M.W=250-300 | Page 10 of 19 | pyrazoles-derivatives

Srivastava, Manish Kumar’s team published research in Main Group Metal Chemistry in 37 | CAS: 4551-69-3

Main Group Metal Chemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C6H8N2, COA of Formula: C17H14N2O2.

Srivastava, Manish Kumar published the artcileCoordination propensity of N-protected amino acids and sterically congested heterocyclic 尾-diketones toward BuSnCl₃: preparation and structural features of some new seven coordinated organic-inorganic hybrid formulations of monobutyltin(IV), COA of Formula: C17H14N2O2, the publication is Main Group Metal Chemistry (2014), 37(3-4), 75-83, database is CAplus.

Organotin carboxylate complexes I (1–4; 1, X = CH₂CH, R = H, R¹ = Ph; 2, X = CH₂CH, R = H, R¹ = Me; 3, X = CH, R = s-Bu, R¹ = Ph; 4, X = CH, R = s-Bu, R¹ = 4-ClC₆H₄) and II (5–8; 5, X = CH₂CH, R = H, R¹ = P h; 6, X = CH, R = s-Bu, R¹ = Ph; 7, X = CH, R = s-Bu, R¹ = 4-ClC₆H₄; 8, X = CH, R = s-Bu, R¹ = Me), derived from phthaloyl-protected amino acids, were prepared by the reactions of monobutyltin(IV) chloride with sodium salts of N-protected amino acids and sterically congested heterocyclic 尾-diketones in 1:1:1 and 1:2:1 molar ratios in refluxing dry THF and characterized by spectral methods. Plausible structures of these N-protected amino acids and sterically congested heterocyclic 尾-diketones-modified BuSnCl₃ formulations were suggested on the basis of physicochem. and spectral studies. These newly prepared organic-inorganic hybrid complexes of monobutyltin(IV) contain seven coordinated tin centers as revealed by ¹¹⁹Sn NMR spectral data.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Ryu, Jae Wook’s team published research in Bioorganic & Medicinal Chemistry Letters in 21 | CAS: 1190875-39-8

Bioorganic & Medicinal Chemistry Letters published new progress about 1190875-39-8. 1190875-39-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Piperidine,Boronic acid and ester,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (1-(1-(tert-Butoxycarbonyl)piperidin-4-yl)-1H-pyrazol-4-yl)boronic acid, and the molecular formula is C13H22BN3O4, Recommanded Product: (1-(1-(tert-Butoxycarbonyl)piperidin-4-yl)-1H-pyrazol-4-yl)boronic acid.

Ryu, Jae Wook published the artcileDesign and synthesis of triazolopyridazines substituted with methylisoquinolinone as selective c-Met kinase inhibitors, Recommanded Product: (1-(1-(tert-Butoxycarbonyl)piperidin-4-yl)-1H-pyrazol-4-yl)boronic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(23), 7185-7188, database is CAplus and MEDLINE.

A series of triazolopyridazines substituted with methylisoquinolinone, e.g. I (R = Ph, pyrrolidin-1-yl, thiazol-3-yl, 3-FC₆H₄), were designed and synthesized. Some of the triazolopyridazines strongly inhibited c-Met kinase and showed good anti-proliferative activity against a panel of c-Met-amplified gastric cancer cell lines (MKN-45, SNU-5 and Hs746T).

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Wang, Yu’s team published research in He Huaxue Yu Fangshe Huaxue in 36 | CAS: 4551-69-3

He Huaxue Yu Fangshe Huaxue published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C6H8O3, Product Details of C17H14N2O2.

Wang, Yu published the artcilePreparation of trace single oxidation state plutonium solutions, Product Details of C17H14N2O2, the publication is He Huaxue Yu Fangshe Huaxue (2014), 36(4), 200-204, database is CAplus.

The trace levels of single oxidation state plutonium (Pu(IV,V,VI)) solution was prepared, and the stability was monitored over time. The oxidation state distribution of the solution was analyzed by solvent extraction methods, in which Pu (IV) was extracted with TTA and Pu (IV + VI) was separated by HDEHP. The Pu (IV) solution is prepared by heating the solution until dryness in 1 mol/L HNO₃ repeatedly, and Pu (VI) solution is obtained by keeping Pu (IV) in 0.5-1 mol/L HNO₃-0.1 mmol/L KMnO₄ system for 24 h. Pu (1M) is reduced automatically to Pu (V) in the dark for 5 d. All of these single plutonium solutions could not keep steady in PH = 3.0, 0.01 mol/L NaCl system. Consequently, single oxidation state plutonium solutions need to be prepared freshly for each experiment

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Pei, Lixia’s team published research in Polymers (Basel, Switzerland) in 9 | CAS: 4551-69-3

Polymers (Basel, Switzerland) published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Related Products of pyrazoles-derivatives.

Pei, Lixia published the artcileHomo- and copolymerizations of ethylene and norbornene using bis(尾-ketoamino) titanium catalysts containing pyrazolone rings, Related Products of pyrazoles-derivatives, the publication is Polymers (Basel, Switzerland) (2017), 9(7), 262/1-262/12, database is CAplus and MEDLINE.

A series of bis(尾-ketoamino) titanium complexes containing pyrazolone rings (1-3) have been synthesized, characterized, and used as precursors for homo- and copolymerization of ethylene and norbornene. The titanium complexes activated with methylaluminoxane (MAO) exhibited good activities for homopolymerization of ethylene (E) to produce linear polyethylenes (PEs). Ethylene-norbornene copolymers (E-N) were also prepared by these catalysts with moderate activities, and influences of ligand substituents and norbornene addition on copolymer microstructure were studied in detail. Microstructure anal. of the E-N copolymers by ¹³C NMR and differential scanning calorimetry (DSC) techniques showed that alternating (ENEN) and isolated (ENEE) norbornene predominately appeared in the copolymer chain, and the NN dyad and NNN triad sequences were also present in the copolymers obtained by the less bulky catalyst 1.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Thakar, Amit S.’s team published research in South African Journal of Chemistry in 68 | CAS: 4551-69-3

South African Journal of Chemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C16H12O, Product Details of C17H14N2O2.

Thakar, Amit S. published the artcileIsolation, characterization and X-ray structure determination of the Schiff base ligand: 5-methyl-2-phenyl-4-[phenyl-(4-phenyl-thiazol-2-ylamino)- methylene]-2,4-dihydro-pyrazol-3-one, Product Details of C17H14N2O2, the publication is South African Journal of Chemistry (2015), 39-44, database is CAplus.

The structure of the amine tautomer of the new Schiff base derived from 4-benzoyl-5-methyl-2-phenyl-2,4-dihydro-pyrazol- 3-one and 4-phenyl-thiazol-2-ylamine was confirmed by means of single crystal X-ray diffraction. The title compound was synthesized and crystals were grown from a mixture of dichloromethane and n-hexane (1:3). Single crystal X-ray diffraction anal. showed that the structure was primarily stabilized by strong intramol. N3-H3A···O1 hydrogen bonds [N3-H3A = 0.883(19) Å, H3A···O1 = 1.925(18) Å, N3···O1 = 2.6901(13) Å, with an angle for N3-H3A···O1 = 144.1(17) °] and this lead to the formation of a pseudo nine-membered hydrogen bonded pattern. Elemental anal., FTIR and NMR analyses was employed to characterize the crystal.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Tsai, Chen-Yen’s team published research in RSC Advances in 4 | CAS: 4551-69-3

RSC Advances published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C6H12F3NO5S, Product Details of C17H14N2O2.

Tsai, Chen-Yen published the artcileRing-opening polymerization of cyclic esters initiated by zirconium, titanium and yttrium complexes, Product Details of C17H14N2O2, the publication is RSC Advances (2014), 4(28), 14527-14537, database is CAplus.

A series of dinuclear zirconium [(Lⁿ)Zr(OⁱPr)₂]₂[(μ-OⁱPr)₂] (1–3, n = 1-3) as well as mononuclear titanium [(L³)Ti(OⁱPr)₂] (4), yttrium [(L²)YCl] (5) and zirconium [(Lⁿ)Zr(OⁱPr)₂] (6, n = 4; 7, n = 5) salen-type complexes (Lⁿ = dianionic [ONNO]-tetradentate ancillary ligand) have been prepared and characterized. Dinuclear zirconium salen complexes [(Lⁿ)Zr(OⁱPr)₂]₂[(μ-OⁱPr)₂] (1–3) showed effective activity toward the ring opening polymerization of lactides and ε-caprolactone. However, mononuclear titanium, yttrium and zirconium complexes 4–7 are almost inactive for the ROP of L-lactide. Solvent-free bulk polymerization of L-lactide initiated by dinuclear zirconium complex 2 with a conversion > 90% can be achieved within 10 min, yielding high mol. weight polylactide with low polydispersity index. Kinetic studies reveal the ROP of L-lactide initiated by dinuclear zirconium complex 3 has a first-order dependency on [LA].

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

El-Kousy, S. M.’s team published research in International Journal of Chemistry (Calcutta, India) in 5 | CAS: 13599-22-9

International Journal of Chemistry (Calcutta, India) published new progress about 13599-22-9. 13599-22-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid,Benzene, name is 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid, and the molecular formula is C16H12N2O2, Application of 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid.

El-Kousy, S. M. published the artcileA study on rearrangement of arylazo furanones and pyrrolinones, Application of 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid, the publication is International Journal of Chemistry (Calcutta, India) (1994), 5(2), 65-75, database is CAplus.

Rearrangement of 5-phenyl-2,3-furandione 3-(phenylhydrazones) and 5-phenyl-2,3-furandione 3-[(4-chlorophenyl)hydrazones] gave 5-phenyl-1H-pyrrole-2,3-dione 3-(phenylhydrazones) and 5-phenyl-1H-pyrrole-2,3-dione 3-[(4-chlorophenyl)hydrazones]. Rearrangement of 5-phenyl-1H-pyrrole-2,3-dione 3-(phenylhydrazones) gave 1H-pyrazole-3-carboxylic acids. The oxopyrroline derivatives 4 were converted into 5 by treatment with phosphorous oxychloride. Replacement of chlorine atom in 5 was affected using aniline to give 6.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Zhang, Pengfei’s team published research in Asian Journal of Chemistry in 26 | CAS: 4551-69-3

Asian Journal of Chemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C44H28ClFeN4, Synthetic Route of 4551-69-3.

Zhang, Pengfei published the artcileSynthesis, crystal structure and quantum chemistry calculation of two novel compounds derived from amino-phenol, Synthetic Route of 4551-69-3, the publication is Asian Journal of Chemistry (2014), 26(18), 6176-6184, database is CAplus.

Two novel compounds [(Z)-3-(2-hydroxy-4-methylphenylimino)indolin-2-one][methanol] (A) and 4-[(Z)-(3-hydroxy-4-methoxyphenylimino)(phenyl)methyl]-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one (B) derived from aminophenol were synthesized and characterized by IR spectroscopy, elemental anal. and X-ray diffraction single-crystal anal. Compound A crystallized in monoclinic space group P21/c with a = 15.6637 (12) °, b = 12.3527 (9) °, c = 7.4461 (6) °, α = 90°, β = 100.9460 (10)°, γ = 90°, V = 1414.53 (19) nm³, Z = 4, F (000) = 600, S = 1.055, R₁ = 0392, wR₂ = 0.0967. Compound B crystallized in triclinic, space group P-1 with a = 8.8111 (9) °, b = 11.4716 (12) °, c = 11.4947 (14) °, α = 115.376 (2)°, β = 99.5470 (10)°, γ = 97.6320 (10)°, V = 1007.74 (19) nm³, Z = 2, F (000) = 420, S = 1.046, R₁ = 0.0643, wR₂ = 0.1479. Theor. studies of compounds A and B were carried out by d. functional theory B3LYP method. The results showed that N (1), O (1) and O (2) of compound A and N (3), O (1) and O (2) of compound B were major active sites. Furthermore, N (1) in compound A was preferentially attacked by nucleophilic, followed by the N (3) in compound B. The theor. studies showed that compound A may have higher biol. activity, such as anti-proliferative activity, compared with compound B. The result might be because that compound A was Schiff base and compound B showed proton transfer and tautomerism.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Saida, Keraghel’s team published research in Acta Crystallographica, Section E: Structure Reports Online in 68 | CAS: 4551-69-3

Acta Crystallographica, Section E: Structure Reports Online published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Application of 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one.

Saida, Keraghel published the artcile4-[(3-Hydroxyanilino)(phenyl)methylidene]-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one, Application of 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, the publication is Acta Crystallographica, Section E: Structure Reports Online (2012), 68(6), o1909-o1910, database is CAplus and MEDLINE.

In the title compound, C₂₃H₁₉N₃O₂, the dihedral angles formed by the pyrazolone ring with the three benzene rings are 30.91 (6), 60.96 (4) and 57.01 (4)°. The ligand is in the enamine-keto form and its structure is stabilized by an intramol. N-H···O hydrogen bond. In the crystal, O-H···N hydrogen bonds link mols. into chains parallel to [01-1]. Crystallog. data are given.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Maiwald, Martin M.’s team published research in Applied Geochemistry in 104 | CAS: 4551-69-3

Applied Geochemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Category: pyrazoles-derivatives.

Maiwald, Martin M. published the artcileThe complexation of neptunium(V) with fluoride at elevated temperatures: Speciation and thermodynamics, Category: pyrazoles-derivatives, the publication is Applied Geochemistry (2019), 10-18, database is CAplus.

The complexation of NpO⁺2 with fluoride is studied in aqueous solution using Vis/NIR absorption spectroscopy. The total ligand concentration (NaF), ionic strength (NaClO₄), and temperature (T = 20-85°C) is varied, yielding detailed information on the thermodn. of the complexation reaction. Two distinct complex species (NpO₂F^1-nn, n = 1, 2) are identified by peak deconvolution of the absorption spectra. At 20°C and I_m = 1.0 the absorption band of NpO₂F is located at 983.8 ± 0.2 nm. The absorption band of the NpO₂F^–2 complex is located at 988.4 ± 0.2 nm. With increasing temperature and ionic strength the chem. equilibrium of the complexation reaction shifts towards the complexed Np(V) species. The conditional stability constants log β’_n(T) are calculated according to the law of mass action and are extrapolated to I_m = 0 for each temperature with the specific ion interaction theory (SIT). The determined log β⁰n(T) values increase by 0.2-0.6 in the studied temperature range. Furthermore, the log β⁰n(T) values correlate linearly with the reciprocal temperature and fitting the data according to the integrated Van’t Hoff equation yields the standard reaction enthalpies (Δ_rH⁰m) and entropies (Δ_rS⁰m).

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics