Tag: M.W:100-200

Reference of 852227-86-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 852227-86-2 as follows.

Example 42 3-Bromo-5-(3-cyano-2-methyl-5-oxo-7-propyl-1,4,5,6,7,8-hexahydro-quinolin-4-yl)-2-(2,5-dimethyl-2H-pyrazol-3-ylmethoxy)-N,N-dimethyl-benzenesulfonamide A mixture of the compound described in example 41a (153 mg), potassium carbonate (125 mg), and 5-chloromethyl-1,3-dimethyl-1H-pyrazole (55 mg) in DMF (1.4 ml) was heated at 60 C. for 3 h. The mixture was diluted with 1N hydrochloric acid and extracted with ethyl acetate. The organic layer was dried (MgSO4), filtered and concentrated in vacuo. The residue was purified by preparative HPLC (Method B), then purified by chromatography on aluminum oxide using ethyl acetate as eluent.Yield: 51 mg. MS-ESI: [M+H]+=616.2/618.2; anal. HPLC: Rt=18.40 min. (method 2)

According to the analysis of related databases, 852227-86-2, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 17635-45-9, name is 4-Pyrazol-1-yl-phenylamine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17635-45-9, SDS of cas: 17635-45-9

The title compound was prepared according to Scheme 7. To a stirred solution of 4- (i//-pyrazol-l~yl)anilme (CAS Number 17635-45-9, 0.5 g, 3.140 mmol) in chloroform (25 mL) was added K2CO3 (1.3 g, 9.422 mmol) at ambient temperature and the reaction mixture was cooled to 0-5 ¡ãC. Thiophosgene (0.73 g, 6.281 mmol) was added the reaction mixture at 0-5 ¡ãC. The resulting reaction mixture was stirred at ambient temperature for 3 h and then poured into water (15 mL). Tire obtained mixture was neutralized by NaHCCb and extracted with EtOAc (2 x 100 mL). The combined organic phase was dried over NaiSOg filtered and concentrated under reduced pressure yielding l-(4-isothiocyanatophenyl)-lii-pyrazole (compound 20.2; 0.56 g, 2.785 mmol). LCMS: Method A, 3.379 min MS: ES+ 202.1 (M+l).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Synthetic Route of 127107-23-7,Some common heterocyclic compound, 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, molecular formula is C4H8ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[00664] Synthesis of compound 1-94. To a 20-mL sealed microwave tube containing compound 112.5 (120 mg, 0.27 mmol, 1.00 equiv), 1 -methyl- lH-pyrazol-4-amine hydrochloride (77.7 mg, 0.58 mmol, 2.10 equiv) in 5 mL of isopropanol was added 0.02 mL of hydrochloric acid (4 M in dioxane) at room temperature. The reaction mixture was heated on microwave for 2.5 h at 140 C and resulting solids were collected by filtration. Crude collected was purified via flash column chromatography to give 72.2 mg (53%) of compound 1-94 as a off- white solid. LCMS (ES, m/z): 498 [M+H]+. 1H NMR(400MHz, <-DMSO): delta 8.94 (s, IH), 7.80 (s, IH), 7.46 (s, IH), 5.75-5.60 (s, IH), 4.65 (s, 2H), 34.08-3.95 (m, IH), 3.80 (s, 3H), 3.59 (t, 4H), 2.85 (s, 2H), 2.52 (s, 4H), 2.30-2.22 (m, IH), 2.10 (d, 2H), 1.92 (d, 2H), 1.55-1.32 (m, 4H), 1.28 (s, 6H). These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-pyrazol-4-amine hydrochloride, its application will become more common.

Electric Literature of 5334-40-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5334-40-7 name is 4-Nitro-1H-pyrazole-3-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The 4-nitro-1H-pyrazole-3-carboxylic acid (20.0 g, 0.127 mmol) was dissolved in methanol (100 mL) and thionyl chloride (18.1 g, 0.152 mmol) was added , allowed to react for 2 hours at 25 C. , then heated to 60 C, and allowed to react for 2 hours. The reaction was concentrated in vacuo and methyl tert-butyl ether (80 mL) was added and filtered to give a white solid which was dried in vacuo to give the product (20.0 g, 92.1% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Nitro-1H-pyrazole-3-carboxylic acid, and friends who are interested can also refer to it.

26308-42-9, name is 3-Ethyl-1-methyl-1H-pyrazole-5-carboxylic acid, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C7H10N2O2

General procedure: Pyrazole acid 9a-k (3 mmol) and thionyl chloride (7.5 mmol)were successively added to 20 mL 1,2-dichloroethane, the mixturewere stirred under reflux for 3 h and then concentrated underreduced pressure, the crude products were added in drops into asolution of 5?a-f (5a-h) (3 mmol) and trimethylamine (6 mmol) inTHF (15 mL).The reaction mixturewas stirred under the 0 C for thenight. After reaction the mixture was poured in Na2CO3 solutionand aqueous phase was extracted with ethyl acetate (2 20 mL).The combined organic phase was washed with saturated salt water(2 20 mL), dried over anhydrous Na2SO4, and concentrated underreduced pressure and the residue was purified by silica gel columnchromatography.

The synthetic route of 26308-42-9 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 82560-12-1,Some common heterocyclic compound, 82560-12-1, name is 3-Amino-5-tert-butylpyrazole, molecular formula is C7H13N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3-tert-butyl-1H-pyrazol-5-amine (J-III) (1 equiv., 40 g) was dissolved in dilute HCl (120 mL HCl in 120 mL water) and NaNO2(1.03 equiv., 25 g in 100 mL) was added dropwise over 30 min. After stirring for 30 min the reaction mixture was neutralised with Na2CO3. A diazonium salt obtained by reacting KCN (2.4 equiv., 48 g), water (120 mL) and CuCN (1.12 equiv., 31 g) was added dropwise within 30 min to the reaction mixture, which was then stirred for a further 30 min at 75 C. After complete conversion the reaction mixture was extracted with EE (3¡Á500 mL), the combined phases were dried over sodium sulphate and the solvent was removed in vacuo. The column chromatography purification (SiO2, 20% EE/Hexane) of the residue yielded a white solid (J-IV) (6.5 g, 15.1% yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Amino-5-tert-butylpyrazole, its application will become more common.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 4-Nitro-1H-pyrazole-3-carboxylic acid

Step 1 Thionyl chloride (9.2 mL) was added dropwise to a solution of 4-nitro-1H-pyrazole-3-carboxylic acid (19.77 g, 125.9 mmol) in methanol (200 mL) at 0C. The reaction mixture was stirred at room temperature overnight, and the solvent was evaporated under reduced pressure. Water was added to the residue, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium hydrogencarbonate solution and saturated brine, dried and concentrated. The obtained crude crystals were washed with diisopropyl ether to give methyl 4-nitro-1H-pyrazole-5-carboxylate (17.8 g, 82%). 1H-NMR (300MHz, CDCl3) delta: 4.06 (3H, s), 8.50 (1H, s).

The synthetic route of 5334-40-7 has been constantly updated, and we look forward to future research findings.

Application of 1260243-04-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1260243-04-6, name is Ethyl 5-amino-1H-pyrazole-4-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a stirred mixture of 3.2 G (20 MMOL) of ethyl 5-amino-1 H-PYRAZOLE-4-CARBOXYLATE in 95 mL of CH212 AT-10¡ãC, 24 mL of isoamyl nitrite (180 MMOL) were added during 30 minutes. The mixture was stirred two hours at 100¡ãC and, after cooling, it was concentrated under reduced pressure (first 10 mmHg then 0.1 mmHg). The residue was dissolved in ethyl acetate and the resulting solution washed with NA2S205, HCI (1N) and water. Organic phase was separated, dried over Na2SO4, filtered and concentrated under reduced pressure to give a brown solid that was purified by column chromatography, eluting with 30percent ethyl acetate in hexane to give 4.11 G (75percent) of the title compound as a yellow solid. 1 H-NMR (DMSOD6), diagnostic signals (ppm): 13.71 (s, 1H), 8.25 (s, 1H), 4.19 (q, 2H), 1.26 (t, 3H) [M+H] + =267

The synthetic route of Ethyl 5-amino-1H-pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.

Electric Literature of 143426-52-2, The chemical industry reduces the impact on the environment during synthesis 143426-52-2, name is 1-(4-(Chloromethyl)phenyl)-1H-pyrazole, I believe this compound will play a more active role in future production and life.

4 mmol of the compound IIIb was dissolved in 20 mL of acetonitrile, and intermediate 77 mmol and 8 mmol ofcesium carbonatewere added thereto at room temperature.After heating, the reaction was refluxed for 13 hours.The reaction was stopped, the reaction solution was rotary evaporated to dryness under reduced pressure, the resulting residue was purified by columnseparation and purification to give the title compound analysis Ib

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(4-(Chloromethyl)phenyl)-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Related Products of 34334-96-8,Some common heterocyclic compound, 34334-96-8, name is 3-Methyl-5-nitro-1H-pyrazole, molecular formula is C4H5N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Add acetonitrile (56 mL) to a mixture of 5-methyi-3-nitro-1H-pyrazoie (3.0 g, 22 mniol), potassium carbonate (6.2 g, 2.0 eq), and I -bromo-3-methoxypropane (3.8 g, 1.1 eq). Stir at 65 C overnight. Cool to EtOAc (50 mE) and filter. Concentrate the filtrate in vacuo. Subject the residue to normal phase chromatography, eluting with 35% EtOAc in hexanes, to give the title compound (3.3 g, 70%). MS (ES) ,n/z 200 (M-fH).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Methyl-5-nitro-1H-pyrazole, its application will become more common.