Tag: M.W=0-100

Related Products of 1192-21-8,Some common heterocyclic compound, 1192-21-8, name is 1-Methyl-1H-pyrazol-5-amine, molecular formula is C4H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Electrolysis was carried out usinga B5-49 direct current source, 0.2 m aqueous NaOH as the supportingelectrolyte, in a glass temperature-controlled (25 ¡ãC) cell (V = 150 ml)with a NiO(OH) anode (S = 48 cm2) prepared by a reported procedure36and a Ti cathode (S = 20 cm2). The supporting electrolyte (100 ml) andamine 1a?e (0.003 mol) were placed into the cell and electrolysis wascarried out at a current of 290 mA. Once a 2 F per mole of the startingamine was passed (Q = 579 C), electrolysis was stopped. The reactionmixture was stirred for more 0.5 h in the absence of current and analyzedby TLC with light petroleum?ethyl acetate (1:1) as the eluent. ConcentratedHCl was then added to the reaction mixture to pH ~ 3 andthe mixture was extracted with CHCl3 (3¡Á50 ml). The extracts werecombined, dried with anhydrous MgSO4 and concentrated in vacuo.Column chromatography on SiO2 with light petroleum?ethyl acetate(10:1) as the eluent gave azopyrazoles 2a?e which were identified usingthe reported characteristics.26,28 The aqueous solution that remainedafter extraction (see above) was concentrated in vacuo and NaOH wasadded with stirring (to pH ~ 10). The nonreacted starting amines 1a?ewere extracted with CHCl3 (3¡Á30 ml) and identified by TLC and 1H NMR.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-pyrazol-5-amine, its application will become more common.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31230-17-8, name is 5-Methyl-1H-pyrazol-3-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 31230-17-8

A mixture of compound C (1.0 g, 2.94 mmol)and 3-amino-5-methylpyrazole (314 mg, 3.23 mmol) in dimethylforrnamide (6 ml) was treated with diisopropylethylamine (0.614 ml, 3.53 mmol) and sodium iodide (530 mg, 3.53 mmol). The mixture was stirred under nitrogen at 85 ¡ã for 4 hours, cooled to room temperature and diluted with ethyl acetate. The solution was washed with water (x 4), dried over magnesium sulphate and concentrated to 5 ml to afford, upon crystallization and harvesting of colourless crystals, the title compound D (920 mg, 78percent). 1H-NMR DMSO-d6, delta 0.80-0.87 (4H, m), 1.77-1.85 (IH, m), 1.92 (IH, s), 5.24 (IH, br s), 6.47 (IH, br s), 7.55 (2H, d), 7.70-7.80 (2H, m), 10.24 (IH, s), 10.47 (IH, s), 11.92 (IH, s).

The synthetic route of 31230-17-8 has been constantly updated, and we look forward to future research findings.

Application of 1192-21-8, The chemical industry reduces the impact on the environment during synthesis 1192-21-8, name is 1-Methyl-1H-pyrazol-5-amine, I believe this compound will play a more active role in future production and life.

3rd Generation BrettPhos precatalyst (12.42 mg, 0.01 mmol) was added to (5)-2-(2-chloro- 5-methylpyrimidin-4-yl)-6-methyl-7-((6-(trifluoromethyl)pyrimidm dihydroimidazo[l,2-a]pyrazin-8(5H)-one (Intermediate 87; 120 mg, 0.27 mmol), 1-methyl- lH-pyrazol-5-amine (66.5 mg, 0.69 mmol) and CS2CO3 (179 mg, 0.55 mmol) in 1,4- dioxane (4mL) at 25¡ãC under nitrogen. The resulting mixture was stirred at 100 ¡ãC for 8 hours. The solvent was then removed under reduced pressure. The crude product was purified by flash silica chromatography, elution gradient 0 to 6percent MeOH in DCM. Pure fractions were evaporated to dryness to afford a yellow residue. This residue was purified further by preparative HPLC (XSelect CSH Prep C18 OBD column, 5mu silica, 19 mm diameter, 150 mm length), using decreasingly polar mixtures of water (containing 0.03percent NH3) and MeCN as eluents. Fractions containing the desired compound were evaporated to dryness to afford (5)-6-methyl-2-(5-methyl-2-((l-methyl-lH-pyrazol-5- yl)amino)pyrimidin-4-yl)-7-((6-(trifluoromethyl)pyrimidin-4-yl)methyl)-6,7- dihydroimidazo[l,2-a]pyrazin-8(5H)-one (Example 32; 60 mg, 43.9percent) as a white solid. H NMR (300 MHz, DMSO) delta 1.25 (d, 3H), 3.71 (s, 3H), 4.14 – 4.21 (m, 1H), 4.34 – 4.46 (m, 1H), 4.56 – 4.71 (m, 2H), 5.27 (d, 1H), 6.32 (d, 1H), 7.35 (d, 1H), 7.98 (s, 1H), 8.13 (d, 1H), 8.34 (s, 1H), 9.24 (s, 1H), 9.41 (s, 1H). m/z (ES+), [M+H]+ = 499.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-pyrazol-5-amine, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 36650-74-5,Some common heterocyclic compound, 36650-74-5, name is 1H-Pyrazole-3-carbonitrile, molecular formula is C4H3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a suspension of Compound SA (100 mg, 0.25 mmol) in THF (25 niL) was added lH-pyrazole- 3-carbonitrile (70 mg, 0.75 mmol) and K2CO3 ( 103 mg, 0.75mmol). The mixture was stirred at 35C for 15h. Then the reaction mixture was extracted 50 mL EtOAc, washed with 100 111L H20 and 100 mL brine and evaporated in vacuo. The resulting residue was purified by reverse- phase prep-HPLC to afford SA-22 as a white solid ( 23 mg, 0.056mnol, 24 % yield). 1H NMR (500 MHz, CDCI3), delta (ppm), 7.48 (d, IH), 6.73 (d, IH), 5.03(1H,AB), 4.93(1H,AB), 2.60 (t,lH), 1.00-2.25 (24H, m), 0.68 (s, 3H). LCMS: Rt = 2.38 mm, MS (ESI) m/z: 410.2 [M+H] +

The synthetic route of 36650-74-5 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 81945-73-5, name is 1H-Pyrazol-1-ol, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 81945-73-5, Quality Control of 1H-Pyrazol-1-ol

Methyl-phenyl-carbamic Acid pyrazol-1-yl Ester The title compound was prepared from 1-hydroxypyrazole and N-methyl-N-phenylcarbamoyl chloride. The crude product was subjected to flash chromatography (Quad flash 25, EtOAc-heptane) (79%, oil which slowly crystallizes). HPLC-MS m/z=218.1 (M+1), Rt: 2.82 min. Mp 63-67 C. deltaH(300 MHz; CDCl3): 3.45 (bs, 3H), 6.28 (s, 3H), 7.30-7.47 (m, 7H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 288-13-1, name is 1H-Pyrazole, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C3H4N2

4-( 1 H-pyrazol- 1 -yl)- benzonitrile4-Fluorobenzonitrile (204.2 g), pyrazole (138.6 g, 1.22 eq) and potassium carbonate (281.5 g, 1.22 eq) in DMF (1110 ml) were heated at 120 0C for 7 hours. The suspension was cooled to 25 0C and water (2920 ml) added. The reaction was extracted with MTBE (3 x 1460 ml) and the combined extracts were washed with water (3 x 1460 ml) and saturated aqueous sodium chloride (1460 ml). The organic phase was concentrated at atmospheric pressure until the pot temperature rose to 65 0C. Heptane (1700 ml) was added over 30 minutes at 60-65 0C, and then a further 300 ml of distillate was collected. The solution was stirred at 60-65 0C for 15 minutes and then cooled to <5 0C. The slurry was filtered and washed with heptane (2 x 200 ml), and dried under vacuum to constant weight to give the title compound as a solid (245.3 g, 87%). 1H NMR (400 MHz, CDCl3): 6.51 (q, IH), 7.71 (d, 2H), 7.75 (d, IH), 7.81 (d, 2H), 7.98 (d, IH).

According to the analysis of related databases, 288-13-1, the application of this compound in the production field has become more and more popular.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1453-58-3, name is 3-Methylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 1453-58-3

General procedure: The N-nucleophile (1.47 mmol), CuI (Sigma-Aldrich, 99.999percent purity, 0.147 mmol), MnF2 (Sigma-Aldrich, 98percent purity, 0.441 mmol), KOH (2.94 mmol), the aryl halide (2.21 mmol), trans-1,2-diaminocyclohexane (0.294 mmol) and water (0.75 mL) were added to a reaction vial and a screw cap was fitted to it. The reaction mixture was stirred under air in a closed system at 60C for 24 h. After cooling to room temperature, the mixture was diluted with dichloromethane and filtered through a pad of Celite. The combined organic extracts were dried with anhydrous Na2SO4 and the solvent was removed under reduced pressure. The crude product was purified by silica-gel column chromatography to afford the N-arylated product. The identity and purity of known products was confirmed by 1H and 13C NMR spectroscopic analysis.

The synthetic route of 1453-58-3 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 28466-26-4, name is 4-Aminopyrazole, molecular formula is C3H5N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 28466-26-4

Compound 31-a (130 mg, 1.5 mmol) and compound 5 (222 mg, 0.5 mmol) were dissolved in n-butanol (10 mL), p-toluene sulfonic acid monohydrate (344 mg, 2.0 mmol) was added. The mixture was heated to 120 C. and stirred for 3 hours. After cooled to room temperature, the mixture was treated with saturated aqueous sodium bicarbonate solution (10 mL), then extracted with dichloromethane (10 mL¡Á3). The organic layers were combined, washed with water (10 mL¡Á3) and saturated brine (10 mL) in sequence, dried over anhydrous sodium sulfate, then filtrated. The residue was purified by preparation HPLC (mobile phase:water (0.04% trifluoroacetic acid), acetonitrile; gradient: 32%-62%) to give compound T-31 (143 mg, yield: 61%). LC-MS (ESI): m/z=470 [M+H]+. (0255) 1H-NMR (400 MHz, DMSO-d6) delta: 9.43 (s, 1H), 8.81 (s, 1H), 8.37 (s, 1H), 8.34 (d, J=4.0 Hz, 1H), 7.87 (s, 2H), 739 (d, J=4.0 Hz, 1H), 4.57 (d, J=8 Hz, 2H), 4.27 (d, J=8 Hz, 2H), 3.91 (s, 4H), 3.24 (q, J=6 Hz, 2H), 1.25 (t, J=6 Hz, 3H) ppm

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 28466-26-4, its application will become more common.

Application of 930-36-9, These common heterocyclic compound, 930-36-9, name is 1-Methylpyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 1. Synthesis of 2-methyl-2H-pyrazole-3-carbaldehyde In a dry 50 ml Vial is placed a solution of 1.642 g (20 mmol) N-Methylpyrazole in 30 ml dry THF. The mixture is cooled to -20 C and while stirring 8 ml (20 mmol, 2.5M in hexane) n-BuLi-solution is slowly added. The reaction mixture is stirred for 2.5 h at -20 C. With vigorous stirring 4.7 ml (4.39g, 60 mmol) dry DMF is slowly added at -20 C and the mixture kept at this temperature for 1 h. The reaction mixture is then poured into 100 ml of a 1 M acetic acid / sodium acetate buffer (pH: 4.5), 50 ml MTBE is added and the organic layer is separated, washed with 50 ml sat. Na2CO3-solution to remove excess acetic acid (extraction with ethyl acetate leads to DMF in the final product). The organic layer is separated, dried with MgSO4 and the solvent is removed by om a rotary evaporator. The crude product is purified by vacuum distillation (bp: 67 C, 21 mbar). 3 preparations which were distilled together yielded 5.969g (54 mmol, 90%) of the title compound. 1H-NMR (300 MHz, CDCl3): 4.18 (s, 3H, CH3-N), 6.91 (d, 1H, 3J=2.0 Hz, CH=C-N), 7.53 (d, 1H, 3J=2.0 Hz, CH=N), 9.87 (s, 1H, CH=O) ppm. 13C-NMR (100 MHz, CDCl3): 39.31 (CH3-N), 114.78 (CH=C-N), 138.54 (CH=N), 138.98 (CH=C-N), 179.83 (CH=O) ppm.

Statistics shows that 1-Methylpyrazole is playing an increasingly important role. we look forward to future research findings about 930-36-9.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 930-36-9, name is 1-Methylpyrazole, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 1-Methylpyrazole

N-methylpyrazole (16.4 g, 200 mmol) and acetic anhydride (38 mL, 400 mmol) were added to the reaction flask.Concentrated sulfuric acid (1 mL, 20 mmol) was added dropwise with stirring, and then reacted under a nitrogen atmosphere at 140 C for 12 h.After the reaction is completed, the system is poured into ice water, extracted with dichloromethane, dried over anhydrous sodium sulfate, and the solvent is removed for column chromatography.(Eluent: Petroleum ether / EtOAc (v/v) = 3/1) afforded 17.7 g of product as a yellow oil. Yield: 71%.

According to the analysis of related databases, 930-36-9, the application of this compound in the production field has become more and more popular.