Tag: M.W:200-300

Related Products of 15802-75-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 15802-75-2, name is 4-Iodo-3-methyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.

Under nitrogen protection,To a 10 ml Schlek reaction tube (a glass instrument commonly used in anhydrous oxygenless operation) was added 1.0 mmol2-iodo-5- (2-iodopyrimidine-3) pyrimidine, 2.0 mmol of 3-methyl-4-iodopyrazole, 0.03 mmol of palladium acetate,0.05 mmol di-t-butyl (2 ‘, 4′, 6′-triisopropyl-3,6-dimethoxybiphenyl-2-yl)4.0 mmol of sodium tert-butoxide, and 5 ml of toluene, the reaction tube was purged with nitrogen three times,And then heated to 110 C with an oil bath under magnetic stirring, and the reaction was refluxed for 24 hours. Down to room temperatureThe reaction solution was further added, 3.0 mmol of 4-carboxyphenylboronic acid, 0.02 mmol of palladium acetate, 0.04 mmol2′-dicyclohexyl-2,6-dimethoxy-3-sulfonic acid-1,1’-biphenyl sodium salt, 7.0 mmol sodium carbonate,And 100 mmol of water; then heated to 100 C with an oil bath under magnetic stirring and the reaction was refluxed for 24 hours.Down to room temperature; add 20 ml of water, filtration, with concentrated hydrochloric acid to adjust the pH of the filtrate to 1, room temperature stirring 3h,Filtered, washed with ethanol, dried product 16, yield 72%. The product (C30H22N8O4)Of the mass spectrum (ESI) of 558.20.

The chemical industry reduces the impact on the environment during synthesis 4-Iodo-3-methyl-1H-pyrazole. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Luoyang Normal College; Li Hongmei; Xu Chen; Wang Zhiqiang; Tu Tianyong; Hao Xinqi; (10 pag.)CN106674208; (2017); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 129768-30-5 as follows. category: pyrazoles-derivatives

Example 11; N-(2-ethoxybenzyl)-1-(1-(2-(methylamino)ethyl)piperidin-4-yl)-3-(trifluoromethyl)-1 H-pyrazole-5-carboxamide (98); Step 1 tert-butyl 4-(5-(ethoxycarbonyl)-3-(trifluoromethyl)-1 H-pyrazol-1-yl)piperidine-1- carboxylate (93); [0268] tert-Butyl 4-iodopiperidine-i-carboxylate (5 683, 18 26 mmol, E G Corley et al, JOC, 2004, 69, 5120-5123) in DMF (30 7 ml) was added to a mixture of ethyl 3- (trifluoromethyl)-1 H-pyrazole-5-carboxylate (3 2 g, 15 37 mmol, M -A Plancquaert et al, Tetrahedron, 52, 4383-4396) and potassium carbonate 95 31 g, 38 4 mmol) and the mixture was stirred at 80oC for 16h After cooling, water was added and the mixture was extracted with EtOAc, and the organic extraxts were dried, filtered and concentrated Chromatographic purification of the residue by Biotage (5-20% EtOAc m Hexanes, 25M column) gave compound 93 as colorless oil (2 4 g, 39 9% yield) LFRMS (ESI) calc 391 4, found 414 1 (M+Na)+

According to the analysis of related databases, 129768-30-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; METHYLGENE INC.; WO2008/104077; (2008); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 5932-30-9, These common heterocyclic compound, 5932-30-9, name is Ethyl 5-phenyl-1H-pyrazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The starting material (100 mg, 0.46 mmol) was dissolved in 10 mL of acetone.Add potassium carbonate (190 mg, 1.38 mmol) and potassium iodide (8 mg, 0.046 mmol),Dimethyl sulfate (31.5 mg, 0.25 mmol), refluxing for 4 h,After TLC detects the reaction, it is filtered.The filter cake was washed with 10 mL of ethyl acetate and 10 mL of dichloromethane until no fluorescence.The filtrates were combined and concentrated.Column chromatography purification (petroleum ether: ethyl acetate = 4:1)Yellow solid99mg,Yield 93.4%,

The synthetic route of 5932-30-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; China Pharmaceutical University; Wang Jinxin; Yang Kan; Zhi Zhuoer; Nong Keyi; (8 pag.)CN109232426; (2019); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile

[0383] A mixture of 5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile (1.0 g, 3.6mmol), ethyl2-(l-benzylpiperidin-4-ylidene)acetate (1.1 g, 4.3 mmol) and K2C03 (745 mg, 5.4mmol) in DMF (20 mL) was heated to 80 °C for 16 hr under N2? The reaction was quenchedwith water (20 mL) and extracted with EA (20 mL x 3). The combined organic layers were driedover Na2S04, concentrated and purified by chromatography column on silica gel using 30percent ofEA in PEas eluant to give the product (950 mg, 54.9percent) as a yellow solid. 1H NMR (400 MHz,DMSO-d6) 8 11.92 (s, 1H), 7.84 (d, J = 8.8 Hz, 2H), 7.48-7.40 (m, 2H), 7.36-7.29 (m, 4H), 7.27-7.23 (m, 1H), 7.20 (t, J = 7.6 Hz, 1H), 7.15-7.07 (m, 4H), 3.55 (s, 2H), 3.01 (s, 2H), 2.81-2.73(m, 2H), 2.39-2.27 (m, 2H), 2.26-2.16 (m, 2H), 1.83-1.74 (m, 2H). MS (ESI, m/e) [M+1t 489.9.

The synthetic route of 330792-70-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GUO, Yunhang; BEIGENE, LTD.; WANG, Zhiwei; WO2014/173289; (2014); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 16078-71-0, name is Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16078-71-0, Recommanded Product: Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate

A mixture of 1.50 g (6 mmol) of ethyl 5-amine-1-phenyl-1Hpyrazole-4-carboxylate (13) and 20 mL of 85% phosphoric acidwas maintained under reflux and stirring for 6 h at 170 C. Aftercompletion of the reaction, 50 mL of crushed ice was added, andthen the mixture was basified to pH 7 with NaOH (6 M aq). Themixture was extracted with dichloromethane (3 30 mL). Thecombined organic solution was washed with water (3 50 mL),dried (anhydrous sodium sulfate), filtered, and concentrated undervacuum to afford 14 as a brown oil.Yield: 86%. IR (KBr. cm1): 3418-3182; 1618; 1597; 1550;760-694. 1H NMR (400 MHz, CDCl3, TMS, d in ppm): 3.84 (s, 2H,NH2); 5.61 (d, 1H, J = 2.0 Hz, H4); 7.42 (d, 1H, J = 1.8 Hz, H3);7.57-7.32 (m, 5H, H20, H30, H40, H50, H60). 13C NMR (100 MHz,CDCl3, TMS, d in ppm): 90.6; 123.9; 127.4; 129.4; 138.6; 140.3;144.7. EI [M1] 157.8.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Silva, Thais B.; Bernardino, Alice M.R.; Ferreira, Maria de Lourdes G.; Rogerio, Kamilla R.; Carvalho, Leonardo J.M.; Boechat, Nubia; Pinheiro, Luiz C.S.; Bioorganic and Medicinal Chemistry; vol. 24; 18; (2016); p. 4492 – 4498;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 15001-11-3, These common heterocyclic compound, 15001-11-3, name is Ethyl 5-amino-1-(p-tolyl)-1H-pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate (2a, 1.60 g, 6.92 mmol) in 4N HCl in 1,4-dioxane (35 mL) at room temperature was added methyl cyanoformate (1.77 g, 20.8 mmol). The mixture was stirred at 100 C for 14 h and was cooled to room temperature. After 1,4-dioxane was removed in vacuo and the residue was partitioned between methylene chloride and water. The organic layer was dried over magnesium sulfate and was evaporated in vacuo. The residue was chromatographed on a silica gel column with a mixture of methylene chloride and ethyl acetate (7:1) to give the desired product 3a (1.47 g, 78 %).

The synthetic route of 15001-11-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Heo, Yun-Jeong; Jeon, Moon-Kook; Tetrahedron; vol. 73; 40; (2017); p. 5959 – 5973;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 18048-64-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 18048-64-1 as follows.

5- (2-hydroxy-3-amino-5,6,7,8-tetrahydronaphthalen-2-yl) – furan-2-carboxylic acid(1.0g, 3.66m mol), dissolved in 40ml 1mol / l of HCl solution, cooled to0 , thereto was slowly added dropwise of NaNO2(303 mg of the, 4.39m mol) in 40ml aqueoussolution; BI dropwise, maintaining the reaction temperature of the reaction was continued for 30min, TLC trace starting material 5- (2-hydroxy – 3-amino-5,6,7,8-tetrahydronaphthalen-2-yl) -furan-2-carboxylic acid.Was added1- (3,4-dimethylphenyl) methyl-1H-pyrrol-5 (4 hydrogen) -one (740 mg of, -3-3.66m mol), adjusted pH with saturated sodium bicarbonate solution after 15min about 8, was added40ml of absolute ethanol, the reaction naturally to room temperature.24h after LC-MS testing of raw materials reactionwas complete.Filtered, the filter cake washed with water to prepare a suspension adjust PH around 5, and then filtered, the filter cake after dryingcolumn chromatography to obtain the target product (Z) -5- (3- (2- (1- (3,4-dimethyl phenyl) -3-methyl-5-oxo-1,5-dihydro – pyrazol-4-ylidene) hydrazino) -2-hydroxy-5,6,7,8-tetrahydronaphthalene -1 -yl) – furan-2-carboxylic acid (compound 18) (192mg, 10.8% yield).

According to the analysis of related databases, 18048-64-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Qilu Pharmaceutical Co., Ltd; Wang, Jingyi; Fan, Chuanwen; Zhang, Long; Yan, Shousheng; Zhang, Soming; Zhao, Hongbing; Zhou, Haojie; Yang, Chuanwei; Zhao, Hongling; Yang, Yingying; (46 pag.)CN103360317; (2016); B;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 15802-75-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15802-75-2, name is 4-Iodo-3-methyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Under nitrogen protection,To a 10 ml Schlek reaction tube (a glass instrument commonly used in anhydrous oxygenless operation) was added 1.0 mmolBromo-5- (4- (6-bromopyridyl-3) phenyl) pyridine, 2.2 mmol3-methyl-4-iodopyrazole,0.03 mmol of palladium acetate, 0.05 mmol of di-t-butyl (2 ‘, 4′, 6′-triisopropyl-3,6-dimethoxybiphenyl-2-yl) phosphine, 6.0 mmol of sodium tert-butoxide ,And 5 ml of toluene,The reaction tube was purged with nitrogen three times,And then heated to 110 C with an oil bath under magnetic stirring, and the reaction was refluxed for 24 hours. Down to room temperatureThe reaction solution was further added, 4.0 mmol of 4-carboxyphenylboronic acid, 0.03 mmol of palladium acetate,0.06 mmol 2′-dicyclohexylphosphino-2,6-di-I-propyl-4-sulfonate-1,1’-biphenyl sodium,8.0 mmol of potassium carbonate, and 100 mmol of water; and then heated to 100 C with an oil bath under magnetic stirring,The reaction was refluxed for 40 hours. Down to room temperature; add 20 ml of water, filtration, with concentrated hydrochloric acid to adjust the pH of the filtrate to 1,After stirring at room temperature for 3 h, the mixture was filtered, washed with ethanol and dried to obtain product 21, yield 77%.The mass spectrum (ESI) data for this product (C38H28N6O4) was 632.26.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodo-3-methyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Luoyang Normal College; Li Hongmei; Xu Chen; Wang Zhiqiang; Tu Tianyong; Hao Xinqi; (10 pag.)CN106674208; (2017); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 294877-29-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 294877-29-5 name is 1-(3-Bromophenyl)-3,5-dimethyl-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Synthesis of 3-(3-(3,5-dimethyl-1H-pyrazol-1-yl)phenoxy)-9,9-dimethyl-10-(pyridin-2-yl)-9,10-dihydroacridine ON’1 ligand To a solution of Fg-1 (302 mg, 1 mmol) in DMSO (5 mL) were added 1-(3-bromophenyl)-3,5-dimethyl-1H-pyrazole (301 mg, 1.2 mmol), CuI (19 mg, 0.1 mmol), 2-picolinic acid (25 mg, 0.2 mmol), and K3PO4 (318 mg, 1.5 mmol) under the protection of N2. The mixture was heated to 100 C. and maintained at this temperature for 2 days. The reaction was cooled to room temperature and 20 mL was then added. The mixture was extracted with ethyl acetate and dried with anhydrous Na2SO4.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(3-Bromophenyl)-3,5-dimethyl-1H-pyrazole, and friends who are interested can also refer to it.

Reference:
Patent; Arizona Board of Regents on behalf of Arizona State University; Li, Jian; Li, Guijie; Zhu, Zhi-Qiang; US2015/349279; (2015); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 16078-71-0, These common heterocyclic compound, 16078-71-0, name is Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Ethyl 5-amino-1-phenylpyrazole-4-carboxylate (2.31 g) was added to 20 mL of formamide and heated to 180 C. for 4 hours.Cool to room temperature, add 30ml of water, filter and filter cake washed with ethanol (2 x 10mL).Obtained 1-phenyl-pyrazole [3,4-d]pyrimidine-4-one, 1.93 g, 91% yield, HPLC: 98.08%.

Statistics shows that Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate is playing an increasingly important role. we look forward to future research findings about 16078-71-0.

Reference:
Patent; Central South University of Forestry and Technology; Ma Qiang; Wang Wenlei; Hu Yunchu; Xie Lianwu; Wen Ruizhi; (8 pag.)CN107955008; (2018); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics