Tag: M.W=0-100

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1H-Pyrazole-4-carbaldehyde

Sodium hydride (60percent, 6.3 g, 1.0 eq) was added to a solution of 1H-pyrazole-4-carbaldehyde (15 g, 156 mmol) in DMF (150 ml) at 0¡ã C. The mixture was allowed to warm and was stirred at room temperature. (2-Bromoethoxy)benzene (30.2 g, 1 eq) was then added and the resulting mixture was stirred overnight at room temperature. It was quenched by addition of aqueous ammonium chloride, diluted with water and extracted with EtOAc. The combined organic layers were dried over Na2SO4, filtered, and concentrated. The residue was purified by column chromatography using a hexane/ EtOAc gradient (10:1 to 0:100). Pure fractions were combined and evaporated under reduced pressure to yield 1-(2-phenoxyethyl)-1H-pyrazole-4-carbaldehyde (24 g, 71percent).

According to the analysis of related databases, 35344-95-7, the application of this compound in the production field has become more and more popular.

Related Products of 35344-95-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows.

Preparation of (lR, 4R)-N1-((lH-prazol-4-l)methl)-N4-(4-(5- (cvclopropylmethyl)-l-methyl-lH-pyrazol-4-yl)pyrimidin-2-yl)cvclohexane-l,4- diamine (A80) To a solution of A-14 (200.00 mg, 612.67 mupiiotaomicron, 1.00 eq) and lH-pyrazole-4- carbaldehyde (58.87 mg, 612.67 muetaiotaomicron, 1.00 eq) were added AcOH (36.79 mg, 612.67 02429524H5-01 muetaiotaomicron, 35.04 uL, 1.00 eq) and NaBH3CN (77.00 mg, 1.23 mmol, 2.00 eq). The mixture was sitrred at 15 ¡ãC for 16 hours. The mixture was quenched with aqueous NaHCCb (1 mL) and concentrated. The residue was purified by prep-HPLC (basic condition) to give A-80 (20.00 mg, 48.90 muiotaetaomicron, 8percent yield, 99.4percent purity) as a yellow solid. LCMS: RT = 2.418 min, m/z 407.2 [M+H]+ NMR (CDCb, 400 MHz) delta 8.17 (d, /=5.2Hz, IH), 7.83 (s, IH), 7.58 (s, IH), 6.71 (d, /=6.2Hz, IH), 4.88 (d, /=7.6Hz, IH), 3.89 (s, 4H), 3.81 (s, 2H), 3.21 (d, /=6.0Hz, 2H), 2.61 (s, IH), 2.21-2.03 (m, 4H), 1.36-1.25 (m, 4H), 1.09 (s, IH), 0.48-0.46 (m, 2H), 0.25-0.24 (m, 2H).

The chemical industry reduces the impact on the environment during synthesis 1H-Pyrazole-4-carbaldehyde. I believe this compound will play a more active role in future production and life.

Electric Literature of 1192-21-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1192-21-8, name is 1-Methyl-1H-pyrazol-5-amine, This compound has unique chemical properties. The synthetic route is as follows.

Step 1: A clean 100 L cylindrical reaction vessel was charged with THF (13 kg) then (S)-1-(2-((tert-butyldimethylsilyl)oxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)pyridin-2(1H)-one (I, 5 kg) and 1-methyl-1H-pyrazol-5-amine (1.1 kg) were added sequentially with medium agitation followed by THF (18 kg). The mixture was cooled to ?35¡ã C. and to the resulting thin slurry was added slowly a THF solution of LiHMDS (17.4 kg, 1.0 M) at a rate that maintained the internal temperature below ?25¡ã C. After the addition was completed, the reaction was held between ?35 and ?25¡ã C. for 20 min and monitored by HPLC. If the HPLC result indicated ?98.5percent conversion, additional LiHMDS (0.34 kg, 1.0 M, 0.05 mol percent) was added slowly at ?35¡ã C. The reaction was quenched slowly at the same temperature with H3PO4 solution (4.4 kg of 85percent H3PO4 and 15 kg of water) and the internal temperature was kept below 30¡ã C. The reaction was diluted with EtOAc (18 kg) and the phases separated, the organic layer was washed with H3PO4 solution (1.1 kg of 85percent H3PO4 and 12 kg of water) followed by a second H3PO4wash (0.55 kg of 85percent H3PO4 and 12 kg of water). If 1-methyl-1H-pyrazol-5-remained, the organic layer was washed again with H3PO4 solution (0.55 kg of 85percent H3PO4 and 12 kg of water). Finally the organic layer was washed sequentially with water (20 kg) and a NaCl and NaHCO3 solution (2 kg of NaCl, 0.35 kg of NaHCO3 and 10 kg of water). After the phase separation, residue water in organic solution was removed through an azeotropic distillation with EtOAc to <0.5percent (by KF) and then solution was concentrated to 20-30 L under a vacuum below 50¡ã C. The solvent was then swapped to MeOH using 35 kg of MeOH and then concentrated to between 20 and 30 L for the next step. The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-pyrazol-5-amine. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 132712-71-1, name is 3-Methyl-1H-pyrazol-5-ol, A new synthetic method of this compound is introduced below., COA of Formula: C4H6N2O

General procedure: 5-Amino-4-arylazo-3-methyl-1-phenylpyrazoles (0.01 mol) weredissolved in a mixture of glacial acetic acid and concentrated hydrochloricacid (20 ml, ratio 1:1) and the solutionwas then cooled to 0-5 C. Sodiumnitrite (0.69 g, 0.01 mol) in water (10 ml) was then added to this solution dropwise with vigorous stirring, for about 1 h, while cooling at0-5 C. Then the resulting diazonium solution was added in portionsover 30 min to a vigorously stirred solution of 5-hydroxy-3-methyl-1H-pyrazole or 5-hydroxy-3-methyl-1-phenylpyrazole (0.01 mol) in KOH (0.56 g, 0.01mol) andwater (10ml) between 0 and 5 C,maintainingthe pHat 7-8 by simultaneous sodiumacetate solution addition. The mixture was then stirred for 2 h at 0-5 C. The precipitated product separated upon dilution with water (50 ml) was filtered off, washed with water several times, dried and crystallized from DMF-H2O

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., Computed Properties of C4H7N3

2-Chloro-4-(4-fluorophenyl)pyridine (1 ) (1 .0g, 4.8mmol), 1 -methyl-1 H-pyrazol-3- amine (2) (470mg, 4.8mmol), Xantphos (0.28g, 0.48mmol), and Cs2C03 (2.35g, 7.24mmol) were combined in dry 1 ,4-dioxane (15ml_). The reaction mixture was degassed with N2(g) and placed under vacuum for 10min. Pd2(dba)3 (0.22g, 0.24mmol) was then added and the resulting reaction mixture was heated at 90¡ãC for 30h. It was then poured onto demineralized water (200ml_), and extracted with EtOAc (3 x 100ml_). The organic phases were combined, dried over Na2S04, filtered and subsequently concentrated in vacuo. The resulting residue was purified by flash chromatography with EtOAc/Hexane (1 : 1 ) to provide 4-(4-fluorophenyl)-N-(1 -methyl-1 H-pyrazol-3-yl)pyridin-2-amine (3) as a yellow solid (1 .0g, 71 percent). LCMS (ES): Found 269.1 [M+H]+

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 31230-17-8,Some common heterocyclic compound, 31230-17-8, name is 5-Methyl-1H-pyrazol-3-amine, molecular formula is C4H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of compound C (1.0 g, 2.94 mmol)and 3-amino-5- methylpyrazole (314 mg, 3.23 mmol) in dimethylformamide (6 ml) was treated with diisopropylethylamine (0.614 ml, 3.53 mmol) and sodium iodide (530 mg, 3.53 mmol). The mixture was stirred under nitrogen at 85 ¡ã for 4 hours, cooled to room temperature and diluted with ethyl acetate. The solution was washed with water (x 4), dried over magnesium sulphate and concentrated to 5 ml to afford, upon crystallization and harvesting of colourless crystals, the title compound D (920 mg, 78percent). 1H-NMR DMSO-d6, delta 0.80-0.87 (4H, m), 1.77-1.85 (IH, m), 1.92 (IH, s), 5.24 (IH, br s), 6.47 (IH, br s), 7.55 (2H, d), 7.70-7.80 (2H, m), 10.24 (IH, s), 10.47 (IH, s), 11.92 (IH, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Methyl-1H-pyrazol-3-amine, its application will become more common.

Application of 28466-26-4, These common heterocyclic compound, 28466-26-4, name is 4-Aminopyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: N,N-Diisopropylethylamine (3.0-4.0 eq) was added to 8-methoxyquinoline-3-carboxylic acid (1.0 eq) in solvent (dichloromethane, tetrahydrofuran,or N,N-dimethylformamide, 0.05 to 0.2 M) at room temperature. Then, 1-((dimethylamino)(dimethyliminio)methyl)-1H-[1,2,3]triazolo[4,5-b]pyridine 3-oxide hexafluorophosphate(V)(1.0-1.5 eq) was added and the reaction mixture was stirred for five minutes. Then, amine (1.0 – 2.0 eq) was added and the reaction mixture was stirred for one to sixteen hours. 10% Aqueous citric acid was added and the reaction mixture was extracted with dichloromethane, washed with saturated sodium bicarbonate, dried over magnesium sulfate, filtered,and concentrated. The resulting residue was purified by RP HPLC or silica gel chromatography to give the quinoline-3-carboxamide (1%-95% yield).

The synthetic route of 28466-26-4 has been constantly updated, and we look forward to future research findings.

Application of 35344-95-7, These common heterocyclic compound, 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

into a 100-mL round-bottom flask, was placed a solution of tert-butyl N-[3- (methanesulfonyloxy)cyclobutyl]carbamate (2.65 g, 9.99 mmol, 1.00 eq.), lH-pyrazole-4- carbaldehyde (1.152 g, 11.99 mmol, 1.20 eq.) and Cs2C03 (6.52 g, 20.01 mmol, 2.00 eq.) in DMF (20 mL). The resulting solution was stirred for 4 h at room temperature. The reaction was then quenched by the addition of 100 mL of water. The resulting solution was extracted with 3×100 mL of ethyl acetate and the organic layers combined. The resulting mixture was washed with 100 mL of brine. The mixture was dried over anhydrous sodium sulfate and concentrated under vacuum. The crude product was purified by Flash-Prep-HPLC with the following conditions (CombiFlash-1): Column, CI 8 silica gel; mobile phase, MeCN/H2O=60:40 increasing to MeCN/H2O=70:30 within 3 min; Detector, UV 254 nm. The crude product was purified by Prep-SFC with the following conditions (prep SFC 350-2): Column: Phenomenex Lux 5u Cellulose-4 250*50mm; mobile Phase A: CO2:70, Mobile Phase B: MeOH-HPLC:30; Flow rate: 150 mL/min; 254 nm; RTL4.53; RT2:5.36. This resulted in 712 mg (54%) of tert-butyl N-[cw-3-(4-formyl-lH-pyrazol-l-yl)cyclobutyl]carbamate as a white solid.

Statistics shows that 1H-Pyrazole-4-carbaldehyde is playing an increasingly important role. we look forward to future research findings about 35344-95-7.

Application of 67-51-6, These common heterocyclic compound, 67-51-6, name is 3,5-Dimethyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Powdered potassium hydroxide (1.751 g, 31.2 mmol) was added to a solution of 3,5-dimethylpyrazole (2 g, 20.81 mmol) in anhydrous DMSO (10.40 ml) and the resulting heterogeneous solution was stirred for 1.5 hr at 80 C before being cooled to roomtemperature. 2-Chloro benzylchloride (2.64 ml, 20.81 mmol) was then added in 6 M DMSO over 15 min, and the solution was stirred for a further 1.5 hrs. Upon completion as observed by TLC, the reaction was poured over water and the resulting aqueous phase was extracted with two 20 mL portions of CHCI3. The combined organic layers were washed with 100 mL of water, dried with anhydrous MgS04 and concentrated under reduced pressure to yield 4.55 g (99%) of l-(2-chlorobenzyl)-3,5-dimethyl-lH-pyrazole as a clear liquid. 1H NMR (300 MHz, CDCI3) delta 7.41 – 7.31 (m, 1H), 7.24 – 7.09 (m, 2H), 6.59 – 6.50 (m, 1H), 5.90 (s, 1H), 5.31 (s, 2H), 2.26 (s, 3H), 2.15 (s, 3H). 13C NMR (75 MHz, CDCI3) delta 148.32, 139.96, 135.46, 131.96, 129.42, 128.76, 127.72, 127.48, 105.84, 50.12, 13.80, 11.15. HRMS (m z): [MNa]+ calc for C12Hi3ClN2Na+ 243.07; found 243.0651.

Statistics shows that 3,5-Dimethyl-1H-pyrazole is playing an increasingly important role. we look forward to future research findings about 67-51-6.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 132712-71-1, name is 3-Methyl-1H-pyrazol-5-ol, A new synthetic method of this compound is introduced below., Quality Control of 3-Methyl-1H-pyrazol-5-ol

General procedure: 5-Amino-4-arylazo-3-methyl-1-phenylpyrazoles (0.01 mol) weredissolved in a mixture of glacial acetic acid and concentrated hydrochloricacid (20 ml, ratio 1:1) and the solutionwas then cooled to 0-5 C. Sodiumnitrite (0.69 g, 0.01 mol) in water (10 ml) was then added to this solution dropwise with vigorous stirring, for about 1 h, while cooling at0-5 C. Then the resulting diazonium solution was added in portionsover 30 min to a vigorously stirred solution of 5-hydroxy-3-methyl-1H-pyrazole or 5-hydroxy-3-methyl-1-phenylpyrazole (0.01 mol) in KOH (0.56 g, 0.01mol) andwater (10ml) between 0 and 5 C,maintainingthe pHat 7-8 by simultaneous sodiumacetate solution addition. The mixture was then stirred for 2 h at 0-5 C. The precipitated product separated upon dilution with water (50 ml) was filtered off, washed with water several times, dried and crystallized from DMF-H2O

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.