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Moraes, Paulo A.’s team published research in ChemistrySelect in 2020 | CAS: 20154-03-4

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Formula: C4H3F3N2

Formula: C4H3F3N2In 2020 ,《Pyrazole-Enaminones as Promising Prototypes for the Development of Analgesic Drugs》 appeared in ChemistrySelect. The author of the article were Moraes, Paulo A.; Brum, Evelyne S.; Brusco, Indiara; Marangoni, Mario A.; Lobo, Marcio M.; Camargo, Adriano F.; Nogara, Pablo A.; Bonacorso, Helio G.; Martins, Marcos A. P.; Da Rocha, Joao Batista T.; Oliveira, Sara M.; Zanatta, Nilo. The article conveys some information:

This study reports the chemo- and regioselective synthesis, at good yields, of (E)-4-(amino)-1,1,1-trifluoro-5-(4,5-alkyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)pent-3-en-2-ones (pyrazole-enaminones), from the of N-alkylation reaction of trifluoromethyl pyrazoles with 5-bromo enaminones. The obtained compounds were tested as potential analgesics in a screening test involving mice. Three of these compounds significantly reduced the spontaneous nociception induced by the application of capsaicin, which is an algogenic substance. Compound I presented satisfactory antinociceptive activity compared to celecoxib, a drug used as a pos. control, without promoting locomotor changes in the mice. Moreover, mol. modeling simulations showed that compound I interacts with the cyclooxygenase enzyme at the same binding site as celecoxib. Together, present data suggest that compound I is a promising prototype for the development of new analgesic drugs. After reading the article, we found that the author used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Formula: C4H3F3N2)

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Cheema, Hammad’s team published research in Dyes and Pigments in 2015 | CAS: 20154-03-4

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Computed Properties of C4H3F3N2

In 2015,Cheema, Hammad; Islam, Ashraful; Han, Liyuan; El-Shafei, Ahmed published 《Monodentate pyrazole as a replacement of labile NCS for Ru (II) photosensitizers: Minimum electron injection free energy for dye-sensitized solar cells》.Dyes and Pigments published the findings.Computed Properties of C4H3F3N2 The information in the text is summarized as follows:

A mono-dentate ligand of 3-(trifluoromethyl) pyrazole, instead of the labile isothiocyanate ligand for Ru (II) photosensitizers, was developed. This mol. modulation resulted in a new structure motif (HD-11) with 50 nm red shift in the low energy metal-to-ligand charge transfer (MLCT) absorption peak. However, electrochem. measurements revealed that both ground and excited state oxidation potentials were stabilized, this is attributed to the presence of strong electron withdrawing group CF3 tethered to pyrazole, which resulted in more free energy for dye regeneration, but less driving force for electron injection into the conduction band of TiO2. Hence HD-11, resulted in lower Jsc of 12.89 mA cm-2 compared to 17.07 mA cm-2 of N719 under similar conditions. Addnl., Voc of HD-11 was lower than N719, owing to decreased eTiO2 life time of 0.674 ms compared to 8.8 ms of N719 for injected electrons as found by impedance measurements. In addition to this study using 3-(Trifluoromethyl)-1H-pyrazole, there are many other studies that have used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Computed Properties of C4H3F3N2) was used in this study.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Akrem, A. A.’s team published research in Tetrahedron Letters in 1973 | CAS: 15366-34-4

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Name: Methyl 1H-pyrazole-3-carboxylate

In 1973,Akrem, A. A.; Kvasyuk, E. I.; Mikhailopulo, I. A. published 《Unusual reaction of 3-(methoxycarbonyl)-Δ2-pyrazoline with lead tetraacetate》.Tetrahedron Letters published the findings.Name: Methyl 1H-pyrazole-3-carboxylate The information in the text is summarized as follows:

The title reaction gave 70% 3-(methoxycarbonyl)-1-[1-(methoxycarbonyl)-cyclopropyl]pyrazole (I) and 14% 3-(methoxycarbonyl)-1-[3-(methoxycarbonyl)pyrazol-1-yl]-2-pyrazoline (II). NMR, ir, and uv spectral data for I, II, 3-(methoxycarbonyl)pyrazole, and 7-acetyl-3-(methoxycarbonyl)-2-pyrazoline were determined The experimental process involved the reaction of Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Name: Methyl 1H-pyrazole-3-carboxylate)

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

De Mendoza, Javier’s team published research in Heterocycles in 1985 | CAS: 15366-34-4

Formula: C5H6N2O2In 1985 ,《N,N’-Linked biazoles. Part 5. Synthesis of pyrazolyl dimers by the reaction of 3-methoxycarbonyl-2-pyrazoline with lead tetraacetate》 appeared in Heterocycles. The author of the article were De Mendoza, Javier; Rosario Gonzalez-Muniz, M.; Rosario Martin, M.. The article conveys some information:

Depending on the reaction conditions, the title oxidation gave all products earlier reported and several new ones, e.g. I-III. In the experiment, the researchers used Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Formula: C5H6N2O2)

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Maspero, Angelo’s team published research in Solid State Sciences in 2013 | CAS: 114474-26-9

4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, monoamine oxidase inhibitory, anti-inflammatory, antidiabetic and antibacterial activities. Electric Literature of C9H7N3O2

《Synthesis and solid-state structure of thermally stable linear bi-pyrazoles》 was written by Maspero, Angelo; Cernuto, Giuseppe; Galli, Simona; Palmisano, Giovanni; Tollari, Stefano; Masciocchi, Norberto. Electric Literature of C9H7N3O2 And the article was included in Solid State Sciences on August 31 ,2013. The article conveys some information:

The long and rigid bi-pyrazolyl-based ligands 2,6-bis[4-(1H-pyrazol-4-yl)phenyl]pyrrolo[3,4-f]isoindole-1,3,5,7(2H,6H)-tetrone, , and 2,5-bis[4-(1H-pyrazol-4-yl)phenyl]thiazolo[5,4-d]thiazole, were isolated in pure form, with satisfying yields, as very insoluble polycrystalline materials. Their thermal behavior was studied by coupling thermal analyses and variable-temperature x-ray powder diffraction measurements. Their crystal structures were unraveled from powder diffraction data by a rather unconventional structure determination approach, without the a priori knowledge of the unit cell parameters. Inline with shorter analogs, successfully employed in the formation of porous MOFs with intriguing functional properties, 2,6-bis[4-(1H-pyrazol-4-yl)phenyl]pyrrolo[3,4-f]isoindole-1,3,5,7(2H,6H)-tetrone and 2,5-bis[4-(1H-pyrazol-4-yl)phenyl]thiazolo[5,4-d]thiazole are promising to construct higher-porosity materials, potentially capable of hosting nano-sized guests.4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9Electric Literature of C9H7N3O2) was used in this study.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Akhrem, A. A.’s team published research in Zhurnal Obshchei Khimii in 1976 | CAS: 15366-34-4

Formula: C5H6N2O2In 1976 ,《Modified nucleosides. V. Synthesis of pyrazole nucleosides》 appeared in Zhurnal Obshchei Khimii. The author of the article were Akhrem, A. A.; Garbuz, N. I.; Kvasyuk, E. I.; Mikhailopulo, I. A.. The article conveys some information:

Pyrazole nucleosides I, II (R = Ac, R1 = OEt) were obtained in 52 and 26% yields by treatment of Et acetoxymethylpyrazolecarboxylate with α-D-glucopyranose pentaacetate. Subsequent aminolysis yielded 90% I, II (R = H, R1 = NH2). Analogously obtained were 71 and 11% III, IV (R = Bz, R1 = Ac, R2 = OEt) which were treated with NH3 to give 90% III, IV (R = R1 = H, R2 = NH2). Similar results were obtained by glucosylation of Me pyrazolecarboxylate and by ribosylation of Et 4-acetoxymethyl-3-pyrazolecarboxylate. The experimental part of the paper was very detailed, including the reaction process of Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Formula: C5H6N2O2)

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Yuan, Jingli’s team published research in Journal of Luminescence in 2004 | CAS: 15366-34-4

Computed Properties of C5H6N2O2In 2004 ,《Synthesis and luminescence properties of lanthanide(III) chelates with polyacid derivatives of thienyl-substituted terpyridine analogues》 was published in Journal of Luminescence. The article was written by Yuan, Jingli; Tan, Mingqian; Wang, Guilan. The article contains the following contents:

Two new polyacid derivative ligands of thienyl-substituted terpyridine analogs, N,N,N1,N1-[4′-(2”’-thienyl)-2,2′:6′,2”-terpyridine-6,6”-diyl]bis(methylenenitrilo) tetrakis(acetic acid) (TTTA) and N,N,N1,N1-[2,6-bis(3′-aminomethyl-1′-pyrazolyl)-4-(2”-thienyl)pyridine]tetrakis(acetic acid) (BTTA), were synthesized, and the luminescence properties of their Eu3+ and Tb3+ chelates were studied. The Eu3+chelates of the two ligands are strongly luminescent having luminescence quantum yields of 0.150 (TTTA-Eu3+) and 0.114 (BTTA-Eu3+), and lifetimes of 1.284 ms (TTTA-Eu3+) and 1.352 ms (BTTA-Eu3+), whereas their Tb3+ chelates are weakly luminescent. The TTTA-Eu3+ chelate was used for streptavidin (SA) labeling, and the labeled SA was used for time-resolved fluoroimmunoassay of insulin in human sera. The method gives the detection limits of 33 pg ml-1. In the part of experimental materials, we found many familiar compounds, such as Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Computed Properties of C5H6N2O2)

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Zerbi, Giuseppe’s team published research in Spectrochimica Acta in 1962 | CAS: 52096-24-9

1-Butyl-1H-pyrazole(cas: 52096-24-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Recommanded Product: 52096-24-9

The author of 《Infrared spectra of pyrazoles. I. Monoalkyl-substituted pyrazoles》 were Zerbi, Giuseppe; Alberti, Carlo. And the article was published in Spectrochimica Acta in 1962. Recommanded Product: 52096-24-9 The author mentioned the following in the article:

The compounds studied were pyrazole, 3-alkyl-, 4-alkyl-, and N-alkylpyrazole, where the substituents were Me, Et, Pr, Bu, and amyl. The spectral region was 2-15 μ. Observed bands can be used to recognize the pyrazole structure and the position of the substituent. Most of the observed bands were assigned. In addition to this study using 1-Butyl-1H-pyrazole, there are many other studies that have used 1-Butyl-1H-pyrazole(cas: 52096-24-9Recommanded Product: 52096-24-9) was used in this study.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Molander, Gary A.’s team published research in Organic Letters in 2010 | CAS: 1258323-45-3

Potassium trifluoro(1-methyl-1H-pyrazol-5-yl)borate(cas: 1258323-45-3) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Related Products of 1258323-45-3

Molander, Gary A.; Argintaru, O. Andreea; Aron, Ioana; Dreher, Spencer D. published their research in Organic Letters on December 17 ,2010. The article was titled 《Nickel-Catalyzed Cross-Coupling of Potassium Aryl- and Heteroaryltrifluoroborates with Unactivated Alkyl Halides》.Related Products of 1258323-45-3 The article contains the following contents:

A method for the cross-coupling of alkyl electrophiles with various potassium aryl- and heteroaryltrifluoroborates has been developed. Nearly stoichiometric amounts of organoboron species could be employed to cross-couple a large variety of challenging heteroaryl nucleophiles. Several functional groups were tolerated on both the electrophilic and the nucleophilic partners. Chemoselective reactivity of C(sp3)-Br bonds in the presence of C(sp2)-Br bonds was achieved. In the experiment, the researchers used many compounds, for example, Potassium trifluoro(1-methyl-1H-pyrazol-5-yl)borate(cas: 1258323-45-3Related Products of 1258323-45-3)

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Kabir, M. Shahjahan’s team published research in Organic Letters in 2010 | CAS: 20154-03-4

Safety of 3-(Trifluoromethyl)-1H-pyrazoleIn 2010 ,《First Application of an Efficient and Versatile Ligand for Copper-Catalyzed Cross-Coupling Reactions of Vinyl Halides with N-Heterocycles and Phenols》 appeared in Organic Letters. The author of the article were Kabir, M. Shahjahan; Lorenz, Michael; Namjoshi, Ojas A.; Cook, James M.. The article conveys some information:

2-Pyridin-2-yl-1H-benzoimidazole (I) is presented as a new, efficient, and versatile bidentate N-donor ligand suitable for the copper-catalyzed formation of vinyl C-N and C-O bonds. This inexpensive and easily prepared ligand facilitates copper-catalyzed cross-coupling reactions of alkenyl bromides and iodides with N-heterocycles and phenols to afford the desired cross-coupled products in good to excellent yields with full retention of stereochem. This method is particularly noteworthy given its efficiency, i.e., mild reaction conditions, low catalyst loading, simplicity, versatility, and exceptional level of functional group tolerance. The results came from multiple reactions, including the reaction of 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Safety of 3-(Trifluoromethyl)-1H-pyrazole)

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics