Tag: M.W=250-300

Zhang, Anyun published the artcileAssociation Behavior of 4-Acylpyrazolone Derivative and Tertiary Amine of High Molecular Weight in Antagonistic Synergistic Extraction of Palladium, Computed Properties of 1691-93-6, the main research area is TOA hydrogen bond complexation fluoroacyl pyrazolone derivative spectrophotometry; palladium cation solvent extraction TOA fluoroacyl pyrazolone derivative spectrophotometry.

To find an effective extraction and removal method for palladium(II), which is one of the main fission products from an acidic nuclear spent fuel solution, the extraction behavior of palladium(II) from a nitric acid medium by an acidic chelating extractant, 1-phenyl-3-methyl-4-trifluoroacetylpyrazolone-5-one (HPMTP) and a tertiary amine of high mol. weight, tri-n-octylamine (TOA), has been studied by spectrophotometry. A noticeable antagonistic extraction effect was observed in the extraction system under the given conditions. To understand this phenomenon, a preliminary investigation was performed to explain the mechanism of this reaction. According to the theory of corresponding solutions (TCS), the association reaction between HPMTP and TOA is proposed in the organic phase. An associated species, HPMTP·TOA, formed through hydrogen bonding in a chloroform medium might be the main reason why an antagonistic extraction effect occurred. The association constant between HPMTP and TOA was calculated to be 2.86 ± 0.05.

Journal of Solution Chemistry published new progress about Complexation. 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Computed Properties of 1691-93-6.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Umetani, Shigeo published the artcileRole of the intramolecular hydrogen bond and ligand rigidity in the complexation of trifluoroacetylcycloalkanones with lanthanides: novel strategy for the design of organic ligands of high selectivity, Recommanded Product: 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, the main research area is intramol hydrogen bond ligand rigidity complexation; trifluoroacetylcycloalkanone lanthanide complexation extraction.

Trifluoroacetylcyclopentanone (1), -cyclohexanone (2) and -cycloheptanone (3) were synthesized and the complexation with lanthanides (La3+, Pr3+, Eu3+, Ho3+ and Yb3+) was studied via the solvent extraction technique. The strength of the intramol. hydrogen bond depends on the distance between the two donating oxygens in the enol form estimated by semi-empirical MNDO/H and ab initio calculations The O-O distance for 1 is larger than those for 2 and 3 as predicted from their cyclic structures. The strength of the intramol. hydrogen bond increases in the order, 1<2≈3, which is also supported by 1H NMR and IR spectra. The acid dissociation constants (pKa) were measured by potentiometric titration in 30 dioxane-water. The pKa values increase in the order, 1<2≤3, reflecting the strength of the intramol. hydrogen bond. Lanthanides were readily extracted by 1 owing to its strong acidity. However, better separation for lanthanides was achieved with 2 and 3. The extractability and separability were discussed in terms of the ligand rigidity and the intramol. hydrogen bond originating from the distance between the two donating oxygens. Inorganica Chimica Acta published new progress about Complexation. 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Recommanded Product: 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Sugiura, Masaaki published the artcileEffect of quaternary ammonium salts on carrier-mediated transport of lanthanide ions through cellulose triacetate membranes, Category: pyrazoles-derivatives, the main research area is lanthanide membrane transport quaternary ammonium; acetate cellulose membrane lanthanide transport; lanthanum transport cellulose acetate membrane; cerium transport cellulose acetate membrane; benzoylmethylphenylpyrazolone carrier membrane transport lanthanide; tfluoroacetylmethylphenylpyrazolone carrier membrane transport lanthanide; plasticizer quaternary ammonium salt membrane; nitrophenyloctyl ether plasticizer membrane.

Fluxes of all lanthanides, except Pm, across cellulose triacetate membranes were determined by using mixtures of o-nitrophenyl n-octyl ether and quaternary ammonium salts as plasticizers, and 4-benzoyl-3-methyl-1-phenyl-5-pyrazolone (I) and 4-trifluoroacetyl-3-methyl-1-phenyl-5-pyrazolone (II) as carriers. The quaternary ammonium salts used were didodecyldimethyl-, distearyldimethyl-, tetrahexyl-, tetraoctyl-, and tetradecylammonium bromides [referred to as (C12)2NBr, (C18)2NBr, (C6)4NBr, (C8)4NBr, and (C10)4NBr, resp.]. The effect of these quaternary ammonium bromides on the flux was demonstrated. For membranes containing 0.1 M (C12)2NBr and (C18)2NBr, I exhibited considerably high fluxes. The fluxes of La and Ce using I for (C12)2NBr were higher than those of the other lanthanides. For the membranes containing 0.5 M (C12)2NBr and 0.1 M (C18)2NBr, however, no difference in flux among the lanthanides was observed The fluxes using II for (C12)2NBr and (C18)2NBr were very small, with the exception of some lanthanides. Appreciably high fluxes were observed for membranes containing 0.1 M (C6)4NBr using I. For (C8)4NBr and (C10)4NBr, I exhibited low fluxes. For these membranes using II, the lanthanides were scarcely transported.

Separation Science and Technology published new progress about Plasticizers. 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Category: pyrazoles-derivatives.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Barkanov, Artem published the artcileNIR-OLED structures based on lanthanide coordination compounds: synthesis and luminescent properties, SDS of cas: 1691-93-6, the main research area is lanthanide complex NIR OLED luminescence.

Electroluminescence complexes based on ytterbium and 5-methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-2,4-dihydro-3H-pyrazol-3-one (HL) ligand and various diimine-type ancillary ligands (2,2-bipyridine, bathophenanthroline, 1,10-phenanthroline) have been synthesized, and corresponding crystals were investigated. [Yb(L)3(bipy)] and [Yb(L)3(bath)] complexes have triclinic structure (P-1), while [Yb(L)3(phen)] complex has orthorhombic structure (P212121). The crystallog. parameters were determined The photoluminescence of the complexes demonstrated only bands resulted from 2F5/2→2F7/2 transition and corresponding three Stark subcomponents generated due to the crystal field action. NIR-OLED structures with emitting layers based on the [Yb(L)3(bipy)], [Yb(L)3(bath)], and [Yb(L)3(phen)] complexes have been fabricated, and their electroluminescence demonstrated maxima intensities at 978 and 1005 nm. Comparison of NIR-OLEDs power d. showed that the maximal power densities of 2.17 (978 nm) and 1.92 (1005 nm) μW x cm-2 were determined for the NIR-OLED based on [Yb(L)3(bath)] complex.

Journal of Materials Science published new progress about Crystal structure. 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, SDS of cas: 1691-93-6.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Drozdov, A. published the artcileNew volatile heterocyclic metal diketonates for MOCVD, Application of 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, the main research area is crystal structure copper barium acylpyrazolone phen bipy tetraglyme; acylpyrazolone copper barium phen bipy tetraglyme preparation structure; copper acylpyrazolone phen bipy preparation structure CVD; barium acylpyrazolone phen tetraglyme preparation structure.

The new type of β-diketonate ligand, 4-acylpyrazol-5-ones were used for preparation of Cu(II) and Ba complexes. Two Cu and two Ba complexes containing neutral N- and O-donor ligands (such as phen, bipy, tetraglyme) were structurally characterized by single crystal x-ray diffractometry. The volatility of Cu compounds obtained was studied. The preliminary CVD experiments were conducted.

Journal de Physique IV: Proceedings published new progress about Crystal structure. 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Application of 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Marchetti, Fabio published the artcileSynthesis and characterization of copper(I) and copper(II) coordination compounds containing 4-acylpyrazolon-5-ato ligands. Crystal structure of [(4-trifluoroacetyl-1-phenyl-3-methylpyrazolon-5-ato)bis(triphenylphosphine)copper(I)], SDS of cas: 1691-93-6, the main research area is crystal structure copper trifluoroacetylphenylmethylpyrazolone triphenylphosphine; copper acylpyrazolone derivative preparation triphenylphosphine reduction.

New [(Q)2CuII] and [(Q)2(L)CuII] derivatives (in general QH is 1-R-3-methyl-4-R’-pyrazol-5-one; in particular: Q’H: R = C6H5, R’ = C6H5(C=O); Q”H: R = C6H5, R’ = CH3(C=O); QFH: R = C6H5, R’ = CF3(C=O); QClH: R = C6H5, R’ = CCl3(C=O); QBrH: R = C6H5, R’ = p-BrC6H4(C=O); QAH: R = C6H5, R’ = p-CH3O-C6H4(C=O), QEH: R = C6H5, R’ = C6H13(C=O); QMH: R = CH3, R’ = C6H5(C=O); QDH: R = CH3, R = CH3(C=O); QBH: R = C6H5, R’ = C6H5(C=N(p-CH3C6H4)); L = 2,2′-bipyridine or 1,10-phenanthroline) were synthesized and characterized through anal. and spectral techniques. When (Q)2CuII interacted with an excess of PPh3, reduction to Cu(I) was observed and (Q)Cu1(PPh3)2 complexes were synthesized. (QF)CuI(PPh3)2 was characterized by single crystal x-ray diffraction in monoclinic space group P21/c, R = 0.069. The coordination environment of Cu is a distorted tetrahedron: the P-Cu-P angle is 127.8(1)° and the ligand bite O-Cu-O angle is 87.8(3)°; the Cu-O bond distances are 2.075(7) and 2.109(7) Å, while Cu-P are 2.246(3) and 2.254(3) Å.

Polyhedron published new progress about Crystal structure. 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, SDS of cas: 1691-93-6.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Marchetti, Fabio published the artcileA new family of ionic dinuclear strontium (imH2)2[Sr2(Q)6] compounds (imH = imidazole; QH = 1-phenyl-3-methyl-4-acylpyrazol-5-one), Safety of 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, the main research area is strontium acylpyrazolonato imidazolium preparation structure; crystal structure strontium pivaloylpyrazolonato methoxyethanol imidazolium.

New neutral [Sr(Q)2(L)n]m or ionic (imH2)2[Sr2(Q)6] air stable complexes (QH = 1-phenyl-3-methyl-4-R(C:O)-pyrazol-5-one; in detail Q = QT for R = CH2CMe3, Q = QP for R = Ph and Q = QF for R = CF3; n = m = 1 for L = tetraglyme (2,5,8,11,14-pentaoxapentadecane); n = m = 2 for L = H2O; n = 2 and m = 1 for moeH (2-methoxyethanol), dmaeH (N,N-dimethylaminoethanol) or phen (1,10-phenanthroline); imH = imidazole) were synthesized and fully characterized. The x-ray crystal structures of [Sr(QT)2(moeH)2]2 and of (imH2)2[Sr2(QT)6] were determined [Sr(QT)2(moeH)2]2 contains an eight-coordinate Sr atom in a square antiprismatic environment, due two bidentate chelating Q donors and two bidentate 2-methoxyethanol ligands. The compound (imH2)2[Sr2(QT)6] is composed of two imidazolium cations and a dianionic fragment [Sr2(QT)6]2-, which is a centrosym. dimer containing four terminal and two bridging Q donor ligands.

Journal of the Chemical Society, Dalton Transactions published new progress about Crystal structure. 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Safety of 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Modi, C. K. published the artcileSynthetic, spectroscopic and thermal aspects of some heterochelates, Recommanded Product: 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, the main research area is transition metal pyrazolylethylideneaminobenzoate benzylideneethylenediamine preparation; reaction kinetics activation energy thermolysis transition metal pyrazolylethylideneaminobenzoate benzylideneethylenediamine; activation entropy enthalpy thermolysis transition metal pyrazolylethylideneaminobenzoate benzylideneethylenediamine; free energy thermolysis transition metal pyrazolylethylideneaminobenzoate benzylideneethylenediamine.

The present article describes the synthesis, structural features and thermal studies of heterochelates [M(SB)(benen)(H2O)]·nH2O [where H2SB = (Z)-2-(2,2,2-trifluoro-1-(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)ethylideneamino)benzoic acid, benen = bis(benzylidene)ethylenediamine and M = Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and VO(IV)]. The Schiff base (H2SB) was characterized from elemental anal., IR, 1H and 13C NMR. The heterochelates were characterized from elemental analyses, magnetic measurements, solid state conductivity measurements, IR, reflectance spectra, and thermal studies. The FAB mass spectrum of [Co(SB)(benen)(H2O)] was carried out. The kinetic parameters such as order of reaction (n) and the energy of activation (Ea) are reported using Freeman-Carroll method. The pre-exponential factor (A), the activation entropy (ΔS#), the activation enthalpy (ΔH#) and the free energy of activation (ΔG#) were calculated

Journal of Thermal Analysis and Calorimetry published new progress about Activation energy (thermolysis). 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Recommanded Product: 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

McElroy, William T. published the artcilePotent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation, Recommanded Product: tert-Butyl 4-(5-amino-1H-pyrazol-3-yl)piperidine-1-carboxylate, the main research area is preparation amidopyrazole inhibitor IRAK4 inflammation structure; Interleukin-1 receptor-associated kinase 4; SAR; drug discovery; inflammation; structure-based drug design.

IRAK4 is a critical upstream kinase in the IL-1R/TLR signaling pathway. Inhibition of IRAK4 is hypothesized to be beneficial in the treatment of autoimmune related disorders. A screening campaign identified a pyrazole class of IRAK4 inhibitors that were determined by X-ray crystallog. to exhibit an unusual binding mode. SAR efforts focused on the identification of a potent and selective inhibitor with good aqueous solubility and rodent pharmacokinetics. Pyrazole C-3 piperidines were well tolerated, with N-sulfonyl analogs generally having good rodent oral exposure but poor solubility N-Alkyl piperidines exhibited excellent solubility and reduced exposure. Pyrazoles possessing N-1 pyridine and fluorophenyl substituents were among the most active. Piperazine 32 was a potent enzyme inhibitor with good cellular activity. Compound 32 reduced the in vivo production of proinflammatory cytokines and was orally efficacious in a mouse antibody induced arthritis disease model of inflammation.

ACS Medicinal Chemistry Letters published new progress about Anti-inflammatory agents. 1169563-99-8 belongs to class pyrazoles-derivatives, name is tert-Butyl 4-(5-amino-1H-pyrazol-3-yl)piperidine-1-carboxylate, and the molecular formula is C13H22N4O2, Recommanded Product: tert-Butyl 4-(5-amino-1H-pyrazol-3-yl)piperidine-1-carboxylate.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Nwankwoala, Reginaid N. P. published the artcileAnti inflammatory property of new pyrazolon derivatives, Safety of 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, the main research area is antiinflammatory inflammation pyrazolone derivative phenylbutazone.

The anti inflammatory effects of 4-trifluoroacety1-1-pheny1-3-methy1 pyrazolone (HTFP) and 4-sebacyl-1-bis 1-pheny1-3-methy1 pyrazolone (HSP) were investigated and compared with those of phenylbutazone (PTZ) using carrageenan-induced paw inflammation model in rats. Different doses of PTZ, HTFP and HSP were intra-peritoneally administered to rats and one hour thereafter, inflammation was induced by injecting carrageenan into the left foot of the rat. The right foot received saline. Five (5) rats received carrageenan and saline only. Both the left and right feet were measured hourly for four hours. PTZ, HTFP and HSP significantly reduced carrageenan induced inflammation. 100Mg/kg PTZ caused 62.5 ± 5.25% reduction of the inflammatory response whereas 10mg/kg HTFP and 10mg/kg HSP reduced inflammatory response by 53.6 ± 5.0% and 32.5 ± 4.50% resp. Thus anti-inflammatory properties of these drugs were less at lower doses. These results show that (1) HTFP and HSP possess anti-inflammatory property, (2) HTFP is more potent than HSP and (3) The anti-inflammatory potency of phenylbutazone drug is greatly enhanced by substitution of trifluoroacety1-1-group at position 4 of the pyrazolone mol.

Research Journal of Medicine and Medical Sciences published new progress about Anti-inflammatory agents. 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Safety of 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics