Tag: M.W:100-200

Related Products of 637336-53-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 637336-53-9, name is Methyl 4-amino-1-methyl-1H-pyrazole-3-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A solution of compound from step a (775 mg, 5 mmol), 1-chloro-2-(2-chloroethoxy)ethane(1420 mg, 10 mmol), KI (1660 mg, 10 mmol) and K2C03 (2070 mg,15 mmol) in DMF (60mL) was stirred for 3 hours at 120 C. The solvent was removed and it was purified by reversephase C18 column chromatography (MeCN/H20) to give desired compound as a light yellowsolid. (450 mg, 40%). ESI-MS m/z: 226.0 [M+Hf.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-amino-1-methyl-1H-pyrazole-3-carboxylate, other downstream synthetic routes, hurry up and to see.

Electric Literature of 687635-04-7,Some common heterocyclic compound, 687635-04-7, name is (3-(1H-Pyrazol-1-yl)phenyl)methanamine, molecular formula is C10H11N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To pyrazol- 1 -ylbenzylamine (0.5 mmol) in tetrahydrofuran (2 mL) at room temperature are added cyclopropylmethylaldehyde (0.6 mmol) and anhydrous magnesium sulfate (60 mg). After stirring for 1.5h at room temperature, sodium borohydride (0.5 mmol) is added and the mixture is then stirred for a further 2h. Water (3 mL) is added to the mixture and stirring resumes for 1 Omin. Additional water is added (1 mL) and the mixture is extracted with dichloromethane (10 mL x 3). After being dried over anhydrous magnesium sulfate the solvent is removed under reduced pressure to give the crude product. This material may be used in subsequent steps without further purification. [0290] The amine obtained using the methods described in the previous step (0.26 mmol) is added to a solution of chloro-l-methyl-3-tert-butyl-l,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one (0.13 mmol) in t-BuOH (0.5 mL). The reaction is heated in a sealed tube to 1000C for 24h. On complete reaction (monitored by LCMS), the mixture is allowed to cool to room temperature and the solvent is then removed under reduced pressure. The final compound may be isolated by preparative HPLC. [0291] Preparative HPLC: Waters XBridge Prep C 18 5mum ODB 19mm ID x 100mm L. The method uses MeCN/H2O 65-90% gradients. H2O contains 0.1% Trifluoroacetic acid (TFA)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (3-(1H-Pyrazol-1-yl)phenyl)methanamine, its application will become more common.

660845-30-7, name is 5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 660845-30-7

Step 1 : preparation of of 5-chloro-3-(difluoromethyl)-1-methyl-1 H-pyrazole-4-carboxylic acid (Ilia)In a 500 ml flask, 6.0 g (31 mmol) of 5-chloro-3-(difluoromethyl)-1-methyl-1 H-pyrazole-4-carbaldehyde are added to 30 ml of toluene. A solution of 2.4 g (62 mmol) of sodium hydroxide in 6ml of water is added to the reaction mixture, followed by 103 ml of a 30% solution of hydrogen peroxide in water, whilst keeping the temperature below 37C. After the end of the addition, the reaction mixture is stirred at 50C for 7 hours. Once the reaction mixture is back to room temperature, the two phases are separated and the organic phase is extracted with 100 ml of water. The combined aqueous phases are acidified to pH 2 with aqueous hydrochloric acid. The resulting white precipitate is filtered, washed twice with 20 ml of water, and dried to yield 3.2 g of 5-chloro-3-(difluoromethyl)-1-methyl-1 H-pyrazole-4-carboxylic acid as a white solid. H NMR (400 MHz, DMSO-c/6) delta ppm : 3.78 (s, 3H); 7.12 (t, 1 H, JHF = 53.60 Hz)13.19 (s, 1 H); IR (KBr) : 1688 cm”1 (C=0); 2200-3200 cm”1 broad (hydrogen bond).

The synthetic route of 660845-30-7 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 57012-20-1, name is (1,3-Dimethyl-1H-pyrazol-5-yl)methanol, molecular formula is C6H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of (1,3-Dimethyl-1H-pyrazol-5-yl)methanol

71 a) To a stirring solution of (2,5-dimethyl-2H-pyrazol-3-yl)-methanol (100 mg, 0.79 mmol) in diethyl ether (3 mL) is added PBr3 (25 muL, 0.26 mmol). The reaction is stirred at room temperature for 18 hours, then water is added. The diethyl ether layer is separated and stored over solid NaOH and used in Step 71 b without further characterization. 71b) BEMP (137 pL, 0.47 mmol) is added to a solution of (2-methyl-1H-pyrrolo[2,3- b]pyridin-3-yl)-acetic acid methyl ester (60 mg, 0.29 mmol) in DMF (0.8 mL). After 35 minutes, the diethyl ether layer from Step 71 a (1.8 mL) is added. After 3 days, the reaction is partitioned between water and 1:1 EtOAc/ether. The organic layer is washed with brine then evaporated. The residue is purified by flash column chromatography (49:1 EtOAc/MeOH elution) to furnish [1-(2,5-dimethyl-2H-pyrazol-3-ylmethyl)-2-methyl-1H- pyrrolo[2,3-b]pyridin-3-yl]-acetic acid methyl ester; MH+ = 313.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 57012-20-1, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 612511-81-6, name is (1-Methyl-1H-pyrazol-3-yl)methanamine, A new synthetic method of this compound is introduced below., Computed Properties of C5H9N3

A mixture of 334 5,7-dibromo-1-isopropyl-3-methyl-1H-pyrazolo[4,3-b]pyridine (0.3 g, 0.9 mmol), 722 (1-methyl-1H-pyrazol-3-yl)methanamine (120 mg, 1.08 mmol) and 133 CsF (274 mg, 1.80 mmol) in NMP (8 mL) was stirred at 100 C. for 12 hours. The mixture was poured into water (20 mL), the aqueous phase was extracted with ethyl acetate (10 mL¡Á3).The combined organic phase was washed with brine (10 mL¡Á1), dried with anhydrous Na2SO4, filtered and concentrated. The residue was purified by silica gel chromatography (silica gel, petroleum ether/ethyl acetate=1/0, 1/1) to afford 768 5-bromo-1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-3-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine. A mixture of 768 5-bromo-1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-3-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine (30 mg, 0.083 mmol), 770 (3-ethoxypyridin-4-yl)boronic acid (28 mg, 0.17 mmol), Pd(dppf)Cl2 (6 mg, 0.008 mmol), 54 K2CO3 (23 mg, 0.17 mmol) and 136 dioxane (1.5 mL) in 99 H2O (1.5 mL) was stirred at 100 C. for 2 hours. The mixture was concentrated. The residue was purified by column chromatography (SiO2, petroleum ether/ethyl acetate=1/0 to 0:1) and preparative HPLC to afford the 771 title compound. (0891) 1H NMR (CD3CN 400 MHz): delta=8.39 (s, 1H), 8.26 (d, J=4.8 Hz, 1H), 7.74 (d, J=4.8 Hz, 1H), 7.41 (d, J=2.4 Hz, 1H), 7.19 (s, 1H), 6.20 (d, J=2.4 Hz, 1H), 5.71 (brt, J=5.2 Hz, 1H), 5.04-4.94 (m, 1H), 4.50 (d, J=5.2 Hz, 2H), 4.19 (q, J=7.2 Hz, 2H), 3.80 (s, 3H), 2.50 (s, 3H), 1.54 (d, J=6.8 Hz, 6H), 1.35 (t, J=6.8 Hz, 3H). LC-MS: tR=1.71 minutes (Method L), m/z=406.1 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 42098-25-9, name is 5-Chloro-1-methyl-4-nitro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C4H4ClN3O2

Nitrogen was bubbled through a solution of 3-chloro-2-methyl-4-nitro-pyrazole (16 g, 100 mmol), potassium vinyltrifluoroborate (18 g, 134 mmol) and cesium carbonate (3.7 M in water, 50 mL, 190 mmol) in DMF (100 mL). l,l’-Bis(diphenylphosphino)ferrocene- palladium(II)dichloride dichloromethane complex (900 mg, 1.10 mmol) was added and degassing continued for 30 min. The reaction mixture was heated at 110 C for 18 hr. More l, -bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex (900 mg, 1.10 mmol) was added and heating continued for 24 hr. More 1,1′- bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex (400 mg, 0.49 mmol) was added and heating continued for 4 hr. The reaction was cooled to room temperature and brine (200 mL) and EtOAc (500 mL) were added. The organic layer was washed with water (4 x 300 mL), separated, dried over Na2S04 and concentrated under reduced pressure. Purification via silica gel column chromatography (0-40% EtOAc/isohexane) gave l-methyl-4-nitro-5-vinyl-lH-pyrazole as a colourless solid (9.1 g). Through a solution of this solid (9.1 g, 59 mmol) in DCM (400 mL) cooled to -78 C was bubbled ozone. When the solution turned blue, ozone addition was stopped. Nitrogen was passed through the solution until the blue colour was discharged. The mixture was allowed to warm to room temperature and flushed with nitrogen for 15 min. Anhydrous dimethyl sulfide (5 mL) was added and the mixture warmed to room temperature. After stirring for 12 hr, the solvents were removed under reduced pressure. DCM (150 mL) was added and the mixture was washed with water (50 mL). The aqueous layer was extracted with DCM (3 x 100 mL) and the combined organic layers were washed with brine (100 mL), separated, dried over Na2S04 and concentrated to give 2-methyl-4-nitro-pyrazole-3-carbaldehyde as a yellow- orange solid (6.6 g, 43% over two steps). NMR (400 MHz, CDC13) delta 10.51 (s, 1H), 8.11 (s, 1H), 4.23 (s, 3H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 42098-25-9.

Synthetic Route of 400877-57-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 400877-57-8 name is Methyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

240 mg (1.30 mM) of the compound obtained in Preparative Example 7 was dissolved in 5 ml of methanol, to which 24 mg of 10% palladium/charcoal was added dropwise, and the resulting mixture was stirred under hydrogen pressure of 40 atm for 30 minutes. After the reaction was terminated, the resulting reaction solution was filtered through cellite, and distilled under reduced pressure, to obtain 191 mg (95%) of the title compound.1H NMR (300 MHz, CDCl3) delta 3.86 (s, 3H), 3.92 (s, 3H), 6.91 (s, 1H).Mass: 155 (M+)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate, and friends who are interested can also refer to it.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5203-77-0, name is 1,3-Dimethyl-1H-pyrazol-5-ol belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. name: 1,3-Dimethyl-1H-pyrazol-5-ol

At room temperature, 1,3-dimethyl-1H-pyrazole-5-ol (1.12 g, 0.01 mol) and (1.58 g, 0.02 mol) pyridine were sequentially dissolved in 20 ml of dichloromethane. The low temperature bath was cooled to 0 C. To the above mixture was added dropwise a solution of 3,7-dichloroquinoline-8-acyl chloride (2.73 g, 0.0105 mol) in dichloromethane (10 ml),The dropping rate was 5 drops / 30 seconds. After the addition was complete, the mixture naturally rose to room temperature and reacted for 4 hours. To the reaction mixture was added 10 ml of a saturated aqueous sodium hydrogen carbonate solution, and the mixture was extracted with dichloromethane (3 * 15 ml). The organic layers were combined,Wash with water (1 * 15ml), saturated brine, and dry over anhydrous magnesium sulfate. desolvate under reduced pressure to obtain 2.52 g of product with a yield of 75%

The synthetic route of 5203-77-0 has been constantly updated, and we look forward to future research findings.

113100-53-1, name is 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Example P5: Preparation of 1 -Methyl-3-trifluoromethyl-1 H-pyrazole-4-carboxylic acid (3-tert- butyl-2-vinylphenyl)amide; 197 mg (1 ,01 mmol) 1 -methyl-3-trifIuoromethyl-1 H-pyrazole-4-carboxyIic acid and 135 mg(1 ,07 mmol) oxalylic acid chloride are dissolved in 8 ml methylenechloride. The solution is stirred for 3 hours at room temperature in the presence of a catalytic amount of dimethylformamide (DMF). After this the solution is slowly added to a solution consisting of180 mg (1 ,01 mmol) 3-tert-butyl-2-vinyl-phenylamine, 155 mg (1 ,52 mmol) triethylamine and7 ml methylenechloride. The resulting reaction mixture is then stirred at room temperature for 16 hours. After removal of the solvent in a water jet vacuum, the residue is purified by flash chromatography over silicagel (eluent: hexane/ethylacetate 2:1). This gives 0,27 g 1- methyl-3-trifluoromethyl-1 H-pyrazole-4-carboxylic acid (3-tert-butyl-2-vinylphenyl)amide in the form of a colourless solid (m.p. 118-119C; 76% of theory).

The synthetic route of 113100-53-1 has been constantly updated, and we look forward to future research findings.

Related Products of 78208-72-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 78208-72-7, name is Ethyl 3-isopropyl-1H-pyrazole-5-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

5-isopropyl-1H-pyrazol-3-carboxylic acid ethyl ester (18.9 g, 104 mmol) and 1M NaOH solution (260 mL, 259 mmol) were dissolved in 1,4-dioxane (300 mL), the reaction was heated to 50¡ã C. under nitrogen and stirred for 3 h. The reaction mixture was cooled, adjusted to pH 2 using concentrated hydrochloric acid and the solvent was removed under reduced pressure. The residual solid was azeotroped with toluene (2.x.30 mL), dissolved in ethyl acetate (500 mL) and washed with water. The aqueous phase was removed, extracted with ethyl acetate (2.x.200 mL) and the combined organic extracts were dried over MgSO4. The solvent was removed under reduced pressure and the residue was azeotroped with dichloromethane (2.x.50 mL) to give the title product (14.7 g) as a white solid; 1H NMR (400 MHz, DMSO-D6): delta 12.50-13.30 (bs, 2H), 6.42 (s, 1H), 2.84-2.94 (quin, 1H), 1.15-1.19 (d, 6H) ppm; LRMS (electrospray): m/z [M-H]+ 153.

The chemical industry reduces the impact on the environment during synthesis Ethyl 3-isopropyl-1H-pyrazole-5-carboxylate. I believe this compound will play a more active role in future production and life.