Tag: M.W=0-100

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1453-58-3, name is 3-Methylpyrazole, A new synthetic method of this compound is introduced below., 1453-58-3

10298] To a solution of 3-methyl-1H-pyrazole (10.99 g, 134 mmol) in N,N-dimethylformamide (100 ml) at 0¡ã C. was added sodium hydride (3.71 g, 154 mmol, 60percent dispersion). The reaction was stirred at 0¡ãC. for2 hours. 3-Fluoropyridine (10.0 g, 103 mmol) was added, and the reaction was stirred at 100¡ã C. overnight. The reaction was cooled to room temperature and water was added slowly. The mixture was extracted with dichloromethane and the combined organic phases were washed with brine, concentrated and chromatographed (0-100percent ethyl acetate/hexanes) to afford 3-(3-methyl-1H- pyrazol-1-yl)pyridine (8.4 g, 52.77 mmol, 5 1.2percent) and 3-(5- methyl-i H-pyrazol- 1 -yl)pyridine (1.0 g, 6percent). Analytical data of both products is consistent with that reported under Example 6, Step 1.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

25222-43-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25222-43-9, name is (1H-Pyrazol-4-yl)methanol, A new synthetic method of this compound is introduced below.

(11H-Pyrazol-4-yl) methanol was Boc-protected by reaction with Boc-anhydride (1 .2 eq) and triethylamine (2.5 eq) in DCM at 0 ¡ãC, with warming to ambient temperature. The alcohol of this Boc-protected amine was then converted to the mesylate by reaction with methanesulfonyl chloride (1 .5 eq) and triethylamine (2.5 eq) in DCM at 0 ¡ãC, with warming to ambient temperature for 2 h. N-[1 -(Fluoromethyl)cyclopropyl]-3-[(1 -methylpyrazol-4- yl)methyl]-2,4-dioxo-1 H-quinazoline-6-sulfonamide (100 mg, 0.260 mmol), the mesylate (79 mg, 0.286 mmol) and potassium carbonate (54 mg, 0.39 mmol) in DMF was conventionally heated to 70 ¡ãC for 4 h. After Boc-deprotection with HCI in dioxane, usual work-up afforded the desired product (14 mg, 0.029 mmol, 1 1 percent) as a white powder.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

A common heterocyclic compound, 35277-02-2, name is 4-Fluoro-1H-pyrazole, molecular formula is C3H3FN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 35277-02-2.

A mixture of tert-butyl 4-[[2-[5-bromo-3-(methoxymethoxy)-2-pyridyl]thiazolo[5,4-d]thiazol-5- yl]-methyl-amino]piperidine-l-carboxylate (86 mg, 0.15 mmol), obtained using the chemistry described in Example 16, Step 2, 4-fluoro-lH-pyrazole (19 mg, 0.22 mmol), cuprous iodide (3 mg, 0.016 mmol), trans-N,N’-dimethylcyclohexane-l, 2-diamine (5 mg, 0.034 mmol) and K2CO3 (52 mg, 0.38 mmol) in toluene (0.3 mL) was stirred at 100 C for 12 h. The reaction was concentrated, diluted with CH2CI2 and washed with aqueous NH4CI, brine and dried. After the removal of the solvent, the residue was chromatographed (EtOAc in CH2CI2, 0-100%) to provide tert-butyl 4- [ [2- [5-(4-fluoropyrazol- 1 -yl)-3 -(methoxymethoxy)-2-pyridyl] thiazolo [5 ,4-d] thiazol- 5-yl]-methyl-amino]piperidine-l-carboxylate. The product was treated with HC1 in dioxane (3.0 mL, 4.0 M) at room temperature for 4 h and the precipitate was collected, wahsed with diethyl ether and dried to provide 5-(4-fluoropyrazol-l-yl)-2-[5-[methyl(4-piperidyl)amino]thiazolo[5,4- d]thiazol-2-yl]pyridin-3-ol hydrochloride (46 mg, 65.2%). LC-MS 432.4 [M+H]+, RT 1.21 min, 1H NMR (DMSO -d6) d: 11.15 (br s, 1H), 8.69-8.94 (m, 3H), 8.65 (d, 7=2.1 Hz, 1H), 7.97 (d, 7=4.0 Hz, 1H), 7.86 (d, 7=2.1 Hz, 1H), 4.37-4.62 (m, 1H), 3.33- 3.42 (m, 2H), 3.04-3.19 (m, 2H), 3.01 (s, 3H), 2.03-2.18 (m, 2H), 1.84-1.97 (m, 2H).

The synthetic route of 4-Fluoro-1H-pyrazole has been constantly updated, and we look forward to future research findings.

The chemical industry reduces the impact on the environment during synthesis 288-13-1, name is 1H-Pyrazole, I believe this compound will play a more active role in future production and life. 288-13-1

Following General Procedure A (90 0C, 30 hours), 1H-pyrazole (205 mg, 3.0 mmol) is coupled with 1-(4-bromophenyl)ethanone (398 mg, 2.0 mmol). The crude brown oil is purified by flash chromatography on silica gel (eluent: dichloromethane/hexanes = 50/50) to provide 300 mg (81 % isolated yield) of the desired product as a white solid. IdentificationMp: 108 JOC.1H NMR (400 MHz, CDCI3): delta 7.98-8.00 (m, 3H, H3|5,7), 7.70-7.76 (m, 3H, H2>6.9), 6.46 (s, 1H, H8), 2.56 (s, 3H, H11).13C NMR (100 MHz, CDCI3): delta 196.84 (C10), 143.33 (C1), 142.09 (C9), 134.80 (C4), 130.01 (C3,beta), 126.91 (C7), 118.39 (C216), 108.62 (C8), 26.60 (C11).IR (KBr) : v (crrf1) = 3135, 3114, 3101 , 1673(C=O), 1605, 1528, 1395, 1264,1210, 935, 838, 762, 611 , 589, 518.GC/MS: rt = 19.96 min, M/Z = 186.HRMS: 187.0893 (M+H). Theoretical: 187.0871.

The chemical industry reduces the impact on the environment during synthesis 288-13-1. I believe this compound will play a more active role in future production and life.

288-13-1, These common heterocyclic compound, 288-13-1, name is 1H-Pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Reference Production Example 1-1 1H-pyrazole-1-ylmethanol The mixture of 2.04 g of pyrazole, 2.00 g of paraformaldehyde and 1 ml of triethylamine was stirred at 130 C for 10 hours. After the reaction mixture was cooled to room temperature, acetone was added to the reaction mixture, and then the mixture was filtered. The filterate was concentrated under reduced pressure. Hexane was added to the residue, and then crystalline was formed. The crystalline was collected to obtain 3.10 g of 1H-pyrazole-1-ylmethanol. 1H-NMR(CDCl3,TMS,delta(ppm)):5.51(2H,s),6.30(1H,t),7.58-7.61(2H, m)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 288-13-1.

35277-02-2,Some common heterocyclic compound, 35277-02-2, name is 4-Fluoro-1H-pyrazole, molecular formula is C3H3FN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of tert-butyl ((6-chloropyridazin-3-yl)methyl)carbamate (300 mg, 1.2 mmol), 4-fluoro-1H-pyrazole (106 mg, 1.2 mmol) and Cs2CO3 (1.2 g, 3.6 mmol) in ACN (20 ml) was stirred at 80 C for 6 h. The reaction mixture was then filtered, and the filtrate was concentrated to give tert-butyl ((6-(4-fluoro-1H-pyrazol-1-yl)pyridazin- 3-yl)methyl)carbamate (246 mg, Purity: 80%), which was used in the next step without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Fluoro-1H-pyrazole, its application will become more common.

288-13-1, Name is 1H-Pyrazole, 288-13-1, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

To the suspension of sodium hydride (1.10 eq.) in tetrahydrofurane (0.20 mL/rnmol) wasadded the solution of pyrazole (1.0 eq.) in tetrahydrofurane (0.12 mL/mmol) dropwise,while the temperature was kept under 20 C. After the mixture was stirred at room temperature for 30 minutes, the appropriate halide (1.20 eq.) was added and the mixture was stirred further at same temperature for 16 hours. Next, the reaction mixture was refluxed for 15 hours. After completion the resulting precipitate was filtered off; the filtratewas concentrated then the residue was poured onto a mixture of water and ethyl acetate. The phases were separated, and the aqueous layer was extracted with ethyl acetate. The combined organic layers were dried over Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified via distillation. Using 2-bromopropanc in General Procedure 9G 1-isopropylpyrazole was obtained.

Statistics shows that 1H-Pyrazole is playing an increasingly important role. we look forward to future research findings about 288-13-1.

288-13-1, The chemical industry reduces the impact on the environment during synthesis 288-13-1, name is 1H-Pyrazole, I believe this compound will play a more active role in future production and life.

General procedure: 1-benzyl-4-chloro-3,5-dimethyl-1H-pyrazole. To a 16 mL vial containing 1-benzyl-3,5-dimethyl-1H-pyrazole (196 mg, 1.05 mmol) and a magnetic stir bar, 0.7 mL of water and 0.3 mL of ethyl acetate was added. Next, NaCl (123 mg, 2 mmol) was added and the vial was placed in a room temperature water bath to control exotherms. Finally, Oxone (322 mg, 0.52 mmol or 1.05 mmol KHSO5) was added and the vial was capped. The reaction proceeded with continuous and vigorous stirring until no starting material remained as indicated by TLC (1 h). The remaining oxidants were reduced with solid sodium bisulfite until starch iodide paper tested negative. Water (5 mL) was added and the mixture was extracted with 1:1 hexanes/diethyl ether (3 x 5 mL). The combined organic fractions were dried (MgSO4) and concentrated to yield crude product that was purified by flash chromatography (14 x 1 cm), 9:1 hexane/ethyl acetate eluent. Pure 1-benzyl-4-chloro-3,5-dimethyl-1H-pyrazole was obtained as a pale yellow oil (215 mg, 93% yield).

The chemical industry reduces the impact on the environment during synthesis 1H-Pyrazole. I believe this compound will play a more active role in future production and life.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1453-58-3, name is 3-Methylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. 1453-58-3

Potassium t-butoxide (3.9 g, 0.33 mmol) was dissolved in DMSO (25 mL). Tothis solution was added 3-methyl pyrazole (2.7 g, 0.33 mmol) and the reactionwas heated at 50 C for 30 min. 1-Bromo-4-chloro-2-fluorobenzene (4.6 g, 0.22mmol) was then added and the reaction was stirred at 50 C for 16 h. The reaction was cooled to RT and extractedwith water and ethyl acetate, washed with brine, and dried over Na2SO4,filtered and concentrated in vacuo. Purification by normal phase silica gelcolumn chromatography (ethyl acetate/heptane) provided 1-(2-bromo-5-chlorophenyl)-3-methyl-1H-pyrazoleand 1-(2-bromo-5-chlorophenyl)-5-methyl-1H-pyrazole as a 4:1 mixture (41 & 42) that was used in the nextstep directly (5.4 g).

The synthetic route of 1453-58-3 has been constantly updated, and we look forward to future research findings.

1453-58-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1453-58-3, name is 3-Methylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: The N-nucleophile (1.47 mmol), CuI (Sigma-Aldrich, 99.999percent purity, 0.147 mmol), MnF2 (Sigma-Aldrich, 98percent purity, 0.441 mmol), KOH (2.94 mmol), the aryl halide (2.21 mmol), trans-1,2-diaminocyclohexane (0.294 mmol) and water (0.75 mL) were added to a reaction vial and a screw cap was fitted to it. The reaction mixture was stirred under air in a closed system at 60C for 24 h. After cooling to room temperature, the mixture was diluted with dichloromethane and filtered through a pad of Celite. The combined organic extracts were dried with anhydrous Na2SO4 and the solvent was removed under reduced pressure. The crude product was purified by silica-gel column chromatography to afford the N-arylated product. The identity and purity of known products was confirmed by 1H and 13C NMR spectroscopic analysis.

The synthetic route of 1453-58-3 has been constantly updated, and we look forward to future research findings.