Tag: M.W:100-200

Application of 5334-40-7,Some common heterocyclic compound, 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, molecular formula is C4H3N3O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A) Methyl 1-methyl-4-nitro-1H-pyrazole-5-carboxylate To a suspension of 4-nitro-1H-pyrazole-3-carboxylic acid (37 g) and potassium carbonate (97.6 g) in DMF (600 mL), dimethyl sulfate (71.2 g) was added dropwise under ice cooling, and the mixture was stirred at room temperature for 16 hours. The reaction mixture was poured to water, followed by extraction with ethyl acetate. The extract was dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether) to obtain the title compound (8.62 g). 1H NMR (400 MHz, CDCl3) delta 4.02 (3H, s), 4.03 (3H, s), 8.01 (1H, s).

The synthetic route of 5334-40-7 has been constantly updated, and we look forward to future research findings.

Reference of 360056-45-7, These common heterocyclic compound, 360056-45-7, name is Methyl 4-amino-1H-pyrazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2,6-dichlorobenzoyl chloride (8.2 g; 39.05 mmol) was added cautiously to a solution of 4- amino-1 H-pyrazole-3-carboxylic acid methyl ester (5 g; 35.5 mmol) and triethylamine (5.95 ml; 42.6 mmol) in dioxane (50 ml) then stirred at room temperature for 5 hours. The reaction mixture was filtered and the filtrate treated with methanol (50 ml) and 2M sodium hydroxide solution (100 ml), heated at 50 0C for 4 hours, and then evaporated. 100 ml of water was added to the residue then acidified with concentrated hydrochloric acid. The solid was collected by filtration, washed with water (100 ml) and sucked dry to give 10.05 g of 4-(2,6-dichloro-benzoylamino)-1 H-pyrazole-3-carboxylic acid as a pale violet solid. (LC/MS: Rt 2.26, [M+H]+ 300 / 302).

The synthetic route of 360056-45-7 has been constantly updated, and we look forward to future research findings.

Application of 49633-25-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 49633-25-2, name is 3-Isopropylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 3-isopropyl-IH-pyrazole (380 mg, 3.45 mmol) inDMF (8 mE) were added iodomethane (2.50 g, 17.3 mmol) and K2C03 (1.40 g, 10.4 mmol). The suspension was stirred at 20 C for 16 h before it was diluted with H20 (20 mL) and extracted with Et20 (3 x20 mL). The combined organic layers were washed with brine, dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated under reduced pressure to afford a mixture of 3 -isopropyl- 1-methyl- 1H-pyrazole and 5-isopropyl- 1-methyl- 1H-pyrazole as a brown solid (350 mg, 82%).

The synthetic route of 3-Isopropylpyrazole has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 5334-39-4, name is 3-Methyl-4-nitro-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5334-39-4, Product Details of 5334-39-4

To a stirred solution of 3-methyl-4-nitro-lH-pyrazole (869 mg, 0.068 mmol, 1 equiv) l-bromo-2,4-bis(trifluoromethyl)benzene (2 g, 0.068 mmoles, leq) in DMF (20 mL) was added K CO (1.89 g, 0.0136 mmol, 2 equiv) and the reaction mixture was stirred for 15 minutes. Cul (0.026 g, 0.2eq, O.OOlmoles) and L-proline (0.317 g, 0.02 mmol, 0.4 equiv.) were added to the reaction mixture. The reaction mixture was allowed to stir for 24 hour at 100 C. Product formation was confirmed by LCMS. After completion of reaction, reaction mixture was diluted with water and extracted with ethyl acetate (3×100 mL). Combined organic extracts were washed with water (4×100 mL), dried over anhydrous NaSCL and concentrated under reduced pressure to obtain which was purified by flash chromatography (EtOAc/ Hexane) to obtain titile compound l-(2,4-bis(trifluoromethyl)phenyl)-3-methyl-4- nitro-lH-pyrazole (1.0 g). LCMS 339 [M+H] +.

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Reference of 57999-06-1,Some common heterocyclic compound, 57999-06-1, name is 4-Phenyl-1H-pyrazol-5-amine, molecular formula is C9H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A suspension of 3(5)-amino-4-(thien-2-yl)pyrazole (1h) or 3(5)-amino-4-phenylpyrazole (1i) 11,13 (10 mmoles) and ethyl 2-(pyrazol-10-yl)-2-formylacetate (A) or ethyl 2-(imidazol-10-yl)-2-formylacetate (B) (10 mmoles) in dyglime (20 mL) was refluxed under magnetic stirring until the starting material disappeared. The precipitate was collected by filtration from the reaction mixture and recrystallized by suitable solvent, obtaining compounds 5a, 5b, 6a and 6b respectively.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Phenyl-1H-pyrazol-5-amine, its application will become more common.

Related Products of 16034-46-1,Some common heterocyclic compound, 16034-46-1, name is 1-Methyl-1H-pyrazole-5-carboxylic acid, molecular formula is C5H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

DIPEA (370 )lL, 2.24 mmol) was added to a stirred solution of glycine methyl20 ester hydrochloride (70 mg, 0.56 mmol), 1-methyl-1H-pyrazole-5-carboxylic acid (71 mg,0.57 mmol) and HATU (255 mg, 0.67 mmol) in anhydrous DMF (1 mL) under a nitrogenatmosphere. The mixture was stirred at 20C for 15 h, then quenched by the addition ofsaturated aqueous sodium hydrogen carbonate solution (7 mL) and water (7 mL). Thematerial was extracted sequentially with ethyl acetate (3 x 7 mL) and 1:1 isopropanol/25 chloroform (2 x 7 mL). The combined organic layers were washed with brine (2 x 7 mL)and dried over sodium sulfate, then filtered and concentrated in vacuo. The residue waspurified by flash column chromatography, using a gradient of ethyl acetate in heptane (0-100%), to afford the title compound (110 mg, quantitative) as an orange-brown oil. DH(250 MHz, DMSO-d6) 8.92 (t,J5.6 Hz, 1H), 7.48 (d,J2.1 Hz, 1H), 6.89 (d,J2.1 Hz,30 1H), 4.04 (s, 3H), 3.98 (d, J 5.9 Hz, 2H), 3.66 (s, 3H). HPLC-MS (method 6): MH+ m/z198, RT 0.52 minutes.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-pyrazole-5-carboxylic acid, its application will become more common.

Reference of 1008-79-3, The chemical industry reduces the impact on the environment during synthesis 1008-79-3, name is 1-Phenyl-1H-pyrazol-3(2H)-one, I believe this compound will play a more active role in future production and life.

A solution of 3-hydroxy-1-methyl-1H-pyrazole (1) [ 38 ] (710mg, 7.2mmol) in dry DMF (20mL) was cooled to 0C under inert atmosphere and NaH (60% dispersion in mineral oil, 290mg, 7.2mmol) was added portion wise. After stirring mixture for 15min benzyl chloride (0.82mL, 7.2mmol) was added drop wise. The mixture was stirred at 60C for 1h, then poured into water and extracted with ethyl acetate. The organic layers were combined, washed with brine, dried over Na2SO4, filtrated, and the solvent was evaporated. The residue was purified by column chromatography (SiO2, eluent: ethyl acetate/n-hexane, 1:7, v/v) to give pure 3 as a brown liquid. Yield 90%, 1205mg.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Phenyl-1H-pyrazol-3(2H)-one, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 133228-21-4, name is N,N-Dimethyl-1H-pyrazole-1-sulfonamide, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 133228-21-4, Safety of N,N-Dimethyl-1H-pyrazole-1-sulfonamide

Step 2: Preparation of 3-bromo-pyrazole-l-sulfonic acid dimethylamide; Pyrazole-1-sulfone acid dimethylamide (17.6 g) was dissolved in dry THF (200 mL) and cooled to -78C. A solution of n-butyllithium (80 mL, 1.3 M) was added slowly over a period of 15 min and stirred for further 15 min at – 78C. A solution of 1, 2-dibromo-l, 1, 2 , 2-tetrachloroethane(35.8 g) in dry THF (60 mL) was added within 10 min to this solution and stirred for further 15 min at -78C, then the cool bath was removed and the mixture was quenched with water after stirring for 1 h. The reaction mixture was extracted 3x with ethyl acetate, the combined org. layers were washed with brine, dried over MgSO4 and concentrated in vacuum.The residue was purified by column chromatography (silica gel 60, hexane/ethyl acetate = 5:1, Rf = 0.25) to afford 21.3 g of the title compound of the formulae2 as a colorless oil.1H-NMR (CDCl3, TMS) delta (ppm) : 3.08 (6H, s) , 6.43 (IH, m) , 7.61 IH, m) .

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Reference of 151521-49-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 151521-49-2 as follows.

A mixture of methyl 3-oxo-3-(3-pyridyl)propanoate (100 mg, 558.12 muiotaetaomicron, 1 eq) and 4-isopropyl- 1H-pyrazol-5-amine (69.86 mg, 558.12 muiotaetaomicron, 1 eq) in AcOH (2 mL) was stirred at 120C for 0.5 h. The reaction mixture was concentrated under reduced pressure to give the crude product 3- isopropyl-5-(3-pyridyl)pyrazolo[l,5-a]pyrimidin-7-ol (120 mg, 471.91 muiotaetaomicron, 84.6% yield, crude purity) as brown oil which was used in the next step without further purification. MR (400 MHz, OMSO-de) delta ppm 9.47-8.95 (m, 1H), 8.80-8.70 (m, 1H), 8.30-8.20 (m, 1H), 7.87, 7.38 (m, 1H), 7.60-7.50 (m, 1H), 7.08, 1.24 (d, J = 6.8 Hz, 3H), 1.07 (dd, J = 3.5, 6.8 Hz, 3H); ES-LCMS m/z 255.1 [M+H].

According to the analysis of related databases, 151521-49-2, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 4522-35-4, name is 3-Iodo-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4522-35-4, Formula: C3H3IN2

A mixture of 5-iodo-1H-pyrazole (10 g, 51.55 mmol), 3,4-dihydro-2H-pyran (13 g, 154.55 mmol), TsOH (443 mg, 2.57 mmol) in ethyl acetate (200 mL) was stirred for 3 h at 80 C. The resulting mixture was washed with water. The organic phase was dried with anhydrous sodium sulfate. After filtration, the filtrate was concentrated under vacuum. The residue was purified by flash chromatography on silica gel eluting with dichloromethane/petroleum ether (3/7) to afford 3-iodo-1-(oxan-2-yl)-1H-pyrazole (7.0 g, 25.18 mmol) as a white solid. LCMS (ESI) [M+H]+=279

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