Tag: M.W=300-400

Application of 1355249-29-4, These common heterocyclic compound, 1355249-29-4, name is Ethyl 4-iodo-1-(4-methoxybenzyl)-1H-pyrazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step A: ethyl 1-(4-methoxybenzyl)-4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-3-formate Under the protection of nitrogen gas, to a solution of ethyl 4-iodo-1-(4-methoxybenzyl)-1H-pyrazol-3-formate (1.0 g, 2.6 mmol, 1.0 eq., prepared from the step C of Example 26), diboronic acid pinacol ester (0.7 g, 2.8 mmol, 1.1 eq.) and potassium acetate (0.76 g, 7.8 mmol, 3.0 eq.) in DMSO (30 mL) was added Pd(dppf)Cl2 (95 mg, 0.13 mmol, 0.05 eq.). The reactants were protected with nitrogen gas and stirred overnight at 80C. After the resulting mixture was cooled to room temperature, the resulting mixture was diluted with water and ethyl acetate, and extracted with ethyl acetate. The combined organic phase was washed with water and brine, dried over sodium sulfate, filtered and concentrated in vacuo to give 3-(ethoxycarbonyl)-1-(4-methoxybenzyl)-1H-pyrazol-4-yl boronic acid pinacol ester (1.2 g) as a crude product.

The synthetic route of 1355249-29-4 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 162758-35-2, name is 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., category: pyrazoles-derivatives

Step 1: N-butanoyl-N’-[5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carbonyl]-hydrazine Added to a solution of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid (0.40 g, 1.05 mmol), N-butanoyl-hydrazine (0.11 g, 1.05 mmol) and EDCI (0.24 g, 1.26 mmol) dissolved in DCM (11 ml), was DMAP (0.15 g, 1.26 mmol) in one portion at room temperature. The reaction mixture was stirred at room temperature for 6 hrs, and then treated with 10% aq. HCl. The organic layer was collected, and evaporated under a vacuum. The crude mixture was further purified by preparative HPLC, to obtain 0.38 g (0.81 mmol, 77%) of the title compound as yellow solid. 1H NMR (400 MHz, CDCl3) delta 7.40 (br s, 1H), 7.31-7.27 (m, 4H), 7.08-7.03 (m, 2H), 2.33 (s, 3H), 2.31 (t, J=7.8 Hz, 2H), 1.72 (m, 2H), 0.97 (t, J=7.3 Hz, 3H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 162758-35-2.

Related Products of 162758-35-2, A common heterocyclic compound, 162758-35-2, name is 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid, molecular formula is C17H11Cl3N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 5 5-(4-Chlorophenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carbonyl chloride A solution of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid (1.50 g, 3.94 mmol) in dry toluene (80 mL) was treated with thionyl chloride (0.6 mL, 8.22 mmol) under nitrogen, and heated at reflux for 3.5 hours. The solvent was removed under reduced pressure to afford the title compound (1.52 g, 97%).

The synthetic route of 162758-35-2 has been constantly updated, and we look forward to future research findings.

Electric Literature of 120068-79-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 120068-79-3 name is 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

REFERENCE EXAMPLE 1 A solution of 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole (20.0g) in dichloromethane (100ml) was stirred magnetically and treated dropwise with a solution of trifluoromethylsulphenyl chloride (10.8g) in dichloromethane (50ml) during 1 hour. The solution was stirred overnight at room temperature, then washed with water (100ml), dried over anhydrous magnesium sulphate, filtered, and evaporated in vacuo to give a solid (26.3g). This solid was recrystallized from toluene/hexane to give 5-amino-3-cyano-1-(2,6-dichloro4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole as fawn crystals (24.2g) m.p. 169-171C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 120068-79-3, name is 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 120068-79-3, Formula: C11H5Cl2F3N4

General procedure: A mixture of compound A (5 mmol) and corresponding benzaldehyde (5 mmol) in 10 mL ethanol was refluxed for 24 hours in a reaction flask wrapped up by silver paper. Upon the reactions completed (monitored by TLC), tawny solids were obtained through suction filtration. The precipitates were washed with ethanol (5 mLx3) and recrystallized from ethanol with 50-84% yields.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 152120-54-2, name is tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate, A new synthetic method of this compound is introduced below., Safety of tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate

To a solution of compound 14 (40 mg, 1 eq) in 2 ml anhydrous DCM, TEA (40 muIota, 4 eq) was added. The solution was cooled down to 0 C and N, N’-Di-Boc-1 H-pyrazole-1-carboxamidine (42 mg, 2 eq) added. The reaction mixture was allowed to warm up to room temperature and kept stirring overnight. After completion, the reaction was quenched with water, extracted with ethyl acetate. The organic phase was washed with brine, dried over Na2S04, concentrated and purified by flash chromatography to give the desired product. Crude product, 40 mg (72%).1H NMR (500 MHz, CD3OD) delta 8.55 (s, 1 H, Triazole-H5), 8.06 (d, J = 8.3 Hz, 2H, Ar-H), 7.92 (d, J = 8.3 Hz, 2H), 6.00 (d, J = 2.3 Hz, 1 H, H-3), 5.58 (d, J = 1.5 Hz, 1 H, H-7), 5.56 – 5.52 (m, 1 H, H-8), 5.31 (dd, J = 14.8, 2.4 Hz, 1 H, H-9), 5.02 (dd, J = 10.2, 2.3 Hz, 1 H, H-4), 4.74 (dd, J = 14.8, 9.0 Hz, 1 H, H-9′), 4.53 (dd, J = 10.2, 1.5 Hz, 1 H, H-6), 4.27 (t, J = 10.2 Hz, 1 H, H-5), 3.91 , 3.80 (2 x s, 3H, COOCH3), 2.12, 1 .94, 1.85 (3 x s, 3 x 3H, 3 x COCH3), 1 .51 , 1 .46 (2 x s, 2 x 9H, 2 x Boc).13C NMR (125 MHz, CD3OD) delta 173.57, 171 .77, 171.41 , 168.07, 164.32, 163.39, 158.01 (C=0), 153.82 (C=N), 147.64 (Triazole-C4), 124.50 (Triazole-C5), 145.61 (C-2), 136.34, 131.27, 131.27, 126.55 (Ar-C), 11 1.83 (C-3), 84.84, 80.57 (>Boc-C(CH3)3), 78.89 (C-6), 74.00 (C-8), 69.87 (C-7), 53.07, 52.74 (COOCH3), 51.27 (C-9), 50.84 (C- 4), 47.90 (C-5), 28.59, 28.26 (‘Betaomicronomicron-0(OmicronEta3)3), 22.77, 20.86, 20.65 (COCH3). HR-MS (ESI) calcd. for C37H49N7NaOi4 [M+Na]+, 838.3235; found 838.3226.

The synthetic route of 152120-54-2 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 120068-79-3 as follows. Application In Synthesis of 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile

General procedure: A mixture of compound A (5 mmol) and corresponding benzaldehyde (5 mmol) in 10 mL ethanol was refluxed for 24 hours in a reaction flask wrapped up by silver paper. Upon the reactions completed (monitored by TLC), tawny solids were obtained through suction filtration. The precipitates were washed with ethanol (5 mLx3) and recrystallized from ethanol with 50-84% yields.

According to the analysis of related databases, 120068-79-3, the application of this compound in the production field has become more and more popular.

Related Products of 162758-35-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 162758-35-2 name is 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a suspension of carboxylic acid in CH2Cl2 (0.1 M) at rt. was added (COCl)2(3 eq) and a catalytic amount of DMF (1 drop). The mixture was then stirred for 1 h and concentratedin vacuo. The resultant crude acid chloride was dissolved in CH2Cl2 then DIPEA (6 eq) and the amine(1.5 eq) were added. The mixture was stirred at rt. for a further 16 h, washed with H2O three times,dried over Mg2SO4, filtered, and concentrated in vacuo. The resultant crude oil was then purified byflash chromatography to give the amide product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 95162-14-4, name is 4-Bromo-1-tritylpyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 95162-14-4, Application In Synthesis of 4-Bromo-1-tritylpyrazole

To a suspension of 4-bromo-trityl-1H-pyrazole (0.7 g) in N,N-dimethylformamide (14 ml) was added 4-fluorophenylboronic acid (0.377 g), cesium carbonate (1.758 g), and tetrakis triphenylphosphine palladium (0.208 g). The resulting suspension was stirred at room temperature for 10 min. The irradiation of microwaves at 160 C. for 10 min was sufficient to complete a reaction in the suspension. The product was filtered through silica gel, diluted in ethyl acetate (30 ml) and washed with saturated ammonium chloride solution (30 ml) and then with brine (30 ml). The washed organic layer thus formed was dried over anhydrous magnesium sulfate and concentrated by evaporation in a vacuum. The residue thus obtained was separated using silica gel chromatography to produce 4-(4-fluorophenyl)-1-trityl-1H-pyrazole (yield 51%).1H-NMR (300 MHz, CDCl3): delta7.93 (s, 1H), 7.62 (s, 1H), 7.36-7.29 (m, 11H), 7.21-7.18 (m, 6H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-tritylpyrazole, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 152120-54-2, name is tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate, A new synthetic method of this compound is introduced below., Safety of tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate

Step 1 : 3-{[{[(ferf-butoxy)carbonyl]amino}({[(ferf-butoxy)carbonyl]imino})methyl]amino} propanoic acid (INT- 16) beta-alanine (1 .0 mmol) and A/,/V-di-(Boc)-1 H-pyrazole-1 -carboxamide (1 .0 mmol) are suspended in pyridine (2.0 mL) and stirred at 25 C for 2 days. The homogenous reaction is treated with 1 N NaOH and extracted into ethyl acetate. The aqueous layer is acidified (pH 3) with 1 N HCI and then extracted into ethyl acetate. The combined organic layers are washed with brine, dried over sodium sulfate, filtered and concentrated under reduced pressure to provide 3-{[{[(ferf-butoxy)carbonyl]amino}({[(ferf- butoxy)carbonyl]imino})methyl]amino}propanoic acid (INT-16).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.