Tag: M.W=0-100

Adding a certain compound to certain chemical reactions, such as: 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35344-95-7, SDS of cas: 35344-95-7

To a stirred solution of lH-pyrazole-4-carbaldehyde (S2-1) (200 mg, 2.08 mmol) in DMF (2 rnL) was added 2-iodopropane (707.66 mg, 4.16 mmol, 416.27 uL) and Cesium carbonate (1.36 g, 4.16 mmol) at ambient temperature. The resulting mixture was heated at 80C for 16 hours. It was then cooled to room temperature, diluted with ice cold w’ater and extracted with ethyl acetate. The combined extract was washed with brine, dried over sodium sulfate, and concentrated under reduced pressure. The reaction mixture was purified by flash chromatography (eluting with 30% ethyl acetate-hexane) to afford l-isopropylpyrazoJe-4-carbaldehyde (S2-2) (200 mg, 1.45 mmol, 69.54% yield) as brown liquid. LCMS: ES+ 139.1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Pyrazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, A new synthetic method of this compound is introduced below., Formula: C4H4N2O

A suspension of 1H-pyrazole-4-carbaldehyde (1.00 g, 10.41 mmol) in DCM (30 mL) was stirred under nitrogen. Triethylamine (1.45 mL, 10.41 mmol) was added resulting in a solution. The reaction was cooled to 0 oC with a cooling bath and benzyl carbonochloridate (1.49 mL, 10.41 mmol) was added as dropwise over 5 min maintaining the internal temperature below 10 oC. The reaction was allowed to stir at 4 oC with a cooling bath for 1 h. An aqueous 1M solution of hydrochloric acid (30 mL) was added cautiously. The layers were separated and the aqueous portion was extracted with DCM (2 x 30 mL). The combined organic extracts were washed with water (20 mL) and brine (20 mL). The combined organic extracts were passed through a phase separation cartridge and concentrated under reduced pressure. The resulting yellow residue was purified by flash silica chromatography eluting with a gradient of 0-50percent EtOAc in heptane. Product containing fractions were concentrated under reduced pressure to afford benzyl 4-formylpyrazole-1-carboxylate (1.78 g, 74percent) as a white solid. IR: 1736 (CO), 1674 (CO) cm-1; 1H NMR (400 MHz, CDCl3) 5.51 (s, 2H), 7.35 ? 7.47 (m, 3H), 7.47 ? 7.55 (m, 2H), 8.15 (s, 1H), 8.57 ? 8.71 (m, 1H), 9.96 (s, 1H); 13C NMR (400 MHz, CDCl3) 71.00, 126.11, 128.90, 129.02, 129.35, 133.62, 135.14, 142.86, 148.56, 183.49; HRMS [M+Na]+ measured 253.0578, C12H10O3N2 requires 253.0589.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 1904-31-0,Some common heterocyclic compound, 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, molecular formula is C4H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 4 1-Methylpyrazole-3-sulfonyl chloride To 120 ml of water and 120 ml of 12N hydrochloric acid was added 45 g of 1-methylpyrazole-3-amine at -10 C. followed by the dropwise addition of 33.9 g sodium nitrite dissolved in 75 ml water. The temperature was maintained at -10 C. and the mixture was stirred for an additional half hour after the additions were completed. The above solution was then added portionwise with stirring at -10 C. to a mixture containing 348 ml acetic acid, 5.8 g of CuCl and 48 ml (liquified) of sulfur dioxide. After being stirred for one hour at -10 C., the reaction mixture was allowed to warm to 10 C. and was poured into 1500 ml of ice and water. The resultant mixture was extracted three times with 500 ml portions of methylene chloride. The extracts were combined, dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to yield a red oil. This material was used for the preparation of 1-methylpyrazole-3-sulfonamide without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-pyrazol-3-amine, its application will become more common.

Synthetic Route of 930-36-9, These common heterocyclic compound, 930-36-9, name is 1-Methylpyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 14-(Azetidin-1 -yl)-1 -methyl-3-[1 -methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]-1H- pyrazolo[3,4-d]pyrimidine1Step 1: Synthesis of (1-methyl-1H-pyrazol-5-yl)boronic acid (C1) To a solution of 1 -methyl-1 /-/-pyrazole (1 10 g, 1 .34 mol) in anhydrous tetrahydrofuran (2 L), with stirring, was added drop-wise n-butyllithium (2.5 M, 590 imL, 1 .47 mol) at -78 C. After completion of the addition, the mixture was stirred for 1 .5 hours at -78 C. Then triisopropyl borate (277 g, 1 .47 mol) was added and the mixture was gradually warmed to room temperature and stirred overnight. Saturated aqueous ammonium chloride solution (1 L) was added drop- wise, while keeping the temperature of the reaction mixture below 10 C. The resulting mixture was acidified to a pH of approximately 6 with 1 N aqueous hydrochloric acid. The organic phase was separated and the aqueous phase was extracted with ethyl acetate (3 x 1 L). The combined organic layers were washed with saturated aqueous sodium chloride solution, dried over sodium sulfate, and filtered; and the solvent was removed under reduced pressure. The residue was washed with petroleum ether (3 x 300 mL) and the resulting solid was dried under vacuum to afford the product as a white solid. Yield: 157 g, 1.25 mol, 93%. H NMR (400 MHz, DMSO-cf6) delta 3.97 (s, 3H), 6.72-6.74 (m, 1 H), 7.34-7.36 (m, 1 H), 8.35 (br s, 2H).

The synthetic route of 930-36-9 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows., Safety of 1-Methyl-1H-pyrazol-3-amine

Step a) tert-butyl 1-(1 -hydro xy-2-(l -methyl- 1 H-pyrazol-3 -ylamino)-2-oxoethyl)- cyclobutylcarbamate (9-a)1 – Methyl- 1 H-pyrazol-3 -amine (158 mg, 1.63 mmol) and DIEA (1.08 mL, 6.52 mmol) was added to a solution of 2-(l-(teri-butoxycarbonylamino)cyclobutyl)-2-hydroxyacetic acid (400 mg, 1.63 mmol) dissolved in DMF (20 mL). The solution was cooled to 0 ¡ãC and after 10 minutes HATU (620 mg, 1.63 mmol) was added. After approximately 2 hours at RT, LC-MS showed product and no starting material and the solvent was removed by rotary evaporation. The crude product was dissolved in 40 mL EtOAc and washed with 25 mL sat. NaHC03 (aq). The organic phase was dried with Na2S04, filtered and evaporated to dryness. The crude product was purified on a 25 g silica column on a Biotage Flashmaster, which gave the title product as a white solid (488 mg, 92percent).TLC rf: 0.07 in heptane:ethyl acetate 1 : 1. [M+H]+ = 325.

According to the analysis of related databases, 1904-31-0, the application of this compound in the production field has become more and more popular.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 930-36-9, name is 1-Methylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Formula: C4H6N2

Step 1; [00116] q-Methyl-lH-pyrazol-5-yl)phihenyl)methanol: At about -78 0C, n- butyllithium (58.5 mL, 2.5M) was added to a solution of 1 -methyl- lH-pyrazole (10 g, 121.95 mmol, 1.00 equiv.) in tetrahydrofuran (200 mL). The mixture was stirred at about -78 0C for about 1 hour, and then benzaldehyde (14.2 g, 133.96 mmol, 1.10 equiv.) was added. The mixture was stirred at ambient temperature for about 16 hours, and then a saturated aqueous solution of ammonium chloride (100 mL) was added. Following standard extractive workup with ethyl acetate (2 x 100 mL), the resulting residue was purified by silica gel column chromotagraphy (ethyl acetate / petroleum ether (1:1)) to give the title product as a white solid (20.2 g; yield = 88%). LC-MS: m/z = 189 (MH)+. 1H NMR (300 MHz, CHCl3) delta: 7.26-7.38 (m, 6H), 6.00 (d, / = 1.8 Hz, IH), 5.85 (s, IH), 3.70 (s, 4H).

The synthetic route of 930-36-9 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 81945-73-5, name is 1H-Pyrazol-1-ol, A new synthetic method of this compound is introduced below., Recommanded Product: 81945-73-5

(General Procedure 16)4-Benzo[1,3]dioxol-5-yl-piperazine-1-carboxylic Acid pyrazol-1-yl Ester The title compound was prepared from 1-hydroxypyrazole and 1-Benzo[1,3]dioxol-5-ylpiperazine applying the general procedure 16. The crude product was purified by flash chromatography (Quad flash 12, EtOAc-heptane) (92%, crystals). 1H NMR (300 MHz; CDCl3): delta 3.11 (bt, 4H), 3.71 (bs, 2H), 3.83 (bs, 2H), 5.93 (s, 2H), 6.32 (t, 1H), 6.39 (dd, 1H), 6.57 (d, 1H), 6.74 (d, 1H), 7.37 (dd, 1H), 7.41 (dd, 1H); HPLC-MS: m/z=317.2 (M+1); Rt=2.96 min.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 35344-95-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35344-95-7 as follows.

To the stirred solution of lH-pyrazole-4-carbaldehyde 19-4 (200 mg, 2.08 mmol) in DMF (2 ml) in a sealed tube were added potassium carbonate (719.19 mg, 5.20 mmol, 314.06 uL) and bromocyclopropane 19-5 (251.80 mg, 2.08 mmol, 166.76 uL). The reaction mixture was heated at H0C for 16 hours and then cooled to room temperature, diluted with ethyl acetate, washed with water, brine, dried over sodium sulfate and concentrated under reduced pressure. The crude material was purified by column chromatography to afford l-cyclopropylpyrazole-4-carbafdehyde 19-6 (25 mg, 183.62 umol, 8.82% yield) as gum. NMR (400 MHz, DMSO-d6) d 9.75 (s, 1H), 8.53 (s, 1H), 7.95 (s, 1 1 1 ), 3.86-3.82 (m, 1 1 1 ), 1. 10-1.08 (m, 2) 1 ).. 1.03-0.98 (m, 21 1).

According to the analysis of related databases, 35344-95-7, the application of this compound in the production field has become more and more popular.

Synthetic Route of 31108-57-3, These common heterocyclic compound, 31108-57-3, name is 1H-Pyrazole-4-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-chloro-5-nitrobenzenesulfonamide (250 mg, 1.06 mmol) was dissolved in acetonitrile5 (10 mL), followed by addition of 1H-pyrazole-4-carbonitrile (148 mg, 1.59 mmol) and finely powdered potassium carbonate (438 mg, 3.17 mmol). The reaction mixture was stirred overnight at 10000. After cooling to room temperature dichloromethane and water were added and the organic phase was washed with brine solution, dried over sodium sulfate and concentrated in vacuo. Purification by preparative HPLC (Chromatorex 0-18 10pm,10 125x30mm, acetonitrile/water + 0.1% formic acid) gave the title compound (128 mg, 0.436 mmol, 41 % yield, 70 % purity).LC-MS (Method A): Rt = 0.78 mm; MS (ESIpos): mlz = 294 [M+H]1HNMR (400MHz, DMSO-d6) oe [ppm]: 7.94 (br d, 2H), 7.98 (d, 1 H), 8.42 (d, 1 H), 8.61 (dd,1H), 8.83 (d, 1H), 9.04 (d, 1H).

Statistics shows that 1H-Pyrazole-4-carbonitrile is playing an increasingly important role. we look forward to future research findings about 31108-57-3.

Electric Literature of 1904-31-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

2-Bromopyridine (1 ) (1 .0g, 6.3mmol), 1 -methyl-1 H-pyrazol-3-amine (2) (0.79g, 8.2mmol), Xantphos (0.37g, 0.63mmol), and Cs2C03 (4.1 g, 12.6mmol) were combined in dry 1 ,4-dioxane (15mL). The reaction mixture was then degassed with N2(g), and placed under vacuum for 10min. Pd2(dba)3 (0.29g, 0.31 mmol) was added and the resulting reaction mixture was heated at 90¡ãC for 30h. It was then poured onto demineralized water (200ml_), and extracted with EtOAc (3 x 100ml_). The organic phases were combined, dried over Na2S04, filtered and subsequently concentrated in vacuo. The resulting residue was purified by flash chromatography with EtOAc/Hexane (1 : 1 ) to provide N-(1 -methyl-1 H-pyrazol-3- yl)pyridin-2-amine (3) as a yellow solid (0.75g, 68percent). LCMS (ES): Found 175.2 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-pyrazol-3-amine, other downstream synthetic routes, hurry up and to see.