Tag: 100-200

Shi, Jiale; Yuan, Tao; Wang, Rong; Zheng, Meifang; Wang, Xinchen published their research in Green Chemistry in 2021. The article was titled 《Boron carbonitride photocatalysts for direct decarboxylation: the construction of C(sp3)-N or C(sp3)-C(sp2) bonds with visible light》.COA of Formula: C5H6N2O2 The article contains the following contents:

A metal-free protocol was established for the decarboxylative N-H or C(sp2)-H functionalization of acids via metal-free boron carbon nitride (BCN) photocatalysis, delivering the desired products under ambient conditions. This methodol.was applicable to the late-stage modification of pharmaceutical mols. and gram-scale experiments as well as in the recovery and reuse of the photocatalysts without the loss of reactivity. The developed photochem. reaction system fulfills the requirements of green and sustainable chem. In the experiment, the researchers used Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4COA of Formula: C5H6N2O2)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.COA of Formula: C5H6N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《Efficient copper-catalyzed cross-coupling of nitrogen nucleophiles with N,N-dibenzyl-4-iodobenzenesulfonamide and its application in the synthesis of Celecoxib intermediate》 was written by Yong, Fui-Fong; Azri, Miskal; Darrell Lim, Yong-En; Teo, Yong-Chua. Product Details of 20154-03-4 And the article was included in Tetrahedron in 2020. The article conveys some information:

A practical and efficient strategy has been developed for the cross-coupling of N,N-dibenzyl-4-iodobenzenesulfonamide with nitrogen nucleophiles using 0.5-20 mol% of CuI under ligand-free conditions. A variety of nitrogen nucleophiles including nitrogen heterocycles, sulfonamides and amides afforded the corresponding products in moderate to good yields (up to 98%) under the optimized conditions. The application of this catalytic system to the synthesis of Celecoxib intermediate was also successfully demonstrated. In addition to this study using 3-(Trifluoromethyl)-1H-pyrazole, there are many other studies that have used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Product Details of 20154-03-4) was used in this study.

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Product Details of 20154-03-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2014,Seo, Samuel; Simoni, Luke D.; Ma, Mengting; DeSilva, M. Aruni; Huang, Yong; Stadtherr, Mark A.; Brennecke, Joan F. published 《Phase-Change Ionic Liquids for Postcombustion CO2 Capture》.Energy & Fuels published the findings.Recommanded Product: 3-(Trifluoromethyl)-1H-pyrazole The information in the text is summarized as follows:

Phase-change ionic liquids, or PCILs, are salts that are solids at normal flue gas processing temperatures (e.g., 40-80°) and that react stoichiometrically and reversibly with CO2 (one mole of CO2 for every mole of salt at typical postcombustion flue gas conditions) to form a liquid Thus, the m.p. of the PCIL-CO2 complex is below that of the pure PCIL. A new concept for CO2 separation technol. that uses this key property of PCILs offers the potential to significantly reduce parasitic energy losses incurred from postcombustion CO2 capture by using the heat of fusion (ΔHfus) to provide part of the heat needed to release CO2 from the absorbent. The phase transition yields almost a step-change absorption isotherm, so only a small pressure or temperature swing is required between the absorber and the stripper. Using aprotic heterocyclic anions (AHAs), the enthalpy of reaction with CO2 can be readily tuned, and the phys. properties, such as m.p., can be adjusted by modifying the alkyl chain length of the tetra-alkylphosphonium cation. Here, the authors present data for 4 tetrabutylphosphonium salts that exhibit PCIL behavior, as well as detailed measurements of the CO2 solubility, phys. properties, phase transition behavior, and H2O uptake for tetraethylphosphonium benzimidazolide ([P2222][BnIm]). The process based on [P2222][BnIm] has the potential to reduce the amount of energy required for the CO2 capture process substantially compared to the current technol. that employs aqueous monoethanolamine (MEA) solvents. The experimental part of the paper was very detailed, including the reaction process of 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Recommanded Product: 3-(Trifluoromethyl)-1H-pyrazole)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Recommanded Product: 3-(Trifluoromethyl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2015,Huang, Qi; Tran, Gael; Gomez Pardo, Domingo; Tsuchiya, Tomoki; Hillebrand, Stefan; Vors, Jean-Pierre; Cossy, Janine published 《Palladium-catalyzed phosphonylation of pyrazoles substituted by electron-withdrawing groups》.Tetrahedron published the findings.SDS of cas: 20154-03-4 The information in the text is summarized as follows:

A series of bromopyrazoles substituted by electron-withdrawing groups such as an ester, a trifluoromethyl group or a cyano group was involved in Pd-catalyzed phosphonylation. Moderate to good yields were obtained in the corresponding phosphonylated pyrazoles. In the experimental materials used by the author, we found 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4SDS of cas: 20154-03-4)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.SDS of cas: 20154-03-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of C4H3F3N2In 2019 ,《Phosphine Ligand-Free Ruthenium Complexes as Efficient Catalysts for the Synthesis of Quinolines and Pyridines by Acceptorless Dehydrogenative Coupling Reactions》 appeared in ChemCatChem. The author of the article were Guo, Bin; Yu, Tian-Qi; Li, Hong-Xi; Zhang, Shi-Qi; Braunstein, Pierre; Young, David J.; Li, Hai-Yan; Lang, Jian-Ping. The article conveys some information:

A series of phosphine-free Ru(III)/Ru(II) complexes of NH functionalized N N N pincer ligands exhibit excellent activity for acceptorless dehydrogenative coupling (ADC) of secondary alcs. RCH(OH)CH2R1 [R = Ph, thiophen-2-yl, Et, etc.; R1 = H, Me, Et, n-Pr; RR1 = -(CH2)4-] and bicyclo[2.2.1]heptan-2-ol with 2-aminobenzyl 2-NH2-R3C6H3CH(R2)OH [R2 = H, Me; R3 = H, 5-Me, 4-Cl] or γ-amino alcs. R4CH(NH2)(CH2)2OH (R4 = Ph, Me) to quinolines I (R5 = H, 6-Me, 7-Cl), 1,2,3,4-tetrahydro-1,4-methanoacridine and pyridines II. Ru(III) complexes [LRuCl3] III (R6 = R7 = R8 = H, R9 = Cl; R6 = H, R7 = R8 = Me, R9 = Cl; R6 = R7 = H, R8 = Ph, R9 = Cl, etc.) were obtained by refluxing RuCl3.xH2O with the corresponding ligand in EtOH. Five Ru(II) complexes [LRu(DMSO-κS)Cl2] III [R9 = S(CH3)2(O)] were formed by reducing the corresponding Ru(III) complex in refluxing EtOH. The latter complexes could also be prepared directly by refluxing Ru(DMSO)4Cl2 with the corresponding ligand in EtOH. These Ru(III) and Ru(II) complexes, especially III exhibited high catalytic efficiency and broad functional group tolerance in ADC reactions of secondary alcs. with 2-aminobenzyl or γ-amino alcs. to quinolines I and pyridines II. A detail mechanistic study indicated that the Ru(III) complex III (R9 = Cl) was reduced into the Ru(II) species III (R9 = S(CH3)2(O)), which was the active catalytic center for ADC via a Ru-H/N-H bifunctional outer-sphere mechanism. This protocol provides a reliable, atom-economical and environmentally benign procedure for C-N and C-C bond formation. In the experimental materials used by the author, we found 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Synthetic Route of C4H3F3N2)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Synthetic Route of C4H3F3N2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Yang, Tao; Li, Xiaoqian; Deng, Shuang; Qi, Xiaotian; Cong, Hengjiang; Cheng, Hong-Gang; Shi, Liangwei; Zhou, Qianghui; Zhuang, Lin published an article in 2022. The article was titled 《From N-H Nitration to Controllable Aromatic Mononitration and Dinitration-The Discovery of a Versatile and Powerful N-Nitropyrazole Nitrating Reagent》, and you may find the article in JACS Au.Reference of Methyl 1H-pyrazole-3-carboxylate The information in the text is summarized as follows:

Herein,the identification of a powerful nitrating reagent, 5-methyl-1,3-dinitro-1H-pyrazole, from the N-nitro-type reagent library constructed using a practical N-H nitration method was reported. This nitrating reagent behaved as a controllable source of the nitronium ion, enabling mild and scalable nitration of a broad range of (hetero)arenes with good functional group tolerance. Of note, this nitration method was controlled by manipulating the reaction conditions to furnish mononitrated or dinitrated product selectively. The value of this method in medicinal chem. was well established by its efficient late-stage C-H nitration of complex biorelevant mols. D. functional theory (DFT) calculations and preliminary mechanistic studies reveal that the powerfulness and versatility of this nitrating reagent were due to the synergistic “”nitro effect”” and “”methyl effect””.Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Reference of Methyl 1H-pyrazole-3-carboxylate) was used in this study.

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Reference of Methyl 1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《Magnesium-Catalyzed N2-Regioselective Alkylation of 3-Substituted Pyrazoles》 was published in Synlett in 2020. These research results belong to Xu, Di; Frank, Lena; Nguyen, Tina; Stumpf, Andreas; Russell, David; Angelaud, Remy; Gosselin, Francis. HPLC of Formula: 15366-34-4 The article mentions the following:

A highly regioselective Mg-catalyzed alkylation of 3-substituted pyrazoles, I (R1 = Ph, Br, i-Pr, etc.; R2 = H, Br, CHO) and 2,4-dihydro-[1]benzopyrano[4,3-c]pyrazole has been developed to provide N2-alkylated regioisomers II (R3 = C(O)N(CH3)2, C6H5, [4-(morpholin-4-yl)piperidin-1-yl]carbonyl, etc.) and 2-(1H,4H-chromeno[4,3-c]pyrazol-1-yl)-N,N-dimethylacetamide. Using α-bromoacetates like iso-Pr 2-bromoacetate and acetamides R3CH2Br as alkylating agents, this new method was applied to a variety of 3-substituted and 3,4-disubstituted pyrazoles I to produce the N2-alkylated products II with high regioselectivities ranging from 76:24 to 99:1 and 44-90% yields. In the experimental materials used by the author, we found Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4HPLC of Formula: 15366-34-4)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.HPLC of Formula: 15366-34-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Tanwar, Lalita; Boergel, Jonas; Lehmann, Johannes; Ritter, Tobias published their research in Organic Letters in 2021. The article was titled 《Selective C-H Iodination of (Hetero)arenes》.SDS of cas: 15366-34-4 The article contains the following contents:

A strategy for selective C-H iodination of (hetero)arenes was decribed with a broad functional group tolerance. The utility and differentiation to other iodination methods of supposed sulfonyl hypoiodites for a set of carboarenes and heteroarenes was described.Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4SDS of cas: 15366-34-4) was used in this study.

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.SDS of cas: 15366-34-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2016,Zhang, Jin; Jia, Run-Ping; Wang, Dong-Hui published 《Copper-catalyzed C-N cross-coupling of arylboronic acids with N-acylpyrazoles》.Tetrahedron Letters published the findings.Category: pyrazoles-derivatives The information in the text is summarized as follows:

A copper-catalyzed C-N bond forming reaction of arylboronic acids and N-acylpyrazoles was developed. This procedure used N-acetyl protected pyrazoles as starting material instead of free pyrazoles (NH). The reaction worked under neutral conditions and did not require any base or ligand. The reaction showed good functional group tolerance. In addition to this study using 3-(Trifluoromethyl)-1H-pyrazole, there are many other studies that have used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Category: pyrazoles-derivatives) was used in this study.

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Category: pyrazoles-derivatives

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The author of 《Acid Catalyzed N-Alkylation of Pyrazoles with Trichloroacetimidates》 were Meador, Rowan I. L.; Mate, Nilamber A.; Chisholm, John D.. And the article was published in Organics in 2022. Safety of 4-(4-Nitrophenyl)-1H-pyrazole The author mentioned the following in the article:

A new method for the N-alkylation of pyrazoles has been developed using trichloroacetimidate electrophiles C(Cl)3C=(NH)OR1 (R1 = 1-phenylethyl, 1-(naphthalen-2-yl)ethyl, benzyl, 2H-1,3-benzodioxol-5-yl(phenyl)methyl, etc.) and a Bronsted acid catalyst. These reactions provide ready access to N-alkyl pyrazoles, e.g., I, which are present in a variety of medicinally relevant lead structures. Benzylic, phenethyl and benzhydryl trichloroacetimidates provide good yields of the N-alkyl pyrazole products. Unsym. pyrazoles provide a mixture of the two possible regioisomers, with the major product being controlled by sterics. This methodol. provides an alternative to other alkylation methods that require strong base or high temperature In addition to this study using 4-(4-Nitrophenyl)-1H-pyrazole, there are many other studies that have used 4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9Safety of 4-(4-Nitrophenyl)-1H-pyrazole) was used in this study.

4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, antidiabetic and antibacterial activities. Safety of 4-(4-Nitrophenyl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics