Tag: M.W:100-200

These common heterocyclic compound, 25016-11-9, name is 1-Methyl-1H-pyrazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 1-Methyl-1H-pyrazole-4-carbaldehyde

General procedure: A mixture of appropriate aldehyde (10 mmol) from the list a-t, compound 4 (10 mmol), ZnO Nano particles (2 mmol) and ethanol (25 mL) was stirred at rt for 30 min to 1 h. After completion of reaction (monitored by TLC), the reaction mixture was filtered through a nanofiltration membrane (Make: Synder, Model: NFS 100-250Da). The filtrate was evaporated under reduced pressure and dried to obtain crude product 5a-t which was further purified by recrystallization in ethanol to afford pure compounds.

The synthetic route of 1-Methyl-1H-pyrazole-4-carbaldehyde has been constantly updated, and we look forward to future research findings.

Reference of 180207-57-2, A common heterocyclic compound, 180207-57-2, name is 2-(1H-Pyrazol-4-yl)ethanol, molecular formula is C5H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Reference Example 22: 2-[1-(5-Fluoropyridin-2-yl)-1H-pyrazol-4-yl]ethanol To a solution of 2-(1H-pyrazol-4-yl)ethanol (1.0 g, 8.9 mmol) and 2,5-difluoropyridine (0.89 mL, 9.8 mmol) in acetonitrile (45 mL), Cs2CO3 (9.7 g, 17.8 mmol) was added, and the resulting mixture was stirred for 3 hours at 80C. The reaction mixture was allowed to cool, then water was added thereto, followed by extraction with EtOAc. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried over Na2SO4, then the drying agent was filtered off, and then the solvent was distilled off under reduced pressure. The obtained residue was purified by column chromatography (HP-Sil 25 g, hexane/EtOAc = 90/10 to 30/70) to obtain the title compound (0.63 g) (colorless solid). MS (ESI pos.) m/z: 208 [M+H]+

The synthetic route of 180207-57-2 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6994-25-8, name is Ethyl 3-amino-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., Application In Synthesis of Ethyl 3-amino-1H-pyrazole-4-carboxylate

General procedure: After standard evacuation and back-fill cycles with argon, a Schlenk tube fitted with a magnetic stirrer bar was charged with pyrazole derivative (1.29 mmol), aryl iodide (1.1 eq), K3PO4 (2 eq) and copper iodide (0.1 eq). N,N’-dimethyl-cyclohexane-1,2-diamine (0.2 eq) and anhydrous dioxane (3 mL) were then added under a stream of argon by syringe at room temperature. The sealed tube is stirred at 110 C for 24-48 h. A 28% solution of ammonia and water are added at room temperature to the reaction mixture. The resulting aqueous layer is extracted with DCM. The combined organic layers are dried on MgSO4, filtered and evaporated under reduced pressure. The residue is triturated in an appropriate solvent or purified on silica gel.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 34334-96-8, name is 3-Methyl-5-nitro-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 34334-96-8, Formula: C4H5N3O2

General procedure: The reaction was performed in 2 batches. In a sealed tube, cyanomethylenetributyl phosphorane (9.28 mL, 35.40 mmol) was added to a solution of 3-methyl-5-nitro-lH- pyrazole (1.50 g, 1 1.80 mmol) and 3-hydroxymethyl-3-methyloxethane (3.53 mL, 35.40 mmol) in toluene (100 mL). The solution was heated at 60 C for 18 h. The 2 batches were combined and the solvent was evaporated in vacuo. The residue (black oil) was purified by column chromatography on silica gel (irregular SiOH, 15-40 muiotaeta, 330 g, liquid loading on DCM, mobile phase: heptane/EtOAc, gradient from 90: 10 to 50:50). The fractions containing the product were combined and evaporated to dryness to give 3.95 g of intermediate 303 (79% yield, orange oil) directly used as it in the next step.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Methyl-5-nitro-1H-pyrazole, and friends who are interested can also refer to it.

Synthetic Route of 139756-02-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 139756-02-8, name is 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

2) 1-methyl-3-propyl-4 – (2-propoxy benzamido- ) pyrazole-5-carboxamide preparation: heating 7.5mmol2-propoxy benzoyl chloride is dissolved in a 50 mu L methylene chloride, by adding 0.07g4-dimethyl aminopyridine, 0.5 ml triethylamine, stirring slowly dripping 6.8mmol4-amino-1-methyl-3-n-propyl -1H-pyrazole-5-carboxamide, microwave heating 100 C reaction 5 minutes, after the reaction of the organic solvent is removed by reduced pressure distillation, a small amount of ethanol re-crystallization, drying after filtration, a kind of white obtained 1-methyl-3-propyl-4 – (2-propoxy benzamido- ) pyrazole-5-carboxamide, the yield is 80-84%;

The synthetic route of 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide has been constantly updated, and we look forward to future research findings.

Application of 35100-92-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35100-92-6, name is 1,5-Dimethyl-1H-pyrazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows.

Combine c/s-4-[(4-bromo- I -methyi-1H-benzimidazoi-6-vi)oxyj cyciohexanamine(25.70 g, 79.27 rnrnol), 1.5-dimethyi-1H-pyrazol-3-arnine (9.08 g, 1.0 eq), potassiumcarbonate (28.48 g, 2.6 eq), 2-(dicyclohexvlphosphino)3,6-dimethoxy-2?,4?,6?- tisopropyi- 1,1 ?-biphenyl (8.60 g, 0,20 eq), tris(dibenzylideneacetone)dipailadium(0) (3.63 g, 0.050 eq), and acetic acid (0.14 rnL) in tert-butyl alcohol (250 mL). Heat at reflux overnight. Concentrate the reaction mixture in vacuo. Add DCM and water;separate the layers. Dry the organics over anhydrous magnesium sulfate, filter, and concentrate in vacuo. Triturate from EtOAc and hexanes to give a tan solid. Subject the tan solid to normal phase chromatography, eluting with hexanes, then 5% MeOFI in DCM, then 20% 2M amrnoniated MeOH in DCM, to give the title compound as a tan solid (21,71 g, 77%). MS (ES) m/z = 355 (M-t-H).

The chemical industry reduces the impact on the environment during synthesis 1,5-Dimethyl-1H-pyrazol-3-amine. I believe this compound will play a more active role in future production and life.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 31728-75-3, name is 1,5-Dimethyl-1H-pyrazole-4-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Formula: C6H8N2O2

The 1,5-Dimethyl-1H-pyrazole-4-carboxylic acid [3-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide was prepared from 3-nitrobenzoyl chloride using the following multiple step procedure: Step 1: 1,5-Dimethyl-1H-pyrazole-4-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide.; A dry flask was charged with 1,5-Dimethyl-1H-pyrazole-4-carboxylic acid (0.144 g, 1.03 mmol) and thionyl chloride (5 mL) and allowed to stir at 79 C. for 3 h. The thionyl chloride was then removed by concentration in vacuo. The crude acid chloride was cooled to room temperature, and then dissolved in THF (101 mL). 6-(3-Amino-benzoyl)-1,3-dihydro-indol-2-one (as prepared in Example 40, 0.260 g, 1.03 mmol) was added to the THF solution of the acid chloride, and the mixture was allowed to reflux overnight. The reaction mixture was then allowed to cool to room temperature and filtered. The solid residue was washed with 0 C. THF and collected to afford the 1,5-Dimethyl-1H-pyrazole-4-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide as a solid (0.177 g, 0.47 mmol, 46%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 31728-75-3.

Synthetic Route of 111493-52-8,Some common heterocyclic compound, 111493-52-8, name is 5-Chloro-1-methyl-1H-pyrazole-4-carbonitrile, molecular formula is C5H4ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 4: 5-(5-chloro- l -methyl-lH-pyrazole-4-yl)-2H-tetrazole The above product, 5-chloro- l -methyl- lH-pyrazole-4-carbonitrile ( 13.0 gm, 0.092 moles), was dissolved in DMF (40 ml), followed by addition of ammonium chloride (9.9 gm, 0.184 moles) and sodium azide (12.0 gm, 0.184 moles) and stirred at 100- 140C for 10- 16 hours. The progress of the reaction was monitored by HPLC. The reaction mixture was cooled at 0- 5C and quenched with aqueous HC1 (78.0 ml) and stirred for 30-60 min at 0-5C. The solid material obtained was filtered, washed with cold DM water (40 ml) and dried at 60-65C to yield the product, 5-(5-chloro-l -methyl- lH-pyrazole-4-yl)-2H-tetrazole Dry wt : 16.2 gm Yield . : 1 .25 w/w (96%) HPLC purity : 99.26% MP : 215-219C

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Chloro-1-methyl-1H-pyrazole-4-carbonitrile, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 360056-45-7, name is Methyl 4-amino-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., name: Methyl 4-amino-1H-pyrazole-3-carboxylate

2A. 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid 2,6-dichlorobenzoyl chloride (8.2 g; 39.05 mmol) was added cautiously to a solution of 4-amino-1H-pyrazole-3-carboxylic acid methyl ester (prepared in a manner analogous to 165B) (5 g; 35.5 mmol) and triethylamine (5.95 ml; 42.6 mmol) in dioxan (50 ml) then stirred at room temperature for 5 hours. The reaction mixture was filtered and the filtrate treated with methanol (50 ml) and 2M sodium hydroxide solution (100 ml), heated at 50 C. for 4 hours, and then evaporated. 100 ml of water was added to the residue then acidified with concentrated hydrochloric acid. The solid was collected by filtration, washed with water (100 ml) and sucked dry to give 10.05 g of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid as a pale violet solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 6715-84-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6715-84-0, name is Methyl 4-Nitro-1H-pyrazole-1-acetate, This compound has unique chemical properties. The synthetic route is as follows.

A clear, pale yellow solution of methyl 2-(4-nitro-1H-pyrazol-1-yl)acetate (0.250 g, 1.35 mmol) in EtOH (27.0 ml) was degassed with argon for 10 min. Then 10% Pd-C (0.072 g, 0.068 mmol) was added. The reaction was degassed with hydrogen from a balloon for several minutes and then the reaction was stirred vigorously under a hydrogen atmosphere. After 3 h, the reaction was stopped. The vessel was purged with argon/vacuum three times. Then Celite was added. After 10 min, the reaction was filtered through a plug of Celite, rinsing with EtOH, to give a clear, colorless filtrate. The filtrate was concentrated to give methyl 2-(4-amino-1H-pyrazol-1-yl)acetate (0.204 g, 97 % yield) as a clear, orange oil. The material was used in the next step without further purification. MS(ESI) m/z: 156.1 (M+H)+.

The chemical industry reduces the impact on the environment during synthesis Methyl 4-Nitro-1H-pyrazole-1-acetate. I believe this compound will play a more active role in future production and life.