Tag: 100-200

Kosuru, Someswara Rao et al. published their research in Inorganic Chemistry in 2017 | CAS: 15953-73-8

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.SDS of cas: 15953-73-8

Enhanced Catalytic Activity of Aluminum Complexes for the Ring-Opening Polymerization of ε-Caprolactone was written by Kosuru, Someswara Rao;Sun, Ting-Han;Wang, Li-Fang;Vandavasi, Jaya Kishore;Lu, Wei-Yi;Lai, Yi-Chun;Hsu, Sodio C. N.;Chiang, Michael Y.;Chen, Hsuan-Ying. And the article was included in Inorganic Chemistry in 2017.SDS of cas: 15953-73-8 This article mentions the following:

A series of dinuclear aluminum (Al2Pyr2) complexes bridged by two ligands were synthesized, and their catalytic activity toward ring-opening polymerization of ε-caprolactone (CL) was investigated. Different types of the Al-N-N-Al-N-N skeletal ring were found among these Al2Pyr2 complexes. The butterfly form, LThio2Al2Me4, exerted the highest catalytic activity for CL polymerization κ2-2-CL coordination with both Al centers within the butterly form LThio2Al2Me4 facilitates the initiation process. Generally speaking, the Al2Pyr2 complexes exhibited substantially higher catalytic activity for CL polymerization than literature examples such as β-diketiminate- or traiaza-bearing aluminum complexes. In fact, the Al2Pyr2 complexes can even carry out CL polymerization at 25°. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8SDS of cas: 15953-73-8).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.SDS of cas: 15953-73-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Zhuang, Wuyoung et al. published their research in Asian Journal of Chemistry in 2005 | CAS: 3528-58-3

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Application of 3528-58-3

Analysis of volatile constituents of Baimaohou (Camellia sinensis L.) by gas chromatography-mass spectrum was written by Zhuang, Wuyoung;Cai, Jibao;Su, Qingde. And the article was included in Asian Journal of Chemistry in 2005.Application of 3528-58-3 This article mentions the following:

Volatile oil of Baimaohou (Camellia sinensis L.) was obtained by simultaneous distillation-solvent extraction Following, the essential oil was analyzed by gas chromatog.-mass spectrum. 48 Components at least were identified, constituting approx. 74% of the oil. The main constituents of the essential oil were phytol (16.4%) and 5,6,7,7a-tetrahydro-4,4,7a-trimethyl-2(4H)-benzofuranone (10.6%), a very expensive flavor material. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Application of 3528-58-3).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Application of 3528-58-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Bouklah, M. et al. published their research in Applied Surface Science in 2005 | CAS: 19959-77-4

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Application In Synthesis of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine

Pyridine-pyrazole compound as inhibitor for steel in 1M HCl was written by Bouklah, M.;Attayibat, A.;Hammouti, B.;Ramdani, A.;Radi, S.;Benkaddour, M.. And the article was included in Applied Surface Science in 2005.Application In Synthesis of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine This article mentions the following:

The influence of 3,5-dimethyl-1H-pyrazole, pyridine and 2-(3-methyl-1H-pyrazol-5-yl) pyridine (P3) on the corrosion inhibition of carbon steel in 1M HCl solution was studied by using weight-loss, potentiodynamic and EIS measurements. P3 was the best inhibitor, and its inhibition efficiency increases with increasing inhibitor concentration to attain 89% at 10-3 M. Potentiodynamic polarization studies clearly reveal that it acts essentially as a cathodic inhibitor. The inhibitor decreased the corrosion rates. The efficiency values obtained by the various methods used were in agreement. Adsorption of P3 on the steel surface has an S-shaped adsorption isotherm. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Application In Synthesis of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Application In Synthesis of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Das, Rupasree R. et al. published their research in Materials Research Society Symposium Proceedings in 2005 | CAS: 934-48-5

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Electric Literature of C6H9N3O

A new bis-cyclometalated iridium (III) complex as a triplet emitter in organic light emitting devices was written by Das, Rupasree R.;Kwon, Ohyun;Byun, Younghun;Lyu, Yi-Yeol;Kim, Myeong Suk;Kim, Heekyung;Han, Eun Sil;Kim, Mu Gyum;Park, Jong-Jin;Pu, Lyong Sun. And the article was included in Materials Research Society Symposium Proceedings in 2005.Electric Literature of C6H9N3O This article mentions the following:

