Tag: M.W:100-200

Application of 863548-52-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 863548-52-1, name is (1-Methyl-1H-pyrazol-5-yl)methanamine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of C-(2-methyl-2H-pyrazol-3-yl)-methylamine (78 mg, 0.7 mmol) in dioxane (30 mL) was added 4-phenoxycarbonylamino-benzoic acid ethyl ester (200 mg, 0.7 mmol) and TEA (213 mg, 2.1 mmol). After stirred at 90 C overnight, the reaction mixture was concentrated in vacuum. The residue was purified by pre-HPLC to afford ethyl 4-(3-((1-methyl-1H-pyrazol-5- yl)methyl)ureido)benzoate (45 mg, 21%) as a white solid. ?H NIVIR (400 IVIHz, CD3OD): oe = 7.91 (d, J= 8.8 Hz, 2H), 7.49 (d, J= 8.4 Hz, 2H), 7.36 (d, J= 1.6 Hz, 1H), 6.24 (d, J= 1.6 Hz, 1H), 4.47 (s, 2H), 4.32 (q, J= 7.2 Hz, 2H), 3.87 (s, 3H), 1.37 (t, J= 7.2 Hz, 3H). MS: m/z 303.0 (M+H).

The synthetic route of (1-Methyl-1H-pyrazol-5-yl)methanamine has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1260243-04-6, name is Ethyl 5-amino-1H-pyrazole-4-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H9N3O2

Cs2CO3 (64.20 g, 197.20 mmol) was added to a solution of ethyl 5-amino-1H-pyrazole- 4-carboxylate (20.40 g, 131.40 mmol) and ethyl-3-ethoxyacrylate (28.6 mL, 197.20 mmol) in DMF (250 mL). The reaction mixture was stirred at 110 ¡ãC for 16 h. The mixture was cooled to room temp and the pH was adjusted to 4 by the addition of AcOH (80 mL). The mixture was concentrated in vacuo and the residue partitioned between CH2Cl2 H2O (1000 mL, 1:1). The organic layer was separated and the aqueous layer was extracted with CH2Cl2 (3 X 500 mL). The combined organics were washed with brine, dried (MgS04) and concentrated. The crude residue was suspended in EtOH (300 mL) and heated to boiling. After cooling to room temperature the solid was collected by filtration, rinsed with EtOH, then Et20 and dried under vacuum to give ethyl 5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate (25.16 g, 92 percent). MS (ESI) calcd for C9H9N3O3 (m/z): 207.06; found: 208 [M+H]

According to the analysis of related databases, 1260243-04-6, the application of this compound in the production field has become more and more popular.

Synthetic Route of 42027-81-6,Some common heterocyclic compound, 42027-81-6, name is 2-(4-Nitro-1H-pyrazol-1-yl)ethanol, molecular formula is C5H7N3O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of compound 19a (6.4 g, 50.0 mmol) and Pd/C (10 wt%, 0.6 g) in ethanol (50 mL) was stirred at room temperature under ahydrogen atmosphere for 2 days. The reaction mixture was then filteredthrough Celite and concentrated to provide

The synthetic route of 42027-81-6 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 1752-88-1, name is 3-Pyrazolidinone hydrochloride, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1752-88-1, name: 3-Pyrazolidinone hydrochloride

EXAMPLE X31 1-[10-(4-Acetonylphenoxy)decyl]pyrazolidin-3-one. A mixture of 10-(4-acetonylphenoxy)decylbromide, ethylene ketal (3.0 g), potassium carbonate (3.8 g), pyrazolidin-3-one hydrochloride (1.47 g) and potassium iodide (0.5 g) in acetonitrile:water (95:5), was heated under reflux for 3 hr. The reaction mixture was allowed to cool, filtered and the solvent evaporated in vacuo. The residue was dissolved in chloroform, washed with water (2*50 ml), dried (magnesium sulphate), fitered and the solvent removed in vacuo. The residue was dissolved in acetone (50 ml) and treated with 2M hydrochloric acid solution (3 ml) and allowed to stand at room temperature for 3 hr. The solvent was removed in vacuo and the residue was dissolved in chloroform and washed with 1.2M sodium bicarbonate solution (1*50 ml), water (2*50 ml), dried (magnesium sulphate), filtered and the solvent removed in vacuo to give 1-[10-(4-acetonylphenoxy)decyl]pyrazolidin-3-one (0.66 g). 1 H NMR (CDCl3) ppm: 1.1-2.1(16H,m); 2.2(3H,s); 2.3-3.0(4H,m); 3.3(2H,m); 3.7(2H,s); 4.0(2H,m); 7.1(4H,dd); 8.0-92(1H, very broad, exchanges with D2 O).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Pyrazolidinone hydrochloride, other downstream synthetic routes, hurry up and to see.

Application of 6825-71-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6825-71-4, name is Ethyl 3,5-diamino-1H-pyrazole-4-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of ethyl 3,5-diamino-lH-pyrazole-4-carboxylate (5.00 g, 29.38 mmol) in DMF (80 mL) were added 1 , 1 ,3,3-tetramethoxypropane (14.50 mL, 88.15 mmol) and AcOH (0.34 mL, 5.88 mmol). The reaction mixture was stirred at 100 C for 14 h, and then concentrated in vacuo. The residue was partitioned between DCM (50 mL) and water (50 mL). The organic phase was separated and the aqueous phase was extracted with DCM (100 mL x 3). The combined organic phases were washed with brine (100 mL), dried over anhydrous Na2S04, filtered and concentrated in vacuo. The residue was purified by a silica gel column chromatography (a solution of NH3in MeOH (7 M)/DCM (v/v) =1/100) to give the title compound as a pale yellow solid (3.52 g, 58.1%).MS (ESI, pos. ion) m/z: 207.1 [M+H]+; H NMR (400 MHz, CDC1 ): delta (ppm) 8.60 (dd, J= 4.40 Hz, 1.76 Hz, 1H), 8.46 (dd, J = 6.76 Hz, 1.76 Hz, 1H), 6.86 (dd, J = 6.72 Hz, 4.40 Hz, 1H), 4.50 (q, J = 7.08 Hz, 2H), 1.47 (t, J = 7.08 Hz, 3H).

The synthetic route of Ethyl 3,5-diamino-1H-pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.

Related Products of 5334-40-7, These common heterocyclic compound, 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1:4-nitropyrazol-3-carbonyl chloride 4-nitro-pyrazol-3-formic acid (3g, 19.1 mmol), thionyl chloride (100mL) and N, N-dimethylformamide (0.1mL) were added to a 250mL reaction flask. The reaction mixture was heated up to reflux and stirred for 3 hours. After completion of the reaction, the reaction solution was concentrated to obtain the title compound (3.33g), the crude product was used directly for the subsequent reaction. (MS: [M+1] none)

Statistics shows that 4-Nitro-1H-pyrazole-3-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 5334-40-7.

Reference of 35100-92-6,Some common heterocyclic compound, 35100-92-6, name is 1,5-Dimethyl-1H-pyrazol-3-amine, molecular formula is C5H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate IVa (R)-tert-butyl 4-(2-chloro-4-(( 1 ,5 -dimethyl- 1 H-pyrazol-3 -yl)amino)pyrimidin-5 -yl)-2- methylpiperazine- 1 -carboxylate In a 25 mL Biotage microwave vial (R)-tert-butyl 4-(2,4-dichloropyrimidin-5-yl)-2- methylpiperazine-1 -carboxylate (500 mg, 1.44 mmol, Intermediate III ) and 1,5- dimethyl-lH-pyrazol-3 -amine (160 mg, 1.44 mmol, Princeton Bio.) was taken in ethanol (10 mL). N,N-diisopropylethylamine (0.754 mL, 4.32 mmol) was added and the reaction mass was subjected to microwave irradiation at 120 C for 4 hours. The reaction was monitored by LCMS and identified the required mass. Reaction mass was cooled and evaporated to dryness and the residue was then chromatographed with EtoAc/Hexane on silica to get pure solid of (R)-tert-butyl 4-(2-chloro-4-((l,5-dimethyl- lH-pyrazol-3-yl)amino)pyrimidin-5-yl)-2-methyl piperazine-l-carboxylate (300 mg, 49.4 %) MS (ES+), (M+H)+= 422.20 for Ci9H28ClN702

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,5-Dimethyl-1H-pyrazol-3-amine, its application will become more common.

64517-88-0, name is 1,3-Dimethyl-1H-pyrazol-4-amine, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 1,3-Dimethyl-1H-pyrazol-4-amine

Example 1.012- [ [5-C yano-2- [(1 ,3-dimethylpyrazol-4-yl)aminol -4-pyridyll amino I -N-methyl- benzamide 2-[(2-Chloro-5-cyanopyridin-4-yl)amino]-N-methylbenzamide (200 mg, 0.70 mmol), palladium(II) acetate (12.53 mg, 0.06 mmol), l,3-dimethylpyrazol-4-amine (155 mg, 1.40 mmol), 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene (48.4 mg, 0.08 mmol) and cesium carbonate (273 mg, 0.84 mmol) were suspended in dioxane (5 mL). The mixture was purged for 5 minutes with nitrogen and then heated at 900C for 24 hours. The mixture was allowed to cool to room temperature and then loaded onto an SCX column. The mixture was eluted first with MeOH and then with a solution of 7N NH3 in MeOH. Fractions containing product were combined and then evaporated. The residue was purified by preparative HPLC and fractions containing product were combined and evaporated to afford example 1.01 (126 mg, 50% yield); 1U NMR spectrum: (300 MHz, DMSO) delta 2.12 (3H, s), 2.84 (3H, d), 3.77 (3H, s), 6.60 (IH, s), 7.21 (IH, ddd), 7.58 (2H, d), 7.79 (IH, d), 7.88 (IH, s), 8.35 (IH, s), 8.66 (IH, s), 8.72 (IH, d), 10.28 (IH, s); Mass spectrum: m/z (ESI+) (M+H)+ = 362.11.

The synthetic route of 64517-88-0 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10010-93-2, name is 3-Methyl-5-(trifluoromethyl)-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 10010-93-2

Example 8 Synthesis of 1-[1-(4-fluorophenyl)-6,7-dihydro-5H-pyrazolo[4,3-b]pyridin-4-yl]-2-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanone 2-Chloro-1-(1-(4-fluorophenyl)-6,7-dihydro-1H-pyrazolo[4,3-b]pyridin-4(5H)-yl)ethanone (118 mg, 0.4 mmol) was diluted in 1.2 mL of 2:1 THF:DMF and treated with K2CO3 (111 mg, 0.8 mmol) and 5-methyl-3-(trifluoromethyl)-1H-pyrazole (60 mg, 0.4 mmol). The slurry was heated to 75 C. for 2 hours. The reaction slurry was purified by normal phase flash chromatography (24 g column, eluting with 10-80% EtOAc in hexanes) to provide 109 mg (67%) of the title compound as a white solid. 1H NMR (400 MHz, CDCl3) delta 8.36 (s, 0.8H), 7.59 (s, 0.2H), 7.42-7.47 (m, 2H), 7.12-7.25 (m, 2H), 5.25 (s, 0.4H), 5.14 (s, 1.6H), 3.92 (m, 0.4H), 3.86 (m, 1.6H), 2.86 (t, J=6.2 Hz, 2H), 2.37 (s, 2.4H), 2.36 (m, 0.6H), 2.11 (m, 1.6H), 2.04 (m, 0.4H); MS: (ES) m/z calculated for C19H18F4N5O [M+H]+ 408.1, found 408.1.

The synthetic route of 10010-93-2 has been constantly updated, and we look forward to future research findings.

5334-39-4, name is 3-Methyl-4-nitro-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 3-Methyl-4-nitro-1H-pyrazole

A mixture of 3-methyl-4-nitro-lH-pyrazole (2.1 g, 17 mmol) and 4- methylsulfonylphenylboronic acid (5.0 g, 25 mmol), copper (II) acetate monohydrate (0.91 g, 5.0 mmol) and pyridine (0.5 g, 6.6 mmol) in DMF was stirred at 95 C under an oxygen atmosphere for 7 hours. The reaction was diluted with water, extracted with EtOAc (3x). The combined extracts were washed with brine, dried over sodium sulfate, filtered and concentrated. The crude product was purified by flash chromatography to give a mixture of 3 -methyl- 1 -(4- (methylsulfonyl)phenyl)-4-nitro-lH-pyrazole compound and 5 -methyl- 1 -(4-(methylsulfonyl)phenyl)-4-nitro-lH-pyrazole (1.3 g, 28%).

The synthetic route of 5334-39-4 has been constantly updated, and we look forward to future research findings.