrazol-4-ylmethyl)-piperazin-l-yl]-3,4,5,6-tetrahydro- 2H-[1, 2′]bipyridinyl-4-yl} -methanol hydrochlorideHCl To a solution of (3′-piperazin-l-yl-3,4,5,6-tetrahydro-2H-[l,2′]bipyridinyl-4- yl)-methanol (0.145 g, 0.524 mmol, 1 eq) and 1 -ethyl- lH-pyrazole-4-carbaldehyde (97.69 mg, 0.787 mmol, 1.5 eq) in 1 ,2-dichloroethane (10 mL) add sodium triacetoxyborohydride (166.79 mg, 0.787 mmol, 1.5 eq) in one portion as a solid. Stir the mixture at room temperature under nitrogen for 20 hr. Add 2 M aqueous sodium hydroxide solution (20 ml) and DCM (20 ml). Separate using a phase separator and extract the aqueous layer with DCM (10 ml). Concentrate the combined organic extracts and purify by high pH reverse phase HPLC. Dissolve this material (120 mg, 0.31 mmol) in the minimum quantity of 50% aqueous acetonitrile. Add 2 M aqueous hydrogen chloride (155 muL, 0.31 mmol) and lyophilize to give the title compound (127 mg, 58%). MS (m/z): 385.2 (M+l).

The synthetic route of 304903-10-4 has been constantly updated, and we look forward to future research findings.

Related Products of 176969-34-9,Some common heterocyclic compound, 176969-34-9, name is 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid, molecular formula is C6H6F2N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 3-(difiuoromethyl)-l-methyl-lH-pyrazole-4-carboxylic acid (0.25 g, 1.42 mmol) and thionyl chloride (5 mL) was heated to reflux for 1 h. The cooled reaction mixture was concentrated under reduced pressure and the resulting residue was twice diluted with toluene and concentrated under reduced pressure. The residual 3 -(difiuoromethyl)- 1-methyl- lH-pyrazole-4-carbonyl chloride was taken up in dichloromethane (5 mL) and treated dropwise at room temperature with a mixture of 6-chloro-N-cyclopropyl-a-methyl-3- pyridinemethanamine (i.e. the product of Step A, 0.23 g, 1.18 mmol) and triethylamine (0.12 g, 1.18 mmol) in dichloromethane. The reaction mixture was stirred overnight at ambient temperature, and then partitioned between IN hydrochloric acid and dichloromethane. The organic phase was separated and the aqueous phase extracted again with dichloromethane. The combined organic phases were dried (MgSC^) and concentrated under reduced pressure. The residue was chromatographed on silica gel eluting with 30 to 100% ethyl acetate in hexanes to yield the title compound (0.27 g). in NMR delta 8.39 (m, 1H), 7.65 (m, 2H), 7.28 (d, 1H), 7.01 (t, 1H), 5.68 (m, 1H), 3.96 (s, 3H), 2.62 (m, 1H), 1.79 (d, 3H), 0.64 (m, 2H), 0.52 (m, 1H), 0.35 (m, 1H).

The synthetic route of 176969-34-9 has been constantly updated, and we look forward to future research findings.

660845-30-7, name is 5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C6H5ClF2N2O

In 1000 mL reaction flask, 38.9g 3- difluoromethyl-1-methyl-5-chloro-4-carbaldehyde and 390ml of water, 8.4g of sodium hydroxide was added, followed by stirring, 1g of nano copper oxide, control of the reaction temperature is 25-30 C, air through an oxidation reaction 15 hours, starting material HPLC i.e.3- difluoromethyl-1-methyl-5-chloro-4-carbaldehyde , less than the total amount of an amount of 0.2%; the reaction was stopped by filtration, recovery of copper catalyst. The reaction mixture was cooled to below 10 C, add 31% hydrochloric acid to a pH of 1-2, the precipitated solid was filtered; the solid was washed with a small amount of water; and dried to give the product 3-methyl-5-fluoro-1- chloro-pyrazole-4-carboxylic acid 40g, HPLC content 99%; LC-MS: m / e = 210.

The synthetic route of 660845-30-7 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 16461-94-2, These common heterocyclic compound, 16461-94-2, name is 4-Bromo-1H-pyrazol-3-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A soln. of amine BB-34 (1 eq) and aldehyde or ketone BB-12 (1.05 to 1.1 eq) in MeOH (2 to 4 mL/mmol) was stirred for 1 h at RT. NaBI-U (1.6 to 2 eq) was added portionwise at 0C and the rxn mixture was stirred at a given temperature for a given time (see Table 52). It was quenched with H2O at 0C and extracted with EtOAc. The combined org. phases were washed with brine, dried over MgSCh and concentrated in vacuo. When necessary, the crude was purified by CC using EtOAc/MeOH

The synthetic route of 16461-94-2 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 360056-45-7, name is Methyl 4-amino-1H-pyrazole-3-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C5H7N3O2

2,6-dichlorobenzoyl chloride (8.2 g; 39.05 mmol) was added cautiously to a solution of 4-AMINO-LH-PYRAZOLE-3-CARBOXYLIC acid methyl ester (prepared in a manner analogous to 165B) (5 g; 35.5 mmol) and triethylamine (5.95 ml; 42.6 mmol) in dioxan (50 ml) then stirred at room temperature for 5 hours. The reaction mixture was filtered and the filtrate treated with methanol (50 ml) and 2M sodium hydroxide solution (100 ml), heated at 50 C for 4 hours, and then evaporated. 100 ml of water was added to the residue then acidified with concentrated hydrochloric acid. The solid was collected by filtration, washed with water (100 ml) and sucked dry to give 10.05 g OF 4-(2, 6-DICHLORO-BENZOYLAMINO)-LH-PYRAZOLE-3-CARBOXYLIC acid as a pale violet solid.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 360056-45-7.