We report a new iridium(III) complex and the study of its optical, electrochem. and electroluminescence properties. The crystal structure shows an octahedral environment around Ir(III) center. OLED. D. functional theory (DFT) calculations indicate the contribution of the d-orbitals of Ir and the π-orbitals of the cyclometalating and ancillary ligands toward HOMO, whereas LUMO is concentrated on only the cyclometalating ligand. These complexes emit in the sky blue color region from an admixture of triplet metal-to-ligand-charge-transfer (3MLCT) and ligand π-π* states. A maximum external (ηex) quantum efficiency and luminance efficiency of 2.4% and 5.5 cd/A at 0.12 mA/cm2 was obtained from the device consisting of a 5% doped polymeric and low mol. host. A maximum brightness of 10,200 cd/m2 at 14.8 V was obtained from the device. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Electric Literature of C6H9N3O).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Electric Literature of C6H9N3O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Lyalin, Boris V. et al. published their research in Tetrahedron Letters in 2018 | CAS: 55361-49-4

1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Name: 1-Ethyl-1H-pyrazol-3-amine

Electrosynthesis of azopyrazoles via the oxidation of N-alkylaminopyrazoles on a NiO(OH) anode in aqueous alkali – A green method for N-N homocoupling was written by Lyalin, Boris V.;Sigacheva, Vera L.;Kokorekin, Vladimir A.;Petrosyan, Vladimir A.. And the article was included in Tetrahedron Letters in 2018.Name: 1-Ethyl-1H-pyrazol-3-amine This article mentions the following:

A nickel oxyhydroxide [NiO(OH)] anode was exploited to develop a new synthetic route for the electrocatalytic N-N homocoupling of N-alkylaminopyrazoles in an alk. aqueous medium. The advantages of this green electrochem. methodol. include low cost, atom economy and high yields. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4Name: 1-Ethyl-1H-pyrazol-3-amine).

1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Name: 1-Ethyl-1H-pyrazol-3-amine

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Hoehn, Hans et al. published their research in Zeitschrift fuer Chemie in 1970 | CAS: 3528-58-3

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.HPLC of Formula: 3528-58-3

5-Aminopyrazoles synthesis was written by Hoehn, Hans. And the article was included in Zeitschrift fuer Chemie in 1970.HPLC of Formula: 3528-58-3 This article mentions the following:

1-(R-Substituted)-5-aminopyrazoles and their 3-methyl and 4-methyl derivatives (57 compounds where R = aliphatic, cycloaliphatic, aralkyl, 2-furylmethyl, or 2-thienylmethyl) were prepared by treating CHR1:CR2CN (R1 = H, Me, etc., R2 = H, Me, Et) with N2H4 to give NH2NHCHR1CHR2CN, adding aldehyde or ketone R3R4CO to give R3CR4:NNHCHR1CHR2CN and treating the hydrazone with BuONa for 2-5 hr at 90-130°. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3HPLC of Formula: 3528-58-3).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.HPLC of Formula: 3528-58-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Yang, Guo-Ping et al. published their research in Applied Organometallic Chemistry in 2018 | CAS: 15953-73-8

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Safety of 4-Chloro-3,5-dimethyl-1H-pyrazole

Cu1.5PMo12O40-catalyzed condensation cyclization for the synthesis of substituted pyrazoles was written by Yang, Guo-Ping;He, Xing;Yu, Bing;Hu, Chang-Wen. And the article was included in Applied Organometallic Chemistry in 2018.Safety of 4-Chloro-3,5-dimethyl-1H-pyrazole This article mentions the following:

A convenient and direct approach has been developed for the preparation of pyrazole derivatives by the condensation cyclization of hydrazines/hydrazide and 1,3-diketones in the presence of Cu1.5PMo12O40 (0.33 mol%) under mild conditions (r.t.-60°, 10-30 min). Notably, the reaction was found to be scalable as 99% yield was obtained when the reaction was performed at a 5-mmol scale. This solvent-free and halogen-free catalytic system represents an effective economic and environmentally friendly method for the construction of pyrazoles. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Safety of 4-Chloro-3,5-dimethyl-1H-pyrazole).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Safety of 4-Chloro-3,5-dimethyl-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

North, E. Jeffrey et al. published their research in Bioorganic & Medicinal Chemistry in 2013 | CAS: 55361-49-4

1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Application In Synthesis of 1-Ethyl-1H-pyrazol-3-amine

Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3-heteroaryl ureas with improved in vitro pharmacokinetic properties was written by North, E. Jeffrey;Scherman, Michael S.;Bruhn, David F.;Scarborough, Jerrod S.;Maddox, Marcus M.;Jones, Victoria;Grzegorzewicz, Anna;Yang, Lei;Hess, Tamara;Morisseau, Christophe;Jackson, Mary;McNeil, Michael R.;Lee, Richard E.. And the article was included in Bioorganic & Medicinal Chemistry in 2013.Application In Synthesis of 1-Ethyl-1H-pyrazol-3-amine This article mentions the following:

Out of the prominent global ailments, tuberculosis (TB) is still one of the leading causes of death worldwide due to infectious disease. Development of new drugs that shorten the current tuberculosis treatment time and have activity against drug resistant strains is of utmost importance. Towards these goals we have focused our efforts on developing novel anti-TB compounds with the general structure of 1-adamantyl-3-Ph urea. This series is active against Mycobacteria and previous lead compounds were found to inhibit the membrane transporter MmpL3, the protein responsible for mycolic acid transport across the plasma membrane. However, these compounds suffered from poor in vitro pharmacokinetic (PK) profiles and they have a similar structure/SAR to inhibitors of human soluble epoxide hydrolase (sEH) enzymes. Therefore, in this study the further optimization of this compound class was driven by three factors: (1) to increase selectivity for anti-TB activity over human sEH activity, (2) to optimize PK profiles including solubility and (3) to maintain target inhibition. A new series of 1-adamantyl-3-heteroaryl ureas was designed and synthesized replacing the Ph substituent of the original series with pyridines, pyrimidines, triazines, oxazoles, isoxazoles, oxadiazoles and pyrazoles. This study produced lead isoxazole, oxadiazole and pyrazole substituted adamantyl ureas with improved in vitro PK profiles, increased selectivity and good anti-TB potencies with sub μg/mL min. inhibitory concentrations In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4Application In Synthesis of 1-Ethyl-1H-pyrazol-3-amine).

1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Application In Synthesis of 1-Ethyl-1H-pyrazol-3-amine

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Tundel, Rachel E. et al. published their research in Journal of Organic Chemistry in 2006 | CAS: 3528-58-3

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Application of 3528-58-3

Expedited Palladium-Catalyzed Amination of Aryl Nonaflates through the Use of Microwave-Irradiation and Soluble Organic Amine Bases was written by Tundel, Rachel E.;Anderson, Kevin W.;Buchwald, Stephen L.. And the article was included in Journal of Organic Chemistry in 2006.Application of 3528-58-3 This article mentions the following:

Microwave-assisted, palladium-catalyzed C-N bond-forming reactions with aryl/heteroaryl nonaflates and amines using the soluble amine bases DBU or MTBD and ligands 2,4,6-(Me2CH)3C6H2C6H4PR2-2 [R = cyclohexyl, CMe3] and XantPhos resulted in good to excellent yields (71-99%) of arylamines in short reaction times (1-45 min). In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Application of 3528-58-3).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Application of 3528-58-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Gough, Geo. A. C. et al. published their research in Journal of the Chemical Society in 1933 | CAS: 45887-08-9

3-(1H-Pyrazol-3-yl)pyridine (cas: 45887-08-9) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Application of 45887-08-9

4-Nitro-5-(3-pyridyl)pyrazole, a new oxidation product of nicotine. III. Confirmatory synthetical experiments was written by Gough, Geo. A. C.;King, Harold. And the article was included in Journal of the Chemical Society in 1933.Application of 45887-08-9 This article mentions the following:

The by-product in the oxidation of nicotine to nicotinic acid, 4-nitro-5-(3-pyridyl)pyrazole (C. A. 26, 990), gives the 4-NH2 derivative, which on deamination gives 3-(5-pyridyl)pyrazole (I), whose picrate, crystals with 1 H2O, m. 194-5°, methiodide, m. 217.5°, methopicrate, m. 185°, flavianate, crystals with 2 H2O, orange, m. 229° (decomposition). β-Pyridoylacetone and N2H4 give quant. 3-methyl-5-(3-pyridyl)pyrazole, crystals with 1.5 H2O, m. 81-3°, and then 137-8°; picrate, m. 202-3°; HCl salt, m. 214-6°; oxidation with KMnO4 gives 5-(3-pyridyl)pyrazole-3-carboxylic acid, m. 308-10° (decomposition); picrate, m. 242-5°; heating at 310° gives I. In the experiment, the researchers used many compounds, for example, 3-(1H-Pyrazol-3-yl)pyridine (cas: 45887-08-9Application of 45887-08-9).

3-(1H-Pyrazol-3-yl)pyridine (cas: 45887-08-9) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Application of 45887-08-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics