Tag: M.W=0-100

Synthetic Route of 1904-31-0,Some common heterocyclic compound, 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, molecular formula is C4H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3,5-Dibromo-l-methyl-lH-pyridin-2-one (469mg, 1.76mmol), 1 -Methyl- lH-pyrazo 1-3 -ylamine (205mg, 2.11mmol), tris(dibenzylidineacetone)dipalladium(0) (80mg, 0.087mmol), 2,2′-bis(di- phenylphosphino-l,l ‘-binaphthalene (82mg, 0.13mmol), and cesium carbonate (801mg, 2.46mmol) were deposited in a sealed vial with 1OmL toluene. This was heated at 1300C for 18 hours. The resulting mixture was poured into 50 mL water. This was extracted with ethyl- acetate. The ethylacetate layer was washed with brine, dried over anhydrous magnesium sulfate, filtered, concentrated in vacuo, and purified by flash chromatography (eluted with ethylacete/- hexanes) to yield 5-Bromo-l-methyl-3-(l-methyl-lH-pyrazol-3-ylamino)-lH-pyridin-2-one (271mg, 0.957mmol). MS (ESI) 284.9 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-pyrazol-3-amine, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., category: pyrazoles-derivatives

Example 8; A. 1-{3-[2-(1-Methyl-1H-pyrazol-3-ylamino)pyridin-4-yl]-[2,6]naphthyridin-1- yl}piperidine-4-carboxylic acid amide.; 1 -[3-(2-Chloropyridin-4-yl)-[2,6]naphthyridin-1 -yl]-piperidine-4-carboxylic acid amide Example 4A (200 mg, 0.54 mmol), 1 -methyl-1/-/-pyrazol-3-ylamine (110 mg, 1.10 mmol), and cesium carbonate (1.1 g, 3.3 mmol) are dissolved in anhydrous lambda/-methylpyrrolidinone (8.00 ml_) in a dried pressure vessel under argon. The mixture is sparged with argon for 5 min, then palladium(O) tris(tri-f-butylphosphine) (28 mg, 0.05 mmol) is added. The vessel is flushed with argon and sealed, and then heated in a 120 0C oil bath for 5 h. The resulting dark red solution is cooled to rt, then diluted with MeOH and filtered. The filtrate is acidified with several drops of TFA, then purified by preparative reverse-phase HPLC (X-Bridge C18 column, flow rate = 30 mL/min, gradient 10percent–> 80percent acetonitrile/5 mM aqueous trifluoroacetic acid over 30 min). The isolated TFA salt of the product is dissolved in water and basified with 28percent aqueous ammonium hydroxide. The aqueous layer is extracted three times with dichloromethane. The combined organic layers are washed with brine, dried over sodium sulfate, filtered, and concentrated to give the free base. Further purification by preparative reverse-phase HPLC (X-Bridge C18 column, flow rate = 40 mL/min, gradient 10percent –> 80percent acetonitrile/5 mM aqueous ammonium hydroxide over 20 min) afforded the title compound as a white solid (40 mg, 17percent): MS (ESI) m/z 429.4 (M+1 ); 1H NMR (400 MHz, DMSO-d6) delta ppm 9.38 (d, J = 0.76 Hz, 1 H), 9.31 (br s, 1 H), 8.64 (d, J = 5.8 Hz, 1 H), 8.24 (s, 1 H), 8.22 (d, J = 5.3 Hz, 1 H), 8.1 (s, 1 H), 7.87 (d, J = 5.8 Hz, 1 H), 7.53 (d, J = 2.3 Hz, 1 H), 7.42 (dd, J = 5.4, 1.6 Hz, 1 H), 7.34 (br s, 1 H), 6.83 (br s, 1 H), 6.30 (d, J = 2.0 Hz, 1 H), 4.07 (br d, J = 13.4 Hz, 2 H), 3.77 (s, 3 H), 3.10 (m, 2 H), 2.43 (m, 1 H), 1.92 (br m, 4 H).

The synthetic route of 1904-31-0 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 36650-74-5,Some common heterocyclic compound, 36650-74-5, name is 1H-Pyrazole-3-carbonitrile, molecular formula is C4H3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 60. Synthesis of 2-(4-(3-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-lH- pyrazol-l-yl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)-3-fluorobenzonitrile, 1-60 Synthesis of compound 60.2. To a mixture of 60.1 (0.14g, 1.50mmol, 1.0 eq) and aminoalcohol (0.20g, 2.25 mmol, 1.5eq) was added ZnCl2 (0.041g, 0.30mmol, 0.2 eq) and stirred at 95 C under microwave irradiation for 4 h. Upon completion of the reaction, mixture was quenched with water. Resulting mixture was extracted with EtOAc. Organic layers were combined, washed with brine, dried over Na2S04 and concentrated under reduced pressure. The residue was purified by flash column chromatography to obtain pure 60.2 (0.10 g, 41.6%). MS(ES): m/z 166.2 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-Pyrazole-3-carbonitrile, its application will become more common.

Electric Literature of 35277-02-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35277-02-2, name is 4-Fluoro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 2-ch loro-N-(2 ,4-d imethoxybenzyl )-5-nitrobenzenesulfonam ide (5.00 g, 11.6 mmol) in acetonitrile (135 mL) were added 4-fluoro-1H-pyrazole (1.50 g, 17.4 mmol) and powdered potassium carbonate (4.82 g, 34.9 mmol) and it was stirred overnight at10000. The reaction mixture was concentrated in vacuo and the residue was extracted with dichioromethane and water. The organic phase was washed with brine and dried over sodium sulfate. Concentration in vacuo led to the crude title compound (5.54 g, quant., app. 85 % purity) that was used without further purification in the next step.LC-MS (Method A): Rt = 1.23 mm; MS (ESIpos): mlz = 437 [M+H]1HNMR (400MHz, DMSO-d6) oe [ppm]: 3.48 (s, 3H), 3.62 (s, 3H), 4.13 (s, 2H), 6.15 (d,1H), 6.28 (dd, 1H), 7.09 (d, 1H), 7.81 (d, 1H), 8.00-8.10 (m, 2H), 8.23 (d, 1H), 8.43 (dd,H), 8.59 (s, 1 H).

The chemical industry reduces the impact on the environment during synthesis 4-Fluoro-1H-pyrazole. I believe this compound will play a more active role in future production and life.

Synthetic Route of 3920-50-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3920-50-1, name is Pyrazole-3-carboxaldehyde belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a suspension of 0.60 g (6.24 mmol, 1.0 eq.) of 1H-pyrazole-3-carbaldehyde in 12 mL ofmethylene chloride at -40 ¡ãC under a nitrogen atmosphere was added 1.63 mL (9.37 mmol,1.5 eq.) of 1VN-diisopropylethyl amine, followed by 1.66 mL (9.37 mmol, 1.5 eq.) of[2- (chloromethoxy)ethyl]trimethylsilane. The mixture was allowed to warm to room temperature and stirred for 16 h. The reaction mixture was then diluted with 20 mL brine, and extracted with 3 x 30 mL of methylene chloride. The combined organic extracts were dried(Na2SO4), filtered, and the solvent was removed in vacuo. The residue was absorbed on CELITE? and purified by flash chromatography (Si02, eluting with a gradient of 0-30percent ethyl acetate/hexanes) to provide 1 g (66percent) of a mixture of 1-((2-(trimethylsilyl)ethoxy)methyl)- 1H-pyrazole-5 -carbaldehyde and 1 -((2-(trimethyl silyl)ethoxy)methyl)- 1H-pyrazole-3 – carbaldehyde in an approximately 1:1 ratio.

The synthetic route of Pyrazole-3-carboxaldehyde has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 81945-73-5, name is 1H-Pyrazol-1-ol, This compound has unique chemical properties. The synthetic route is as follows., name: 1H-Pyrazol-1-ol

1. N-2-[4-(1,1-Dimethylethoxy)phenoxy]ethoxypyrazole A solution of 12.7 g (0.15 mol) of N-hydroxypyrazole in 20 ml of DMF was added dropwise to a suspension of 4.95 g (1.1 eq.) of NaH (80% dispersion in mineral oil) in 40 ml of DMF at RT, and the mixture was heated at 70 C. for 1 h. A solution of 40.95 g (0.15 mol) of 2-[4-(1,1-dimethylethoxy)phenoxy]ethyl bromide in 100 ml of DMF was added and the mixture was then heated at 125 C. for 15 h. The solvent was then stripped off in a rotary evaporator, the residue was taken up in ethyl acetate, and the solution was washed twice each with 5% strength NaOH solution and water. Drying and removal of the solvent under reduced pressured resulted in 38.4 g (93%) of the required compound as a pale oil which was employed without further purification in the next stage. 1 H-NMR (250 MHz, CDCl3): delta=7.38 (d, 1H); 7.28 (d, 1H); 6.93 (d, 2H); 6.83 (d, 2H); 6.17 (t, 1H); 4.63 (m, 2H); 4.17 (m, 2H); 1.30 (s, 9H) ppm

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 81945-73-5.

Adding a certain compound to certain chemical reactions, such as: 288-13-1, name is 1H-Pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 288-13-1, Formula: C3H4N2

To the three-necked flask, CuI (19 mg, 0.1 mmol, 10 mol%), 1,10-phenanthroline N,N’-dioxide (39 mg, 0.2 mmol, 20 mol%), Cs2CO3 (650 mg, 2.0 mmol). The reaction flask was evacuated under argon. To the p-nitroiodobenzene (249 mg, 1.0 mmol) was added pyrazole (102 mg, 1.5 mmol) and DMF (2 ml) under argon atmosphere. Reacted at room temperature for 18 hours until starting material is fully reacted (TLC detection reaction is complete). After completion of the reaction, a brown oil was obtained which was diluted with ethyl acetate. The inorganic salt was removed by filtration and the solvent was removed by rotary evaporation. The residue was eluted with petroleum ether / ethyl acetate Was purified by silica gel column chromatography to give 1-(4-nitrophenyl)pyrazole as a pale yellow oil. The yield was 82%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Pyrazole, other downstream synthetic routes, hurry up and to see.

Related Products of 28466-26-4, These common heterocyclic compound, 28466-26-4, name is 4-Aminopyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

As shown in step 5-i of Scheme 5, methyl 4-bromo-2-(bromomethyl)benzoate (Compound 2018, 2.08 g, 6.75 mmol; prepared by reacting l-(4-bromo-2- methylphenyl)ethanone with NBS),lH-pyrazol-4-amine (561 mg, 6.75 mmol), and DIEA (873 mg, 1.18 mL, 6.75 mmol) were combined in DMF (7.78 mL) and heated at 110 C for 90 min. The reaction mixture was diluted with MeOH (60 mL) and the resulting white crystaline solid was collected by filtration and dried under vacuum to give 5-bromo-2-(lH- pyrazol-4-yl)isoindolin-l-one (Compound 2019, 1.21 g, 4.35 mmol, 64% yield): ESMS (Mu+Eta) 279.99

Statistics shows that 4-Aminopyrazole is playing an increasingly important role. we look forward to future research findings about 28466-26-4.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 288-13-1, name is 1H-Pyrazole, A new synthetic method of this compound is introduced below., HPLC of Formula: C3H4N2

4-lodopyrazole (1); [00188] A mixture of iodic acid (3.6g 20mmole), iodine (10.2g 40mmole), 30% w/w sulfuric acid (4ml_) and acetic acid (30ml_) was stirred to give a solution/suspension. About half of this mix was added in portions to a solution of pyrazole (6.8g, 100 mmole) in acetic acid (60ml_) maintained at 60C. The colour was allowed to fade after each addition before adding the next aliquot. The rest of the solution/suspension was added in one portion and the mix stirred and heated at 60C for another 1 .75 hours. The final mix still had an iodine colour. The reaction was cooled and added to saturated sodium hydrogen carbonate (100ml_). Sodium carbonate solution (200ml of a 15% solution) was added carefully and then solid sodium carbonate was added until there was no more carbon dioxide evolved. The product was extracted with chloroform (3x60ml_) and the combined extracts were washed with water (50ml_). The extracts were dried and evaporated and the solid obtained was dried in vacuum over sodium hydroxide to give the title compound (17.4g, 89%), spectroscopic data for which was consistent with data reported in G.Zoppellaro, A.Geiss, V.Enkelmann, M.Baumgarten, Eur. J.Org.Chem., 2004, 2367-2374.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 132712-71-1, These common heterocyclic compound, 132712-71-1, name is 3-Methyl-1H-pyrazol-5-ol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Dichloromethane (10 mL) was taken in a round-bottomed flask,into which 1.0 equivalent (1 mmol) of triethylamine and pyrazolonewere poured. The mixture was stirred for 2 min without heating. To this mixture, 1.0 equivalent of corresponding presynthesized benzylidene from malononitrile was added. Then the mixture was agitated for 25-30 min. The reaction was observed by TLC. The desired products appeared as precipitates. The precipitates were washed with water to remove the unreacted pyrazolone to obtain pure products. Melting points were recordedfor crystalline substances.

Statistics shows that 3-Methyl-1H-pyrazol-5-ol is playing an increasingly important role. we look forward to future research findings about 132712-71-1.