M.W:100-200 | Page 249 of 325 | pyrazoles-derivatives

Continuously updated synthesis method about 17635-45-9

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Pyrazol-1-yl-phenylamine, its application will become more common.

Reference of 17635-45-9,Some common heterocyclic compound, 17635-45-9, name is 4-Pyrazol-1-yl-phenylamine, molecular formula is C9H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of N-(4-aminophenyl) azoles 2a-d (1 mmol), benzil (1 mmol, 0.21 g), aromatic aldehyde (1 mmol), and ammonium acetate (1 mmol, 0.077 g) was stirred vigorously. Bi(NO3)3*5H2O (0.15 mmol, 0.073 g, 15 molpercent) and SiO2 (0.5 g) were mixed effectively and added to the mixed reactants. The resulting mixture was heated at 110 ¡ãC for 24 h. Acetone (50 mL) was then added and the mixture was stirred at 50 ¡ãC for 10 min. Filtering the hot mixture and then concentration of the filtrate produced the crude product. Recrystallization of the crude products in 96percent EtOH gave the desired product 3-5.

New downstream synthetic route of 956951-01-2

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Nitro-1H-pyrazole-1-ethanol, other downstream synthetic routes, hurry up and to see.

Related Products of 956951-01-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 956951-01-2, name is 3-Nitro-1H-pyrazole-1-ethanol belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

2- (3-Nitro-lH-pyrazol-l-yl) ethanol (2.48 g, 15.8 mmol) was dissolved in ethyl acetate (15 ml) . 10%wt Pd/C (1 g) was added and the suspension was stirred under hydrogen gas at room temperature for overnight. The suspension was filtered through celite and concentrated in vacuo to give 1.8 g of the title compound (90%) as a light yellow oil. [M+H] calc’d for C5H9N3O, 128 found, 128.

The origin of a common compound about 105434-90-0

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 5-amino-1H-pyrazole-3-carboxylate, its application will become more common.

Application of 105434-90-0,Some common heterocyclic compound, 105434-90-0, name is Ethyl 5-amino-1H-pyrazole-3-carboxylate, molecular formula is C6H9N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of compound 226-1 (1.0 g, 6.45 mmol) in THF (10 mL) was added LiBH4 (8.0 mL,16.01 mmol, 2M in THF) drop- wisely at 0 oC and the reaction was stirred at 60 oC overnight. After completion of the reaction, the reaction mixture was quenched with MeOH and concentrated to dryness under reduced pressure. The residue was purified by column chromatography on silica gel (DCM: MeOH = 80: 1 to 20: 1) to give compound 2 (600 mg, yield 82.3%) as white solid. LC/MS (ESI) m/z: 114 (M+H)+.

Application of 607-34-1

According to the analysis of related databases, 607-34-1, the application of this compound in the production field has become more and more popular.

Synthetic Route of 607-34-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 607-34-1 as follows.

General procedure: A solution of the appropriate amide (1 mmol) in anhydrous DMSO (4 ml) was treated at room temperature by adding a suspension of NaH in paraffin oil (40 mg, 1 mmol of NaH) and 5-nitroquinoline (1) (87 mg, 0.5 mmol). The mixture was vigorously stirred at room temperature for the duration indicated in Table 1. The reaction mixture was then poured onto ice (50 g) and after warming to room temperature was acidified with dilute HCl solution to pH ~7. The precipitate that formed was filtered off, washed with water, and dried. The obtained mixture was separated into fractions by the dry silica gel flash chromatography.

According to the analysis of related databases, 607-34-1, the application of this compound in the production field has become more and more popular.

Application of 75457-13-5

The synthetic route of 75457-13-5 has been constantly updated, and we look forward to future research findings.

75457-13-5, name is 3-Methylquinolin-8-ol, belongs to quinolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C10H9NO

A) A solution of 3-methyl-8-hydroxyquinoline (15.9 g, 0.10 mole) is added to a mixture of 70% nitric acid (162 g, 1.8 mole) (18 molar equivalents) and Manganese dioxide (0.33 g, 0.0038 mole) (0.038 molar equivalents) at a temperature of 80-100 C. over a 1 hour period, with stirring. The resultant overhead gases are scrubbed and vented. The reaction mixture is heated at 100-105 C. for 4 hours, cooled to 85 C., treated with 88% formic acid at 85-95 C. over a 20 minute period, further heated at 85-95 C. for 0.5 hour, cooled to 0 C., stirred for 0.5 hour and filtered. The filtercake is washed with acetone to give 5-methyl-2,3-pyridinedicarboxylic acid, 13.6 g (78.3% yield), 98.8% purity by HPLC analysis.

The synthetic route of 75457-13-5 has been constantly updated, and we look forward to future research findings.

Simple exploration of 3033-82-7

According to the analysis of related databases, 3033-82-7, the application of this compound in the production field has become more and more popular.

Related Products of 3033-82-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3033-82-7 as follows.

After adding 53.26 parts of cyclododecane to 7.00 parts of the compound represented by the formula (X-1)And heated to 180 C to dissolve them.After confirming the dissolution,13.88 parts of 8-chloroquinaldine was added and refluxed at 200 C for 9 hours. After completion of the reaction,The reaction solution was pouredTo 500 parts of acetonitrile and the precipitate was collected by filtration.The resulting precipitate was washed with 500 parts of ethanol,The use of dimethyl subunit 500Were each repulpered to give a yellow solid.The yellow solid under reduced pressure at 60 Followed by drying(Z-2).

According to the analysis of related databases, 3033-82-7, the application of this compound in the production field has become more and more popular.

Continuously updated synthesis method about 68500-37-8

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 68500-37-8, its application will become more common.

Some common heterocyclic compound, 68500-37-8, name is 4-Chloro-7-methoxyquinoline, molecular formula is C10H8ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C10H8ClNO

2-hydroxyacetic acid (5.00 g, 65 mmol) and KOH (6.00 g,90 mmol) were mixed and heated to 170 C. 4-chloro-7-methoxyquinoline (5.00 g, 26 mmol) dissolved in DMSO (20 mL)was added dropwise. The reaction mixture was stirred at 170 C for2.5 h. After cooled to room temperature, the solutionwas poured to50 mL ice water. Saturated aqueous sodium carbonate solutionwasadded to adjust the PH to 7-8. The mixture was filtered and driedin vacuo to give 3.70 g of 4 as brown solid: 62% yield. m.p.:223-225 C; HRMS (ESI+) m/z 234.0763 (234.0761 calcd forC12H12NO4+, [M+H]+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 68500-37-8, its application will become more common.

Introduction of a new synthetic route about 5234-86-6

According to the analysis of related databases, 5234-86-6, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5234-86-6 as follows. Quality Control of 2,3,4,6,7,11b-Hexahydro-1H-pyrazino[2,1-a]isoquinoline

General procedure: To a stirred solution of compound 16 (500 mg, 2.7 mmol) in DCM (50 mL), cyclohexanecarbonyl chloride (532 L, 4.0 mmol) was added at 0 C. The mixture was stirred at room temperature overnight. The reaction was quenched with NaHCO3 (aq.), extracted with DCM (50 mL ¡Á 3). The organic phases were then processed in the usual way and chromatographed (1:1 petroleum ether/ EtOAc) to afforded compound 19 (350 mg, 43%) as white solid.

According to the analysis of related databases, 5234-86-6, the application of this compound in the production field has become more and more popular.

Discovery of 22246-16-8

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6-Nitro-3,4-dihydroquinolin-2(1H)-one, its application will become more common.

Related Products of 22246-16-8,Some common heterocyclic compound, 22246-16-8, name is 6-Nitro-3,4-dihydroquinolin-2(1H)-one, molecular formula is C9H8N2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 6 6-nitro-1-(2-(pyrrolidin-1-yl)ethyl)-3,4-dihydroquinolin-2(1H)-one A suspension of 6-nitro-3,4-dihydroquinolin-2(1H)-one (230 mg, 1.06 mmol), 1-(2-chloroethyl)pyrrolidine hydrochloride (234 mg, 1.37 mmol) and potassium carbonate (440 mg, 3.18 mmol) in 5 mL DMF was stirred at room temperature for 4 days. After this time, the mixture was poured into 20 mL H2O then extracted with 2*30 mL CH2Cl2. The organic layers were combined together, washed with brine (20 mL) and concentrated. Product was subjected to flash chromatography on the biotage using 5% 2M NH3 in MeOH/CH2Cl2 to give a yellow solid. Yield: 218 mg of yellow solid (71%). 1H NMR (CDCl3) delta: 8.14 (dd, J=2.7, 9 Hz, 1H), 8.06 (d, J=2.4 Hz, 1H), 7.20 (d, J=9.0 Hz, 1H), 4.13 (t, J=7.5 Hz, 2H), 3.00 (t, J=6.9 Hz, 2H), 2.73-2.68 (m, 4H), 2.63-2.60 (m, 4H), 1.82-1.78 (m, 4H). MS (ESI): 290.2 (M+1, 100%).

New learning discoveries about 553-03-7

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,4-Dihydroquinolin-2(1H)-one, its application will become more common.

Related Products of 553-03-7,Some common heterocyclic compound, 553-03-7, name is 3,4-Dihydroquinolin-2(1H)-one, molecular formula is C9H9NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3,4-Dihydro-2 (lH)-quinolinone (1.0 g, 6.70 mmol) is dissolved in 20 mL of concentrated sulfuric acid at-10C, and then 5 mL of water is added slowly to the solution. After 5 minutes, 61% nitric acid (0.5 mL, 6.70 mmol) is added dropwise to the solution. The reaction mixture turns from yellow to dark red, and eventually solidifies. After 1 hour, water (50 mL) is added slowly at-10C and precipitate appears. The solution is poured into a separatory funnel, extracted with ethyl acetate (20 mL x 2) and washed with saline (20 mL). The organic layers are collected and dried over MgS04. Solvent is removed and the title compound is obtained as a pale yellow solid (1.0 g, 76%) ; 1H NMR (300 MHz, DMSO) 8 10.66 (s, 1H), 8.08-8. 01 (m, 2H), 6.96 (d, 1H), 2.98 (t, 2H), 2.49 (dd, 2H).